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GC-072: A Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens.

Shearer JD, Saylor ML, Butler CM, Treston AM, Heine HS, Chirakul S, Schweizer HP, Louie A, Drusano GL, Zumbrun SD, Warfield KL.

Antimicrob Agents Chemother. 2019 Sep 23. pii: AAC.00834-19. doi: 10.1128/AAC.00834-19. [Epub ahead of print]


An in situ high-throughput screen identifies inhibitors of intracellular Burkholderia pseudomallei with therapeutic efficacy.

Bulterys PL, Toesca IJ, Norris MH, Maloy JP, Fitz-Gibbon ST, France B, Toffig B, Morselli M, Somprasong N, Pellegrini M, Schweizer HP, Tuanyok A, Damoiseaux R, French CT, Miller JF.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18597-18606. doi: 10.1073/pnas.1906388116. Epub 2019 Aug 22.


Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane.

Krishnamoorthy G, Weeks JW, Zhang Z, Chandler CE, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00956-19. doi: 10.1128/AAC.00956-19. Print 2019 Oct.


Next Generation of Tn7-Based Single-Copy Insertion Elements for Use in Multi- and Pan-Drug-Resistant Strains of Acinetobacter baumannii.

Ducas-Mowchun K, De Silva PM, Crisostomo L, Fernando DM, Chao TC, Pelka P, Schweizer HP, Kumar A.

Appl Environ Microbiol. 2019 May 16;85(11). pii: e00066-19. doi: 10.1128/AEM.00066-19. Print 2019 Jun 1.


Tn7-Based Single-Copy Insertion Vectors for Acinetobacter baumannii.

Ducas-Mowchun K, De Silva PM, Patidar R, Schweizer HP, Kumar A.

Methods Mol Biol. 2019;1946:135-150. doi: 10.1007/978-1-4939-9118-1_13.


Burkholderia pseudomallei acquired ceftazidime resistance due to gene duplication and amplification.

Chirakul S, Somprasong N, Norris MH, Wuthiekanun V, Chantratita N, Tuanyok A, Schweizer HP.

Int J Antimicrob Agents. 2019 May;53(5):582-588. doi: 10.1016/j.ijantimicag.2019.01.003. Epub 2019 Jan 9.


Development and validation of a triplex quantitative real-time PCR assay to detect efflux pump-mediated antibiotic resistance in Burkholderia pseudomallei.

Webb JR, Price EP, Somprasong N, Schweizer HP, Baird RW, Currie BJ, Sarovich DS.

Future Microbiol. 2018 Sep;13:1403-1418. doi: 10.2217/fmb-2018-0155. Epub 2018 Sep 26.


Seroepidemiology of Burkholderia pseudomallei, Etiologic Agent of Melioidosis, in the Ouest and Sud-Est Departments of Haiti.

Weppelmann TA, Norris MH, von Fricken ME, Rahman Khan MS, Okech BA, Cannella AP, Schweizer HP, Sanford DC, Tuanyok A.

Am J Trop Med Hyg. 2018 Nov;99(5):1222-1228. doi: 10.4269/ajtmh.18-0352.


Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei.

Norris MH, Somprasong N, Schweizer HP, Tuanyok A.

Infect Immun. 2018 Sep 21;86(10). pii: e00360-18. doi: 10.1128/IAI.00360-18. Print 2018 Oct.


Molecular determinants of Burkholderia pseudomallei BpeEF-OprC efflux pump expression.

Rhodes KA, Somprasong N, Podnecky NL, Mima T, Chirakul S, Schweizer HP.

Microbiology. 2018 Sep;164(9):1156-1167. doi: 10.1099/mic.0.000691. Epub 2018 Jul 19.


Transcriptional and post-transcriptional regulation of PenA β-lactamase in acquired Burkholderia pseudomallei β-lactam resistance.

Chirakul S, Norris MH, Pagdepanichkit S, Somprasong N, Randall LB, Shirley JF, Borlee BR, Lomovskaya O, Tuanyok A, Schweizer HP.

Sci Rep. 2018 Jul 13;8(1):10652. doi: 10.1038/s41598-018-28843-7.


Outer Membrane Vesicle Vaccines from Biosafe Surrogates Prevent Acute Lethal Glanders in Mice.

Norris MH, Khan MSR, Chirakul S, Schweizer HP, Tuanyok A.

Vaccines (Basel). 2018 Jan 10;6(1). pii: E5. doi: 10.3390/vaccines6010005.


Burkholderia pseudomallei natural competency and DNA catabolism: Identification and characterization of relevant genes from a constructed fosmid library.

