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Items: 1 to 50 of 143

1.

CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells.

Chen L, Tang S, Zhang FF, Garcia V, Falck JR, Schwartzman ML, Arbab AS, Guo AM.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1468-H1479. doi: 10.1152/ajpheart.00690.2018. Epub 2019 Apr 5.

PMID:
30951365
2.

20-HETE in the regulation of vascular and cardiac function.

Rocic P, Schwartzman ML.

Pharmacol Ther. 2018 Dec;192:74-87. doi: 10.1016/j.pharmthera.2018.07.004. Epub 2018 Jul 23. Review.

3.

Corrigendum to "Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation" [J. Mol. Cell. Cardiol. 117 (2018) 88-99].

Soler A, Hunter I, Joseph G, Hutcheson R, Hutcheson B, Yang J, Zhang FF, Joshi SR, Bradford C, Gotlinger KH, Maniyar R, Falck JR, Proctor S, Schwartzman ML, Gupte SA, Rocic P.

J Mol Cell Cardiol. 2018 Aug;121:308. doi: 10.1016/j.yjmcc.2018.03.015. Epub 2018 Apr 4. No abstract available.

PMID:
29625729
4.

Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.

Soler A, Hunter I, Joseph G, Hutcheson R, Hutcheson B, Yang J, Zhang FF, Joshi SR, Bradford C, Gotlinger KH, Maniyar R, Falck JR, Proctor S, Schwartzman ML, Gupte SA, Rocic P.

J Mol Cell Cardiol. 2018 Apr;117:88-99. doi: 10.1016/j.yjmcc.2018.02.005. Epub 2018 Feb 8. Erratum in: J Mol Cell Cardiol. 2018 Apr 4;:.

5.

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.

6.

The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.

Pandey V, Garcia V, Gilani A, Mishra P, Zhang FF, Paudyal MP, Falck JR, Nasjletti A, Wang WH, Schwartzman ML.

J Pharmacol Exp Ther. 2017 Dec;363(3):412-418. doi: 10.1124/jpet.117.243618. Epub 2017 Sep 14.

7.

PGF regulates the basolateral K channels in the distal convoluted tubule.

Wang L, Zhang C, Su XT, Lin DH, Wu P, Schwartzman ML, Wang WH.

Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F254-F261. doi: 10.1152/ajprenal.00102.2017. Epub 2017 Mar 29.

8.

20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.

Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML.

Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21.

9.

Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction.

Joseph G, Soler A, Hutcheson R, Hunter I, Bradford C, Hutcheson B, Gotlinger KH, Jiang H, Falck JR, Proctor S, Schwartzman ML, Rocic P.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H528-H540. doi: 10.1152/ajpheart.00561.2016. Epub 2016 Dec 23.

10.

Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid.

Garcia V, Schwartzman ML.

Curr Opin Nephrol Hypertens. 2017 Mar;26(2):74-82. doi: 10.1097/MNH.0000000000000302. Review.

PMID:
27906746
11.

Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice.

Joshi SR, Lakhkar A, Dhagia V, Zias AL, Soldatos V, Oshima K, Jiang H, Gotlinger K, Capdevila JH, Schwartzman ML, McMurtry IF, Gupte SA.

Pulm Circ. 2016 Sep;6(3):360-8. doi: 10.1086/688060. Erratum in: Pulm Circ. 2016 Dec;6(4):621.

12.

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE.

Dordea AC, Vandenwijngaert S, Garcia V, Tainsh RE, Nathan DI, Allen K, Raher MJ, Tainsh LT, Zhang F, Lieb WS, Mikelman S, Kirby A, Stevens C, Thoonen R, Hindle AG, Sips PY, Falck JR, Daly MJ, Brouckaert P, Bloch KD, Bloch DB, Malhotra R, Schwartzman ML, Buys ES.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1790-800. doi: 10.1152/ajpheart.00877.2015. Epub 2016 May 3.

13.

