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Items: 1 to 50 of 53

1.

Recombinant Purification of the Periplasmic Portion of the LINC Complex.

Cruz VE, Schwartz TU.

Methods Mol Biol. 2018;1840:17-23. doi: 10.1007/978-1-4939-8691-0_2.

PMID:
30141034
2.

Natively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex.

Onischenko E, Tang JH, Andersen KR, Knockenhauer KE, Vallotton P, Derrer CP, Kralt A, Mugler CF, Chan LY, Schwartz TU, Weis K.

Cell. 2017 Nov 2;171(4):904-917.e19. doi: 10.1016/j.cell.2017.09.033. Epub 2017 Oct 12.

3.

Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL.

EMBO Rep. 2017 Jun;18(6):1027-1037. doi: 10.15252/embr.201643764. Epub 2017 Apr 10.

4.

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.

Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL.

MBio. 2016 Dec 13;7(6). pii: e01569-16. doi: 10.1128/mBio.01569-16.

5.

LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.

Lawrence KS, Tapley EC, Cruz VE, Li Q, Aung K, Hart KC, Schwartz TU, Starr DA, Engebrecht J.

J Cell Biol. 2016 Dec 19;215(6):801-821. Epub 2016 Dec 12.

6.

The apo-structure of the leucine sensor Sestrin2 is still elusive.

Saxton RA, Knockenhauer KE, Schwartz TU, Sabatini DM.

Sci Signal. 2016 Sep 20;9(446):ra92. doi: 10.1126/scisignal.aah4497.

7.

Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.

Demircioglu FE, Sosa BA, Ingram J, Ploegh HL, Schwartz TU.

Elife. 2016 Aug 4;5. pii: e17983. doi: 10.7554/eLife.17983.

8.

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.

Saxton RA, Chantranupong L, Knockenhauer KE, Schwartz TU, Sabatini DM.

Nature. 2016 Aug 11;536(7615):229-33. Epub 2016 Aug 3.

9.

Systematic Protein-Protein Interaction Analysis Reveals Intersubcomplex Contacts in the Nuclear Pore Complex.

Apelt L, Knockenhauer KE, Leksa NC, Benlasfer N, Schwartz TU, Stelzl U.

Mol Cell Proteomics. 2016 Aug;15(8):2594-606. doi: 10.1074/mcp.M115.054627. Epub 2016 May 18.

10.

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.

Truttmann MC, Cruz VE, Guo X, Engert C, Schwartz TU, Ploegh HL.

PLoS Genet. 2016 May 3;12(5):e1006023. doi: 10.1371/journal.pgen.1006023. eCollection 2016 May.

11.

The Structure Inventory of the Nuclear Pore Complex.

Schwartz TU.

J Mol Biol. 2016 May 22;428(10 Pt A):1986-2000. doi: 10.1016/j.jmb.2016.03.015. Epub 2016 Mar 22. Review.

12.

The Nuclear Pore Complex as a Flexible and Dynamic Gate.

Knockenhauer KE, Schwartz TU.

Cell. 2016 Mar 10;164(6):1162-1171. doi: 10.1016/j.cell.2016.01.034. Review.

13.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

14.

Purification and Structural Analysis of SUN and KASH Domain Proteins.

Esra Demircioglu F, Cruz VE, Schwartz TU.

Methods Enzymol. 2016;569:63-78. doi: 10.1016/bs.mie.2015.08.011. Epub 2015 Sep 6.

15.

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM.

Science. 2016 Jan 1;351(6268):53-8. doi: 10.1126/science.aad2087. Epub 2015 Nov 19.

16.

Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.

Berchowitz LE, Kabachinski G, Walker MR, Carlile TM, Gilbert WV, Schwartz TU, Amon A.

Cell. 2015 Oct 8;163(2):406-18. doi: 10.1016/j.cell.2015.08.060. Epub 2015 Sep 24.

17.

Allosteric activation of apicomplexan calcium-dependent protein kinases.

