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Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches.

Auer T, Schreppel P, Erker T, Schwarzer C.

Pharmacol Ther. 2019 Oct 15:107422. doi: 10.1016/j.pharmthera.2019.107422. [Epub ahead of print]


Dynorphin-based "release on demand" gene therapy for drug-resistant temporal lobe epilepsy.

Agostinho AS, Mietzsch M, Zangrandi L, Kmiec I, Mutti A, Kraus L, Fidzinski P, Schneider UC, Holtkamp M, Heilbronn R, Schwarzer C.

EMBO Mol Med. 2019 Oct;11(10):e9963. doi: 10.15252/emmm.201809963. Epub 2019 Sep 5.


Functional characterization of novel bumetanide derivatives for epilepsy treatment.

Auer T, Schreppel P, Erker T, Schwarzer C.

Neuropharmacology. 2019 Aug 30;162:107754. doi: 10.1016/j.neuropharm.2019.107754. [Epub ahead of print]


Role for Chromatin Remodeling Factor Chd1 in Learning and Memory.

Schoberleitner I, Mutti A, Sah A, Wille A, Gimeno-Valiente F, Piatti P, Kharitonova M, Torres L, López-Rodas G, Liu JJ, Singewald N, Schwarzer C, Lusser A.

Front Mol Neurosci. 2019 Jan 23;12:3. doi: 10.3389/fnmol.2019.00003. eCollection 2019.


New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines.

Naito R, Kassai H, Sakai Y, Schönherr S, Fukaya M, Schwarzer C, Sakagami H, Nakao K, Aiba A, Ferraguti F.

Front Mol Neurosci. 2018 Dec 3;11:439. doi: 10.3389/fnmol.2018.00439. eCollection 2018.


Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis.

Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C.

Front Mol Neurosci. 2018 Sep 25;11:351. doi: 10.3389/fnmol.2018.00351. eCollection 2018.


Design, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABAA) Receptor Modulators.

Stadler M, Monticelli S, Seidel T, Luger D, Salzer I, Boehm S, Holzer W, Schwarzer C, Urban E, Khom S, Langer T, Pace V, Hering S.

J Med Chem. 2019 Jan 10;62(1):317-341. doi: 10.1021/acs.jmedchem.8b00859. Epub 2018 Oct 23.


In vivo brain GPCR signaling elucidated by phosphoproteomics.

Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu YT, Spetea M, Liu-Chen LY, Schwarzer C, Mann M.

Science. 2018 Jun 22;360(6395). pii: eaao4927. doi: 10.1126/science.aao4927.


Protein kinase N1 critically regulates cerebellar development and long-term function.

zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJ, Parker PJ, Baier G, Baier-Bitterlich G.

J Clin Invest. 2018 May 1;128(5):2076-2088. doi: 10.1172/JCI96165. Epub 2018 Apr 16.


N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts.

Neely AM, Zhao G, Schwarzer C, Stivers NS, Whitt AG, Meng S, Burlison JA, Machen TE, Li C.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12787. Epub 2017 Oct 9.


The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential.

Burtscher J, Schwarzer C.

Front Mol Neurosci. 2017 Aug 7;10:245. doi: 10.3389/fnmol.2017.00245. eCollection 2017. Review.


Periodontal disease-like bone loss after 
adjuvant radiotherapy in the head and neck region: 
A case report and review of the literature.

Güll FD, Deppe H, Kesting M, Schwarzer C.

Quintessence Int. 2017;48(6):451-457. doi: 10.3290/j.qi.a38161. Review.


Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo.

Weth-Malsch D, Langeslag M, Beroukas D, Zangrandi L, Kastenberger I, Quarta S, Malsch P, Kalpachidou T, Schwarzer C, Proia RL, Haberberger RV, Kress M.

Front Cell Neurosci. 2016 Nov 7;10:258. eCollection 2016.


Free flap rescue using an extracorporeal perfusion device.

