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History of suicidality and alcohol craving trajectories during inpatient treatment for alcohol use disorder.

Janakiraman R, Gowin JL, Sloan ME, Schwandt ML, Diazgranados N, Ramchandani VA, Kwako LE.

Drug Alcohol Depend. 2020 Feb 21;209:107918. doi: 10.1016/j.drugalcdep.2020.107918. [Epub ahead of print]


Lower Serum Magnesium Concentrations are associated With Specific Heavy Drinking Markers, Pro-Inflammatory Response and Early-Stage Alcohol-associated Liver Injury§.

Vatsalya V, Gala KS, Mishra M, Schwandt ML, Umhau J, Cave MC, Parajuli D, Ramchandani VA, McClain CJ.

Alcohol Alcohol. 2020 Feb 12. pii: agaa001. doi: 10.1093/alcalc/agaa001. [Epub ahead of print]


Exacerbation of Hangover Symptomology Significantly Corresponds with Heavy and Chronic Alcohol Drinking: A Pilot Study.

Vatsalya V, Hassan HZ, Kong M, Stangl BL, Schwandt ML, Schmidt-Teron VY, Verster JC, Ramchandani VA, McClain CJ.

J Clin Med. 2019 Nov 12;8(11). pii: E1943. doi: 10.3390/jcm8111943.


Early life temperamental anxiety is associated with excessive alcohol intake in adolescence: A rhesus monkey (Macaca mulatta) model.

Wood EK, Kruger R, Cash E, Lindell SG, Schwandt ML, Barr CS, Suomi SJ, Higley JD.

Addict Biol. 2019 Oct 31:e12825. doi: 10.1111/adb.12825. [Epub ahead of print]


A role for the CD38 rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans.

Lee MR, Shin JH, Deschaine S, Daurio AM, Stangl BL, Yan J, Ramchandani VA, Schwandt ML, Grodin EN, Momenan R, Corral-Frias NS, Hariri AR, Bogdan R, Alvarez VA, Leggio L.

Am J Drug Alcohol Abuse. 2019 Jul 31:1-13. doi: 10.1080/00952990.2019.1638928. [Epub ahead of print]


Striatal Dopamine Release in Response to Morphine: A [11C]Raclopride Positron Emission Tomography Study in Healthy Men.

Spagnolo PA, Kimes A, Schwandt ML, Shokri-Kojori E, Thada S, Phillips KA, Diazgranados N, Preston KL, Herscovitch P, Tomasi D, Ramchandani VA, Heilig M.

Biol Psychiatry. 2019 Sep 1;86(5):356-364. doi: 10.1016/j.biopsych.2019.03.965. Epub 2019 Mar 15.


The relationship between impaired control, impulsivity, and alcohol self-administration in nondependent drinkers.

Vaughan CL, Stangl BL, Schwandt ML, Corey KM, Hendershot CS, Ramchandani VA.

Exp Clin Psychopharmacol. 2019 Jun;27(3):236-246. doi: 10.1037/pha0000247. Epub 2019 Jan 28.


Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder.

Kwako LE, Schwandt ML, Ramchandani VA, Diazgranados N, Koob GF, Volkow ND, Blanco C, Goldman D.

Am J Psychiatry. 2019 Sep 1;176(9):744-753. doi: 10.1176/appi.ajp.2018.18030357. Epub 2019 Jan 4. Erratum in: Am J Psychiatry. 2019 Jun 1;176(6):489.


Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes.

Ramchandani VA, Stangl BL, Blaine SK, Plawecki MH, Schwandt ML, Kwako LE, Sinha R, Cyders MA, O'Connor S, Zakhari S.

Alcohol. 2018 Nov;72:75-88. doi: 10.1016/j.alcohol.2018.06.001. Epub 2018 Jun 8.


Alterations in Serum Zinc and Polyunsaturated Fatty Acid Concentrations in Treatment-Naive HIV-Diagnosed Alcohol-Dependent Subjects with Liver Injury.

Vatsalya V, Cave MC, Kumar R, Srivastava S, Khanal S, Jenson AB, Schwandt ML, Barve SS, Ramchandani VA, McClain CJ.

AIDS Res Hum Retroviruses. 2019 Jan;35(1):92-99. doi: 10.1089/AID.2018.0124. Epub 2018 Dec 11.


Association of serum zinc with markers of liver injury in very heavy drinking alcohol-dependent patients.

Vatsalya V, Kong M, Cave MC, Liu N, Schwandt ML, George DT, Ramchandani VA, McClain CJ.

