Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 130


Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL.

Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20.


Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function.

Cannons JL, Preite S, Kapnick SM, Uzel G, Schwartzberg PL.

Front Immunol. 2018 Aug 2;9:1758. doi: 10.3389/fimmu.2018.01758. eCollection 2018.


X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.

Panchal N, Booth C, Cannons JL, Schwartzberg PL.

Front Immunol. 2018 Apr 4;9:666. doi: 10.3389/fimmu.2018.00666. eCollection 2018. Review.


SAP and Lessons Learned from a Primary Immunodeficiency.

Cannons JL, Schwartzberg PL.

J Immunol. 2017 Sep 1;199(5):1531-1533. doi: 10.4049/jimmunol.1701007. No abstract available.


Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.

Ritter AT, Kapnick SM, Murugesan S, Schwartzberg PL, Griffiths GM, Lippincott-Schwartz J.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6585-E6594. doi: 10.1073/pnas.1710751114. Epub 2017 Jul 17.


Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.

Kapnick SM, Stinchcombe JC, Griffiths GM, Schwartzberg PL.

J Immunol. 2017 Apr 1;198(7):2699-2711. doi: 10.4049/jimmunol.1601202. Epub 2017 Feb 17.


The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL.

Sci Immunol. 2016 Dec 23;1(6). pii: eaai8593. doi: 10.1126/sciimmunol.aai8593. Epub 2016 Dec 9.


Type I interferon suppresses virus-specific B cell responses by modulating CD8+ T cell differentiation.

Moseman EA, Wu T, de la Torre JC, Schwartzberg PL, McGavern DB.

Sci Immunol. 2016 Oct;1(4). pii: eaah3565. Epub 2016 Oct 21.


CD84 mediates CLL-microenvironment interactions.

Marom A, Barak AF, Kramer MP, Lewinsky H, Binsky-Ehrenreich I, Cohen S, Tsitsou-Kampeli A, Kalchenko V, Kuznetsov Y, Mirkin V, Dezorella N, Shapiro M, Schwartzberg PL, Cohen Y, Shvidel L, Haran M, Becker-Herman S, Herishanu Y, Shachar I.

Oncogene. 2017 Feb 2;36(5):628-638. doi: 10.1038/onc.2016.238. Epub 2016 Jul 25.


CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.

Huang B, Gomez-Rodriguez J, Preite S, Garrett LJ, Harper UL, Schwartzberg PL.

PLoS One. 2016 Jun 3;11(6):e0156072. doi: 10.1371/journal.pone.0156072. eCollection 2016.


Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.

Gomez-Rodriguez J, Meylan F, Handon R, Hayes ET, Anderson SM, Kirby MR, Siegel RM, Schwartzberg PL.

Nat Commun. 2016 Mar 3;7:10857. doi: 10.1038/ncomms10857.


Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.

Ruffo E, Malacarne V, Larsen SE, Das R, Patrussi L, Wülfing C, Biskup C, Kapnick SM, Verbist K, Tedrick P, Schwartzberg PL, Baldari CT, Rubio I, Nichols KE, Snow AL, Baldanzi G, Graziani A.

Sci Transl Med. 2016 Jan 13;8(321):321ra7. doi: 10.1126/scitranslmed.aad1565.


TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.

Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL.

Cell Rep. 2015 Sep 29;12(12):2099-110. doi: 10.1016/j.celrep.2015.08.049. Epub 2015 Sep 10.


T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice.

Sinai P, Dozmorov IM, Song R, Schwartzberg PL, Wakeland EK, Wülfing C.

Eur J Immunol. 2014 Dec;44(12):3522-31. doi: 10.1002/eji.201444602. Epub 2014 Nov 12.


Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.

Prince AL, Kraus Z, Carty SA, Ng C, Yin CC, Jordan MS, Schwartzberg PL, Berg LJ.

J Immunol. 2014 Jul 15;193(2):688-99. doi: 10.4049/jimmunol.1302059. Epub 2014 Jun 18.


Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.

Prince AL, Watkin LB, Yin CC, Selin LK, Kang J, Schwartzberg PL, Berg LJ.

J Immunol. 2014 Jul 15;193(2):673-87. doi: 10.4049/jimmunol.1302058. Epub 2014 Jun 13.


Global analyses of human immune variation reveal baseline predictors of postvaccination responses.

Tsang JS, Schwartzberg PL, Kotliarov Y, Biancotto A, Xie Z, Germain RN, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F; Baylor HIPC Center; CHI Consortium.

Cell. 2014 Apr 10;157(2):499-513. doi: 10.1016/j.cell.2014.03.031. Erratum in: Cell. 2014 Jul 3;158(1):226.


Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.

Gomez-Rodriguez J, Wohlfert EA, Handon R, Meylan F, Wu JZ, Anderson SM, Kirby MR, Belkaid Y, Schwartzberg PL.

J Exp Med. 2014 Mar 10;211(3):529-43. doi: 10.1084/jem.20131459. Epub 2014 Feb 17.


Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program.

Nakayamada S, Poholek AC, Lu KT, Takahashi H, Kato M, Iwata S, Hirahara K, Cannons JL, Schwartzberg PL, Vahedi G, Sun HW, Kanno Y, O'Shea JJ.

J Immunol. 2014 Mar 1;192(5):2156-66. doi: 10.4049/jimmunol.1300675. Epub 2014 Jan 31.


Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G.

Nat Immunol. 2014 Jan;15(1):88-97. doi: 10.1038/ni.2771. Epub 2013 Oct 28.


Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z, Yu D.

Immunity. 2013 Oct 17;39(4):770-81. doi: 10.1016/j.immuni.2013.09.007.


Ncking BCR-mediated PI3K activation.

Cannons JL, Zhao F, Schwartzberg PL.

EMBO Rep. 2013 Oct;14(10):852-3. doi: 10.1038/embor.2013.133. Epub 2013 Aug 23. No abstract available.


Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.

Dervovic DD, Liang HC, Cannons JL, Elford AR, Mohtashami M, Ohashi PS, Schwartzberg PL, Zúñiga-Pflücker JC.

J Immunol. 2013 Aug 15;191(4):1704-15. doi: 10.4049/jimmunol.1300417. Epub 2013 Jul 12.


T follicular helper cell diversity and plasticity.

Cannons JL, Lu KT, Schwartzberg PL.

Trends Immunol. 2013 May;34(5):200-7. doi: 10.1016/ Epub 2013 Feb 8. Review.


A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.

Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL.

J Immunol. 2013 Mar 1;190(5):2121-8. doi: 10.4049/jimmunol.1202145. Epub 2013 Jan 25.


Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16264-9. doi: 10.1073/pnas.1207528109. Epub 2012 Sep 17.


Lymph node choreography: B cells take the lead.

Cannons JL, Lu KT, Schwartzberg PL.

Nat Immunol. 2012 Jun 19;13(7):630-2. doi: 10.1038/ni.2349. No abstract available.


The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.

Kageyama R, Cannons JL, Zhao F, Yusuf I, Lao C, Locci M, Schwartzberg PL, Crotty S.

Immunity. 2012 Jun 29;36(6):986-1002. doi: 10.1016/j.immuni.2012.05.016. Epub 2012 Jun 7.


Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.

Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL.

Immunity. 2012 Jun 29;36(6):1003-16. doi: 10.1016/j.immuni.2012.05.017. Epub 2012 Jun 7.


Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108.

Dutta M, Schwartzberg PL.

J Immunol. 2012 Apr 1;188(7):3031-41. doi: 10.4049/jimmunol.1103226. Epub 2012 Mar 5.


Early Th1 cell differentiation is marked by a Tfh cell-like transition.

Nakayamada S, Kanno Y, Takahashi H, Jankovic D, Lu KT, Johnson TA, Sun HW, Vahedi G, Hakim O, Handon R, Schwartzberg PL, Hager GL, O'Shea JJ.

Immunity. 2011 Dec 23;35(6):919-31. doi: 10.1016/j.immuni.2011.11.012.


Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells.

Lu KT, Kanno Y, Cannons JL, Handon R, Bible P, Elkahloun AG, Anderson SM, Wei L, Sun H, O'Shea JJ, Schwartzberg PL.

Immunity. 2011 Oct 28;35(4):622-32. doi: 10.1016/j.immuni.2011.07.015. Epub 2011 Oct 20.


A mosaic activating mutation in AKT1 associated with the Proteus syndrome.

Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S, Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG.

N Engl J Med. 2011 Aug 18;365(7):611-9. doi: 10.1056/NEJMoa1104017. Epub 2011 Jul 27.


The human condition: an immunological perspective.

Germain RN, Schwartzberg PL.

Nat Immunol. 2011 May;12(5):369-72. doi: 10.1038/ni0511-369. No abstract available.


Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.

Hall JA, Cannons JL, Grainger JR, Dos Santos LM, Hand TW, Naik S, Wohlfert EA, Chou DB, Oldenhove G, Robinson M, Grigg ME, Kastenmayer R, Schwartzberg PL, Belkaid Y.

Immunity. 2011 Mar 25;34(3):435-47. doi: 10.1016/j.immuni.2011.03.003.


Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.