Norris MH, Heacock-Kang Y, Zarzycki-Siek J, Bluhm AP, McMillan IA, Schweizer HP, Hoang TT.

PLoS One. 2017 Dec 18;12(12):e0189018. doi: 10.1371/journal.pone.0189018. eCollection 2017.


Spatial transcriptomes within the Pseudomonas aeruginosa biofilm architecture.

Heacock-Kang Y, Sun Z, Zarzycki-Siek J, McMillan IA, Norris MH, Bluhm AP, Cabanas D, Fogen D, Vo H, Donachie SP, Borlee BR, Sibley CD, Lewenza S, Schurr MJ, Schweizer HP, Hoang TT.

Mol Microbiol. 2017 Dec;106(6):976-985. doi: 10.1111/mmi.13863. Epub 2017 Nov 17.


Mechanisms of Resistance to Folate Pathway Inhibitors in Burkholderia pseudomallei: Deviation from the Norm.

Podnecky NL, Rhodes KA, Mima T, Drew HR, Chirakul S, Wuthiekanun V, Schupp JM, Sarovich DS, Currie BJ, Keim P, Schweizer HP.

MBio. 2017 Sep 5;8(5). pii: e01357-17. doi: 10.1128/mBio.01357-17.


AOAC SMPR 2016.010.

Gee J, Arce J, Beck LC, Blank TR, Blyn L, Cahall R, Clark AJ, Currie B, Damer K, Davenport M, DeShazer D, Johns M, Keim PS, Kiss K, Lesho M, Lin N, Morse SA, Naraghi-Arani P, Ozanich R, Roberto F, Rozak D, Sahl J, Schaefer F, Schutzer S, Schweizer HP, Sozhamannan S, Tuanyok A, Coates S.

J AOAC Int. 2017 Jan 1;100(1):261-265. doi: 10.5740/jaoacint.SMPR2016.010. No abstract available.


Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster.

Borlee GI, Plumley BA, Martin KH, Somprasong N, Mangalea MR, Islam MN, Burtnick MN, Brett PJ, Steinmetz I, AuCoin DP, Belisle JT, Crick DC, Schweizer HP, Borlee BR.

PLoS Negl Trop Dis. 2017 Jun 28;11(6):e0005689. doi: 10.1371/journal.pntd.0005689. eCollection 2017 Jun.


An avirulent Burkholderia pseudomallei ∆purM strain with atypical type B LPS: expansion of the toolkit for biosafe studies of melioidosis.

Norris MH, Rahman Khan MS, Schweizer HP, Tuanyok A.

BMC Microbiol. 2017 Jun 7;17(1):132. doi: 10.1186/s12866-017-1040-4.


Structural diversity of Burkholderia pseudomallei lipopolysaccharides affects innate immune signaling.

Norris MH, Schweizer HP, Tuanyok A.

PLoS Negl Trop Dis. 2017 Apr 28;11(4):e0005571. doi: 10.1371/journal.pntd.0005571. eCollection 2017 Apr.


Antibiotic Resistance Markers in Burkholderia pseudomallei Strain Bp1651 Identified by Genome Sequence Analysis.

Bugrysheva JV, Sue D, Gee JE, Elrod MG, Hoffmaster AR, Randall LB, Chirakul S, Tuanyok A, Schweizer HP, Weigel LM.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00010-17. doi: 10.1128/AAC.00010-17. Print 2017 Jun.


Finafloxacin overcomes Burkholderia pseudomallei efflux-mediated fluoroquinolone resistance.

Randall LB, Georgi E, Genzel GH, Schweizer HP.

J Antimicrob Chemother. 2017 Apr 1;72(4):1258-1260. doi: 10.1093/jac/dkw529. No abstract available.


Thermoregulation of Biofilm Formation in Burkholderia pseudomallei Is Disrupted by Mutation of a Putative Diguanylate Cyclase.

Plumley BA, Martin KH, Borlee GI, Marlenee NL, Burtnick MN, Brett PJ, AuCoin DP, Bowen RA, Schweizer HP, Borlee BR.

J Bacteriol. 2017 Feb 14;199(5). pii: e00780-16. doi: 10.1128/JB.00780-16. Print 2017 Mar 1.


Antibiotic resistance in Burkholderia species.

Rhodes KA, Schweizer HP.

Drug Resist Updat. 2016 Sep;28:82-90. doi: 10.1016/j.drup.2016.07.003. Epub 2016 Jul 30. Review.