J Nutr Biochem. 2018 Sep;59:49-55. doi: 10.1016/j.jnutbio.2018.05.003. Epub 2018 May 12.


The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.

Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L.

Mol Psychiatry. 2020 Feb;25(2):461-475. doi: 10.1038/s41380-018-0064-y. Epub 2018 May 4.


Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals.

Farokhnia M, Grodin EN, Lee MR, Oot EN, Blackburn AN, Stangl BL, Schwandt ML, Farinelli LA, Momenan R, Ramchandani VA, Leggio L.

Mol Psychiatry. 2018 Oct;23(10):2029-2038. doi: 10.1038/mp.2017.226. Epub 2017 Nov 14.


Intermittent Access to Ethanol Induces Escalated Alcohol Consumption in Primates.

Lindell SG, Schwandt ML, Suomi SJ, Rice KC, Heilig M, Barr CS.

J Addict Behav Ther Rehabil. 2017 Apr;6(1). pii: 163. doi: 10.4172/2324-9005.1000163. Epub 2017 Apr 7.


Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.

Baker M, Lindell SG, Driscoll CA, Zhou Z, Yuan Q, Schwandt ML, Miller-Crews I, Simpson EA, Paukner A, Ferrari PF, Sindhu RK, Razaqyar M, Sommer WH, Lopez JF, Thompson RC, Goldman D, Heilig M, Higley JD, Suomi SJ, Barr CS.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11769-11774. doi: 10.1073/pnas.1706206114. Epub 2017 Oct 16.


Impulsive Personality Traits Mediate the Relationship Between Adult Attention-Deficit/Hyperactivity Symptoms and Alcohol Dependence Severity.

Daurio AM, Aston SA, Schwandt ML, Bukhari MO, Bouhlal S, Farokhnia M, Lee MR, Leggio L.

Alcohol Clin Exp Res. 2018 Jan;42(1):173-183. doi: 10.1111/acer.13538. Epub 2017 Nov 27.


Effect of alcohol use disorder on oxytocin peptide and receptor mRNA expression in human brain: A post-mortem case-control study.

Lee MR, Schwandt ML, Sankar V, Suchankova P, Sun H, Leggio L.

Psychoneuroendocrinology. 2017 Nov;85:14-19. doi: 10.1016/j.psyneuen.2017.07.481. Epub 2017 Jul 15.


The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings.

Suchankova P, Yan J, Schwandt ML, Stangl BL, Jerlhag E, Engel JA, Hodgkinson CA, Ramchandani VA, Leggio L.

Alcohol Alcohol. 2017 Jul 1;52(4):425-430. doi: 10.1093/alcalc/agx021.


Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study.

Farokhnia M, Schwandt ML, Lee MR, Bollinger JW, Farinelli LA, Amodio JP, Sewell L, Lionetti TA, Spero DE, Leggio L.

Transl Psychiatry. 2017 Apr 25;7(4):e1108. doi: 10.1038/tp.2017.71.


The Validity of the Montgomery-Asberg Depression Rating Scale in an Inpatient Sample with Alcohol Dependence.

Hobden B, Schwandt ML, Carey M, Lee MR, Farokhnia M, Bouhlal S, Oldmeadow C, Leggio L.

Alcohol Clin Exp Res. 2017 Jun;41(6):1220-1227. doi: 10.1111/acer.13400. Epub 2017 May 22.


Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant.

Sloan ME, Gowin JL, Yan J, Schwandt ML, Spagnolo PA, Sun H, Hodgkinson CA, Goldman D, Ramchandani VA.

Addict Biol. 2018 Jan;23(1):474-484. doi: 10.1111/adb.12491. Epub 2017 Feb 1.


Differences Between Treatment-Seeking and Nontreatment-Seeking Alcohol-Dependent Research Participants: An Exploratory Analysis.

Rohn MC, Lee MR, Kleuter SB, Schwandt ML, Falk DE, Leggio L.

Alcohol Clin Exp Res. 2017 Feb;41(2):414-420. doi: 10.1111/acer.13304.


Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): A Pilot Study in Alcohol-dependent Women.

Persson A, Back SE, Killeen TK, Brady KT, Schwandt ML, Heilig M, Magnusson Å.

J Addict Med. 2017 Mar/Apr;11(2):119-125. doi: 10.1097/ADM.0000000000000286.


Hepatic, lipid and genetic factors associated with obesity: crosstalk with alcohol dependence?

Goodyear K, Lee MR, Schwandt ML, Hodgkinson CA, Leggio L.

