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Enhanced Sequence Coverage of Large Proteins by Combining Ultraviolet Photodissociation with Proton Transfer Reactions.

Sanders J, Mullen C, Watts E, Holden D, Syka JE, Schwartz JC, Brodbelt JS.

Anal Chem. 2019 Nov 26. doi: 10.1021/acs.analchem.9b04026. [Epub ahead of print]


Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage.

Kawaguchi T, Rollins MG, Moinpour M, Morera AA, Ebmeier CC, Old WM, Schwartz JC.

J Proteome Res. 2019 Dec 2. doi: 10.1021/acs.jproteome.9b00575. [Epub ahead of print]


TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons.

Morera AA, Ahmed NS, Schwartz JC.

Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194434. doi: 10.1016/j.bbagrm.2019.194434. Epub 2019 Oct 23.


Evaluation of the abuse potential of pitolisant, a selective H3-receptor antagonist/inverse agonist, for the treatment of adult patients with narcolepsy with or without cataplexy.

Setnik B, McDonnell M, Mills C, Scart-Grès C, Robert P, Dayno JM, Schwartz JC.

Sleep. 2019 Oct 18. pii: zsz252. doi: 10.1093/sleep/zsz252. [Epub ahead of print]


The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex.

Schwartz JC, Sanderson ND, Bickhart DM, Smith TPL, Hammond JA.

Front Immunol. 2019 Sep 26;10:2302. doi: 10.3389/fimmu.2019.02302. eCollection 2019.


Long-term use of pitolisant to treat patients with narcolepsy: Harmony III Study.

Dauvilliers Y, Arnulf I, Szakacs Z, Leu-Semenescu S, Lecomte I, Scart-Gres C, Lecomte JM, Schwartz JC; HARMONY III study group .

Sleep. 2019 Oct 21;42(11). pii: zsz174. doi: 10.1093/sleep/zsz174.


Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation.

Krasnopolsky S, Marom L, Victor RA, Kuzmina A, Schwartz JC, Fujinaga K, Taube R.

Retrovirology. 2019 Jun 25;16(1):16. doi: 10.1186/s12977-019-0478-x.


Unilateral Reconstruction of the Large Breast: Combining Prosthetic and Autologous Methods for Improved Symmetry.

Schwartz JC.

Plast Reconstr Surg Glob Open. 2019 Feb 11;7(2):e2154. doi: 10.1097/GOX.0000000000002154. eCollection 2019 Feb.


Occupancy of dopamine D2 and D3 receptors by a novel D3 partial agonist BP1.4979: a [11C]-(+)-PHNO PET study in humans.

Di Ciano P, Mansouri E, Tong J, Wilson AA, Houle S, Boileau I, Duvauchelle T, Robert P, Schwartz JC, Le Foll B.

Neuropsychopharmacology. 2019 Jun;44(7):1284-1290. doi: 10.1038/s41386-018-0285-4. Epub 2018 Nov 30.


Effects of signal bandwidth and noise on individual speaker identification.

Schwartz JC, Whyte AT, Al-Nuaimi M, Donai JJ.

J Acoust Soc Am. 2018 Nov;144(5):EL447. doi: 10.1121/1.5078770.


Transcription-Dependent Formation of Nuclear Granules Containing FUS and RNA Pol II.

Thompson VF, Victor RA, Morera AA, Moinpour M, Liu MN, Kisiel CC, Pickrel K, Springhower CE, Schwartz JC.

Biochemistry. 2018 Dec 26;57(51):7021-7032. doi: 10.1021/acs.biochem.8b01097. Epub 2018 Dec 11.


The unique evolution of the pig LRC, a single KIR but expansion of LILR and a novel Ig receptor family.

Schwartz JC, Hammond JA.

Immunogenetics. 2018 Nov;70(10):661-669. doi: 10.1007/s00251-018-1067-1. Epub 2018 Jun 21.


Implementation of Fragment Ion Protection (FIP) during Ultraviolet Photodissociation (UVPD) Mass Spectrometry.

Holden DD, Sanders JD, Weisbrod CR, Mullen C, Schwartz JC, Brodbelt JS.

