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Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus.

Kotliarov Y, Sparks R, Martins AJ, Mulè MP, Lu Y, Goswami M, Kardava L, Banchereau R, Pascual V, Biancotto A, Chen J, Schwartzberg PL, Bansal N, Liu CC, Cheung F, Moir S, Tsang JS.

Nat Med. 2020 Feb 24. doi: 10.1038/s41591-020-0769-8. [Epub ahead of print]


Women in immunology: 2020 and beyond.

Pierce SK, Schwartzberg PL, Shah NN, Taylor N.

Nat Immunol. 2020 Mar;21(3):254-258. doi: 10.1038/s41590-020-0618-4. Epub 2020 Feb 24. Review.


Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion.

Clark DJ, McMillan LE, Tan SL, Bellomo G, Massoue C, Thompson H, Mykhaylechko L, Alibhai D, Ruan X, Singleton KL, Du M, Hedges A, Schwartzberg PL, Verkade P, Murphy RF, Wülfing C.

Elife. 2019 Oct 30;8. pii: e45789. doi: 10.7554/eLife.45789.


Defining 'T cell exhaustion'.

Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D.

Nat Rev Immunol. 2019 Nov;19(11):665-674. doi: 10.1038/s41577-019-0221-9. Epub 2019 Sep 30. Review.


The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.

Collins N, Han SJ, Enamorado M, Link VM, Huang B, Moseman EA, Kishton RJ, Shannon JP, Dixit D, Schwab SR, Hickman HD, Restifo NP, McGavern DB, Schwartzberg PL, Belkaid Y.

Cell. 2019 Aug 22;178(5):1088-1101.e15. doi: 10.1016/j.cell.2019.07.049.


T and B-cell signaling in activated PI3K delta syndrome: From immunodeficiency to autoimmunity.

Preite S, Gomez-Rodriguez J, Cannons JL, Schwartzberg PL.

Immunol Rev. 2019 Sep;291(1):154-173. doi: 10.1111/imr.12790. Review.


Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection.

Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T.

Nat Immunol. 2019 Jul;20(7):890-901. doi: 10.1038/s41590-019-0403-4. Epub 2019 Jun 17.


Mg2+ regulation of kinase signaling and immune function.

Kanellopoulou C, George AB, Masutani E, Cannons JL, Ravell JC, Yamamoto TN, Smelkinson MG, Jiang PD, Matsuda-Lennikov M, Reilley J, Handon R, Lee PH, Miller JR, Restifo NP, Zheng L, Schwartzberg PL, Young M, Lenardo MJ.

J Exp Med. 2019 Aug 5;216(8):1828-1842. doi: 10.1084/jem.20181970. Epub 2019 Jun 13.


A mouse model of Proteus syndrome.

Lindhurst MJ, Brinster LR, Kondolf HC, Shwetar JJ, Yourick MR, Shiferaw H, Keppler-Noreuil KM, Elliot G, Rivas C, Garrett L, Gomez-Rodriguez J, Sebire NJ, Hewitt SM, Schwartzberg PL, Biesecker LG.

Hum Mol Genet. 2019 Sep 1;28(17):2920-2936. doi: 10.1093/hmg/ddz116.


PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity.

Preite S, Huang B, Cannons JL, McGavern DB, Schwartzberg PL.

Front Immunol. 2019 Jan 7;9:3079. doi: 10.3389/fimmu.2018.03079. eCollection 2018. Review.


Efficient CRISPR/Cas9-Mediated Mutagenesis in Primary Murine T Lymphocytes.

Huang B, Johansen KH, Schwartzberg PL.

Curr Protoc Immunol. 2019 Feb;124(1):e62. doi: 10.1002/cpim.62. Epub 2018 Oct 12.


AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization.

Khurana S, Coyle EM, Manischewitz J, King LR, Gao J, Germain RN, Schwartzberg PL, Tsang JS, Golding H; and the CHI Consortium.

NPJ Vaccines. 2018 Oct 1;3:40. doi: 10.1038/s41541-018-0076-2. eCollection 2018.


Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL.

Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20.


Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function.

Cannons JL, Preite S, Kapnick SM, Uzel G, Schwartzberg PL.

Front Immunol. 2018 Aug 2;9:1758. doi: 10.3389/fimmu.2018.01758. eCollection 2018. Review.


X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.

Panchal N, Booth C, Cannons JL, Schwartzberg PL.

Front Immunol. 2018 Apr 4;9:666. doi: 10.3389/fimmu.2018.00666. eCollection 2018. Review.


SAP and Lessons Learned from a Primary Immunodeficiency.

