Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 326

1.

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.

Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, Lund ML, Ghimire S, Nivlet L, Lapp C, Petersen N, Engelstoft MS, Thibault-Carpentier C, Keime C, Correa SJ, Schreiber V, Molina N, Schwartz TW, De Arcangelis A, Gradwohl G.

Mol Metab. 2019 Nov;29:24-39. doi: 10.1016/j.molmet.2019.08.007. Epub 2019 Aug 13.

2.

Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice.

Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, Martin RE, Holst JJ.

Am J Physiol Endocrinol Metab. 2019 Sep 10. doi: 10.1152/ajpendo.00239.2019. [Epub ahead of print]

PMID:
31503512
3.

The Molecular Diversity of Vagal Afferents Revealed.

Egerod KL, Schwartz TW, Gautron L.

Trends Neurosci. 2019 Oct;42(10):663-666. doi: 10.1016/j.tins.2019.08.002. Epub 2019 Aug 14.

PMID:
31421944
4.

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1.

Lückmann M, Trauelsen M, Bentsen MA, Nissen TAD, Martins J, Fallah Z, Nygaard MM, Papaleo E, Lindorff-Larsen K, Schwartz TW, Frimurer TM.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7123-7128. doi: 10.1073/pnas.1811066116. Epub 2019 Mar 14.

5.

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.

Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wüthrich K, Zhao Q.

Nat Commun. 2019 Feb 7;10(1):638. doi: 10.1038/s41467-019-08568-5.

6.

Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males.

Riis S, Christensen B, Nellemann B, Møller AB, Husted AS, Pedersen SB, Schwartz TW, Jørgensen JOL, Jessen N.

J Appl Physiol (1985). 2019 Mar 1;126(3):569-577. doi: 10.1152/japplphysiol.00989.2018. Epub 2018 Dec 20.

PMID:
30571288
7.

Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity.

Arora T, Rudenko O, Egerod KL, Husted AS, Kovatcheva-Datchary P, Akrami R, Kristensen M, Schwartz TW, Bäckhed F.

Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E453-E463. doi: 10.1152/ajpendo.00391.2018. Epub 2018 Dec 18.

PMID:
30562060
8.

Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase.

Ulsund AH, Dahl M, Frimurer TM, Manfra O, Schwartz TW, Levy FO, Andressen KW.

FASEB J. 2019 Mar;33(3):3870-3886. doi: 10.1096/fj.201800805RR. Epub 2018 Dec 3.

PMID:
30508496
9.

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Treebak JT, Howard AD, Schwartz TW.

Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5.

10.

Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1.

Rexen Ulven E, Trauelsen M, Brvar M, Lückmann M, Bielefeldt LØ, Jensen LKI, Schwartz TW, Frimurer TM.

Sci Rep. 2018 Jul 3;8(1):10010. doi: 10.1038/s41598-018-28263-7.

11.

Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine.

Petersen N, Frimurer TM, Terndrup Pedersen M, Egerod KL, Wewer Albrechtsen NJ, Holst JJ, Grapin-Botton A, Jensen KB, Schwartz TW.

Gastroenterology. 2018 Oct;155(4):1164-1176.e2. doi: 10.1053/j.gastro.2018.06.039. Epub 2018 Jun 20.

PMID:
29935151
12.

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms.

Egerod KL, Petersen N, Timshel PN, Rekling JC, Wang Y, Liu Q, Schwartz TW, Gautron L.

Mol Metab. 2018 Jun;12:62-75. doi: 10.1016/j.molmet.2018.03.016. Epub 2018 Apr 3.

13.

Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites.

Lund ML, Egerod KL, Engelstoft MS, Dmytriyeva O, Theodorsson E, Patel BA, Schwartz TW.

Mol Metab. 2018 May;11:70-83. doi: 10.1016/j.molmet.2018.03.004. Epub 2018 Mar 10.

14.

Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa.

Tough IR, Forbes S, Herzog H, Jones RM, Schwartz TW, Cox HM.