Anal Chem. 2018 Jul 17;90(14):8583-8591. doi: 10.1021/acs.analchem.8b01723. Epub 2018 Jul 6.


A New Approach to Nipple-sparing Mastectomy and Reconstruction in the High Risk Ptotic Patient.

Schwartz JC.

Plast Reconstr Surg Glob Open. 2018 May 10;6(5):e1779. doi: 10.1097/GOX.0000000000001779. eCollection 2018 May.


Therapeutic Administration of Broadly Neutralizing FI6 Antibody Reveals Lack of Interaction Between Human IgG1 and Pig Fc Receptors.

Morgan SB, Holzer B, Hemmink JD, Salguero FJ, Schwartz JC, Agatic G, Cameroni E, Guarino B, Porter E, Rijal P, Townsend A, Charleston B, Corti D, Tchilian E.

Front Immunol. 2018 Apr 24;9:865. doi: 10.3389/fimmu.2018.00865. eCollection 2018.


The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine.

Schwartz JC, Hemmink JD, Graham SP, Tchilian E, Charleston B, Hammer SE, Ho CS, Hammond JA.

HLA. 2018 Apr 23. doi: 10.1111/tan.13281. [Epub ahead of print]


Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers.

Duvauchelle T, Robert P, Donazzolo Y, Loyau S, Orlandini B, Lehert P, Lecomte JM, Schwartz JC.

J Allergy Clin Immunol Pract. 2018 Jul - Aug;6(4):1257-1263. doi: 10.1016/j.jaip.2017.09.021. Epub 2017 Nov 3.


The antibody loci of the domestic goat (Capra hircus).

Schwartz JC, Philp RL, Bickhart DM, Smith TPL, Hammond JA.

Immunogenetics. 2018 May;70(5):317-326. doi: 10.1007/s00251-017-1033-3. Epub 2017 Oct 23.


Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.

Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC.

Cell Rep. 2017 Oct 3;21(1):110-125. doi: 10.1016/j.celrep.2017.09.028.


Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.

Ligneau X, Shah RR, Berrebi-Bertrand I, Mirams GR, Robert P, Landais L, Maison-Blanche P, Faivre JF, Lecomte JM, Schwartz JC.

Br J Pharmacol. 2017 Dec;174(23):4449-4463. doi: 10.1111/bph.14047. Epub 2017 Oct 19.


Goldilocks Mastectomy: A Safe Bridge to Implant-Based Breast Reconstruction in the Morbidly Obese.

Schwartz JC.

Plast Reconstr Surg Glob Open. 2017 Jun 28;5(6):e1398. doi: 10.1097/GOX.0000000000001398. eCollection 2017 Jun.


Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding.

Ozdilek BA, Thompson VF, Ahmed NS, White CI, Batey RT, Schwartz JC.

Nucleic Acids Res. 2017 Jul 27;45(13):7984-7996. doi: 10.1093/nar/gkx460.


Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome.

Bickhart DM, Rosen BD, Koren S, Sayre BL, Hastie AR, Chan S, Lee J, Lam ET, Liachko I, Sullivan ST, Burton JN, Huson HJ, Nystrom JC, Kelley CM, Hutchison JL, Zhou Y, Sun J, Crisà A, Ponce de León FA, Schwartz JC, Hammond JA, Waldbieser GC, Schroeder SG, Liu GE, Dunham MJ, Shendure J, Sonstegard TS, Phillippy AM, Van Tassell CP, Smith TP.

Nat Genet. 2017 Apr;49(4):643-650. doi: 10.1038/ng.3802. Epub 2017 Mar 6.


The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation.

Schwartz JC, Gibson MS, Heimeier D, Koren S, Phillippy AM, Bickhart DM, Smith TP, Medrano JF, Hammond JA.

Immunogenetics. 2017 Apr;69(4):255-269. doi: 10.1007/s00251-017-0973-y. Epub 2017 Feb 9.


Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial.

Szakacs Z, Dauvilliers Y, Mikhaylov V, Poverennova I, Krylov S, Jankovic S, Sonka K, Lehert P, Lecomte I, Lecomte JM, Schwartz JC; HARMONY-CTP study group.