Ingram JR, Knockenhauer KE, Markus BM, Mandelbaum J, Ramek A, Shan Y, Shaw DE, Schwartz TU, Ploegh HL, Lourido S.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E4975-84. doi: 10.1073/pnas.1505914112. Epub 2015 Aug 24.

18.

Structural Characterization of Bardet-Biedl Syndrome 9 Protein (BBS9).

Knockenhauer KE, Schwartz TU.

J Biol Chem. 2015 Aug 7;290(32):19569-83. doi: 10.1074/jbc.M115.649202. Epub 2015 Jun 17.

19.

The nuclear pore complex--structure and function at a glance.

Kabachinski G, Schwartz TU.

J Cell Sci. 2015 Feb 1;128(3):423-9. Review.

20.

Atomic structure of the Y complex of the nuclear pore.

Kelley K, Knockenhauer KE, Kabachinski G, Schwartz TU.

Nat Struct Mol Biol. 2015 May;22(5):425-431. doi: 10.1038/nsmb.2998. Epub 2015 Mar 30.

21.

How lamina-associated polypeptide 1 (LAP1) activates Torsin.

Sosa BA, Demircioglu FE, Chen JZ, Ingram J, Ploegh HL, Schwartz TU.

Elife. 2014 Aug 22;3:e03239. doi: 10.7554/eLife.03239.

22.

Finding the missing link.

Schwartz TU.

Elife. 2014 May 27;3:e03128. doi: 10.7554/eLife.03128.

23.

The stoichiometry of the nucleoporin 62 subcomplex of the nuclear pore in solution.

Ulrich A, Partridge JR, Schwartz TU.

Mol Biol Cell. 2014 May;25(9):1484-92. doi: 10.1091/mbc.E13-12-0745. Epub 2014 Feb 26.

24.

Optimized E. coli expression strain LOBSTR eliminates common contaminants from His-tag purification.

Andersen KR, Leksa NC, Schwartz TU.

Proteins. 2013 Nov;81(11):1857-61. doi: 10.1002/prot.24364. Epub 2013 Aug 23.

25.

Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors.

Andersen KR, Onischenko E, Tang JH, Kumar P, Chen JZ, Ulrich A, Liphardt JT, Weis K, Schwartz TU.

Elife. 2013 Jun 11;2:e00745. doi: 10.7554/eLife.00745.

26.

Structural insights into LINC complexes.

Sosa BA, Kutay U, Schwartz TU.

Curr Opin Struct Biol. 2013 Apr;23(2):285-91. doi: 10.1016/j.sbi.2013.03.005. Epub 2013 Apr 15. Review.

27.

Structural and functional studies of the 252 kDa nucleoporin ELYS reveal distinct roles for its three tethered domains.

Bilokapic S, Schwartz TU.

Structure. 2013 Apr 2;21(4):572-80. doi: 10.1016/j.str.2013.02.006. Epub 2013 Mar 14.

28.

LINCing complex functions at the nuclear envelope: what the molecular architecture of the LINC complex can reveal about its function.

Rothballer A, Schwartz TU, Kutay U.

Nucleus. 2013 Jan-Feb;4(1):29-36. doi: 10.4161/nucl.23387. Epub 2013 Jan 1.

29.

Exponential megapriming PCR (EMP) cloning--seamless DNA insertion into any target plasmid without sequence constraints.

Ulrich A, Andersen KR, Schwartz TU.

PLoS One. 2012;7(12):e53360. doi: 10.1371/journal.pone.0053360. Epub 2012 Dec 31. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/7465cec8-d898-4d11-b32d-fcd1a8c24f25.

30.

Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex.

Bilokapic S, Schwartz TU.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15241-6. Epub 2012 Sep 5.

31.

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

Sosa BA, Rothballer A, Kutay U, Schwartz TU.

Cell. 2012 May 25;149(5):1035-47. doi: 10.1016/j.cell.2012.03.046.

32.

3D ultrastructure of the nuclear pore complex.

Bilokapic S, Schwartz TU.