20-HETE contributes to ischemia-induced angiogenesis.

Chen L, Joseph G, Zhang FF, Nguyen H, Jiang H, Gotlinger KH, Falck JR, Yang J, Schwartzman ML, Guo AM.

Vascul Pharmacol. 2016 Aug;83:57-65. doi: 10.1016/j.vph.2016.04.002. Epub 2016 Apr 13.

14.

20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.

Lakhkar A, Dhagia V, Joshi SR, Gotlinger K, Patel D, Sun D, Wolin MS, Schwartzman ML, Gupte SA.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1107-17. doi: 10.1152/ajpheart.00961.2015. Epub 2016 Feb 26.

15.

Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE.

Kizub IV, Lakhkar A, Dhagia V, Joshi SR, Jiang H, Wolin MS, Falck JR, Koduru SR, Errabelli R, Jacobs ER, Schwartzman ML, Gupte SA.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15;310(8):L772-83. doi: 10.1152/ajplung.00377.2015. Epub 2016 Feb 19.

16.

20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding.

Garcia V, Shkolnik B, Milhau L, Falck JR, Schwartzman ML.

J Pharmacol Exp Ther. 2016 Mar;356(3):525-33. doi: 10.1124/jpet.115.229377. Epub 2015 Dec 23.

17.

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.

Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML.

Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R71-8. doi: 10.1152/ajpregu.00039.2015. Epub 2015 Apr 29.

18.

Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis.

Vanella L, Canestraro M, Lee CR, Cao J, Zeldin DC, Schwartzman ML, Abraham NG.

Prostaglandins Other Lipid Mediat. 2015 Jul;120:139-47. doi: 10.1016/j.prostaglandins.2015.04.004. Epub 2015 Apr 20.

19.

Vascular actions of 20-HETE.

Hoopes SL, Garcia V, Edin ML, Schwartzman ML, Zeldin DC.

Prostaglandins Other Lipid Mediat. 2015 Jul;120:9-16. doi: 10.1016/j.prostaglandins.2015.03.002. Epub 2015 Mar 23. Review.

20.

Androgen-induced hypertension in angiotensinogen deficient mice: role of 20-HETE and EETS.

Garcia V, Cheng J, Weidenhammer A, Ding Y, Wu CC, Zhang F, Gotlinger K, Falck JR, Schwartzman ML.

Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:124-30. doi: 10.1016/j.prostaglandins.2014.12.001. Epub 2014 Dec 17.

21.

Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing.

Bellner L, Marrazzo G, van Rooijen N, Dunn MW, Abraham NG, Schwartzman ML.

FASEB J. 2015 Jan;29(1):105-15. doi: 10.1096/fj.14-256503. Epub 2014 Oct 23.

22.

CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.

Abraham NG, Sodhi K, Silvis AM, Vanella L, Favero G, Rezzani R, Lee C, Zeldin DC, Schwartzman ML.

Hypertension. 2014 Dec;64(6):1352-61. doi: 10.1161/HYPERTENSIONAHA.114.03884. Epub 2014 Sep 22.

23.

Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.

Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A.

J Am Soc Nephrol. 2015 Mar;26(3):597-610. doi: 10.1681/ASN.2013090980. Epub 2014 Jul 28.

24.

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

Cheng J, Edin ML, Hoopes SL, Li H, Bradbury JA, Graves JP, DeGraff LM, Lih FB, Garcia V, Shaik JS, Tomer KB, Flake GP, Falck JR, Lee CR, Poloyac SM, Schwartzman ML, Zeldin DC.

FASEB J. 2014 Jul;28(7):2915-31. doi: 10.1096/fj.13-241927. Epub 2014 Mar 25.

25.

Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure.

Sun D, Cuevas AJ, Gotlinger K, Hwang SH, Hammock BD, Schwartzman ML, Huang A.

Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1146-53. doi: 10.1152/ajpheart.00920.2013. Epub 2014 Feb 21.

26.

20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo.

