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Items: 1 to 50 of 170

1.

Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against MDR and XDR Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates.

Idowu T, Ammeter D, Arthur G, Zhanel GG, Schweizer F.

J Antimicrob Chemother. 2019 May 28. pii: dkz228. doi: 10.1093/jac/dkz228. [Epub ahead of print]

PMID:
31139830
2.

Amphiphilic nebramine-based hybrids Rescue legacy antibiotics from intrinsic resistance in multidrug-resistant Gram-negative bacilli.

Yang X, Ammeter D, Idowu T, Domalaon R, Brizuela M, Okunnu O, Bi L, Guerrero YA, Zhanel GG, Kumar A, Schweizer F.

Eur J Med Chem. 2019 Aug 1;175:187-200. doi: 10.1016/j.ejmech.2019.05.003. Epub 2019 May 2.

PMID:
31078866
3.

Polybasic peptide-levofloxacin conjugates potentiate fluoroquinolones and other classes of antibiotics against multidrug-resistant Gram-negative bacteria.

Berry L, Domalaon R, Brizuela M, Zhanel GG, Schweizer F.

Medchemcomm. 2019 Mar 7;10(4):517-527. doi: 10.1039/c9md00051h. eCollection 2019 Apr 1.

PMID:
31057731
4.

Synergistic combinations of anthelmintic salicylanilides oxyclozanide, rafoxanide, and closantel with colistin eradicates multidrug-resistant colistin-resistant Gram-negative bacilli.

Domalaon R, Okunnu O, Zhanel GG, Schweizer F.

J Antibiot (Tokyo). 2019 Apr 26. doi: 10.1038/s41429-019-0186-8. [Epub ahead of print]

PMID:
31028351
5.

Heterodimeric Rifampicin-Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model.

Idowu T, Arthur G, Zhanel GG, Schweizer F.

Eur J Med Chem. 2019 Jul 15;174:16-32. doi: 10.1016/j.ejmech.2019.04.034. Epub 2019 Apr 16.

PMID:
31022550
6.

The Anthelmintic Drug Niclosamide Synergizes with Colistin and Reverses Colistin Resistance in Gram-Negative Bacilli.

Domalaon R, De Silva PM, Kumar A, Zhanel GG, Schweizer F.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02574-18. doi: 10.1128/AAC.02574-18. Print 2019 Apr.

PMID:
30917988
7.

Synthesis of the Non Reducing End Oligosaccharides of Glycosphingolipids from Ascaris suum.

Hada N, Umeda Y, Kumada H, Shimazaki Y, Yamano K, Schweizer F, Oshima N, Takeda T, Kiuchi F.

Chem Pharm Bull (Tokyo). 2019;67(2):143-154. doi: 10.1248/cpb.c18-00768.

8.

Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Zhanel GG, Golden AR, Zelenitsky S, Wiebe K, Lawrence CK, Adam HJ, Idowu T, Domalaon R, Schweizer F, Zhanel MA, Lagacé-Wiens PRS, Walkty AJ, Noreddin A, Lynch Iii JP, Karlowsky JA.

Drugs. 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2. Review.

PMID:
30712199
9.

Ocular features in mucopolysaccharidosis: diagnosis and treatment.

Del Longo A, Piozzi E, Schweizer F.

Ital J Pediatr. 2018 Nov 16;44(Suppl 2):125. doi: 10.1186/s13052-018-0559-9. Review.

10.

Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria.

Domalaon R, Brizuela M, Eisner B, Findlay B, Zhanel GG, Schweizer F.

Amino Acids. 2019 Mar;51(3):383-393. doi: 10.1007/s00726-018-2673-9. Epub 2018 Nov 3.

PMID:
30392097
11.

Development of dilipid polymyxins: Investigation on the effect of hydrophobicity through its fatty acyl component.

Domalaon R, Berry L, Tays Q, Zhanel GG, Schweizer F.

Bioorg Chem. 2018 Oct;80:639-648. doi: 10.1016/j.bioorg.2018.07.018. Epub 2018 Jul 19.

PMID:
30053708
12.

Tobramycin-Linked Efflux Pump Inhibitor Conjugates Synergize Fluoroquinolones, Rifampicin and Fosfomycin against Multidrug-Resistant Pseudomonas aeruginosa.

Yang X, Domalaon R, Lyu Y, Zhanel GG, Schweizer F.

J Clin Med. 2018 Jun 22;7(7). pii: E158. doi: 10.3390/jcm7070158.

