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Development and Validation of a UHPLC-DAD Method for the Quantitative Analysis of Major Dihydrochalcone Glucosides from Thonningia sanguinea VAHL.

Pompermaier L, Schwaiger S, Mawunu M, Lautenschlaeger T, Stuppner H.

Planta Med. 2019 Mar 22. doi: 10.1055/a-0877-7255. [Epub ahead of print]


Mushroom Tyrosinase-Based Enzyme Inhibition Assays Are Not Suitable for Bioactivity-Guided Fractionation of Extracts.

Mayr F, Sturm S, Ganzera M, Waltenberger B, Martens S, Schwaiger S, Schuster D, Stuppner H.

J Nat Prod. 2019 Jan 25;82(1):136-147. doi: 10.1021/acs.jnatprod.8b00847. Epub 2019 Jan 10.


HPTLC Autography Based Screening and Isolation of Mushroom Tyrosinase Inhibitors of European Plant Species.

Revoltella S, Rainer B, Waltenberger B, Pagitz K, Schwaiger S, Stuppner H.

Chem Biodivers. 2019 Mar;16(3):e1800541. doi: 10.1002/cbdv.201800541. Epub 2019 Feb 14.


Treatment Outcome, Toxicity, and Predictive Factors for Radioligand Therapy with 177Lu-PSMA-I&T in Metastatic Castration-resistant Prostate Cancer.

Heck MM, Tauber R, Schwaiger S, Retz M, D'Alessandria C, Maurer T, Gafita A, Wester HJ, Gschwend JE, Weber WA, Schwaiger M, Knorr K, Eiber M.

Eur Urol. 2019 Jun;75(6):920-926. doi: 10.1016/j.eururo.2018.11.016. Epub 2018 Nov 22.


Seasonal variation in the chemical composition of two chemotypes of Lippia alba.

Gomes AF, Almeida MP, Leite MF, Schwaiger S, Stuppner H, Halabalaki M, Amaral JG, David JM.

Food Chem. 2019 Feb 1;273:186-193. doi: 10.1016/j.foodchem.2017.11.089. Epub 2017 Nov 23.


Dihydrochalcone Glucosides from the Subaerial Parts of Thonningia sanguinea and Their in Vitro PTP1B Inhibitory Activities.

Pompermaier L, Heiss EH, Alilou M, Mayr F, Monizi M, Lautenschlaeger T, Schuster D, Schwaiger S, Stuppner H.

J Nat Prod. 2018 Sep 28;81(9):2091-2100. doi: 10.1021/acs.jnatprod.8b00450. Epub 2018 Sep 12.


In vitro metabolism of selected bioactive compounds of Eurycoma longifolia root extract to identify suitable markers in doping control.

Bräuer P, Anielski P, Schwaiger S, Stuppner H, Tran TVA, Vollmer G, Zierau O, Thieme D, Keiler AM.

Drug Test Anal. 2019 Jan;11(1):86-94. doi: 10.1002/dta.2449. Epub 2018 Aug 9.


Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources-The MediHealth Project.

Waltenberger B, Halabalaki M, Schwaiger S, Adamopoulos N, Allouche N, Fiebich BL, Hermans N, Jansen-Dürr P, Kesternich V, Pieters L, Schönbichler S, Skaltsounis AL, Tran H, Trougakos IP, Viljoen A, Wolfender JL, Wolfrum C, Xynos N, Stuppner H.

Molecules. 2018 May 6;23(5). pii: E1097. doi: 10.3390/molecules23051097.


Immunomodulatory Effects of Diterpene Quinone Derivatives from the Roots of Horminum pyrenaicum in Human PBMC.

Becker K, Schwaiger S, Waltenberger B, Fuchs D, Pezzei CK, Schennach H, Stuppner H, Gostner JM.

Oxid Med Cell Longev. 2018 Jan 14;2018:2980295. doi: 10.1155/2018/2980295. eCollection 2018.


Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus.

Revoltella S, Baraldo G, Waltenberger B, Schwaiger S, Kofler P, Moesslacher J, Huber-Seidel A, Pagitz K, Kohl R, Jansen-Duerr P, Stuppner H.

Molecules. 2018 Mar 14;23(3). pii: E653. doi: 10.3390/molecules23030653.


Tyrosinase Inhibitors from the Aerial Parts of Wulfenia carinthiaca Jacq.

Mutschlechner B, Rainer B, Schwaiger S, Stuppner H.

Chem Biodivers. 2018 Apr;15(4):e1800014. doi: 10.1002/cbdv.201800014. Epub 2018 Apr 17.


Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor.

Liu R, Heiss EH, Waltenberger B, Blažević T, Schachner D, Jiang B, Krystof V, Liu W, Schwaiger S, Peña-Rodríguez LM, Breuss JM, Stuppner H, Dirsch VM, Atanasov AG.

Mol Nutr Food Res. 2018 Apr;62(7):e1700860. doi: 10.1002/mnfr.201700860. Epub 2018 Mar 30.


Medicinal plants of northern Angola and their anti-inflammatory properties.