Cannons JL, Schwartzberg PL.

J Immunol. 2017 Sep 1;199(5):1531-1533. doi: 10.4049/jimmunol.1701007. No abstract available.


Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.

Ritter AT, Kapnick SM, Murugesan S, Schwartzberg PL, Griffiths GM, Lippincott-Schwartz J.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6585-E6594. doi: 10.1073/pnas.1710751114. Epub 2017 Jul 17.


Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.

Kapnick SM, Stinchcombe JC, Griffiths GM, Schwartzberg PL.

J Immunol. 2017 Apr 1;198(7):2699-2711. doi: 10.4049/jimmunol.1601202. Epub 2017 Feb 17.


The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL.

Sci Immunol. 2016 Dec 23;1(6). pii: eaai8593. doi: 10.1126/sciimmunol.aai8593. Epub 2016 Dec 9.


Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation.

Moseman EA, Wu T, de la Torre JC, Schwartzberg PL, McGavern DB.

Sci Immunol. 2016 Oct;1(4). pii: eaah3565. Epub 2016 Oct 21.


CD84 mediates CLL-microenvironment interactions.

Marom A, Barak AF, Kramer MP, Lewinsky H, Binsky-Ehrenreich I, Cohen S, Tsitsou-Kampeli A, Kalchenko V, Kuznetsov Y, Mirkin V, Dezorella N, Shapiro M, Schwartzberg PL, Cohen Y, Shvidel L, Haran M, Becker-Herman S, Herishanu Y, Shachar I.

Oncogene. 2017 Feb 2;36(5):628-638. doi: 10.1038/onc.2016.238. Epub 2016 Jul 25.


CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.

Huang B, Gomez-Rodriguez J, Preite S, Garrett LJ, Harper UL, Schwartzberg PL.

PLoS One. 2016 Jun 3;11(6):e0156072. doi: 10.1371/journal.pone.0156072. eCollection 2016.


Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.

Gomez-Rodriguez J, Meylan F, Handon R, Hayes ET, Anderson SM, Kirby MR, Siegel RM, Schwartzberg PL.

Nat Commun. 2016 Mar 3;7:10857. doi: 10.1038/ncomms10857.


Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.

Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A.

Sci Transl Med. 2016 Jan 13;8(321):321ra7. doi: 10.1126/scitranslmed.aad1565.


TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.

Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL.

Cell Rep. 2015 Sep 29;12(12):2099-110. doi: 10.1016/j.celrep.2015.08.049. Epub 2015 Sep 10.


T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice.

Sinai P, Dozmorov IM, Song R, Schwartzberg PL, Wakeland EK, Wülfing C.

Eur J Immunol. 2014 Dec;44(12):3522-31. doi: 10.1002/eji.201444602. Epub 2014 Nov 12.


Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.

Prince AL, Kraus Z, Carty SA, Ng C, Yin CC, Jordan MS, Schwartzberg PL, Berg LJ.

J Immunol. 2014 Jul 15;193(2):688-99. doi: 10.4049/jimmunol.1302059. Epub 2014 Jun 18.


Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.

Prince AL, Watkin LB, Yin CC, Selin LK, Kang J, Schwartzberg PL, Berg LJ.

J Immunol. 2014 Jul 15;193(2):673-87. doi: 10.4049/jimmunol.1302058. Epub 2014 Jun 13.


Global analyses of human immune variation reveal baseline predictors of postvaccination responses.

Tsang JS, Schwartzberg PL, Kotliarov Y, Biancotto A, Xie Z, Germain RN, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F; Baylor HIPC Center; CHI Consortium.

Cell. 2014 Apr 10;157(2):499-513. doi: 10.1016/j.cell.2014.03.031. Erratum in: Cell. 2014 Jul 3;158(1):226.


Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.

Gomez-Rodriguez J, Wohlfert EA, Handon R, Meylan F, Wu JZ, Anderson SM, Kirby MR, Belkaid Y, Schwartzberg PL.

J Exp Med. 2014 Mar 10;211(3):529-43. doi: 10.1084/jem.20131459. Epub 2014 Feb 17.


Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program.

Nakayamada S, Poholek AC, Lu KT, Takahashi H, Kato M, Iwata S, Hirahara K, Cannons JL, Schwartzberg PL, Vahedi G, Sun HW, Kanno Y, O'Shea JJ.

J Immunol. 2014 Mar 1;192(5):2156-66. doi: 10.4049/jimmunol.1300675. Epub 2014 Jan 31.


Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G.

Nat Immunol. 2014 Jan;15(1):88-97. doi: 10.1038/ni.2771. Epub 2013 Oct 28.


Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z, Yu D.

Immunity. 2013 Oct 17;39(4):770-81. doi: 10.1016/j.immuni.2013.09.007.


Ncking BCR-mediated PI3K activation.

Cannons JL, Zhao F, Schwartzberg PL.

EMBO Rep. 2013 Oct;14(10):852-3. doi: 10.1038/embor.2013.133. Epub 2013 Aug 23. No abstract available.


Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.

Dervovic DD, Liang HC, Cannons JL, Elford AR, Mohtashami M, Ohashi PS, Schwartzberg PL, Zúñiga-Pflücker JC.

J Immunol. 2013 Aug 15;191(4):1704-15. doi: 10.4049/jimmunol.1300417. Epub 2013 Jul 12.


T follicular helper cell diversity and plasticity.

Cannons JL, Lu KT, Schwartzberg PL.

Trends Immunol. 2013 May;34(5):200-7. doi: 10.1016/ Epub 2013 Feb 8. Review.


A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.

Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL.

J Immunol. 2013 Mar 1;190(5):2121-8. doi: 10.4049/jimmunol.1202145. Epub 2013 Jan 25.


Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16264-9. doi: 10.1073/pnas.1207528109. Epub 2012 Sep 17.


Lymph node choreography: B cells take the lead.

Cannons JL, Lu KT, Schwartzberg PL.

Nat Immunol. 2012 Jun 19;13(7):630-2. doi: 10.1038/ni.2349. No abstract available.


The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.

Kageyama R, Cannons JL, Zhao F, Yusuf I, Lao C, Locci M, Schwartzberg PL, Crotty S.

Immunity. 2012 Jun 29;36(6):986-1002. doi: 10.1016/j.immuni.2012.05.016. Epub 2012 Jun 7.


Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.

Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL.

Immunity. 2012 Jun 29;36(6):1003-16. doi: 10.1016/j.immuni.2012.05.017. Epub 2012 Jun 7.


Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108.

Dutta M, Schwartzberg PL.

J Immunol. 2012 Apr 1;188(7):3031-41. doi: 10.4049/jimmunol.1103226. Epub 2012 Mar 5.


Early Th1 cell differentiation is marked by a Tfh cell-like transition.

Nakayamada S, Kanno Y, Takahashi H, Jankovic D, Lu KT, Johnson TA, Sun HW, Vahedi G, Hakim O, Handon R, Schwartzberg PL, Hager GL, O'Shea JJ.

Immunity. 2011 Dec 23;35(6):919-31. doi: 10.1016/j.immuni.2011.11.012.


Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.

Lu KT, Kanno Y, Cannons JL, Handon R, Bible P, Elkahloun AG, Anderson SM, Wei L, Sun H, O'Shea JJ, Schwartzberg PL.

Immunity. 2011 Oct 28;35(4):622-32. doi: 10.1016/j.immuni.2011.07.015. Epub 2011 Oct 20.


A mosaic activating mutation in AKT1 associated with the Proteus syndrome.

Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S, Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG.

N Engl J Med. 2011 Aug 18;365(7):611-9. doi: 10.1056/NEJMoa1104017. Epub 2011 Jul 27.


The human condition: an immunological perspective.

Germain RN, Schwartzberg PL.

Nat Immunol. 2011 May;12(5):369-72. doi: 10.1038/ni0511-369. No abstract available.


Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.

Hall JA, Cannons JL, Grainger JR, Dos Santos LM, Hand TW, Naik S, Wohlfert EA, Chou DB, Oldenhove G, Robinson M, Grigg ME, Kastenmayer R, Schwartzberg PL, Belkaid Y.

Immunity. 2011 Mar 25;34(3):435-47. doi: 10.1016/j.immuni.2011.03.003.


Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.

Gomez-Rodriguez J, Kraus ZJ, Schwartzberg PL.

FEBS J. 2011 Jun;278(12):1980-9. doi: 10.1111/j.1742-4658.2011.08072.x. Epub 2011 Mar 29. Review.


SLAM family receptors and SAP adaptors in immunity.

Cannons JL, Tangye SG, Schwartzberg PL.

Annu Rev Immunol. 2011;29:665-705. doi: 10.1146/annurev-immunol-030409-101302. Review.


Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.

Zhang S, Readinger JA, DuBois W, Janka-Junttila M, Robinson R, Pruitt M, Bliskovsky V, Wu JZ, Sakakibara K, Patel J, Parent CA, Tessarollo L, Schwartzberg PL, Mock BA.

Blood. 2011 Jan 27;117(4):1228-38. doi: 10.1182/blood-2010-05-287821. Epub 2010 Nov 15.

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