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Items: 1 to 50 of 314

1.

The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease.

Weigl I, Geschwill P, Reiss M, Bruehl C, Draguhn A, Koenen M, Sedaghat-Hamedani F, Meder B, Thomas D, Katus HA, Schweizer PA.

Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31.

PMID:
31481236
2.

siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction.

Lück S, Kreszies T, Strickert M, Schweizer P, Kuhlmann M, Douchkov D.

Front Plant Sci. 2019 Aug 15;10:1023. doi: 10.3389/fpls.2019.01023. eCollection 2019.

3.

Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling.

Yampolsky P, Koenen M, Mosqueira M, Geschwill P, Nauck S, Witzenberger M, Seyler C, Fink T, Kruska M, Bruehl C, Schwoerer AP, Ehmke H, Fink RHA, Draguhn A, Thomas D, Katus HA, Schweizer PA.

Nat Commun. 2019 Jul 23;10(1):3295. doi: 10.1038/s41467-019-11261-2.

4.

Pacemaker cell characteristics of differentiated and HCN4-transduced human mesenchymal stem cells.

Darche FF, Rivinius R, Köllensperger E, Leimer U, Germann G, Seckinger A, Hose D, Schröter J, Bruehl C, Draguhn A, Gabriel R, Schmidt M, Koenen M, Thomas D, Katus HA, Schweizer PA.

Life Sci. 2019 Sep 1;232:116620. doi: 10.1016/j.lfs.2019.116620. Epub 2019 Jul 7.

PMID:
31291594
5.

Cardiac K2P13.1 (THIK-1) two-pore-domain K+ channels: Pharmacological regulation and remodeling in atrial fibrillation.

Staudacher I, Seehausen S, Illg C, Lugenbiel P, Schweizer PA, Katus HA, Thomas D.

Prog Biophys Mol Biol. 2019 Jul;144:128-138. doi: 10.1016/j.pbiomolbio.2018.06.009. Epub 2018 Jul 6.

PMID:
31182191
6.

Transforming layered MoS2 into functional MoO2 nanowires.

Vogl LM, Schweizer P, Wu M, Spiecker E.

Nanoscale. 2019 Jun 20;11(24):11687-11695. doi: 10.1039/c9nr03346g.

PMID:
31179480
7.

ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier.

Gessner G, Runge S, Koenen M, Heinemann SH, Koenen M, Haas J, Meder B, Thomas D, Katus HA, Schweizer PA.

Biochem Biophys Res Commun. 2019 May 14;512(4):845-851. doi: 10.1016/j.bbrc.2019.03.162. Epub 2019 Mar 28.

PMID:
30929919
8.

High Resolution Genetic and Physical Mapping of a Major Powdery Mildew Resistance Locus in Barley.

Hoseinzadeh P, Zhou R, Mascher M, Himmelbach A, Niks RE, Schweizer P, Stein N.

Front Plant Sci. 2019 Feb 14;10:146. doi: 10.3389/fpls.2019.00146. eCollection 2019.

9.

In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces.

Weidenbacher L, Müller E, Guex AG, Zündel M, Schweizer P, Marina V, Adlhart C, Vejsadová L, Pauer R, Spiecker E, Maniura-Weber K, Ferguson SJ, Rossi RM, Rottmar M, Fortunato G.

ACS Appl Mater Interfaces. 2019 Feb 13;11(6):5740-5751. doi: 10.1021/acsami.8b18121. Epub 2019 Feb 5.

PMID:
30668107
10.

Comparison of speed versus complexity effects on the hemodynamic response of the trail making test in block designs.

Rosenbaum D, Blum L, Schweizer P, Fallgatter AJ, Herrmann MJ, Ehlis AC, Metzger FG.

Neurophotonics. 2018 Oct;5(4):045007. doi: 10.1117/1.NPh.5.4.045007. Epub 2018 Dec 8.

11.

Cloning and characterization of zebrafish K2P13.1 (THIK-1) two-pore-domain K+ channels.