Endocrinology. 2018 Apr 1;159(4):1704-1717. doi: 10.1210/en.2017-03172.

15.

The HETE Is on FFAR1 and Pancreatic Islet Cells.

Trauelsen M, Lückmann M, Frimurer TM, Schwartz TW.

Cell Metab. 2018 Feb 6;27(2):273-275. doi: 10.1016/j.cmet.2018.01.006.

16.

Microbial regulation of the L cell transcriptome.

Arora T, Akrami R, Pais R, Bergqvist L, Johansson BR, Schwartz TW, Reimann F, Gribble FM, Bäckhed F.

Sci Rep. 2018 Jan 19;8(1):1207. doi: 10.1038/s41598-017-18079-2.

17.

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.

Trauelsen M, Rexen Ulven E, Hjorth SA, Brvar M, Monaco C, Frimurer TM, Schwartz TW.

Mol Metab. 2017 Dec;6(12):1585-1596. doi: 10.1016/j.molmet.2017.09.005. Epub 2017 Sep 30.

18.

Structural biology: Full monty of family B GPCRs.

Schwartz TW, Frimurer TM.

Nat Chem Biol. 2017 Jul 18;13(8):819-821. doi: 10.1038/nchembio.2438. No abstract available.

PMID:
28853739
19.

GPCR-Mediated Signaling of Metabolites.

Husted AS, Trauelsen M, Rudenko O, Hjorth SA, Schwartz TW.

Cell Metab. 2017 Apr 4;25(4):777-796. doi: 10.1016/j.cmet.2017.03.008. Review.

20.

Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.

Frimurer TM, Mende F, Graae AS, Engelstoft MS, Egerod KL, Nygaard R, Gerlach LO, Hansen JB, Schwartz TW, Holst B.

J Med Chem. 2017 Feb 9;60(3):886-898. doi: 10.1021/acs.jmedchem.6b00648. Epub 2017 Jan 23.

PMID:
28045522
21.

EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies.

Niss Arfelt K, Barington L, Benned-Jensen T, Kubale V, Kovalchuk AL, Daugvilaite V, Christensen JP, Thomsen AR, Egerod KL, Bassi MR, Spiess K, Schwartz TW, Wang H, Morse HC 3rd, Holst PJ, Rosenkilde MM.

Blood. 2017 Feb 16;129(7):866-878. doi: 10.1182/blood-2016-02-697185. Epub 2016 Dec 21.

22.

Gq and Gs signaling acting in synergy to control GLP-1 secretion.

Hauge M, Ekberg JP, Engelstoft MS, Timshel P, Madsen AN, Schwartz TW.

Mol Cell Endocrinol. 2017 Jul 5;449:64-73. doi: 10.1016/j.mce.2016.11.024. Epub 2016 Nov 28.

PMID:
27908836
23.

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).

Ekberg JH, Hauge M, Kristensen LV, Madsen AN, Engelstoft MS, Husted AS, Sichlau R, Egerod KL, Timshel P, Kowalski TJ, Gribble FM, Reiman F, Hansen HS, Howard AD, Holst B, Schwartz TW.

Endocrinology. 2016 Dec;157(12):4561-4569. Epub 2016 Oct 25.

PMID:
27779915
24.

High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice.

Thieme V, Jolly N, Madsen AN, Bellmann-Sickert K, Schwartz TW, Holst B, Cox HM, Beck-Sickinger AG.

Br J Pharmacol. 2016 Nov;173(22):3208-3221. doi: 10.1111/bph.13582. Epub 2016 Oct 5.

25.

Structure-based discovery of novel US28 small molecule ligands with different modes of action.

Lückmann M, Amarandi RM, Papargyri N, Jakobsen MH, Christiansen E, Jensen LJ, Pui A, Schwartz TW, Rosenkilde MM, Frimurer TM.

Chem Biol Drug Des. 2017 Mar;89(3):289-296. doi: 10.1111/cbdd.12848. Epub 2016 Sep 28.

