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Items: 1 to 50 of 314

1.

Conformational Dynamics of Strand Register Shifts in DNA G-quadruplexes.

Grün JT, Hennecker C, Klötzner DP, Harkness The Fifth RW, Bessi I, Heckel A, Mittermaier AK, Schwalbe H.

J Am Chem Soc. 2019 Dec 9. doi: 10.1021/jacs.9b10367. [Epub ahead of print]

PMID:
31815451
2.

Real-time NMR for studying metabolism.

Schwalbe H, Alshamleh I, Krause N, Richter C, Kurrle N, Serve H, Günther UL.

Angew Chem Int Ed Engl. 2019 Nov 15. doi: 10.1002/anie.201912919. [Epub ahead of print]

PMID:
31730253
3.

Rapid biophysical characterization and NMR structural analysis of small proteins from bacteria and archaea.

Kubatova N, Pyper DJ, Jonker HRA, Saxena K, Remmel L, Richter C, Brantl S, Evguenieva-Hackenberg E, Hess W, Klug G, Marchfelder A, Soppa J, Streit W, Mayzel M, Orekhov VY, Fuxreiter M, Schmitz-Streit R, Schwalbe H.

Chembiochem. 2019 Nov 9. doi: 10.1002/cbic.201900677. [Epub ahead of print]

PMID:
31705614
4.

Genetic code expansion facilitates position-selective labeling of RNA for biophysical studies.

Hegelein A, Müller D, Größl S, Goebel M, Hengesbach M, Schwalbe H.

Chemistry. 2019 Nov 6. doi: 10.1002/chem.201904623. [Epub ahead of print]

PMID:
31692134
5.

G-Quadruplex-Specific Cell-Permeable Guanosine-Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing the c-MYC Gene.

Saha P, Kumar YP, Das T, Müller D, Bessi I, Schwalbe H, Dash J.

Bioconjug Chem. 2019 Nov 12. doi: 10.1021/acs.bioconjchem.9b00655. [Epub ahead of print]

PMID:
31663728
6.

Paramagnetic-iterative relaxation matrix approach: extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules.

Cetiner EC, Jonker HRA, Helmling C, Gophane DB, Grünewald C, Sigurdsson ST, Schwalbe H.

J Biomol NMR. 2019 Dec;73(12):699-712. doi: 10.1007/s10858-019-00282-0. Epub 2019 Oct 12.

PMID:
31606877
7.

Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma.

DiPrima M, Wang D, Tröster A, Maric D, Terrades-Garcia N, Ha T, Kwak H, Sanchez-Martin D, Kudlinzki D, Schwalbe H, Tosato G.

Mol Oncol. 2019 Nov;13(11):2441-2459. doi: 10.1002/1878-0261.12576. Epub 2019 Oct 23.

8.

Modular, triple-resonance, transmission line DNP MAS probe for 500 MHz/330 GHz.

Reese M, George C, Yang C, Jawla S, Tassilo Grün J, Schwalbe H, Redfield C, Temkin RJ, Griffin RG.

J Magn Reson. 2019 Oct;307:106573. doi: 10.1016/j.jmr.2019.106573. Epub 2019 Aug 14.

PMID:
31505305
9.

More than Proton Detection-New Avenues for NMR Spectroscopy of RNA.

Schnieders R, Keyhani S, Schwalbe H, Fürtig B.

Chemistry. 2019 Aug 27. doi: 10.1002/chem.201903355. [Epub ahead of print] Review.

PMID:
31454110
10.

(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp.

Shi YN, Pusch S, Shi YM, Richter C, Maciá-Vicente JG, Schwalbe H, Kaiser M, Opatz T, Bode HB.

J Org Chem. 2019 Sep 6;84(17):11203-11209. doi: 10.1021/acs.joc.9b01229. Epub 2019 Aug 27.

PMID:
31409073
11.

Metabolic Plasticity of Acute Myeloid Leukemia.

Kreitz J, Schönfeld C, Seibert M, Stolp V, Alshamleh I, Oellerich T, Steffen B, Schwalbe H, Schnütgen F, Kurrle N, Serve H.

Cells. 2019 Jul 31;8(8). pii: E805. doi: 10.3390/cells8080805. Review.

12.

Molecular tuning of farnesoid X receptor partial agonism.

Merk D, Sreeramulu S, Kudlinzki D, Saxena K, Linhard V, Gande SL, Hiller F, Lamers C, Nilsson E, Aagaard A, Wissler L, Dekker N, Bamberg K, Schubert-Zsilavecz M, Schwalbe H.