13.

An engineered combinatorial module of transcription factors boosts production of monoterpenoid indole alkaloids in Catharanthus roseus.

Schweizer F, Colinas M, Pollier J, Van Moerkercke A, Vanden Bossche R, de Clercq R, Goossens A.

Metab Eng. 2018 Jul;48:150-162. doi: 10.1016/j.ymben.2018.05.016. Epub 2018 May 28.

PMID:
29852273
14.

Absolute Quantitation of Glycoforms of Two Human IgG Subclasses Using Synthetic Fc Peptides and Glycopeptides.

Roy R, Ang E, Komatsu E, Domalaon R, Bosseboeuf A, Harb J, Hermouet S, Krokhin O, Schweizer F, Perreault H.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1086-1098. doi: 10.1007/s13361-018-1900-7. Epub 2018 May 23.

PMID:
29796736
15.

Correction to: Imipenem-Relebactam and Meropenem-Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations.

Zhanel GG, Lawrence CK, Adam H, Schweizer F, Zelenitsky S, Zhanel M, Lagacé-Wiens PRS, Walkty A, Denisuik A, Golden A, Gin AS, Hoban DJ, Lynch JP 3rd, Karlowsky JA.

Drugs. 2018 May;78(7):787. doi: 10.1007/s40265-018-0910-x.

PMID:
29748749
16.

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

Domalaon R, Idowu T, Zhanel GG, Schweizer F.

Clin Microbiol Rev. 2018 Mar 14;31(2). pii: e00077-17. doi: 10.1128/CMR.00077-17. Print 2018 Apr. Review.

17.

Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa.

Domalaon R, Sanchak Y, Koskei LC, Lyu Y, Zhanel GG, Arthur G, Schweizer F.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02374-17. doi: 10.1128/AAC.02374-17. Print 2018 Apr.

18.

Imipenem-Relebactam and Meropenem-Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations.

Zhanel GG, Lawrence CK, Adam H, Schweizer F, Zelenitsky S, Zhanel M, Lagacé-Wiens PRS, Walkty A, Denisuik A, Golden A, Gin AS, Hoban DJ, Lynch JP 3rd, Karlowsky JA.

Drugs. 2018 Jan;78(1):65-98. doi: 10.1007/s40265-017-0851-9. Review. Erratum in: Drugs. 2018 May 10;:.

PMID:
29230684
19.

Amphiphilic lysine conjugated to tobramycin synergizes legacy antibiotics against wild-type and multidrug-resistant Pseudomonas aeruginosa.

Lyu Y, Domalaon R, Yang X, Schweizer F.

Biopolymers. 2017 Dec 4. doi: 10.1002/bip.23091. [Epub ahead of print]

PMID:
29205266
20.

Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities.

Idowu T, Schweizer F.

Antibiotics (Basel). 2017 Nov 7;6(4). pii: E26. doi: 10.3390/antibiotics6040026. Review.

21.

Polymyxin B3-Tobramycin Hybrids with Pseudomonas aeruginosa-Selective Antibacterial Activity and Strong Potentiation of Rifampicin, Minocycline, and Vancomycin.

Domalaon R, Yang X, Lyu Y, Zhanel GG, Schweizer F.

ACS Infect Dis. 2017 Dec 8;3(12):941-954. doi: 10.1021/acsinfecdis.7b00145. Epub 2017 Oct 27.

PMID:
29045123
22.

Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells.

Idowu T, Samadder P, Arthur G, Schweizer F.

J Med Chem. 2017 Dec 14;60(23):9724-9738. doi: 10.1021/acs.jmedchem.7b01198. Epub 2017 Oct 27.

PMID:
29043812
23.

Identification of Iridoid Glucoside Transporters in Catharanthus roseus.

Larsen B, Fuller VL, Pollier J, Van Moerkercke A, Schweizer F, Payne R, Colinas M, O'Connor SE, Goossens A, Halkier BA.

Plant Cell Physiol. 2017 Sep 1;58(9):1507-1518. doi: 10.1093/pcp/pcx097.

24.

Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells.

Moraya AI, Ali JL, Samadder P, Liang L, Morrison LC, Werbowetski-Ogilvie TE, Ogunsina M, Schweizer F, Arthur G, Nachtigal MW.

J Exp Clin Cancer Res. 2017 May 12;36(1):67. doi: 10.1186/s13046-017-0538-9.

25.

Arabidopsis glucosinolates trigger a contrasting transcriptomic response in a generalist and a specialist herbivore.

