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Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets.

Veluthakal R, Chepurny OG, Leech CA, Schwede F, Holz GG, Thurmond DC.

Diabetes. 2018 Jul 9. pii: db171174. doi: 10.2337/db17-1174. [Epub ahead of print]


Corrigendum: Deciphering the function of the CNGB1b subunit in olfactory CNG channels.

Nache V, Wongsamitkul N, Kusch J, Zimmer T, Schwede F, Benndorf K.

Sci Rep. 2018 Jun 28;8:47000. doi: 10.1038/srep47000.


Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG.

Sci Rep. 2018 Apr 13;8(1):6192. doi: 10.1038/s41598-018-24359-2.


PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.

Isensee J, Kaufholz M, Knape MJ, Hasenauer J, Hammerich H, Gonczarowska-Jorge H, Zahedi RP, Schwede F, Herberg FW, Hucho T.

J Cell Biol. 2018 Jun 4;217(6):2167-2184. doi: 10.1083/jcb.201708053. Epub 2018 Apr 3.


Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration.

Vighi E, Trifunović D, Veiga-Crespo P, Rentsch A, Hoffmann D, Sahaboglu A, Strasser T, Kulkarni M, Bertolotti E, van den Heuvel A, Peters T, Reijerkerk A, Euler T, Ueffing M, Schwede F, Genieser HG, Gaillard P, Marigo V, Ekström P, Paquet-Durand F.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2997-E3006. doi: 10.1073/pnas.1718792115. Epub 2018 Mar 12.


Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.

Chepurny OG, Bonaccorso RL, Leech CA, Wöllert T, Langford GM, Schwede F, Roth CL, Doyle RP, Holz GG.

Sci Rep. 2018 Feb 28;8(1):3749. doi: 10.1038/s41598-018-22106-1. Erratum in: Sci Rep. 2018 Apr 13;8(1):6192.


New cGMP analogues restrain proliferation and migration of melanoma cells.

Vighi E, Rentsch A, Henning P, Comitato A, Hoffmann D, Bertinetti D, Bertolotti E, Schwede F, Herberg FW, Genieser HG, Marigo V.

Oncotarget. 2017 Dec 25;9(4):5301-5320. doi: 10.18632/oncotarget.23685. eCollection 2018 Jan 12.


New dimeric cGMP analogues reduce proliferation in three colon cancer cell lines.

Hoffmann D, Rentsch A, Vighi E, Bertolotti E, Comitato A, Schwede F, Genieser HG, Marigo V.

Eur J Med Chem. 2017 Dec 1;141:61-72. doi: 10.1016/j.ejmech.2017.09.053. Epub 2017 Sep 27.


Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae.

Blötz C, Treffon K, Kaever V, Schwede F, Hammer E, Stülke J.

Front Microbiol. 2017 Jul 13;8:1328. doi: 10.3389/fmicb.2017.01328. eCollection 2017.


Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.

Niewoehner O, Garcia-Doval C, Rostøl JT, Berk C, Schwede F, Bigler L, Hall J, Marraffini LA, Jinek M.

Nature. 2017 Aug 31;548(7669):543-548. doi: 10.1038/nature23467. Epub 2017 Jul 19.


Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging.

Isensee J, Schild C, Schwede F, Hucho T.

J Cell Sci. 2017 Jul 1;130(13):2134-2146. doi: 10.1242/jcs.197327. Epub 2017 May 17.


Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.

Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg FW, Schwede F, Stein C, Jordt SE, Brackmann M, Spahn V.

Eur J Pain. 2017 Jul;21(6):1072-1086. doi: 10.1002/ejp.1008. Epub 2017 Feb 9.


Medicinal Chemistry of the Noncanonical Cyclic Nucleotides cCMP and cUMP.

Schwede F, Rentsch A, Genieser HG.

Handb Exp Pharmacol. 2017;238:307-337. doi: 10.1007/164_2015_41. Review.


PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE.

Mol Metab. 2016 May 11;5(7):459-471. doi: 10.1016/j.molmet.2016.05.003. eCollection 2016 Jul.


Deciphering the function of the CNGB1b subunit in olfactory CNG channels.

Nache V, Wongsamitkul N, Kusch J, Zimmer T, Schwede F, Benndorf K.