PMID:
27569905
26.

Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119.

Hassing HA, Fares S, Larsen O, Pad H, Hauge M, Jones RM, Schwartz TW, Hansen HS, Rosenkilde MM.

Biochem Pharmacol. 2016 Nov 1;119:66-75. doi: 10.1016/j.bcp.2016.08.018. Epub 2016 Aug 26.

27.

In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist.

Lückmann M, Holst B, Schwartz TW, Frimurer TM.

Mol Inform. 2016 Jan;35(1):19-24. doi: 10.1002/minf.201500080. Epub 2015 Sep 16.

PMID:
27491650
28.

Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors.

Engelstoft MS, Schwartz TW.

Trends Endocrinol Metab. 2016 Sep;27(9):665-675. doi: 10.1016/j.tem.2016.07.001. Epub 2016 Jul 27. Review.

PMID:
27474997
29.

Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor.

Hassing HA, Engelstoft MS, Sichlau RM, Madsen AN, Rehfeld JF, Pedersen J, Jones RM, Holst JJ, Schwartz TW, Rosenkilde MM, Hansen HS.

Biofactors. 2016 Nov 12;42(6):665-673. doi: 10.1002/biof.1303. Epub 2016 Jun 14.

PMID:
27297962
30.

Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population.

Vestmar MA, Andersson EA, Christensen CR, Hauge M, Glümer C, Linneberg A, Witte DR, Jørgensen ME, Christensen C, Brandslund I, Lauritzen T, Pedersen O, Holst B, Grarup N, Schwartz TW, Hansen T.

J Med Genet. 2016 Sep;53(9):616-23. doi: 10.1136/jmedgenet-2015-103728. Epub 2016 Apr 11.

PMID:
27068006
31.

Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112.

Peeters MC, Mos I, Lenselink EB, Lucchesi M, IJzerman AP, Schwartz TW.

FASEB J. 2016 May;30(5):1836-48. doi: 10.1096/fj.201500110. Epub 2016 Jan 28.

PMID:
26823453
32.

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics.

Park M, Sivertsen BB, Els-Heindl S, Huber T, Holst B, Beck-Sickinger AG, Schwartz TW, Sakmar TP.

Chem Biol. 2015 Nov 19;22(11):1431-1436. doi: 10.1016/j.chembiol.2015.09.014. Epub 2015 Nov 5.

33.

Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening.

Norn C, Hauge M, Engelstoft MS, Kim SH, Lehmann J, Jones RM, Schwartz TW, Frimurer TM.

Structure. 2015 Dec 1;23(12):2377-2386. doi: 10.1016/j.str.2015.09.014. Epub 2015 Oct 29.

34.

GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness.

Svendsen B, Pais R, Engelstoft MS, Milev NB, Richards P, Christiansen CB, Egerod KL, Jensen SM, Habib AM, Gribble FM, Schwartz TW, Reimann F, Holst JJ.

J Endocrinol. 2016 Jan;228(1):39-48. doi: 10.1530/JOE-15-0247. Epub 2015 Oct 19.

PMID:
26483393
35.

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.

Grunddal KV, Ratner CF, Svendsen B, Sommer F, Engelstoft MS, Madsen AN, Pedersen J, Nøhr MK, Egerod KL, Nawrocki AR, Kowalski T, Howard AD, Poulsen SS, Offermanns S, Bäckhed F, Holst JJ, Holst B, Schwartz TW.

Endocrinology. 2016 Jan;157(1):176-94. doi: 10.1210/en.2015-1600. Epub 2015 Oct 15.

PMID:
26469136
36.

Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells.

Engelstoft MS, Lund ML, Grunddal KV, Egerod KL, Osborne-Lawrence S, Poulsen SS, Zigman JM, Schwartz TW.

Mol Endocrinol. 2015 Nov;29(11):1658-71. doi: 10.1210/me.2015-1106. Epub 2015 Sep 9.

37.