Gomez-Rodriguez J, Kraus ZJ, Schwartzberg PL.

FEBS J. 2011 Jun;278(12):1980-9. doi: 10.1111/j.1742-4658.2011.08072.x. Epub 2011 Mar 29. Review.


SLAM family receptors and SAP adaptors in immunity.

Cannons JL, Tangye SG, Schwartzberg PL.

Annu Rev Immunol. 2011;29:665-705. doi: 10.1146/annurev-immunol-030409-101302. Review.


Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.

Zhang S, Readinger JA, DuBois W, Janka-Junttila M, Robinson R, Pruitt M, Bliskovsky V, Wu JZ, Sakakibara K, Patel J, Parent CA, Tessarollo L, Schwartzberg PL, Mock BA.

Blood. 2011 Jan 27;117(4):1228-38. doi: 10.1182/blood-2010-05-287821. Epub 2010 Nov 15.


To B or not to B.

Lu KT, Schwartzberg PL.

Blood. 2010 Oct 28;116(17):3120-1. doi: 10.1182/blood-2010-08-299222.


Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.

Andrés AM, Dennis MY, Kretzschmar WW, Cannons JL, Lee-Lin SQ, Hurle B; NISC Comparative Sequencing Program, Schwartzberg PL, Williamson SH, Bustamante CD, Nielsen R, Clark AG, Green ED.

PLoS Genet. 2010 Oct 14;6(10):e1001157. doi: 10.1371/journal.pgen.1001157.


Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

Deenick EK, Chan A, Ma CS, Gatto D, Schwartzberg PL, Brink R, Tangye SG.

Immunity. 2010 Aug 27;33(2):241-53. doi: 10.1016/j.immuni.2010.07.015. Epub 2010 Aug 5.


Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.

Cannons JL, Wu JZ, Gomez-Rodriguez J, Zhang J, Dong B, Liu Y, Shaw S, Siminovitch KA, Schwartzberg PL.

J Immunol. 2010 Sep 1;185(5):2819-27. doi: 10.4049/jimmunol.0902182. Epub 2010 Jul 28.


Regulation of microRNA expression and abundance during lymphopoiesis.

Kuchen S, Resch W, Yamane A, Kuo N, Li Z, Chakraborty T, Wei L, Laurence A, Yasuda T, Peng S, Hu-Li J, Lu K, Dubois W, Kitamura Y, Charles N, Sun HW, Muljo S, Schwartzberg PL, Paul WE, O'Shea J, Rajewsky K, Casellas R.

Immunity. 2010 Jun 25;32(6):828-39. doi: 10.1016/j.immuni.2010.05.009. Epub 2010 Jun 3.


T-cell signaling regulated by the Tec family kinase, Itk.

Andreotti AH, Schwartzberg PL, Joseph RE, Berg LJ.

Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002287. doi: 10.1101/cshperspect.a002287. Epub 2010 Jun 2. Review.


Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein.

Nikolov NP, Shimizu M, Cleland S, Bailey D, Aoki J, Strom T, Schwartzberg PL, Candotti F, Siegel RM.

Blood. 2010 Aug 5;116(5):740-7. doi: 10.1182/blood-2009-08-237560. Epub 2010 May 10.


Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

Cannons JL, Qi H, Lu KT, Dutta M, Gomez-Rodriguez J, Cheng J, Wakeland EK, Germain RN, Schwartzberg PL.

Immunity. 2010 Feb 26;32(2):253-65. doi: 10.1016/j.immuni.2010.01.010. Epub 2010 Feb 11.


Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.

Gomez-Rodriguez J, Sahu N, Handon R, Davidson TS, Anderson SM, Kirby MR, August A, Schwartzberg PL.

Immunity. 2009 Oct 16;31(4):587-97. doi: 10.1016/j.immuni.2009.07.009. Epub 2009 Oct 8.


The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1).

Steinfelder S, Andersen JF, Cannons JL, Feng CG, Joshi M, Dwyer D, Caspar P, Schwartzberg PL, Sher A, Jankovic D.

J Exp Med. 2009 Aug 3;206(8):1681-90. doi: 10.1084/jem.20082462. Epub 2009 Jul 27.


Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP).

Rumble JM, Oetjen KA, Stein PL, Schwartzberg PL, Moore BB, Duckett CS.

Cell Immunol. 2009;259(1):82-9. doi: 10.1016/j.cellimm.2009.05.017. Epub 2009 Jun 13.


TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.

Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW.

J Clin Invest. 2009 Jun;119(6):1489-501. doi: 10.1172/JCI36175. Epub 2009 May 11.

Supplemental Content

Loading ...
Support Center