Schweizer F, Heidel-Fischer H, Vogel H, Reymond P.

Insect Biochem Mol Biol. 2017 Jun;85:21-31. doi: 10.1016/j.ibmb.2017.04.004. Epub 2017 Apr 26.

PMID:
28455184
26.

Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline.

Lyu Y, Yang X, Goswami S, Gorityala BK, Idowu T, Domalaon R, Zhanel GG, Shan A, Schweizer F.

J Med Chem. 2017 May 11;60(9):3684-3702. doi: 10.1021/acs.jmedchem.6b01742. Epub 2017 Apr 24.

PMID:
28409644
27.

A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-Resistant Gram-Negative Bacteria.

Yang X, Goswami S, Gorityala BK, Domalaon R, Lyu Y, Kumar A, Zhanel GG, Schweizer F.

J Med Chem. 2017 May 11;60(9):3913-3932. doi: 10.1021/acs.jmedchem.7b00156. Epub 2017 Apr 24.

PMID:
28399372
28.

The Predictive Validity of Four Intelligence Tests for School Grades: A Small Sample Longitudinal Study.

Gygi JT, Hagmann-von Arx P, Schweizer F, Grob A.

Front Psychol. 2017 Mar 13;8:375. doi: 10.3389/fpsyg.2017.00375. eCollection 2017.

29.

Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle.

Sultemeier DR, Choy KR, Schweizer FE, Hoffman LF.

J Neurophysiol. 2017 Jun 1;117(6):2163-2178. doi: 10.1152/jn.00240.2016. Epub 2017 Feb 22.

30.

Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells.

Ogunsina M, Samadder P, Idowu T, Arthur G, Schweizer F.

J Med Chem. 2017 Mar 9;60(5):2142-2147. doi: 10.1021/acs.jmedchem.6b01773. Epub 2017 Feb 21.

PMID:
28177244
31.

Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia.

Zhanel GG, Hartel E, Adam H, Zelenitsky S, Zhanel MA, Golden A, Schweizer F, Gorityala B, Lagacé-Wiens PR, Walkty AJ, Gin AS, Hoban DJ, Lynch JP 3rd, Karlowsky JA.

Drugs. 2016 Dec;76(18):1737-1757. Review.

PMID:
27909995
32.

The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus.

Van Moerkercke A, Steensma P, Gariboldi I, Espoz J, Purnama PC, Schweizer F, Miettinen K, Vanden Bossche R, De Clercq R, Memelink J, Goossens A.

Plant J. 2016 Oct;88(1):3-12. doi: 10.1111/tpj.13230. Epub 2016 Aug 13.

33.

Multiplexed azido-group isotopic capture (MAGIC) beads: Selective analysis of azido compounds using a propargyl-based cleavable linker, a proof of concept.

McLellan M, Doyle MGJ, Bodnar ED, Lopez PG, Domalaon R, Roy R, Cordova K, Schweizer F, Perreault H.

Rapid Commun Mass Spectrom. 2016 Dec 15;30(23):2497-2507. doi: 10.1002/rcm.7744.

PMID:
27650360
34.

Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.

Gorityala BK, Guchhait G, Goswami S, Fernando DM, Kumar A, Zhanel GG, Schweizer F.

J Med Chem. 2016 Sep 22;59(18):8441-55. doi: 10.1021/acs.jmedchem.6b00867. Epub 2016 Aug 30.

PMID:
27524179
35.

Ultrashort cationic lipopeptides and lipopeptoids: Evaluation and mechanistic insights against epithelial cancer cells.

Domalaon R, Findlay B, Ogunsina M, Arthur G, Schweizer F.

Peptides. 2016 Oct;84:58-67. doi: 10.1016/j.peptides.2016.07.007. Epub 2016 Jul 30.

PMID:
27486068
36.

Synthesis and Antigenicity against Human Sera of a Biotin-Labeled Oligosaccharide Portion of a Glycosphingolipid from the Parasite Echinococcus multilocularis.

Hada N, Kitamura A, Yamano K, Schweizer F, Kiuchi F.

Chem Pharm Bull (Tokyo). 2016;64(7):865-73. doi: 10.1248/cpb.c16-00211.

37.

Micro- and nano-technologies to probe the mechano-biology of the brain.

Tay A, Schweizer FE, Di Carlo D.

Lab Chip. 2016 May 24;16(11):1962-77. doi: 10.1039/c6lc00349d. Review.