Chen L, Ackerman R, Saleh M, Gotlinger KH, Kessler M, Mendelowitz LG, Falck JR, Arbab AS, Scicli AG, Schwartzman ML, Yang J, Guo AM.

J Pharmacol Exp Ther. 2014 Mar;348(3):442-51. doi: 10.1124/jpet.113.210120. Epub 2014 Jan 8.

27.

Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.

Toth P, Csiszar A, Tucsek Z, Sosnowska D, Gautam T, Koller A, Schwartzman ML, Sonntag WE, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1698-708. doi: 10.1152/ajpheart.00377.2013. Epub 2013 Oct 4.

28.

20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.

Ding Y, Wu CC, Garcia V, Dimitrova I, Weidenhammer A, Joseph G, Zhang F, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F753-63. doi: 10.1152/ajprenal.00292.2013. Epub 2013 Jul 3.

29.

Dysregulated heme oxygenase-ferritin system in pterygium pathogenesis.

Fox T, Gotlinger KH, Dunn MW, Lee OL, Milman T, Zaidman G, Schwartzman ML, Bellner L.

Cornea. 2013 Sep;32(9):1276-82. doi: 10.1097/ICO.0b013e3182936915.

30.

Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.

Wu CC, Mei S, Cheng J, Ding Y, Weidenhammer A, Garcia V, Zhang F, Gotlinger K, Manthati VL, Falck JR, Capdevila JH, Schwartzman ML.

J Am Soc Nephrol. 2013 Jul;24(8):1288-96. doi: 10.1681/ASN.2012070714. Epub 2013 May 2.

31.

20-HETE and blood pressure regulation: clinical implications.

Wu CC, Gupta T, Garcia V, Ding Y, Schwartzman ML.

Cardiol Rev. 2014 Jan-Feb;22(1):1-12. doi: 10.1097/CRD.0b013e3182961659. Review.

32.

Heme oxygenase-2/adiponectin protein-protein interaction in metabolic syndrome.

Vanella L, Li Volti G, Guccione S, Rappazzo G, Salvo E, Pappalardo M, Forte S, Schwartzman ML, Abraham NG.

Biochem Biophys Res Commun. 2013 Mar 22;432(4):606-11. doi: 10.1016/j.bbrc.2013.02.037. Epub 2013 Feb 21.

33.

Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes.

Kim DH, Puri N, Sodhi K, Falck JR, Abraham NG, Shapiro J, Schwartzman ML.

J Lipid Res. 2013 Mar;54(3):786-93. doi: 10.1194/jlr.M033894. Epub 2013 Jan 4.

34.

Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet.

Cao J, Peterson SJ, Sodhi K, Vanella L, Barbagallo I, Rodella LF, Schwartzman ML, Abraham NG, Kappas A.

Hypertension. 2012 Aug;60(2):467-75. doi: 10.1161/HYPERTENSIONAHA.112.193805. Epub 2012 Jul 2.

35.

Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction.

Cheng J, Garcia V, Ding Y, Wu CC, Thakar K, Falck JR, Ramu E, Schwartzman ML.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1917-24. doi: 10.1161/ATVBAHA.112.248344. Epub 2012 Jun 21.

36.

Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin.

Burgess AP, Vanella L, Bellner L, Gotlinger K, Falck JR, Abraham NG, Schwartzman ML, Kappas A.

Cell Physiol Biochem. 2012;29(1-2):99-110. doi: 10.1159/000337591. Epub 2012 Mar 1.

37.

EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels.

Sodhi K, Puri N, Inoue K, Falck JR, Schwartzman ML, Abraham NG.

Prostaglandins Other Lipid Mediat. 2012 Aug;98(3-4):133-42. doi: 10.1016/j.prostaglandins.2011.12.004. Epub 2011 Dec 24.

38.

Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications.

Burgess A, Vanella L, Bellner L, Schwartzman ML, Abraham NG.

Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):1-16. doi: 10.1016/j.prostaglandins.2011.10.002. Epub 2011 Nov 15. Review.