Staudacher I, Seehausen S, Gierten J, Illg C, Schweizer PA, Katus HA, Thomas D.

J Mol Cell Cardiol. 2019 Jan;126:96-104. doi: 10.1016/j.yjmcc.2018.11.013. Epub 2018 Nov 22.

PMID:
30472253
12.

German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management.

Thomas D, Christ T, Fabritz L, Goette A, Hammwöhner M, Heijman J, Kockskämper J, Linz D, Odening KE, Schweizer PA, Wakili R, Voigt N.

Clin Res Cardiol. 2019 Jun;108(6):577-599. doi: 10.1007/s00392-018-1377-1. Epub 2018 Oct 10. Review.

PMID:
30306295
13.

Novel approach to discriminate left bundle branch block from nonspecific intraventricular conduction delay using pacing-induced functional left bundle branch block.

Scholz EP, Fischer P, Lugenbiel P, Xynogalos P, Schweizer PA, Scherer D, Thomas D, Katus HA, Zitron E.

J Interv Card Electrophysiol. 2018 Dec;53(3):347-355. doi: 10.1007/s10840-018-0449-5. Epub 2018 Sep 19.

PMID:
30232686
14.

Corrigendum to: Abscisic acid influences tillering by modulation of strigolactones in barley.

Wang H, Chen W, Eggert K, Charnikhova T, Bouwmeester H, Schweizer P, Hajirezaei MR, Seiler C, Sreenivasulu N, von Wirén N, Kuhlmann M.

J Exp Bot. 2018 Oct 12;69(21):5307. doi: 10.1093/jxb/ery306. No abstract available.

15.

Evolutionarily conserved partial gene duplication in the Triticeae tribe of grasses confers pathogen resistance.

Rajaraman J, Douchkov D, Lück S, Hensel G, Nowara D, Pogoda M, Rutten T, Meitzel T, Brassac J, Höfle C, Hückelhoven R, Klinkenberg J, Trujillo M, Bauer E, Schmutzer T, Himmelbach A, Mascher M, Lazzari B, Stein N, Kumlehn J, Schweizer P.

Genome Biol. 2018 Aug 15;19(1):116. doi: 10.1186/s13059-018-1472-7.

16.

In situ manipulation and switching of dislocations in bilayer graphene.

Schweizer P, Dolle C, Spiecker E.

Sci Adv. 2018 Aug 10;4(8):eaat4712. doi: 10.1126/sciadv.aat4712. eCollection 2018 Aug.

17.

Butterfly and reverse butterfly: usefulness of a resistance band to provoke exercise-induced arrhythmias during catheter ablation in a patient refractory to pharmacological stimulation.

Xynogalos P, Lugenbiel P, Schweizer P, Katus H, Thomas D, Scholz EP.

Clin Res Cardiol. 2019 Jan;108(1):110-113. doi: 10.1007/s00392-018-1330-3. Epub 2018 Jul 26. No abstract available.

PMID:
30051183
18.

Role of ion channels in heart failure and channelopathies.

Rahm AK, Lugenbiel P, Schweizer PA, Katus HA, Thomas D.

Biophys Rev. 2018 Aug;10(4):1097-1106. doi: 10.1007/s12551-018-0442-3. Epub 2018 Jul 17. Review.

19.

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels.

Staudacher I, Illg C, Chai S, Deschenes I, Seehausen S, Gramlich D, Müller ME, Wieder T, Rahm AK, Mayer C, Schweizer PA, Katus HA, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Oct;391(10):1119-1131. doi: 10.1007/s00210-018-1535-z. Epub 2018 Jul 14.

PMID:
30008082
20.

Abscisic acid influences tillering by modulation of strigolactones in barley.

Wang H, Chen W, Eggert K, Charnikhova T, Bouwmeester H, Schweizer P, Hajirezaei MR, Seiler C, Sreenivasulu N, von Wirén N, Kuhlmann M.