PMID:
27161943
38.

Jasmonates: signal transduction components and their roles in environmental stress responses.

Goossens J, Fernández-Calvo P, Schweizer F, Goossens A.

Plant Mol Biol. 2016 Aug;91(6):673-89. doi: 10.1007/s11103-016-0480-9. Epub 2016 Apr 16. Review.

PMID:
27086135
39.

Cancer stem cells, cancer-initiating cells and methods for their detection.

Akbari-Birgani S, Paranjothy T, Zuse A, Janikowski T, Cieślar-Pobuda A, Likus W, Urasińska E, Schweizer F, Ghavami S, Klonisch T, Łos MJ.

Drug Discov Today. 2016 May;21(5):836-42. doi: 10.1016/j.drudis.2016.03.004. Epub 2016 Mar 11. Review.

PMID:
26976692
40.

Ketones block amyloid entry and improve cognition in an Alzheimer's model.

Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J.

Neurobiol Aging. 2016 Mar;39:25-37. doi: 10.1016/j.neurobiolaging.2015.11.018. Epub 2015 Dec 7.

PMID:
26923399
41.

Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent.

Zhanel GG, Cheung D, Adam H, Zelenitsky S, Golden A, Schweizer F, Gorityala B, Lagacé-Wiens PR, Walkty A, Gin AS, Hoban DJ, Karlowsky JA.

Drugs. 2016 Apr;76(5):567-88. doi: 10.1007/s40265-016-0545-8. Review.

PMID:
26863149
42.

Adjuvants Based on Hybrid Antibiotics Overcome Resistance in Pseudomonas aeruginosa and Enhance Fluoroquinolone Efficacy.

Gorityala BK, Guchhait G, Fernando DM, Deo S, McKenna SA, Zhanel GG, Kumar A, Schweizer F.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):555-9. doi: 10.1002/anie.201508330. Epub 2015 Nov 26.

PMID:
26610184
43.

Ziram, a pesticide associated with increased risk for Parkinson's disease, differentially affects the presynaptic function of aminergic and glutamatergic nerve terminals at the Drosophila neuromuscular junction.

Martin CA, Myers KM, Chen A, Martin NT, Barajas A, Schweizer FE, Krantz DE.

Exp Neurol. 2016 Jan;275 Pt 1:232-41. doi: 10.1016/j.expneurol.2015.09.017. Epub 2015 Oct 9.

44.

Short Antimicrobial Peptides and Peptide Scaffolds as Promising Antibacterial Agents.

Domalaon R, Zhanel GG, Schweizer F.

Curr Top Med Chem. 2016;16(11):1217-30. Review.

PMID:
26369812
45.

Design, synthesis and antitumor properties of glycosylated antitumor ether lipid (GAEL)- chlorambucil-hybrids.

Idowu T, Samadder P, Arthur G, Schweizer F.

Chem Phys Lipids. 2016 Jan;194:139-48. doi: 10.1016/j.chemphyslip.2015.07.003. Epub 2015 Jul 17.

PMID:
26188768
46.

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.

Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, Goossens A.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8130-5. doi: 10.1073/pnas.1504951112. Epub 2015 Jun 15.

47.

Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1).

Jain MV, Jangamreddy JR, Grabarek J, Schweizer F, Klonisch T, Cieślar-Pobuda A, Łos MJ.

Cell Cycle. 2015;14(13):2109-20. doi: 10.1080/15384101.2015.1041692. Epub 2015 Jun 1.

48.

Amphiphilic tobramycins with immunomodulatory properties.

Guchhait G, Altieri A, Gorityala B, Yang X, Findlay B, Zhanel GG, Mookherjee N, Schweizer F.

Angew Chem Int Ed Engl. 2015 May 18;54(21):6278-82. doi: 10.1002/anie.201500598. Epub 2015 Apr 1.

PMID:
25847672
49.

Engineering cortical neuron polarity with nanomagnets on a chip.

Kunze A, Tseng P, Godzich C, Murray C, Caputo A, Schweizer FE, Di Carlo D.

ACS Nano. 2015;9(4):3664-76. doi: 10.1021/nn505330w. Epub 2015 Apr 1.

PMID:
25801533
50.

Compromised white matter integrity in obesity.

Kullmann S, Schweizer F, Veit R, Fritsche A, Preissl H.

Obes Rev. 2015 Apr;16(4):273-81. doi: 10.1111/obr.12248. Epub 2015 Feb 10. Review.

PMID:
25676886

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