Versatile nourseothricin and streptomycin/spectinomycin resistance gene cassettes and their use in chromosome integration vectors.

Lehman SS, Mladinich KM, Boonyakanog A, Mima T, Karkhoff-Schweizer RR, Schweizer HP.

J Microbiol Methods. 2016 Oct;129:8-13. doi: 10.1016/j.mimet.2016.07.018. Epub 2016 Jul 22.


Membrane-Bound PenA β-Lactamase of Burkholderia pseudomallei.

Randall LB, Dobos K, Papp-Wallace KM, Bonomo RA, Schweizer HP.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1509-14. doi: 10.1128/AAC.02444-15.


Absence of Bacteria in the Temporal Arteries of Patients with Giant Cell Arteritis.

Koening CL, Peterson SG, Podnecky NL, Schweizer HP, Li DY, Katz BJ.

J Clin Rheumatol. 2016 Jan;22(1):43-4. doi: 10.1097/RHU.0000000000000344. No abstract available.


Exposing a β-Lactamase "Twist": the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI β-Lactamase.

Papp-Wallace KM, Becka SA, Taracila MA, Winkler ML, Gatta JA, Rholl DA, Schweizer HP, Bonomo RA.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):777-88. doi: 10.1128/AAC.02073-15. Print 2016 Feb.


Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange.

Hmelo LR, Borlee BR, Almblad H, Love ME, Randall TE, Tseng BS, Lin C, Irie Y, Storek KM, Yang JJ, Siehnel RJ, Howell PL, Singh PK, Tolker-Nielsen T, Parsek MR, Schweizer HP, Harrison JJ.

Nat Protoc. 2015 Nov;10(11):1820-41. doi: 10.1038/nprot.2015.115. Epub 2015 Oct 22.


Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies.

El Zowalaty ME, Al Thani AA, Webster TJ, El Zowalaty AE, Schweizer HP, Nasrallah GK, Marei HE, Ashour HM.

Future Microbiol. 2015;10(10):1683-706. doi: 10.2217/fmb.15.48. Epub 2015 Oct 6. Review.


Efflux pump-mediated drug resistance in Burkholderia.

Podnecky NL, Rhodes KA, Schweizer HP.

Front Microbiol. 2015 Apr 14;6:305. doi: 10.3389/fmicb.2015.00305. eCollection 2015.


A Burkholderia pseudomallei colony variant necessary for gastric colonization.

Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI.

MBio. 2015 Feb 3;6(1). pii: e02462-14. doi: 10.1128/mBio.02462-14.


Tn5/7-lux: a versatile tool for the identification and capture of promoters in gram-negative bacteria.

Bruckbauer ST, Kvitko BH, Karkhoff-Schweizer RR, Schweizer HP.

BMC Microbiol. 2015 Feb 4;15:17. doi: 10.1186/s12866-015-0354-3.


Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo.

Sun Z, Kang Y, Norris MH, Troyer RM, Son MS, Schweizer HP, Dow SW, Hoang TT.

PLoS One. 2014 Jul 28;9(7):e103778. doi: 10.1371/journal.pone.0103778. eCollection 2014.


Rapid Burkholderia pseudomallei identification and antibiotic resistance determination by bacteriophage amplification and MALDI-TOF MS.

Cox CR, Saichek NR, Schweizer HP, Voorhees KJ.

Bacteriophage. 2014 Apr 25;4:e29011. eCollection 2014.


New insights from the 7th World Melioidosis Congress 2013.

Schweizer HP, Limmathurotsakul D, Peacock SJ.

Emerg Infect Dis. 2014 Jul;20(7). doi: 10.3201/eid2007.131737. No abstract available.


Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.

Cummings JE, Beaupre AJ, Knudson SE, Liu N, Yu W, Neckles C, Wang H, Khanna A, Bommineni GR, Trunck LA, Schweizer HP, Tonge PJ, Slayden RA.

Antimicrob Agents Chemother. 2014;58(3):1646-51. doi: 10.1128/AAC.02296-13. Epub 2013 Dec 30.


The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.

Cummings JE, Kingry LC, Rholl DA, Schweizer HP, Tonge PJ, Slayden RA.

Antimicrob Agents Chemother. 2014;58(2):931-5. doi: 10.1128/AAC.00176-13. Epub 2013 Nov 25.


Polar lipids of Burkholderia pseudomallei induce different host immune responses.

Gonzalez-Juarrero M, Mima N, Trunck LA, Schweizer HP, Bowen RA, Dascher K, Mwangi W, Eckstein TM.