Nat Commun. 2019 Jul 2;10(1):2915. doi: 10.1038/s41467-019-10853-2.

13.

Solution Structure and Dynamics of the Small Protein HVO_2922 from Haloferax volcanii.

Kubatova N, Jonker HRA, Saxena K, Richter C, Vogel V, Schreiber S, Marchfelder A, Schwalbe H.

Chembiochem. 2019 Jun 4. doi: 10.1002/cbic.201900085. [Epub ahead of print]

PMID:
31161645
14.

Novel 13 C-detected NMR Experiments for the Precise Detection of RNA Structure.

Schnieders R, Wolter AC, Richter C, Wöhnert J, Schwalbe H, Fürtig B.

Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9140-9144. doi: 10.1002/anie.201904057. Epub 2019 May 27.

15.

"CodonWizard" - An intuitive software tool with graphical user interface for customizable codon optimization in protein expression efforts.

Rehbein P, Berz J, Kreisel P, Schwalbe H.

Protein Expr Purif. 2019 Aug;160:84-93. doi: 10.1016/j.pep.2019.03.018. Epub 2019 Apr 4.

PMID:
30953700
16.

Detection of osteoarthritis using acoustic emission analysis.

Kiselev J, Ziegler B, Schwalbe HJ, Franke RP, Wolf U.

Med Eng Phys. 2019 Mar;65:57-60. doi: 10.1016/j.medengphy.2019.01.002. Epub 2019 Jan 23.

PMID:
30685113
17.

Identification of primary and secondary metabolites and transcriptome profile of soybean tissues during different stages of hypoxia.

Coutinho ID, Henning LMM, Döpp SA, Nepomuceno A, Moraes LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA.

Data Brief. 2018 Oct 15;21:1089-1100. doi: 10.1016/j.dib.2018.09.122. eCollection 2018 Dec.

18.

Combined smFRET and NMR analysis of riboswitch structural dynamics.

Bains JK, Blechar J, de Jesus V, Meiser N, Zetzsche H, Fürtig B, Schwalbe H, Hengesbach M.

Methods. 2019 Jan 15;153:22-34. doi: 10.1016/j.ymeth.2018.10.004. Epub 2018 Oct 12. No abstract available.

PMID:
30316819
19.

A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons.

Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman EM, Schwalbe H.

Chembiochem. 2018 Dec 4;19(23):2458-2464. doi: 10.1002/cbic.201800408. Epub 2018 Nov 8.

PMID:
30311996
20.

Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging.

Seyfried P, Heinz M, Pintér G, Klötzner DP, Becker Y, Bolte M, Jonker HRA, Stelzl LS, Hummer G, Schwalbe H, Heckel A.

Chemistry. 2018 Nov 27;24(66):17568-17576. doi: 10.1002/chem.201804040. Epub 2018 Nov 5.

PMID:
30199112
21.

Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation.

Qureshi NS, Bains JK, Sreeramulu S, Schwalbe H, Fürtig B.

Nucleic Acids Res. 2018 Nov 16;46(20):10917-10929. doi: 10.1093/nar/gky746.

22.

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria.

Muthukumar Y, Münkemer J, Mathieu D, Richter C, Schwalbe H, Steinmetz H, Kessler W, Reichelt J, Beutling U, Frank R, Büssow K, van den Heuvel J, Brönstrup M, Taylor RE, Laschat S, Sasse F.

PLoS One. 2018 Jul 31;13(7):e0201605. doi: 10.1371/journal.pone.0201605. eCollection 2018.

23.

On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding Thermodynamics.

Wienen-Schmidt B, Wulsdorf T, Jonker HRA, Saxena K, Kudlinzki D, Linhard V, Sreeramulu S, Heine A, Schwalbe H, Klebe G.

ChemMedChem. 2018 Sep 19;13(18):1988-1996. doi: 10.1002/cmdc.201800438. Epub 2018 Aug 23.

PMID:
30058283
24.

Chemo-Enzymatic Synthesis of Position-Specifically Modified RNA for Biophysical Studies including Light Control and NMR Spectroscopy.

Keyhani S, Goldau T, Blümler A, Heckel A, Schwalbe H.

Angew Chem Int Ed Engl. 2018 Sep 10;57(37):12017-12021. doi: 10.1002/anie.201807125. Epub 2018 Aug 10.

PMID:
30007102
25.

NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.

Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S, Kuster B, Médard G, Kudlinzki D, Schwalbe H.

ChemMedChem. 2018 Aug 20;13(16):1629-1633. doi: 10.1002/cmdc.201800398. Epub 2018 Jul 20.

PMID:
29928781
26.

Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds.

Raab M, Sanhaji M, Pietsch L, Béquignon I, Herbrand AK, Süß E, Gande SL, Caspar B, Kudlinzki D, Saxena K, Sreeramulu S, Schwalbe H, Strebhardt K, Biondi RM.

ACS Chem Biol. 2018 Aug 17;13(8):1921-1931. doi: 10.1021/acschembio.7b01078. Epub 2018 Jun 28.

PMID:
29927572
27.

Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding.

Wienen-Schmidt B, Jonker HRA, Wulsdorf T, Gerber HD, Saxena K, Kudlinzki D, Sreeramulu S, Parigi G, Luchinat C, Heine A, Schwalbe H, Klebe G.

J Med Chem. 2018 Jul 26;61(14):5922-5933. doi: 10.1021/acs.jmedchem.8b00105. Epub 2018 Jul 3.

PMID:
29909615
28.

The domain architecture of PtkA, the first tyrosine kinase from Mycobacterium tuberculosis, differs from the conventional kinase architecture.

Niesteruk A, Jonker HRA, Richter C, Linhard V, Sreeramulu S, Schwalbe H.

J Biol Chem. 2018 Jul 27;293(30):11823-11836. doi: 10.1074/jbc.RA117.000120. Epub 2018 Jun 8.

29.

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.

Garcia-Lopez A, Tessaro F, Jonker HRA, Wacker A, Richter C, Comte A, Berntenis N, Schmucki R, Hatje K, Petermann O, Chiriano G, Perozzo R, Sciarra D, Konieczny P, Faustino I, Fournet G, Orozco M, Artero R, Metzger F, Ebeling M, Goekjian P, Joseph B, Schwalbe H, Scapozza L.

Nat Commun. 2018 May 23;9(1):2032. doi: 10.1038/s41467-018-04110-1.

30.

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex.

Dutta D, Debnath M, Müller D, Paul R, Das T, Bessi I, Schwalbe H, Dash J.

Nucleic Acids Res. 2018 Jun 20;46(11):5355-5365. doi: 10.1093/nar/gky385.

31.

Improved high-yield expression, purification and refolding of recombinant mammalian prion proteins under aerosol-free elevated biological safety conditions.

Rehbein P, Schwalbe H.

Protein Expr Purif. 2018 Oct;150:53-60. doi: 10.1016/j.pep.2018.04.018. Epub 2018 May 8.

PMID:
29751084
32.

Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor.

Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H.

Chemistry. 2018 Jun 4;24(31):7861-7865. doi: 10.1002/chem.201801770. Epub 2018 May 3.

PMID:
29656465
33.

Life times of metastable states guide regulatory signaling in transcriptional riboswitches.

Helmling C, Klötzner DP, Sochor F, Mooney RA, Wacker A, Landick R, Fürtig B, Heckel A, Schwalbe H.

Nat Commun. 2018 Mar 5;9(1):944. doi: 10.1038/s41467-018-03375-w.

34.

Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.

Niesteruk A, Hutchison M, Sreeramulu S, Jonker HRA, Richter C, Abele R, Bock C, Schwalbe H.

FEBS Lett. 2018 Apr;592(7):1233-1245. doi: 10.1002/1873-3468.13022. Epub 2018 Mar 25.

35.

Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus.

Shi YM, Richter C, Challinor VL, Grün P, Girela Del Rio A, Kaiser M, Schüffler A, Piepenbring M, Schwalbe H, Bode HB.

Org Lett. 2018 Mar 16;20(6):1563-1567. doi: 10.1021/acs.orglett.8b00293. Epub 2018 Feb 23.

PMID:
29474084
36.

Human Telomeric G-Quadruplex Selective Fluoro-Isoquinolines Induce Apoptosis in Cancer Cells.

Maiti S, Saha P, Das T, Bessi I, Schwalbe H, Dash J.

Bioconjug Chem. 2018 Apr 18;29(4):1141-1154. doi: 10.1021/acs.bioconjchem.7b00781. Epub 2018 Feb 23.

PMID:
29433312
37.

The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.

Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J, Michel H, Glaubitz C.

Nat Chem Biol. 2018 Mar;14(3):284-290. doi: 10.1038/nchembio.2551. Epub 2018 Jan 15.