Fichter AM, Ritschl LM, Rau A, Schwarzer C, von Bomhard A, Wagenpfeil S, Wolff KD, Mücke T.

J Craniomaxillofac Surg. 2016 Dec;44(12):1889-1895. doi: 10.1016/j.jcms.2016.09.010. Epub 2016 Sep 23.


Donor site morbidity and flap perfusion of subfascial and suprafascial radial forearm flaps: A randomized prospective clinical comparison trial.

Schwarzer C, Mücke T, Wolff KD, Loeffelbein DJ, Rau A.

J Craniomaxillofac Surg. 2016 Sep;44(9):1299-304. doi: 10.1016/j.jcms.2016.06.025. Epub 2016 Jul 2.


Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives.

Khom S, Hintersteiner J, Luger D, Haider M, Pototschnig G, Mihovilovic MD, Schwarzer C, Hering S.

J Pharmacol Exp Ther. 2016 Jun;357(3):580-90. doi: 10.1124/jpet.116.232983. Epub 2016 Apr 18.


Application of a ring cavity surface emitting quantum cascade laser (RCSE-QCL) on the measurement of H<sub>2</sub>S in a CH<sub>4</sub> matrix for process analytics.

Moser H, Genner A, Ofner J, Schwarzer C, Strasser G, Lendl B.

Opt Express. 2016 Mar 21;24(6):6572-85. doi: 10.1364/OE.24.006572.


Chemotaxis and Binding of Pseudomonas aeruginosa to Scratch-Wounded Human Cystic Fibrosis Airway Epithelial Cells.

Schwarzer C, Fischer H, Machen TE.

PLoS One. 2016 Mar 31;11(3):e0150109. doi: 10.1371/journal.pone.0150109. eCollection 2016.


Restricting calcium currents is required for correct fiber type specification in skeletal muscle.

Sultana N, Dienes B, Benedetti A, Tuluc P, Szentesi P, Sztretye M, Rainer J, Hess MW, Schwarzer C, Obermair GJ, Csernoch L, Flucher BE.

Development. 2016 May 1;143(9):1547-59. doi: 10.1242/dev.129676. Epub 2016 Mar 10.


The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.

Zangrandi L, Burtscher J, MacKay JP, Colmers WF, Schwarzer C.

Br J Pharmacol. 2016 Jun;173(11):1756-67. doi: 10.1111/bph.13474. Epub 2016 Apr 21.


Metallothioneins and renal ageing.

Leierer J, Rudnicki M, Braniff SJ, Perco P, Koppelstaetter C, Mühlberger I, Eder S, Kerschbaum J, Schwarzer C, Schroll A, Weiss G, Schneeberger S, Wagner S, Königsrainer A, Böhmig GA, Mayer G.

Nephrol Dial Transplant. 2016 Sep;31(9):1444-52. doi: 10.1093/ndt/gfv451. Epub 2016 Feb 3.


N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins.

Zhao G, Neely AM, Schwarzer C, Lu H, Whitt AG, Stivers NS, Burlison JA, White C, Machen TE, Li C.

Oncotarget. 2016 Feb 2;7(5):5924-42. doi: 10.18632/oncotarget.6827.


Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.

Rizzi S, Knaus HG, Schwarzer C.

J Comp Neurol. 2016 Jul 1;524(10):2093-116. doi: 10.1002/cne.23934. Epub 2015 Dec 15.


The influence of whispering gallery modes on the far field of ring lasers.

Szedlak R, Holzbauer M, MacFarland D, Zederbauer T, Detz H, Andrews AM, Schwarzer C, Schrenk W, Strasser G.

Sci Rep. 2015 Nov 17;5:16668. doi: 10.1038/srep16668.


Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.

Thongrong S, Hausott B, Marvaldi L, Agostinho AS, Zangrandi L, Burtscher J, Fogli B, Schwarzer C, Klimaschewski L.