PLoS One. 2013 Nov 18;8(11):e80368. doi: 10.1371/journal.pone.0080368. eCollection 2013.


Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.

Silva EB, Goodyear A, Sutherland MD, Podnecky NL, Gonzalez-Juarrero M, Schweizer HP, Dow SW.

Infect Immun. 2013 Dec;81(12):4626-34. doi: 10.1128/IAI.00915-13. Epub 2013 Oct 7.


An improved selective culture medium enhances the isolation of Burkholderia pseudomallei from contaminated specimens.

Goodyear A, Strange L, Rholl DA, Silisouk J, Dance DAB, Schweizer HP, Dow S.

Am J Trop Med Hyg. 2013 Nov;89(5):973-982. doi: 10.4269/ajtmh.13-0119. Epub 2013 Sep 23.


High-level pacidamycin resistance in Pseudomonas aeruginosa is mediated by an opp oligopeptide permease encoded by the opp-fabI operon.

Mistry A, Warren MS, Cusick JK, Karkhoff-Schweizer RR, Lomovskaya O, Schweizer HP.

Antimicrob Agents Chemother. 2013 Nov;57(11):5565-71. doi: 10.1128/AAC.01198-13. Epub 2013 Aug 26.


The BpeEF-OprC efflux pump is responsible for widespread trimethoprim resistance in clinical and environmental Burkholderia pseudomallei isolates.

Podnecky NL, Wuthiekanun V, Peacock SJ, Schweizer HP.

Antimicrob Agents Chemother. 2013 Sep;57(9):4381-6. doi: 10.1128/AAC.00660-13. Epub 2013 Jul 1.


Does microbicide use in consumer products promote antimicrobial resistance? A critical review and recommendations for a cohesive approach to risk assessment.

Maillard JY, Bloomfield S, Coelho JR, Collier P, Cookson B, Fanning S, Hill A, Hartemann P, McBain AJ, Oggioni M, Sattar S, Schweizer HP, Threlfall J.

Microb Drug Resist. 2013 Oct;19(5):344-54. doi: 10.1089/mdr.2013.0039. Epub 2013 Jun 14. Review.


An improved method for oriT-directed cloning and functionalization of large bacterial genomic regions.

Kvitko BH, McMillan IA, Schweizer HP.

Appl Environ Microbiol. 2013 Aug;79(16):4869-78. doi: 10.1128/AEM.00994-13. Epub 2013 Jun 7.


Construction of mobilizable mini-Tn7 vectors for bioluminescent detection of gram-negative bacteria and single-copy promoter lux reporter analysis.

Damron FH, McKenney ES, Barbier M, Liechti GW, Schweizer HP, Goldberg JB.

Appl Environ Microbiol. 2013 Jul;79(13):4149-53. doi: 10.1128/AEM.00640-13. Epub 2013 Apr 12.


Mechanisms of antibiotic resistance in Burkholderia pseudomallei: implications for treatment of melioidosis.

Schweizer HP.

Future Microbiol. 2012 Dec;7(12):1389-99. doi: 10.2217/fmb.12.116. Review.


φX216, a P2-like bacteriophage with broad Burkholderia pseudomallei and B. mallei strain infectivity.

Kvitko BH, Cox CR, DeShazer D, Johnson SL, Voorhees KJ, Schweizer HP.

BMC Microbiol. 2012 Dec 7;12:289. doi: 10.1186/1471-2180-12-289.


Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010.

Lipsitz R, Garges S, Aurigemma R, Baccam P, Blaney DD, Cheng AC, Currie BJ, Dance D, Gee JE, Larsen J, Limmathurotsakul D, Morrow MG, Norton R, O'Mara E, Peacock SJ, Pesik N, Rogers LP, Schweizer HP, Steinmetz I, Tan G, Tan P, Wiersinga WJ, Wuthiekanun V, Smith TL.

Emerg Infect Dis. 2012 Dec;18(12):e2. doi: 10.3201/eid1812.120638.


Construction of a broad-host-range Tn7-based vector for single-copy P(BAD)-controlled gene expression in gram-negative bacteria.

Damron FH, McKenney ES, Schweizer HP, Goldberg JB.

Appl Environ Microbiol. 2013 Jan;79(2):718-21. doi: 10.1128/AEM.02926-12. Epub 2012 Nov 2.


Characterization of molecular mechanisms controlling fabAB transcription in Pseudomonas aeruginosa.

Schweizer HP, Choi KH.

PLoS One. 2012;7(10):e45646. doi: 10.1371/journal.pone.0045646. Epub 2012 Oct 2.

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