The MicroRNA Repertoire in Enteroendocrine Cells: Identification of miR-375 as a Potential Regulator of the Enteroendocrine Lineage.

Knudsen LA, Petersen N, Schwartz TW, Egerod KL.

Endocrinology. 2015 Nov;156(11):3971-83. doi: 10.1210/en.2015-1088. Epub 2015 Aug 31.

PMID:
26322371
38.

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.

Peeters MC, Fokkelman M, Boogaard B, Egerod KL, van de Water B, IJzerman AP, Schwartz TW.

Cell Signal. 2015 Dec;27(12):2579-88. doi: 10.1016/j.cellsig.2015.08.015. Epub 2015 Aug 29.

PMID:
26321231
39.

Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.

Valentin-Hansen L, Frimurer TM, Mokrosinski J, Holliday ND, Schwartz TW.

J Biol Chem. 2015 Oct 2;290(40):24495-508. doi: 10.1074/jbc.M115.641944. Epub 2015 Aug 12.

40.

Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells.

Egerod KL, Engelstoft MS, Lund ML, Grunddal KV, Zhao M, Barir-Jensen D, Nygaard EB, Petersen N, Holst JJ, Schwartz TW.

Endocrinology. 2015 Nov;156(11):3909-23. doi: 10.1210/EN.2015-1388. Epub 2015 Jul 16.

PMID:
26181106
41.

Ghrelin.

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.

42.

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB.

Pharmacol Rev. 2015;67(2):338-67. doi: 10.1124/pr.114.009647. Review.

43.

Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.

Manfra O, Van Craenenbroeck K, Skieterska K, Frimurer T, Schwartz TW, Levy FO, Andressen KW.

ACS Chem Neurosci. 2015 Jul 15;6(7):1206-18. doi: 10.1021/cn500339p. Epub 2015 Apr 20.

PMID:
25706089
44.

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.

Hauge M, Vestmar MA, Husted AS, Ekberg JP, Wright MJ, Di Salvo J, Weinglass AB, Engelstoft MS, Madsen AN, Lückmann M, Miller MW, Trujillo ME, Frimurer TM, Holst B, Howard AD, Schwartz TW.

Mol Metab. 2014 Oct 24;4(1):3-14. doi: 10.1016/j.molmet.2014.10.002. eCollection 2015 Jan.

45.

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.

Nøhr MK, Egerod KL, Christiansen SH, Gille A, Offermanns S, Schwartz TW, Møller M.

Neuroscience. 2015 Apr 2;290:126-37. doi: 10.1016/j.neuroscience.2015.01.040. Epub 2015 Jan 28.

PMID:
25637492
46.

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.

Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD.

Cell Metab. 2014 Dec 2;20(6):1018-29. doi: 10.1016/j.cmet.2014.10.004. Epub 2014 Nov 20.

47.

Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119.

Engelstoft MS, Norn C, Hauge M, Holliday ND, Elster L, Lehmann J, Jones RM, Frimurer TM, Schwartz TW.

Br J Pharmacol. 2014 Dec;171(24):5774-89. doi: 10.1111/bph.12877.

48.

Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors.

Tian H, Naganathan S, Kazmi MA, Schwartz TW, Sakmar TP, Huber T.

Chembiochem. 2014 Aug 18;15(12):1820-9. doi: 10.1002/cbic.201402193. Epub 2014 Jul 18.

49.

Mapping substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid.

Valentin-Hansen L, Park M, Huber T, Grunbeck A, Naganathan S, Schwartz TW, Sakmar TP.

J Biol Chem. 2014 Jun 27;289(26):18045-54. doi: 10.1074/jbc.M113.527085. Epub 2014 May 15.

50.

Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men.

Schmidt JB, Gregersen NT, Pedersen SD, Arentoft JL, Ritz C, Schwartz TW, Holst JJ, Astrup A, Sjödin A.

Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1248-56. doi: 10.1152/ajpendo.00569.2013. Epub 2014 Apr 15.

Supplemental Content

Loading ...
Support Center