Hippocampus. 2016 May;26(5):658-67. doi: 10.1002/hipo.22549. Epub 2015 Nov 27.


Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry.

Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E.

Mitochondrion. 2015 Nov;25:104-12. doi: 10.1016/j.mito.2015.10.007. Epub 2015 Oct 26.


Identification of potential novel interaction partners of the sodium-activated potassium channels Slick and Slack in mouse brain.

Rizzi S, Schwarzer C, Kremser L, Lindner HH, Knaus HG.

Biochem Biophys Rep. 2015 Oct 9;4:291-298. doi: 10.1016/j.bbrep.2015.09.024. eCollection 2015 Dec.


STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons.

Kapuralin K, Ćurlin M, Mitrečić D, Kosi N, Schwarzer C, Glavan G, Gajović S.

Mol Cell Neurosci. 2015 Jul;67:104-15. doi: 10.1016/j.mcn.2015.06.009. Epub 2015 Jun 20.


Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone.

Schwarzer C, Fu Z, Morita T, Whitt AG, Neely AM, Li C, Machen TE.

J Biol Chem. 2015 Mar 13;290(11):7247-58. doi: 10.1074/jbc.M114.620039. Epub 2015 Jan 27.


Quantum cascade lasers with a tilted facet utilizing the inherent polarization purity.

Ahn S, Ristanic D, Gansch R, Reininger P, Schwarzer C, MacFarland DC, Detz H, Schrenk W, Strasser G.

Opt Express. 2014 Oct 20;22(21):26294-301. doi: 10.1364/OE.22.026294.


Differences in embryo quality are associated with differences in oocyte composition: a proteomic study in inbred mice.

Pfeiffer MJ, Taher L, Drexler H, Suzuki Y, Makałowski W, Schwarzer C, Wang B, Fuellen G, Boiani M.

Proteomics. 2015 Feb;15(4):675-87. doi: 10.1002/pmic.201400334. Epub 2015 Jan 3.


Developmental stage oxidoreductive states of Chlamydia and infected host cells.

Wang X, Schwarzer C, Hybiske K, Machen TE, Stephens RS.

MBio. 2014 Oct 28;5(6):e01924. doi: 10.1128/mBio.01924-14.


Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor.

Prast JM, Schardl A, Schwarzer C, Dechant G, Saria A, Zernig G.

Front Behav Neurosci. 2014 Sep 24;8:317. doi: 10.3389/fnbeh.2014.00317. eCollection 2014.


GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner.

Kastenberger I, Schwarzer C.

Horm Behav. 2014 Sep;66(4):628-36. doi: 10.1016/j.yhbeh.2014.09.001. Epub 2014 Sep 16.


A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice.

Strommer B, Khom S, Kastenberger I, Cicek SS, Stuppner H, Schwarzer C, Hering S.

J Pharmacol Exp Ther. 2014 Nov;351(2):234-42. doi: 10.1124/jpet.114.218024. Epub 2014 Aug 26.


Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2α.

Grabiner MA, Fu Z, Wu T, Barry KC, Schwarzer C, Machen TE.

J Immunol. 2014 Aug 1;193(3):1459-67. doi: 10.4049/jimmunol.1303437. Epub 2014 Jul 2.


Grating-based far field modifications of ring quantum cascade lasers.

Szedlak R, Schwarzer C, Zederbauer T, Detz H, Andrews AM, Schrenk W, Strasser G.

Opt Express. 2014 Jun 30;22(13):15829-36. doi: 10.1364/OE.22.015829.


DNA replication is an integral part of the mouse oocyte's reprogramming machinery.

Wang B, Pfeiffer MJ, Schwarzer C, Araúzo-Bravo MJ, Boiani M.

PLoS One. 2014 May 16;9(5):e97199. doi: 10.1371/journal.pone.0097199. eCollection 2014.


Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord.

Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE.