World J Biol Psychiatry. 2017 Mar;18(2):120-128. doi: 10.1080/15622975.2016.1249952. Epub 2016 Dec 1.


Defining the role of corticotropin releasing factor binding protein in alcohol consumption.

Haass-Koffler CL, Henry AT, Melkus G, Simms JA, Naemmuddin M, Nielsen CK, Lasek AW, Magill M, Schwandt ML, Momenan R, Hodgkinson CA, Bartlett SE, Swift RM, Bonci A, Leggio L.

Transl Psychiatry. 2016 Nov 15;6(11):e953. doi: 10.1038/tp.2016.208.


Safety Assessment of Liver Injury with Quetiapine Fumarate XR Management in Very Heavy Drinking Alcohol-Dependent Patients.

Vatsalya V, Pandey A, Schwandt ML, Cave MC, Barve SS, Ramchandani VA, McClain CJ.

Clin Drug Investig. 2016 Nov;36(11):935-944.


FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence.

Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Mayo LM, Hillard CJ, Heilig M.

Alcohol Clin Exp Res. 2016 Nov;40(11):2426-2434. doi: 10.1111/acer.13210. Epub 2016 Sep 26.


Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients.

Vatsalya V, Song M, Schwandt ML, Cave MC, Barve SS, George DT, Ramchandani VA, McClain CJ.

Alcohol Clin Exp Res. 2016 Oct;40(10):2085-2093. doi: 10.1111/acer.13197. Epub 2016 Sep 2.


OPRM1 genotype interacts with serotonin system dysfunction to predict alcohol-heightened aggression in primates.

Driscoll CA, Lindell SG, Schwandt ML, Suomi SJ, Higley JD, Heilig M, Barr CS.

Addict Biol. 2017 Nov;22(6):1655-1664. doi: 10.1111/adb.12428. Epub 2016 Aug 3.


Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences.

Sells JR, Waters AJ, Schwandt ML, Kwako LE, Heilig M, George DT, Ramchandani VA.

Drug Alcohol Depend. 2016 Jun 1;163:242-6. doi: 10.1016/j.drugalcdep.2016.03.016. Epub 2016 Mar 26.


The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects.

Schwandt ML, Cortes CR, Kwako LE, George DT, Momenan R, Sinha R, Grigoriadis DE, Pich EM, Leggio L, Heilig M.

Neuropsychopharmacology. 2016 Nov;41(12):2818-2829. doi: 10.1038/npp.2016.61. Epub 2016 Apr 25.


The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers.

Gowin JL, Vatsalya V, Westman JG, Schwandt ML, Bartlett S, Heilig M, Momenan R, Ramchandani VA.

Alcohol Clin Exp Res. 2016 May;40(5):979-87. doi: 10.1111/acer.13046. Epub 2016 Apr 8.


MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1.

Tapocik JD, Ceniccola K, Mayo CL, Schwandt ML, Solomon M, Wang BD, Luu TV, Olender J, Harrigan T, Maynard TM, Elmer GI, Lee NH.

Front Mol Neurosci. 2016 Mar 24;9:20. doi: 10.3389/fnmol.2016.00020. eCollection 2016.


Minimization of Childhood Maltreatment Is Common and Consequential: Results from a Large, Multinational Sample Using the Childhood Trauma Questionnaire.

MacDonald K, Thomas ML, Sciolla AF, Schneider B, Pappas K, Bleijenberg G, Bohus M, Bekh B, Carpenter L, Carr A, Dannlowski U, Dorahy M, Fahlke C, Finzi-Dottan R, Karu T, Gerdner A, Glaesmer H, Grabe HJ, Heins M, Kenny DT, Kim D, Knoop H, Lobbestael J, Lochner C, Lauritzen G, Ravndal E, Riggs S, Sar V, Schäfer I, Schlosser N, Schwandt ML, Stein MB, Subic-Wrana C, Vogel M, Wingenfeld K.

PLoS One. 2016 Jan 27;11(1):e0146058. doi: 10.1371/journal.pone.0146058. eCollection 2016.


Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers.

Vatsalya V, Gowin JL, Schwandt ML, Momenan R, Coe MA, Cooke ME, Hommer DW, Bartlett S, Heilig M, Ramchandani VA.

Int J Neuropsychopharmacol. 2015 Jul 25;18(12). pii: pyv068. doi: 10.1093/ijnp/pyv068.


Effect of Functionally Significant Deiodinase Single Nucleotide Polymorphisms on Drinking Behavior in Alcohol Dependence: An Exploratory Investigation.