J Exp Bot. 2018 Jul 18;69(16):3883-3898. doi: 10.1093/jxb/ery200. Erratum in: J Exp Bot. 2018 Oct 12;69(21):5307.

21.

Identification and functional characterization of zebrafish K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels.

Staudacher I, Illg C, Gierten J, Seehausen S, Schweizer PA, Katus HA, Thomas D.

Eur J Pharmacol. 2018 Jul 15;831:94-102. doi: 10.1016/j.ejphar.2018.05.007. Epub 2018 May 9.

PMID:
29753045
22.

Successful localization and ablation of a Mahaim potential using a high-resolution mapping catheter after a failed conventional ablation attempt.

Lugenbiel P, Xynogalos P, Schweizer P, Katus HA, Thomas D, Scholz EP.

Clin Res Cardiol. 2018 Jul;107(7):607-610. doi: 10.1007/s00392-018-1231-5. Epub 2018 Mar 12. No abstract available.

PMID:
29532157
23.

A comparative analysis of nonhost resistance across the two Triticeae crop species wheat and barley.

Delventhal R, Rajaraman J, Stefanato FL, Rehman S, Aghnoum R, McGrann GRD, Bolger M, Usadel B, Hedley PE, Boyd L, Niks RE, Schweizer P, Schaffrath U.

BMC Plant Biol. 2017 Dec 4;17(1):232. doi: 10.1186/s12870-017-1178-0.

24.

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells.

Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, Müller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D.

Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186/s13287-017-0681-4.

25.

Fully digital data processing during cardiovascular implantable electronic device follow-up in a high-volume tertiary center.

Staudacher I, Nalpathamkalam AR, Uhlmann L, Illg C, Seehausen S, Akhavanpoor M, Buchauer A, Geis N, Lugenbiel P, Schweizer PA, Xynogalos P, Zylla MM, Scholz E, Zitron E, Katus HA, Thomas D.

Eur J Med Res. 2017 Oct 11;22(1):41. doi: 10.1186/s40001-017-0284-7.

26.

Altered Expression of Genes Implicated in Xylan Biosynthesis Affects Penetration Resistance against Powdery Mildew.

Chowdhury J, Lück S, Rajaraman J, Douchkov D, Shirley NJ, Schwerdt JG, Schweizer P, Fincher GB, Burton RA, Little A.

Front Plant Sci. 2017 Mar 31;8:445. doi: 10.3389/fpls.2017.00445. eCollection 2017.

27.

A Distinct Cardiomyopathy: HCN4 Syndrome Comprising Myocardial Noncompaction, Bradycardia, Mitral Valve Defects, and Aortic Dilation.

Schweizer PA, Koenen M, Katus HA, Thomas D.

J Am Coll Cardiol. 2017 Mar 7;69(9):1209-1210. doi: 10.1016/j.jacc.2016.10.085. No abstract available.

28.

An LRR/Malectin Receptor-Like Kinase Mediates Resistance to Non-adapted and Adapted Powdery Mildew Fungi in Barley and Wheat.

Rajaraman J, Douchkov D, Hensel G, Stefanato FL, Gordon A, Ereful N, Caldararu OF, Petrescu AJ, Kumlehn J, Boyd LA, Schweizer P.

Front Plant Sci. 2016 Dec 15;7:1836. doi: 10.3389/fpls.2016.01836. eCollection 2016.

29.

TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.

Lugenbiel P, Wenz F, Syren P, Geschwill P, Govorov K, Seyler C, Frank D, Schweizer PA, Franke J, Weis T, Bruehl C, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D.

Basic Res Cardiol. 2017 Jan;112(1):8. doi: 10.1007/s00395-016-0597-7. Epub 2016 Dec 22.

PMID:
28005193
30.

Ligand-assisted thickness tailoring of highly luminescent colloidal CH3NH3PbX3 (X = Br and I) perovskite nanoplatelets.

Levchuk I, Herre P, Brandl M, Osvet A, Hock R, Peukert W, Schweizer P, Spiecker E, Batentschuk M, Brabec CJ.