Lancet Neurol. 2017 Mar;16(3):200-207. doi: 10.1016/S1474-4422(16)30333-7. Epub 2017 Jan 25.


Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists.

Labeeuw O, Levoin N, Billot X, Danvy D, Calmels T, Krief S, Ligneau X, Berrebi-Bertrand I, Robert P, Lecomte JM, Schwartz JC, Capet M.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5263-5266. doi: 10.1016/j.bmcl.2016.09.049. Epub 2016 Sep 19.


Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.

Levoin N, Labeeuw O, Billot X, Calmels T, Danvy D, Krief S, Berrebi-Bertrand I, Lecomte JM, Schwartz JC, Capet M.

Eur J Med Chem. 2017 Jan 5;125:565-572. doi: 10.1016/j.ejmech.2016.09.074. Epub 2016 Sep 24.


Ultraviolet Photodissociation Induced by Light-Emitting Diodes in a Planar Ion Trap.

Holden DD, Makarov A, Schwartz JC, Sanders JD, Zhuk E, Brodbelt JS.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12417-21. doi: 10.1002/anie.201605850. Epub 2016 Sep 8.


Surgical Delay Facilitates Pedicled Nipple-sparing Mastectomy and Reconstruction in the Ptotic Patient.

Schwartz JC, Skowronksi PP.

Plast Reconstr Surg Glob Open. 2016 Jun 13;4(6):e735. doi: 10.1097/GOX.0000000000000743. eCollection 2016 Jun.


Case report of a definitive autologous reconstruction in a patient requiring immediate postoperative anticoagulation and reduced operative time.

Schwartz JC, Skowronski PP.

Int J Surg Case Rep. 2016;25:86-8. doi: 10.1016/j.ijscr.2016.06.020. Epub 2016 Jun 18.


Exploratory Phase II Trial to Evaluate the Safety and the Antiepileptic Effect of Pitolisant (BF2.649) in Refractory Partial Seizures, Given as Adjunctive Treatment During 3 Months.

Collart Dutilleul P, Ryvlin P, Kahane P, Vercueil L, Semah F, Biraben A, Schwartz JC, De Seze J, Hirsch E, Collongues N.

Clin Neuropharmacol. 2016 Jul-Aug;39(4):188-93. doi: 10.1097/WNF.0000000000000159.


Clinical trials with H3-receptor inverse agonists: What they tell us about the role of histamine in the human brain.

Schwartz JC, Lecomte JM.

Neuropharmacology. 2016 Jul;106:35-6. doi: 10.1016/j.neuropharm.2016.04.006. Epub 2016 Apr 7. No abstract available.


Lifetime racial/ethnic discrimination and ambulatory blood pressure: The moderating effect of age.

Beatty Moody DL, Waldstein SR, Tobin JN, Cassells A, Schwartz JC, Brondolo E.

Health Psychol. 2016 Apr;35(4):333-42. doi: 10.1037/hea0000270.


Total Single-Stage Autologous Breast Reconstruction with Free Nipple Grafts.

Schwartz JC, Skowronski PP.

Plast Reconstr Surg Glob Open. 2016 Jan 7;3(12):e587. doi: 10.1097/GOX.0000000000000563. eCollection 2015 Dec.


Genomic variation in the porcine immunoglobulin lambda variable region.

Guo X, Schwartz JC, Murtaugh MP.

Immunogenetics. 2016 Apr;68(4):285-93. doi: 10.1007/s00251-016-0899-9. Epub 2016 Jan 21.


Improving selectivity of dopamine D3 receptor ligands.

Capet M, Calmels T, Levoin N, Danvy D, Berrebi-Bertrand I, Stark H, Schwartz JC, Lecomte JM.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):885-888. doi: 10.1016/j.bmcl.2015.12.068. Epub 2015 Dec 21.


The assembly and characterisation of two structurally distinct cattle MHC class I haplotypes point to the mechanisms driving diversity.

Schwartz JC, Hammond JA.

Immunogenetics. 2015 Sep;67(9):539-44. doi: 10.1007/s00251-015-0859-9. Epub 2015 Jul 31.


