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Emerging key roles for P2X receptors in the kidney.

Birch RE, Schwiebert EM, Peppiatt-Wildman CM, Wildman SS.

Front Physiol. 2013 Sep 27;4:262. doi: 10.3389/fphys.2013.00262. eCollection 2013.


The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa.

Tucker TA, Fortenberry JA, Zsembery A, Schwiebert LM, Schwiebert EM.

BMC Physiol. 2012 Sep 24;12:12. doi: 10.1186/1472-6793-12-12.


Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease.

Olteanu D, Liu X, Liu W, Roper VC, Sharma N, Yoder BK, Satlin LM, Schwiebert EM, Bevensee MO.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1436-51. doi: 10.1152/ajpcell.00063.2011. Epub 2012 Feb 1.


Compelling "metabolomic" biomarkers may signal PKD pathogenesis.

Schwiebert EM.

Am J Physiol Renal Physiol. 2010 May;298(5):F1103-4. doi: 10.1152/ajprenal.00095.2010. Epub 2010 Mar 3. No abstract available.


Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts.

Wang K, Ho SR, Mao W, Huang P, Zhang F, Schwiebert EM, Kudlow JE, Paterson AJ.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):70-6. doi: 10.1016/j.bbrc.2009.06.132. Epub 2009 Jul 3.


Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway.

Liang L, MacDonald K, Schwiebert EM, Zeitlin PL, Guggino WB.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C131-41. doi: 10.1152/ajpcell.00346.2008. Epub 2008 Nov 5.


Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion.

Richards-Williams C, Contreras JL, Berecek KH, Schwiebert EM.

Purinergic Signal. 2008 Dec;4(4):393-405. doi: 10.1007/s11302-008-9126-y. Epub 2008 Oct 23.


Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts.

Hovater MB, Olteanu D, Welty EA, Schwiebert EM.

Purinergic Signal. 2008 Jun;4(2):109-24. doi: 10.1007/s11302-008-9102-6. Epub 2008 Apr 26.


Extracellular zinc and ATP-gated P2X receptor calcium entry channels: New zinc receptors as physiological sensors and therapeutic targets.

Schwiebert EM, Liang L, Cheng NL, Williams CR, Olteanu D, Welty EA, Zsembery A.

Purinergic Signal. 2005 Dec;1(4):299-310. doi: 10.1007/s11302-005-0777-7. Epub 2005 Dec 3.


Purinergic signaling microenvironments: An introduction.

Schwiebert EM, Fitz JG.

Purinergic Signal. 2008 Jun;4(2):89-92. doi: 10.1007/s11302-007-9091-x.


Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals.

Hovater MB, Olteanu D, Hanson EL, Cheng NL, Siroky B, Fintha A, Komlosi P, Liu W, Satlin LM, Bell PD, Yoder BK, Schwiebert EM.

Purinergic Signal. 2008 Jun;4(2):155-70. doi: 10.1007/s11302-007-9072-0. Epub 2007 Nov 13.


Extracellular autocrine nucleotide signalling in a microenvironment: integrative physiology in a minute volume of airway surface liquid.

Schwiebert EM.

J Physiol. 2007 Apr 15;580(Pt. 2):359-60. Epub 2007 Mar 15. No abstract available.


Altered pH(i) regulation and Na(+)/HCO3(-) transporter activity in choroid plexus of cilia-defective Tg737(orpk) mutant mouse.

Banizs B, Komlosi P, Bevensee MO, Schwiebert EM, Bell PD, Yoder BK.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1409-16. Epub 2006 Dec 20.


Intraluminal autocrine purinergic signaling within cysts: implications for the progression of diseases that involve encapsulated cyst formation.

Olteanu D, Hovater MB, Schwiebert EM.

Am J Physiol Renal Physiol. 2007 Jan;292(1):F11-4. Epub 2006 Aug 29. No abstract available.


Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells.

Siroky BJ, Ferguson WB, Fuson AL, Xie Y, Fintha A, Komlosi P, Yoder BK, Schwiebert EM, Guay-Woodford LM, Bell PD.

Am J Physiol Renal Physiol. 2006 Jun;290(6):F1320-8. Epub 2006 Jan 5.


Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus.