Chem Commun (Camb). 2016 Dec 20;53(1):244-247.

PMID:
27928556
31.

Efficacy, High Procedural Safety And Rapid Optimization Of Cryoballoon Atrial Fibrillation Ablation In The Hands Of A New Operator.

Scholz E, Lugenbiel P, Schweizer PA, Xynogalos P, Seyler C, Zitron E, Becker R, Katus HA, Thomas D.

J Atr Fibrillation. 2016 Feb 29;8(5):1341. doi: 10.4022/jafib.1341. eCollection 2016 Feb-Mar.

32.

Antiarrhythmic gene therapy - will biologics replace catheters, drugs and devices?

Lugenbiel P, Schweizer PA, Katus HA, Thomas D.

Eur J Pharmacol. 2016 Nov 15;791:264-273. doi: 10.1016/j.ejphar.2016.09.001. Epub 2016 Sep 2. Review.

PMID:
27593579
33.

Host-induced silencing of Fusarium culmorum genes protects wheat from infection.

Chen W, Kastner C, Nowara D, Oliveira-Garcia E, Rutten T, Zhao Y, Deising HB, Kumlehn J, Schweizer P.

J Exp Bot. 2016 Sep;67(17):4979-91. doi: 10.1093/jxb/erw263. Epub 2016 Aug 18.

34.

Tempered mlo broad-spectrum resistance to barley powdery mildew in an Ethiopian landrace.

Ge X, Deng W, Lee ZZ, Lopez-Ruiz FJ, Schweizer P, Ellwood SR.

Sci Rep. 2016 Jul 12;6:29558. doi: 10.1038/srep29558.

35.

Down-regulation of the glucan synthase-like 6 gene (HvGsl6) in barley leads to decreased callose accumulation and increased cell wall penetration by Blumeria graminis f. sp. hordei.

Chowdhury J, Schober MS, Shirley NJ, Singh RR, Jacobs AK, Douchkov D, Schweizer P, Fincher GB, Burton RA, Little A.

New Phytol. 2016 Oct;212(2):434-43. doi: 10.1111/nph.14086. Epub 2016 Jul 1.

36.

The barley (Hordeum vulgare) cellulose synthase-like D2 gene (HvCslD2) mediates penetration resistance to host-adapted and nonhost isolates of the powdery mildew fungus.

Douchkov D, Lueck S, Hensel G, Kumlehn J, Rajaraman J, Johrde A, Doblin MS, Beahan CT, Kopischke M, Fuchs R, Lipka V, Niks RE, Bulone V, Chowdhury J, Little A, Burton RA, Bacic A, Fincher GB, Schweizer P.

New Phytol. 2016 Oct;212(2):421-33. doi: 10.1111/nph.14065. Epub 2016 Jun 28.

37.

Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations.

Vermeer AMC, Lodder EM, Thomas D, Duijkers FAM, Marcelis C, van Gorselen EOF, Fortner P, Buss SJ, Mereles D, Katus HA, Wilde AAM, Bezzina CR, Boekholdt SM, Schweizer PA, Christiaans I.

J Am Coll Cardiol. 2016 May 17;67(19):2313-2315. doi: 10.1016/j.jacc.2016.01.086. No abstract available.

38.

Overcoming the Interface Losses in Planar Heterojunction Perovskite-Based Solar Cells.

Hou Y, Chen W, Baran D, Stubhan T, Luechinger NA, Hartmeier B, Richter M, Min J, Chen S, Quiroz CO, Li N, Zhang H, Heumueller T, Matt GJ, Osvet A, Forberich K, Zhang ZG, Li Y, Winter B, Schweizer P, Spiecker E, Brabec CJ.

Adv Mater. 2016 Jul;28(25):5112-20. doi: 10.1002/adma.201504168. Epub 2016 May 4.

PMID:
27144875
39.

Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system.

Wiedmann F, Schmidt C, Lugenbiel P, Staudacher I, Rahm AK, Seyler C, Schweizer PA, Katus HA, Thomas D.