Curr Opin Cell Biol. 2012 Feb;24(1):86-91. doi: 10.1016/j.ceb.2011.12.011. Epub 2012 Jan 11. Review.

33.

Membrane-coating lattice scaffolds in the nuclear pore and vesicle coats: commonalities, differences, challenges.

Leksa NC, Schwartz TU.

Nucleus. 2010 Jul-Aug;1(4):314-8. doi: 10.4161/nucl.1.4.11798. Epub 2010 Mar 12. Review.

34.

Alternate rRNA secondary structures as regulators of translation.

Feng S, Li H, Zhao J, Pervushin K, Lowenhaupt K, Schwartz TU, Dröge P.

Nat Struct Mol Biol. 2011 Feb;18(2):169-76. doi: 10.1038/nsmb.1962. Epub 2011 Jan 9.

PMID:
21217697
35.

Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat.

Whittle JR, Schwartz TU.

J Cell Biol. 2010 Aug 9;190(3):347-61. doi: 10.1083/jcb.201003092.

36.

A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.

Pandya RK, Partridge JR, Love KR, Schwartz TU, Ploegh HL.

J Biol Chem. 2010 Feb 19;285(8):5664-73. doi: 10.1074/jbc.M109.051805. Epub 2009 Dec 10.

37.

Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.

Brohawn SG, Schwartz TU.

Nat Struct Mol Biol. 2009 Nov;16(11):1173-7. doi: 10.1038/nsmb.1713. Epub 2009 Oct 25.

38.

The nuclear pore complex has entered the atomic age.

Brohawn SG, Partridge JR, Whittle JR, Schwartz TU.

Structure. 2009 Sep 9;17(9):1156-68. doi: 10.1016/j.str.2009.07.014. Review.

39.

Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element.

Whittle JR, Schwartz TU.

J Biol Chem. 2009 Oct 9;284(41):28442-52. doi: 10.1074/jbc.M109.023580. Epub 2009 Aug 11.

40.

A lattice model of the nuclear pore complex.

Brohawn SG, Schwartz TU.

Commun Integr Biol. 2009 May;2(3):205-7.

41.

The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture.

Leksa NC, Brohawn SG, Schwartz TU.

Structure. 2009 Aug 12;17(8):1082-91. doi: 10.1016/j.str.2009.06.003. Epub 2009 Jul 2.

42.

Crystallographic and biochemical analysis of the Ran-binding zinc finger domain.

Partridge JR, Schwartz TU.

J Mol Biol. 2009 Aug 14;391(2):375-89. doi: 10.1016/j.jmb.2009.06.011. Epub 2009 Jun 6.

43.

Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.

Brohawn SG, Leksa NC, Spear ED, Rajashankar KR, Schwartz TU.

Science. 2008 Nov 28;322(5906):1369-73. doi: 10.1126/science.1165886. Epub 2008 Oct 30.

44.

Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex.

Boehmer T, Jeudy S, Berke IC, Schwartz TU.

Mol Cell. 2008 Jun 20;30(6):721-31. doi: 10.1016/j.molcel.2008.04.022.

45.

Origins and evolution of cotranslational transport to the ER.

Schwartz TU.

Adv Exp Med Biol. 2007;607:52-60. Review.

PMID:
17977458
46.

Crystal structure of nucleoporin Nic96 reveals a novel, intricate helical domain architecture.

Jeudy S, Schwartz TU.

J Biol Chem. 2007 Nov 30;282(48):34904-12. Epub 2007 Sep 25.

47.

Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex.

Boehmer T, Schwartz TU.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1;63(Pt 9):816-8. Epub 2007 Aug 31.

48.

A general amphipathic alpha-helical motif for sensing membrane curvature.

Drin G, Casella JF, Gautier R, Boehmer T, Schwartz TU, Antonny B.

Nat Struct Mol Biol. 2007 Feb;14(2):138-46. Epub 2007 Jan 14.

PMID:
17220896
49.
50.

Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region.

Schwartz TU, Schmidt D, Brohawn SG, Blobel G.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6823-8. Epub 2006 Apr 20.

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