Banizs B, Pike MM, Millican CL, Ferguson WB, Komlosi P, Sheetz J, Bell PD, Schwiebert EM, Yoder BK.

Development. 2005 Dec;132(23):5329-39.


Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia.

Olteanu D, Yoder BK, Liu W, Croyle MJ, Welty EA, Rosborough K, Wyss JM, Bell PD, Guay-Woodford LM, Bevensee MO, Satlin LM, Schwiebert EM.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C952-63. Epub 2005 Oct 5.


Correlation between DNA transfer and cystic fibrosis airway epithelial cell correction after recombinant adeno-associated virus serotype 2 gene therapy.

Flotte TR, Schwiebert EM, Zeitlin PL, Carter BJ, Guggino WB.

Hum Gene Ther. 2005 Aug;16(8):921-8.


RNA interference targeted to multiple P2X receptor subtypes attenuates zinc-induced calcium entry.

Liang L, Zsembery A, Schwiebert EM.

Am J Physiol Cell Physiol. 2005 Aug;289(2):C388-96. Epub 2005 Mar 30.


Gene delivery systems--gene therapy vectors for cystic fibrosis.

Klink D, Schindelhauer D, Laner A, Tucker T, Bebok Z, Schwiebert EM, Boyd AC, Scholte BJ.

J Cyst Fibros. 2004 Aug;3 Suppl 2:203-12.


Purinergic signaling underlies CFTR control of human airway epithelial cell volume.

Braunstein GM, Zsembery A, Tucker TA, Schwiebert EM.

J Cyst Fibros. 2004 Jun;3(2):99-117.


Extracellular zinc and ATP restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry.

Zsembery A, Fortenberry JA, Liang L, Bebok Z, Tucker TA, Boyce AT, Braunstein GM, Welty E, Bell PD, Sorscher EJ, Clancy JP, Schwiebert EM.

J Biol Chem. 2004 Mar 12;279(11):10720-9. Epub 2003 Dec 29.


Activation of chloride secretion in cystic fibrosis cells and tissues by the substituted imidazole SRI 2931.

Jones JR, Schwiebert EM, DuVall MD, Venglarik CJ, Wen H, Kovacs T, Mazur M, Clancy JP, Braunstein G, Bates E, Greer H, Maddry JA, Sorscher EJ.

Biochemistry. 2003 Nov 18;42(45):13241-9.


Extracellular ATP as a signaling molecule for epithelial cells.

Schwiebert EM, Zsembery A.

Biochim Biophys Acta. 2003 Sep 2;1615(1-2):7-32. Review.


Sustained calcium entry through P2X nucleotide receptor channels in human airway epithelial cells.

Zsembery A, Boyce AT, Liang L, Peti-Peterdi J, Bell PD, Schwiebert EM.

J Biol Chem. 2003 Apr 11;278(15):13398-408. Epub 2003 Feb 3.


Impaired ability of the Na+/Ca2+ exchanger from the Dahl/Rapp salt-sensitive rat to regulate cytosolic calcium.

Hwang EF, Williams I, Kovacs G, Peti-Peterdi J, Siroky B, Rice WC, Bates E, Schwiebert EM, Unlap MT, Bell PD.

Am J Physiol Renal Physiol. 2003 May;284(5):F1023-31. Epub 2003 Jan 14.


Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids.

Tucker TA, Varga K, Bebok Z, Zsembery A, McCarty NA, Collawn JF, Schwiebert EM, Schwiebert LM.

Am J Physiol Cell Physiol. 2003 Mar;284(3):C791-804. Epub 2002 Nov 6.


Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression.

Peter K, Varga K, Bebok Z, McNicholas-Bevensee CM, Schwiebert L, Sorscher EJ, Schwiebert EM, Collawn JF.

J Biol Chem. 2002 Dec 20;277(51):49952-7. Epub 2002 Oct 9.


Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys.

Schwiebert EM, Wallace DP, Braunstein GM, King SR, Peti-Peterdi J, Hanaoka K, Guggino WB, Guay-Woodford LM, Bell PD, Sullivan LP, Grantham JJ, Taylor AL.

Am J Physiol Renal Physiol. 2002 Apr;282(4):F763-75.


Extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cells.

Schwiebert LM, Rice WC, Kudlow BA, Taylor AL, Schwiebert EM.

