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Items: 40


Plasmodium-specific atypical memory B cells are short-lived activated B cells.

Pérez-Mazliah D, Gardner PJ, Schweighoffer E, McLaughlin S, Hosking C, Tumwine I, Davis RS, Potocnik AJ, Tybulewicz VL, Langhorne J.

Elife. 2018 Nov 2;7. pii: e39800. doi: 10.7554/eLife.39800.


Signalling for B cell survival.

Schweighoffer E, Tybulewicz VL.

Curr Opin Cell Biol. 2018 Apr;51:8-14. doi: 10.1016/ Epub 2017 Nov 14. Review.


TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz VLJ.

J Exp Med. 2017 May 1;214(5):1269-1280. doi: 10.1084/jem.20161117. Epub 2017 Mar 29.


BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

Jacque E, Schweighoffer E, Tybulewicz VL, Ley SC.

J Exp Med. 2015 Jun 1;212(6):883-92. doi: 10.1084/jem.20142127. Epub 2015 May 18.


Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

Ackermann JA, Nys J, Schweighoffer E, McCleary S, Smithers N, Tybulewicz VL.

J Immunol. 2015 May 15;194(10):4650-6. doi: 10.4049/jimmunol.1500461. Epub 2015 Apr 10.


Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ.

Eur J Immunol. 2015 Feb;45(2):513-24. doi: 10.1002/eji.201444744. Epub 2014 Dec 8.


IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, Tarlinton DM, Tybulewicz VL, Ley SC.

J Exp Med. 2014 Sep 22;211(10):2085-101. doi: 10.1084/jem.20132019. Epub 2014 Sep 15.


Themis2 is not required for B cell development, activation, and antibody responses.

Hartweger H, Schweighoffer E, Davidson S, Peirce MJ, Wack A, Tybulewicz VL.

J Immunol. 2014 Jul 15;193(2):700-7. doi: 10.4049/jimmunol.1400943. Epub 2014 Jun 6.


Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.

Hara H, Tsuchiya K, Kawamura I, Fang R, Hernandez-Cuellar E, Shen Y, Mizuguchi J, Schweighoffer E, Tybulewicz V, Mitsuyama M.

Nat Immunol. 2013 Dec;14(12):1247-55. doi: 10.1038/ni.2749. Epub 2013 Nov 3.


The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

Schweighoffer E, Vanes L, Nys J, Cantrell D, McCleary S, Smithers N, Tybulewicz VL.

Immunity. 2013 Mar 21;38(3):475-88. doi: 10.1016/j.immuni.2012.11.015. Epub 2013 Feb 28.


CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP.

Blood. 2012 Feb 16;119(7):1747-56. doi: 10.1182/blood-2011-09-380709. Epub 2011 Dec 20.


Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.

Sousa Mda G, Reid DM, Schweighoffer E, Tybulewicz V, Ruland J, Langhorne J, Yamasaki S, Taylor PR, Almeida SR, Brown GD.

Cell Host Microbe. 2011 May 19;9(5):436-43. doi: 10.1016/j.chom.2011.04.005.


Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.

Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, Verbeek JS, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis e Sousa C.

J Exp Med. 2009 Aug 31;206(9):2037-51. doi: 10.1084/jem.20082818. Epub 2009 Aug 24.


Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

Gross O, Poeck H, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J.

Nature. 2009 May 21;459(7245):433-6. doi: 10.1038/nature07965. Epub 2009 Apr 1.


Redundant role for Zap70 in B cell development and activation.

Fallah-Arani F, Schweighoffer E, Vanes L, Tybulewicz VL.

Eur J Immunol. 2008 Jun;38(6):1721-33. doi: 10.1002/eji.200738026.


Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.

Liang B, Workman C, Lee J, Chew C, Dale BM, Colonna L, Flores M, Li N, Schweighoffer E, Greenberg S, Tybulewicz V, Vignali D, Clynes R.

J Immunol. 2008 May 1;180(9):5916-26.


Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.

Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, Kerrigan A, Tsoni SV, Gordon S, Meyer-Wentrup F, Adema GJ, Kullberg BJ, Schweighoffer E, Tybulewicz V, Mora-Montes HM, Gow NA, Williams DL, Netea MG, Brown GD.

Eur J Immunol. 2008 Feb;38(2):500-6. doi: 10.1002/eji.200737741.


Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan.

Slack EC, Robinson MJ, Hernanz-Falcón P, Brown GD, Williams DL, Schweighoffer E, Tybulewicz VL, Reis e Sousa C.

Eur J Immunol. 2007 Jun;37(6):1600-12.


Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.

LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C.