39.

Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes.

Vanella L, Kim DH, Sodhi K, Barbagallo I, Burgess AP, Falck JR, Schwartzman ML, Abraham NG.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):54-62. doi: 10.1016/j.prostaglandins.2011.07.005. Epub 2011 Jul 27.

40.

The role of 20-HETE in androgen-mediated hypertension.

Wu CC, Schwartzman ML.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):45-53. doi: 10.1016/j.prostaglandins.2011.06.006. Epub 2011 Jun 22. Review.

41.

The role of neutrophils in corneal wound healing in HO-2 null mice.

Marrazzo G, Bellner L, Halilovic A, Li Volti G, Drago F, Dunn MW, Schwartzman ML.

PLoS One. 2011;6(6):e21180. doi: 10.1371/journal.pone.0021180. Epub 2011 Jun 17.

42.

Targeted suppression of HO-2 gene expression impairs the innate anti-inflammatory and repair responses of the cornea to injury.

Bellner L, Patil KA, Castellano K, Halilovic A, Dunn MW, Schwartzman ML.

Mol Vis. 2011 Apr 29;17:1144-52.

43.

Knockdown of heme oxygenase-2 impairs corneal epithelial cell wound healing.

Halilovic A, Patil KA, Bellner L, Marrazzo G, Castellano K, Cullaro G, Dunn MW, Schwartzman ML.

J Cell Physiol. 2011 Jul;226(7):1732-40. doi: 10.1002/jcp.22502.

44.

Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.

Wu CC, Cheng J, Zhang FF, Gotlinger KH, Kelkar M, Zhang Y, Jat JL, Falck JR, Schwartzman ML.

Hypertension. 2011 Apr;57(4):788-94. doi: 10.1161/HYPERTENSIONAHA.110.161570. Epub 2011 Feb 14.

45.

CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent.

Sodhi K, Wu CC, Cheng J, Gotlinger K, Inoue K, Goli M, Falck JR, Abraham NG, Schwartzman ML.

Hypertension. 2010 Nov;56(5):871-8. doi: 10.1161/HYPERTENSIONAHA.110.154559. Epub 2010 Sep 13.

46.

High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.

Sun P, Lin DH, Yue P, Jiang H, Gotlinger KH, Schwartzman ML, Falck JR, Goli M, Wang WH.

J Am Soc Nephrol. 2010 Oct;21(10):1667-77. doi: 10.1681/ASN.2009111110. Epub 2010 Jul 1.

47.

Profile of lipid and protein autacoids in diabetic vitreous correlates with the progression of diabetic retinopathy.

Schwartzman ML, Iserovich P, Gotlinger K, Bellner L, Dunn MW, Sartore M, Grazia Pertile M, Leonardi A, Sathe S, Beaton A, Trieu L, Sack R.

Diabetes. 2010 Jul;59(7):1780-8. doi: 10.2337/db10-0110. Epub 2010 Apr 27.

48.

Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ.

Kim DH, Vanella L, Inoue K, Burgess A, Gotlinger K, Manthati VL, Koduru SR, Zeldin DC, Falck JR, Schwartzman ML, Abraham NG.

Stem Cells Dev. 2010 Dec;19(12):1863-73. doi: 10.1089/scd.2010.0098. Epub 2010 Oct 9.

49.

Molecular cloning and enzymatic characterization of sheep CYP2J.

Messina A, Nencioni S, Gervasi PG, Gotlinger KH, Schwartzman ML, Longo V.

Xenobiotica. 2010 Feb;40(2):109-18. doi: 10.3109/00498250903410590.

50.

20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling.

Cheng J, Wu CC, Gotlinger KH, Zhang F, Falck JR, Narsimhaswamy D, Schwartzman ML.

J Pharmacol Exp Ther. 2010 Jan;332(1):57-65. doi: 10.1124/jpet.109.159863. Epub 2009 Oct 19.

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