Sci Rep. 2016 Jul 11;6:29378. doi: 10.1038/srep29378. Erratum in: Sci Rep. 2018 Jun 28;8:47000.


The Chemistry of the Noncanonical Cyclic Dinucleotide 2'3'-cGAMP and Its Analogs.

Schwede F, Genieser HG, Rentsch A.

Handb Exp Pharmacol. 2017;238:359-384. doi: 10.1007/164_2015_43. Review.


Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.

Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL.

Science. 2016 Jul 1;353(6294):45-50. doi: 10.1126/science.aaf7865. Epub 2016 Jun 2.


Application of Synthetic Peptide Arrays To Uncover Cyclic Di-GMP Binding Motifs.

Düvel J, Bense S, Möller S, Bertinetti D, Schwede F, Morr M, Eckweiler D, Genieser HG, Jänsch L, Herberg FW, Frank R, Häussler S.

J Bacteriol. 2015 Aug 31;198(1):138-46. doi: 10.1128/JB.00377-15. Print 2016 Jan 1.


Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.

Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330. Epub 2015 Jun 10.


Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.

Wolfertstetter S, Reinders J, Schwede F, Ruth P, Schinner E, Schlossmann J.

PLoS One. 2015 May 15;10(5):e0126057. doi: 10.1371/journal.pone.0126057. eCollection 2015.


Structure-guided design of selective Epac1 and Epac2 agonists.

Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H.

PLoS Biol. 2015 Jan 20;13(1):e1002038. doi: 10.1371/journal.pbio.1002038. eCollection 2015 Jan.


Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.

Gundlach J, Dickmanns A, Schröder-Tittmann K, Neumann P, Kaesler J, Kampf J, Herzberg C, Hammer E, Schwede F, Kaever V, Tittmann K, Stülke J, Ficner R.

J Biol Chem. 2015 Jan 30;290(5):3069-80. doi: 10.1074/jbc.M114.619619. Epub 2014 Nov 28.


N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo.

Wolter S, Dove S, Golombek M, Schwede F, Seifert R.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Dec;387(12):1163-75. doi: 10.1007/s00210-014-1042-9. Epub 2014 Sep 6.


cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects.

Beckert U, Grundmann M, Wolter S, Schwede F, Rehmann H, Kaever V, Kostenis E, Seifert R.

Biochem Biophys Res Commun. 2014 Sep 5;451(4):497-502. doi: 10.1016/j.bbrc.2014.07.134. Epub 2014 Aug 7.


Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.

Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, Moroni A.

Nat Chem Biol. 2014 Jun;10(6):457-62. doi: 10.1038/nchembio.1521. Epub 2014 Apr 28. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.


Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.

Herfindal L, Krakstad C, Myhren L, Hagland H, Kopperud R, Teigen K, Schwede F, Kleppe R, Døskeland SO.

PLoS One. 2014 Apr 16;9(4):e94926. doi: 10.1371/journal.pone.0094926. eCollection 2014.


Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

Möller S, Alfieri A, Bertinetti D, Aquila M, Schwede F, Lolicato M, Rehmann H, Moroni A, Herberg FW.

ACS Chem Biol. 2014 May 16;9(5):1128-37. doi: 10.1021/cb400904s. Epub 2014 Mar 7.


Epac-Rap signaling reduces oxidative stress in the tubular epithelium.

Stokman G, Qin Y, Booij TH, Ramaiahgari S, Lacombe M, Dolman ME, van Dorenmalen KM, Teske GJ, Florquin S, Schwede F, van de Water B, Kok RJ, Price LS.

J Am Soc Nephrol. 2014 Jul;25(7):1474-85. doi: 10.1681/ASN.2013070679. Epub 2014 Feb 7.


Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.

Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2013 Aug;27(8):1267-82. doi: 10.1210/me.2013-1029. Epub 2013 Jun 24.


Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity.

Brunskole Hummel I, Reinartz MT, Kälble S, Burhenne H, Schwede F, Buschauer A, Seifert R.

PLoS One. 2013 May 31;8(5):e64556. doi: 10.1371/journal.pone.0064556. Print 2013.


Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.

Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Rouhee N, McCormack E, Herfindal L, Kleppe R, Havemann U, Schwede F, Bruserud O, Gjertsen BT, Lanotte M, Ségal-Bendirdjian E, Døskeland SO.