PMID:
29334381
38.

Corrigendum: Randomizing the Unfolded State of Peptides (and Proteins) by Nearest Neighbor Interactions between Unlike Residues.

Toal SE, Kubatova N, Richter C, Linhard V, Schwalbe H, Schweitzer-Stenner R.

Chemistry. 2017 Dec 19;23(71):18084-18087. doi: 10.1002/chem.201705353. Epub 2017 Dec 8. No abstract available.

PMID:
29265638
39.

Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding.

Lehner F, Kudlinzki D, Richter C, Müller-Werkmeister HM, Eberl KB, Bredenbeck J, Schwalbe H, Silvers R.

Chembiochem. 2017 Dec 5;18(23):2340-2350. doi: 10.1002/cbic.201700437. Epub 2017 Nov 7.

PMID:
28950050
40.

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs.

Schnieders R, Richter C, Warhaut S, de Jesus V, Keyhani S, Duchardt-Ferner E, Keller H, Wöhnert J, Kuhn LT, Breeze AL, Bermel W, Schwalbe H, Fürtig B.

J Biomol NMR. 2017 Sep;69(1):31-44. doi: 10.1007/s10858-017-0132-7. Epub 2017 Sep 6.

41.

Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.

Lannes L, Young P, Richter C, Morgner N, Schwalbe H.

Chembiochem. 2017 Oct 18;18(20):2033-2044. doi: 10.1002/cbic.201700390. Epub 2017 Sep 8.

PMID:
28805284
42.

Editorial: New 1.2 GHz NMR Spectrometers- New Horizons?

Schwalbe H.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10252-10253. doi: 10.1002/anie.201705936. Epub 2017 Jul 24.

PMID:
28738448
43.

Mistakes in translation: Reflections on mechanism.

Liu Y, Sharp JS, Do DH, Kahn RA, Schwalbe H, Buhr F, Prestegard JH.

PLoS One. 2017 Jun 29;12(6):e0180566. doi: 10.1371/journal.pone.0180566. eCollection 2017.

44.

Correction for Doller et al., "Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase Cδ Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR".

Doller A, Schlepckow K, Schwalbe H, Pfeilschifter J, Eberhardt W.

Mol Cell Biol. 2017 Jun 15;37(13). pii: e00151-17. doi: 10.1128/MCB.00151-17. Print 2017 Jul 1. No abstract available.

45.

Light-induced antibiotic release from a coumarin-caged compound on the ultrafast timescale.

Herzig LM, Elamri I, Schwalbe H, Wachtveitl J.

Phys Chem Chem Phys. 2017 Jun 7;19(22):14835-14844. doi: 10.1039/c7cp02030a.

PMID:
28548167
46.

Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.

Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhard V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M, Schwalbe H, Kuster B, Médard G.

ChemMedChem. 2017 Jun 21;12(12):999-1011. doi: 10.1002/cmdc.201700217. Epub 2017 Jun 12.

PMID:
28544567
47.

Unprecedented Carbon Signal Enhancement in Liquid-State NMR Spectroscopy.

Pintér G, Schwalbe H.

Angew Chem Int Ed Engl. 2017 Jul 10;56(29):8332-8334. doi: 10.1002/anie.201702766. Epub 2017 May 23.

48.

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation.

Steinert H, Sochor F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM, Keller H, Mooney RA, Landick R, Suess B, Fürtig B, Wöhnert J, Schwalbe H.

Elife. 2017 May 25;6. pii: e21297. doi: 10.7554/eLife.21297.

49.

Conformational dynamics and alignment properties of loop lanthanide-binding-tags (LBTs) studied in interleukin-1β.

Barthelmes D, Barthelmes K, Schnorr K, Jonker HRA, Bodmer B, Allen KN, Imperiali B, Schwalbe H.

J Biomol NMR. 2017 Jul;68(3):187-194. doi: 10.1007/s10858-017-0118-5. Epub 2017 May 22.

PMID:
28534082
50.

Probing the Conformation-Dependent Preferential Binding of Ethanol to Cationic Glycylalanylglycine in Water/Ethanol by Vibrational and NMR Spectroscopy.

DiGuiseppi D, Milorey B, Lewis G, Kubatova N, Farrell S, Schwalbe H, Schweitzer-Stenner R.

J Phys Chem B. 2017 Jun 15;121(23):5744-5758. doi: 10.1021/acs.jpcb.7b02899. Epub 2017 Jun 2.

PMID:
28530400

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