Nucleic acid-binding specificity of human FUS protein.

Wang X, Schwartz JC, Cech TR.

Nucleic Acids Res. 2015 Sep 3;43(15):7535-43. doi: 10.1093/nar/gkv679. Epub 2015 Jul 6.


Biochemical Properties and Biological Functions of FET Proteins.

Schwartz JC, Cech TR, Parker RR.

Annu Rev Biochem. 2015;84:355-79. doi: 10.1146/annurev-biochem-060614-034325. Epub 2014 Dec 8. Review.


Oncoplastic surgeons: heros or villains?

Urban C, Schwartz JC.

Plast Reconstr Surg. 2014 Nov;134(5):845e-846e. doi: 10.1097/PRS.0000000000000597. No abstract available.


FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.

Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR.

Mol Biol Cell. 2014 Sep 1;25(17):2571-8. doi: 10.1091/mbc.E14-05-1007. Epub 2014 Jul 9.


Characterization of a polymorphic IGLV gene in pigs (Sus scrofa).

Schwartz JC, Murtaugh MP.

Immunogenetics. 2014 Aug;66(7-8):507-11. doi: 10.1007/s00251-014-0785-2. Epub 2014 Jun 17.


RNA seeds higher-order assembly of FUS protein.

Schwartz JC, Wang X, Podell ER, Cech TR.

Cell Rep. 2013 Nov 27;5(4):918-25. doi: 10.1016/j.celrep.2013.11.017. Epub 2013 Nov 21.


A differentially pumped dual linear quadrupole ion trap (DLQIT) mass spectrometer: a mass spectrometer capable of MS(n) experiments free from interfering reactions.

Owen BC, Jarrell TM, Schwartz JC, Oglesbee R, Carlsen M, Archibold EF, Kenttämaa HI.

Anal Chem. 2013 Dec 3;85(23):11284-90. doi: 10.1021/ac401956f. Epub 2013 Nov 15.


Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial.

Dauvilliers Y, Bassetti C, Lammers GJ, Arnulf I, Mayer G, Rodenbeck A, Lehert P, Ding CL, Lecomte JM, Schwartz JC; HARMONY I study group.

Lancet Neurol. 2013 Nov;12(11):1068-75. doi: 10.1016/S1474-4422(13)70225-4. Epub 2013 Oct 7.


Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists.

Levoin N, Labeeuw O, Krief S, Calmels T, Poupardin-Olivier O, Berrebi-Bertrand I, Lecomte JM, Schwartz JC, Capet M.

Bioorg Med Chem. 2013 Aug 1;21(15):4526-9. doi: 10.1016/j.bmc.2013.05.035. Epub 2013 Jun 2.


Activated ion ETD performed in a modified collision cell on a hybrid QLT-Oribtrap mass spectrometer.

Ledvina AR, Rose CM, McAlister GC, Syka JE, Westphall MS, Griep-Raming J, Schwartz JC, Coon JJ.

J Am Soc Mass Spectrom. 2013 Nov;24(11):1623-33. doi: 10.1007/s13361-013-0621-1. Epub 2013 May 16.


Structural and functional annotation of the porcine immunome.

Dawson HD, Loveland JE, Pascal G, Gilbert JG, Uenishi H, Mann KM, Sang Y, Zhang J, Carvalho-Silva D, Hunt T, Hardy M, Hu Z, Zhao SH, Anselmo A, Shinkai H, Chen C, Badaoui B, Berman D, Amid C, Kay M, Lloyd D, Snow C, Morozumi T, Cheng RP, Bystrom M, Kapetanovic R, Schwartz JC, Kataria R, Astley M, Fritz E, Steward C, Thomas M, Wilming L, Toki D, Archibald AL, Bed'Hom B, Beraldi D, Huang TH, Ait-Ali T, Blecha F, Botti S, Freeman TC, Giuffra E, Hume DA, Lunney JK, Murtaugh MP, Reecy JM, Harrow JL, Rogel-Gaillard C, Tuggle CK.

BMC Genomics. 2013 May 15;14:332. doi: 10.1186/1471-2164-14-332.

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