Cell Death Dis. 2013 Feb 28;4:e516. doi: 10.1038/cddis.2013.39.


A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X.

Mol Pharmacol. 2013 Jan;83(1):122-8. doi: 10.1124/mol.112.080689. Epub 2012 Oct 11.


Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose.

Hammerschmidt A, Chatterji B, Zeiser J, Schröder A, Genieser HG, Pich A, Kaever V, Schwede F, Wolter S, Seifert R.

PLoS One. 2012;7(7):e39848. doi: 10.1371/journal.pone.0039848. Epub 2012 Jul 9.


Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.

Nache V, Zimmer T, Wongsamitkul N, Schmauder R, Kusch J, Reinhardt L, Bönigk W, Seifert R, Biskup C, Schwede F, Benndorf K.

Sci Signal. 2012 Jul 10;5(232):ra48. doi: 10.1126/scisignal.2003110.


How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels.

Kusch J, Thon S, Schulz E, Biskup C, Nache V, Zimmer T, Seifert R, Schwede F, Benndorf K.

Nat Chem Biol. 2011 Dec 18;8(2):162-9. doi: 10.1038/nchembio.747.


A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa.

Düvel J, Bertinetti D, Möller S, Schwede F, Morr M, Wissing J, Radamm L, Zimmermann B, Genieser HG, Jänsch L, Herberg FW, Häussler S.

J Microbiol Methods. 2012 Feb;88(2):229-36. doi: 10.1016/j.mimet.2011.11.015. Epub 2011 Dec 8.


Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription.

Huseby S, Gausdal G, Keen TJ, Kjærland E, Krakstad C, Myhren L, Brønstad K, Kunick C, Schwede F, Genieser HG, Kleppe R, Døskeland SO.

Cell Death Dis. 2011 Dec 8;2:e237. doi: 10.1038/cddis.2011.124.


Activation of PDE10 and PDE11 phosphodiesterases.

Jäger R, Russwurm C, Schwede F, Genieser HG, Koesling D, Russwurm M.

J Biol Chem. 2012 Jan 6;287(2):1210-9. doi: 10.1074/jbc.M111.263806. Epub 2011 Nov 21.


Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.

Leech CA, Dzhura I, Chepurny OG, Kang G, Schwede F, Genieser HG, Holz GG.

Prog Biophys Mol Biol. 2011 Nov;107(2):236-47. doi: 10.1016/j.pbiomolbio.2011.07.005. Epub 2011 Jul 19. Review.


Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides.

Werner K, Schwede F, Genieser HG, Geiger J, Butt E.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Aug;384(2):169-76. doi: 10.1007/s00210-011-0662-6. Epub 2011 Jun 29.


Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure.

Stokman G, Qin Y, Genieser HG, Schwede F, de Heer E, Bos JL, Bajema IM, van de Water B, Price LS.

J Am Soc Nephrol. 2011 May;22(5):859-72. doi: 10.1681/ASN.2010040423. Epub 2011 Apr 14.


Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.


FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells.

Börner S, Schwede F, Schlipp A, Berisha F, Calebiro D, Lohse MJ, Nikolaev VO.

Nat Protoc. 2011 Apr;6(4):427-38. doi: 10.1038/nprot.2010.198. Epub 2011 Mar 10.


Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG.

Islets. 2009 Nov-Dec;1(3):260-5. doi: 10.4161/isl.1.3.9645.


Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5.

Jäger R, Schwede F, Genieser HG, Koesling D, Russwurm M.

Br J Pharmacol. 2010 Dec;161(7):1645-60. doi: 10.1111/j.1476-5381.2010.00977.x.


Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels.

Kusch J, Biskup C, Thon S, Schulz E, Nache V, Zimmer T, Schwede F, Benndorf K.

Neuron. 2010 Jul 15;67(1):75-85. doi: 10.1016/j.neuron.2010.05.022.


PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E622-33. doi: 10.1152/ajpendo.00630.2009. Epub 2009 Dec 15.


Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB.

Erikstein BS, McCormack E, Tronstad KJ, Schwede F, Berge R, Gjertsen BT.

Leuk Res. 2010 Jan;34(1):77-84. doi: 10.1016/j.leukres.2009.09.005. Epub 2009 Sep 27.


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