Am J Physiol Cell Physiol. 2002 Feb;282(2):C289-301.


Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability.

Roman RM, Lomri N, Braunstein G, Feranchak AP, Simeoni LA, Davison AK, Mechetner E, Schwiebert EM, Fitz JG.

J Membr Biol. 2001 Oct 1;183(3):165-73.


Extracellular nucleotide signaling along the renal epithelium.

Schwiebert EM, Kishore BK.

Am J Physiol Renal Physiol. 2001 Jun;280(6):F945-63. Review.


ATP release mechanisms, ATP receptors and purinergic signalling along the nephron.

Schwiebert EM.

Clin Exp Pharmacol Physiol. 2001 Apr;28(4):340-50. Review.


Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation.

Braunstein GM, Roman RM, Clancy JP, Kudlow BA, Taylor AL, Shylonsky VG, Jovov B, Peter K, Jilling T, Ismailov II, Benos DJ, Schwiebert LM, Fitz JG, Schwiebert EM.

J Biol Chem. 2001 Mar 2;276(9):6621-30. Epub 2000 Nov 10.


Evidence for Gd(3+) inhibition of membrane ATP permeability and purinergic signaling.

Roman RM, Feranchak AP, Davison AK, Schwiebert EM, Fitz JG.

Am J Physiol. 1999 Dec;277(6):G1222-30. doi: 10.1152/ajpgi.1999.277.6.G1222.


Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptors.

McCoy DE, Taylor AL, Kudlow BA, Karlson K, Slattery MJ, Schwiebert LM, Schwiebert EM, Stanton BA.

Am J Physiol. 1999 Oct;277(4):F552-9. doi: 10.1152/ajprenal.1999.277.4.F552.


Epithelial P2X purinergic receptor channel expression and function.

Taylor AL, Schwiebert LM, Smith JJ, King C, Jones JR, Sorscher EJ, Schwiebert EM.

J Clin Invest. 1999 Oct;104(7):875-84.


ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys.

Wilson PD, Hovater JS, Casey CC, Fortenberry JA, Schwiebert EM.

J Am Soc Nephrol. 1999 Feb;10(2):218-29.


CFTR is a conductance regulator as well as a chloride channel.

Schwiebert EM, Benos DJ, Egan ME, Stutts MJ, Guggino WB.

Physiol Rev. 1999 Jan;79(1 Suppl):S145-66. Review.


ABC transporter-facilitated ATP conductive transport.

Schwiebert EM.

Am J Physiol. 1999 Jan;276(1):C1-8. doi: 10.1152/ajpcell.1999.276.1.C1. Review.


Bioluminescence detection of ATP release mechanisms in epithelia.

Taylor AL, Kudlow BA, Marrs KL, Gruenert DC, Guggino WB, Schwiebert EM.

Am J Physiol. 1998 Nov;275(5):C1391-406. doi: 10.1152/ajpcell.1998.275.5.C1391.


Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor.

Jiang Q, Mak D, Devidas S, Schwiebert EM, Bragin A, Zhang Y, Skach WR, Guggino WB, Foskett JK, Engelhardt JF.

J Cell Biol. 1998 Nov 2;143(3):645-57.


Assays of dynamics, mechanisms, and regulation of ATP transport and release: implications for study of ABC transporter function.

Schwiebert EM, Egan ME, Guggino WB.

Methods Enzymol. 1998;292:664-75. No abstract available.


Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in madin-darby canine kidney cells.

Moyer BD, Loffing J, Schwiebert EM, Loffing-Cueni D, Halpin PA, Karlson KH, Ismailov II, Guggino WB, Langford GM, Stanton BA.

J Biol Chem. 1998 Aug 21;273(34):21759-68. Erratum in: J Biol Chem 1998 Oct 2;273(40):26256.


Cystic fibrosis: a multiple exocrinopathy caused by dysfunctions in a multifunctional transport protein.

Schwiebert EM, Benos DJ, Fuller CM.

Am J Med. 1998 Jun;104(6):576-90. Review. No abstract available.


Phosphatidylinositol 3-kinase contributes to cell volume regulation through effects on ATP release.

Feranchak AP, Roman RM, Schwiebert EM, Fitz JG.

J Biol Chem. 1998 Jun 12;273(24):14906-11.

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