Neuron. 2014 May 7;82(3):573-86. doi: 10.1016/j.neuron.2014.02.046. Epub 2014 Apr 10.


Maternal age effect on mouse oocytes: new biological insight from proteomic analysis.

Schwarzer C, Siatkowski M, Pfeiffer MJ, Baeumer N, Drexler HC, Wang B, Fuellen G, Boiani M.

Reproduction. 2014 Jul;148(1):55-72. doi: 10.1530/REP-14-0126. Epub 2014 Mar 31.


Esters of valerenic acid as potential prodrugs.

Hintersteiner J, Haider M, Luger D, Schwarzer C, Reznicek G, Jäger W, Khom S, Mihovilovic MD, Hering S.

Eur J Pharmacol. 2014 Jul 15;735:123-31. doi: 10.1016/j.ejphar.2014.03.019. Epub 2014 Mar 27.


Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

Nguyen AD, Slack K, Schwarzer C, Lee NJ, Boey D, Macia L, Yulyaningsih E, Enriquez RF, Zhang L, Lin S, Shi YC, Baldock PA, Herzog H, Sainsbury A.

Neuropeptides. 2014 Jun;48(3):143-51. doi: 10.1016/j.npep.2014.03.001. Epub 2014 Mar 14.


Time-resolved spectral characterization of ring cavity surface emitting and ridge-type distributed feedback quantum cascade lasers by step-scan FT-IR spectroscopy.

Brandstetter M, Genner A, Schwarzer C, Mujagic E, Strasser G, Lendl B.

Opt Express. 2014 Feb 10;22(3):2656-64. doi: 10.1364/OE.22.002656.


Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia.

Schwarzer C, Ravishankar B, Patanwala M, Shuai S, Fu Z, Illek B, Fischer H, Machen TE.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C844-55. doi: 10.1152/ajpcell.00002.2014. Epub 2014 Mar 5.


Pseudomonas aeruginosa homoserine lactone triggers apoptosis and Bak/Bax-independent release of mitochondrial cytochrome C in fibroblasts.

Schwarzer C, Fu Z, Shuai S, Babbar S, Zhao G, Li C, Machen TE.

Cell Microbiol. 2014 Jul;16(7):1094-104. doi: 10.1111/cmi.12263. Epub 2014 Feb 13.


Effects of embryo culture media do not persist after implantation: a histological study in mice.

Hemkemeyer SA, Schwarzer C, Boiani M, Ehmcke J, Le Gac S, Schlatt S, Nordhoff V.

Hum Reprod. 2014 Feb;29(2):220-33. doi: 10.1093/humrep/det411. Epub 2013 Dec 8.


Quantification of patient compliance with Hawley retainers and removable functional appliances during the retention phase.

Schott TC, Schlipf C, Glasl B, Schwarzer CL, Weber J, Ludwig B.

Am J Orthod Dentofacial Orthop. 2013 Oct;144(4):533-40. doi: 10.1016/j.ajodo.2013.04.020.


Possible role of dynorphins in Alzheimer's disease and age-related cognitive deficits.

Ménard C, Herzog H, Schwarzer C, Quirion R.

Neurodegener Dis. 2014;13(2-3):82-5. doi: 10.1159/000353848. Epub 2013 Aug 22.


Reprogramming of two somatic nuclei in the same ooplasm leads to pluripotent embryonic stem cells.

Pfeiffer MJ, Esteves TC, Balbach ST, Araúzo-Bravo MJ, Stehling M, Jauch A, Houghton FD, Schwarzer C, Boiani M.

Stem Cells. 2013 Nov;31(11):2343-53. doi: 10.1002/stem.1497.


Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging.

Ménard C, Tse YC, Cavanagh C, Chabot JG, Herzog H, Schwarzer C, Wong TP, Quirion R.

J Neurosci. 2013 Jul 31;33(31):12792-804. doi: 10.1523/JNEUROSCI.0290-13.2013.

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