Lee MR, Schwandt ML, Bollinger JW, Dias AA, Oot EN, Goldman D, Hodgkinson CA, Leggio L.

Alcohol Clin Exp Res. 2015 Sep;39(9):1665-70. doi: 10.1111/acer.12814. Epub 2015 Jul 24.


The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence.

Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, Leggio L.

Transl Psychiatry. 2015 Jun 16;5:e583. doi: 10.1038/tp.2015.68.


Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients.

Spagnolo PA, Ramchandani VA, Schwandt ML, Zhang L, Blaine SK, Usala JM, Diamond KA, Phillips MJ, George DT, Momenan R, Heilig M.

Alcohol Clin Exp Res. 2014 Dec;38(12):3024-32. doi: 10.1111/acer.12581.


The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study.

Kwako LE, Spagnolo PA, Schwandt ML, Thorsell A, George DT, Momenan R, Rio DE, Huestis M, Anizan S, Concheiro M, Sinha R, Heilig M.

Neuropsychopharmacology. 2015 Mar 13;40(5):1053-63. doi: 10.1038/npp.2014.306.


Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons.

Senatorov VV, Damadzic R, Mann CL, Schwandt ML, George DT, Hommer DW, Heilig M, Momenan R.

Brain. 2015 Jan;138(Pt 1):69-79. doi: 10.1093/brain/awu305. Epub 2014 Nov 2.


The prevalence of sleep disturbance in alcoholics admitted for treatment: a target for chronic disease management.

Wallen GR, Brooks AT, Whiting B, Clark R, Krumlauf MC, Yang L, Schwandt ML, George DT, Ramchandani VA.

Fam Community Health. 2014 Oct-Dec;37(4):288-97. doi: 10.1097/FCH.0000000000000040.


The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study.

Kwako LE, George DT, Schwandt ML, Spagnolo PA, Momenan R, Hommer DW, Diamond CA, Sinha R, Shaham Y, Heilig M.

Psychopharmacology (Berl). 2015 Jan;232(1):295-304. doi: 10.1007/s00213-014-3665-4. Epub 2014 Jul 18.


Topiramate for alcoholism treatment: novel pharmacogenetic evidence for the journey to personalized medicine?

Leggio L, Schwandt ML.

Int J Neuropsychopharmacol. 2014 Oct;17(10):1541-4. doi: 10.1017/S1461145714000790. Epub 2014 Jun 3. No abstract available.


Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes.

Kwako LE, Schwandt ML, Sells JR, Ramchandani VA, Hommer DW, George DT, Sinha R, Heilig M.

Addict Biol. 2015 Jul;20(4):733-46. doi: 10.1111/adb.12150. Epub 2014 May 7.


FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice.

Huang MC, Schwandt ML, Chester JA, Kirchhoff AM, Kao CF, Liang T, Tapocik JD, Ramchandani VA, George DT, Hodgkinson CA, Goldman D, Heilig M.

Neuropsychopharmacology. 2014 Jul;39(8):2029-38. doi: 10.1038/npp.2014.55. Epub 2014 Mar 7.


Fasting-induced increase in plasma ghrelin is blunted by intravenous alcohol administration: a within-subject placebo-controlled study.

Leggio L, Schwandt ML, Oot EN, Dias AA, Ramchandani VA.

Psychoneuroendocrinology. 2013 Dec;38(12):3085-91. doi: 10.1016/j.psyneuen.2013.09.005. Epub 2013 Sep 13.


A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.

Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M.

J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013.


Low vitamin D status and suicide: a case-control study of active duty military service members.

Umhau JC, George DT, Heaney RP, Lewis MD, Ursano RJ, Heilig M, Hibbeln JR, Schwandt ML.

PLoS One. 2013;8(1):e51543. doi: 10.1371/journal.pone.0051543. Epub 2013 Jan 4. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/9af84cbe-5576-4c4b-871c-f7ab0c64b9fd.


Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism.

Schwandt ML, Heilig M, Hommer DW, George DT, Ramchandani VA.

Alcohol Clin Exp Res. 2013 Jun;37(6):984-92. doi: 10.1111/acer.12053. Epub 2012 Dec 27.


Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients.

Huang MC, Schwandt ML, Ramchandani VA, George DT, Heilig M.

Alcohol Clin Exp Res. 2012 Jun;36(6):1099-107. doi: 10.1111/j.1530-0277.2011.01695.x. Epub 2012 Mar 15.

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