Nat Immunol. 2007 Jun;8(6):630-8. Epub 2007 Apr 22.


GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Hughan SC, Hughes CE, McCarty OJ, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VL, Watson SP.

Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):422-9. Epub 2006 Nov 16.


A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

Suzuki-Inoue K, Fuller GL, García A, Eble JA, Pöhlmann S, Inoue O, Gartner TK, Hughan SC, Pearce AC, Laing GD, Theakston RD, Schweighoffer E, Zitzmann N, Morita T, Tybulewicz VL, Ozaki Y, Watson SP.

Blood. 2006 Jan 15;107(2):542-9. Epub 2005 Sep 20.


Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.

Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis e Sousa C.

Immunity. 2005 Apr;22(4):507-17. Erratum in: Immunity. 2005 Jun;22(6):773-4.


Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages.

Herre J, Marshall AS, Caron E, Edwards AD, Williams DL, Schweighoffer E, Tybulewicz V, Reis e Sousa C, Gordon S, Brown GD.

Blood. 2004 Dec 15;104(13):4038-45. Epub 2004 Aug 10.


NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F.

Nat Immunol. 2003 Jun;4(6):565-72. Epub 2003 May 11.


Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

Schweighoffer E, Vanes L, Mathiot A, Nakamura T, Tybulewicz VL.

Immunity. 2003 Apr;18(4):523-33.


A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.

Sedlik C, Orbach D, Veron P, Schweighoffer E, Colucci F, Gamberale R, Ioan-Facsinay A, Verbeek S, Ricciardi-Castagnoli P, Bonnerot C, Tybulewicz VL, Di Santo J, Amigorena S.

J Immunol. 2003 Jan 15;170(2):846-52.


Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases.

Colucci F, Schweighoffer E, Tomasello E, Turner M, Ortaldo JR, Vivier E, Tybulewicz VL, Di Santo JP.

Nat Immunol. 2002 Mar;3(3):288-94. Epub 2002 Feb 11.


Syk-deficient eosinophils show normal interleukin-5-mediated differentiation, maturation, and survival but no longer respond to FcgammaR activation.

Lach-Trifilieff E, Menear K, Schweighoffer E, Tybulewicz VL, Walker C.

Blood. 2000 Oct 1;96(7):2506-10.


Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.

Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP.

J Biol Chem. 2000 Oct 27;275(43):33427-34.


A new look at Syk in alpha beta and gamma delta T cell development using chimeric mice with a low competitive hematopoietic environment.

Colucci F, Guy-Grand D, Wilson A, Turner M, Schweighoffer E, Tybulewicz VL, Di Santo JP.

J Immunol. 2000 May 15;164(10):5140-5.


Tyrosine kinase SYK: essential functions for immunoreceptor signalling.

Turner M, Schweighoffer E, Colucci F, Di Santo JP, Tybulewicz VL.

Immunol Today. 2000 Mar;21(3):148-54. Review.


LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

Pasquet JM, Gross B, Quek L, Asazuma N, Zhang W, Sommers CL, Schweighoffer E, Tybulewicz V, Judd B, Lee JR, Koretzky G, Love PE, Samelson LE, Watson SP.

Mol Cell Biol. 1999 Dec;19(12):8326-34.


Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation.

Colucci F, Turner M, Schweighoffer E, Guy-Grand D, Di Bartolo V, Salcedo M, Tybulewicz VL, Di Santo JP.

J Immunol. 1999 Aug 15;163(4):1769-74.


Notch activity influences the alphabeta versus gammadelta T cell lineage decision.

Washburn T, Schweighoffer E, Gridley T, Chang D, Fowlkes BJ, Cado D, Robey E.

Cell. 1997 Mar 21;88(6):833-43.


Positive selection of T cells.

Fowlkes BJ, Schweighoffer E.

Curr Opin Immunol. 1995 Apr;7(2):188-95. Review.


Oncogene expression in thymocytes after emetine treatment of mice.

Schweighoffer T, Schweighoffer E, Sviresheva M, Apati A, Balogh A, Csuka I, Luat NN, Banfalvi G.

Cell Mol Biol Res. 1993;39(7):647-56.


Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A.

Schweighoffer T, Schweighoffer E, Apati A, Antoni F, Molnar G, Lapis K, Banfalvi G.

Histochemistry. 1991;96(1):93-7.


[Rupture of a traumatic aneurysmatic renal vein after a recent accident].


Zentralbl Chir. 1961 Sep 16;86:2004-6. German. No abstract available.


[Steroid therapy in surgery].


Zentralbl Chir. 1961 Jul 15;86:1632-6. German. No abstract available.


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