Clin Sci (Lond). 2016 May;130(9):643-50. doi: 10.1042/CS20150533. Review.

PMID:
26993052
40.

Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation".

Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D.

Circulation. 2016 Mar 15;133(11):e440-1. doi: 10.1161/CIRCULATIONAHA.115.020662. No abstract available.

PMID:
26976923
41.

Metabolic and transcriptional response of central metabolism affected by root endophytic fungus Piriformospora indica under salinity in barley.

Ghaffari MR, Ghabooli M, Khatabi B, Hajirezaei MR, Schweizer P, Salekdeh GH.

Plant Mol Biol. 2016 Apr;90(6):699-717. doi: 10.1007/s11103-016-0461-z. Epub 2016 Mar 7.

PMID:
26951140
42.

Long-term use of amiodarone before heart transplantation significantly reduces early post-transplant atrial fibrillation and is not associated with increased mortality after heart transplantation.

Rivinius R, Helmschrott M, Ruhparwar A, Schmack B, Erbel C, Gleissner CA, Akhavanpoor M, Frankenstein L, Darche FF, Schweizer PA, Thomas D, Ehlermann P, Bruckner T, Katus HA, Doesch AO.

Drug Des Devel Ther. 2016 Feb 16;10:677-86. doi: 10.2147/DDDT.S96126. eCollection 2016.

43.

It's all in your head: sinus node dysfunction secondary to a sphenoid wing meningioma.

Rivinius R, Darche FF, Campos B, Unterberg A, Schweizer L, Thomas D, Katus HA, Schweizer PA.

Herzschrittmacherther Elektrophysiol. 2015 Sep;26(3):300-2. doi: 10.1007/s00399-015-0380-8. Epub 2015 Jul 4.

PMID:
26141412
44.

Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation.

Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D.

Circulation. 2015 Jul 14;132(2):82-92. doi: 10.1161/CIRCULATIONAHA.114.012657. Epub 2015 May 7.

PMID:
25951834
45.

Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins.

Lugenbiel P, Wenz F, Govorov K, Schweizer PA, Katus HA, Thomas D.

PLoS One. 2015 Mar 16;10(3):e0116395. doi: 10.1371/journal.pone.0116395. eCollection 2015.

46.

Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran and rivaroxaban), and bridging therapy in patients with atrial fibrillation and flutter.

Zylla MM, Pohlmeier M, Hess A, Mereles D, Kieser M, Bruckner T, Scholz E, Zitron E, Schweizer PA, Katus HA, Thomas D.

Am J Cardiol. 2015 Mar 1;115(5):635-40. doi: 10.1016/j.amjcard.2014.12.016. Epub 2014 Dec 18.

PMID:
25591898
47.

Discovery of genes affecting resistance of barley to adapted and non-adapted powdery mildew fungi.

Douchkov D, Lück S, Johrde A, Nowara D, Himmelbach A, Rajaraman J, Stein N, Sharma R, Kilian B, Schweizer P.

Genome Biol. 2014;15(12):518.

48.

Effects of β-blocker therapy on electrocardiographic and echocardiographic characteristics of left ventricular noncompaction.

Li J, Franke J, Pribe-Wolferts R, Meder B, Ehlermann P, Mereles D, Andre F, Abdelrazek MA, Merten C, Schweizer PA, Becker R, Katus HA, Thomas D.

Clin Res Cardiol. 2015 Mar;104(3):241-9. doi: 10.1007/s00392-014-0778-z. Epub 2014 Oct 21.

PMID:
25331160
49.

Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.

Kisselbach J, Seyler C, Schweizer PA, Gerstberger R, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2014 Dec;171(23):5182-94. doi: 10.1111/bph.12596. Epub 2014 Aug 28.

50.

The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel.

Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, Buss SJ, Seyler C, Bruehl C, Draguhn A, Koenen M, Meder B, Katus HA, Thomas D.

J Am Coll Cardiol. 2014 Aug 26;64(8):757-67. doi: 10.1016/j.jacc.2014.06.1155.

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