Pompermaier L, Marzocco S, Adesso S, Monizi M, Schwaiger S, Neinhuis C, Stuppner H, Lautenschläger T.

J Ethnopharmacol. 2018 Apr 24;216:26-36. doi: 10.1016/j.jep.2018.01.019. Epub 2018 Feb 3.


Development of a selective HPLC-DAD/ELSD method for the qualitative and quantitative assessment of commercially available Eurycoma longifolia products and plant extracts.

Mutschlechner B, Schwaiger S, Tran TVA, Stuppner H.

Fitoterapia. 2018 Jan;124:188-192. doi: 10.1016/j.fitote.2017.11.015. Epub 2017 Nov 14.


Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level.

Malainer C, Schachner D, Sangiovanni E, Atanasov AG, Schwaiger S, Stuppner H, Heiss EH, Dirsch VM.

J Nat Prod. 2017 Dec 22;80(12):3186-3193. doi: 10.1021/acs.jnatprod.7b00503. Epub 2017 Nov 17.


Anti-Inflammatory and Anti-Oxidant Potential of the Root Extract and Constituents of Doronicum austriacum.

Marzocco S, Adesso S, Alilou M, Stuppner H, Schwaiger S.

Molecules. 2017 Jun 16;22(6). pii: E1003. doi: 10.3390/molecules22061003.


Aristolic Acid Derivatives from the Bark of Antidesma ghaesembilla.

Schäfer S, Schwaiger S, Stuppner H.

Planta Med. 2017 Aug;83(12-13):1097-1102. doi: 10.1055/s-0043-110141. Epub 2017 May 12.


Fast and improved separation of major coumarins in Ammi visnaga (L.) Lam. by supercritical fluid chromatography.

Winderl B, Schwaiger S, Ganzera M.

J Sep Sci. 2016 Oct;39(20):4042-4048. doi: 10.1002/jssc.201600734. Epub 2016 Sep 8.


Controlling the Spontaneous Emission Rate of Quantum Wells in Rolled-Up Hyperbolic Metamaterials.

Schulz KM, Vu H, Schwaiger S, Rottler A, Korn T, Sonnenberg D, Kipp T, Mendach S.

Phys Rev Lett. 2016 Aug 19;117(8):085503. doi: 10.1103/PhysRevLett.117.085503. Epub 2016 Aug 17.


Characterization of the XIAP-Inhibiting Proanthocyanidin Fraction of the Aerial Parts of Ephedra sinica.

Schäfer S, Salcher S, Seiter M, Ranninger C, Möst M, Obexer P, Huber CG, Ausserlechner MJ, Schwaiger S, Stuppner H.

Planta Med. 2016 Jul;82(11-12):973-85. doi: 10.1055/s-0042-107253. Epub 2016 May 24.


Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages.

Wang L, Ladurner A, Latkolik S, Schwaiger S, Linder T, Hošek J, Palme V, Schilcher N, Polanský O, Heiss EH, Stangl H, Mihovilovic MD, Stuppner H, Dirsch VM, Atanasov AG.

J Nat Prod. 2016 Jun 24;79(6):1651-7. doi: 10.1021/acs.jnatprod.6b00227. Epub 2016 May 24.


The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ.

Papadakis ES, Barker CR, Syed H, Reeves T, Schwaiger S, Stuppner H, Troppmair J, Blaydes JP, Cutress RI.

Oncogenesis. 2016 Apr 4;5:e215. doi: 10.1038/oncsis.2016.10.


A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells.

Papadakis E, Robson N, Yeomans A, Bailey S, Laversin S, Beers S, Sayan AE, Ashton-Key M, Schwaiger S, Stuppner H, Troppmair J, Packham G, Cutress R.

Oncotarget. 2016 Apr 5;7(14):18851-64. doi: 10.18632/oncotarget.7944.


Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation.

Waltenberger B, Liu R, Atanasov AG, Schwaiger S, Heiss EH, Dirsch VM, Stuppner H.

Molecules. 2015 Nov 13;20(11):20381-90. doi: 10.3390/molecules201119703.


Discovery and resupply of pharmacologically active plant-derived natural products: A review.

Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H.

Biotechnol Adv. 2015 Dec;33(8):1582-1614. doi: 10.1016/j.biotechadv.2015.08.001. Epub 2015 Aug 15. Review.


Prevention of False-Positive Results: Development of an HPTLC Autographic Assay for the Detection of Natural Tyrosinase Inhibitors.

Taibon J, Ankli A, Schwaiger S, Magnenat C, Boka VI, Simões-Pires C, Aligiannis N, Cuendet M, Skaltsounis AL, Reich E, Stuppner H.

Planta Med. 2015 Aug;81(12-13):1198-204. doi: 10.1055/s-0035-1546250. Epub 2015 Jul 28.


Phytochemical profile of the aerial parts of Sedum sediforme and anti-inflammatory activity of myricitrin.

Winekenstädde D, Angelis A, Waltenberger B, Schwaiger S, Tchoumtchoua J, König S, Werz O, Aligiannis N, Skaltsounis AL, Stuppner H.

Nat Prod Commun. 2015 Jan;10(1):83-8.


Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: assessing the activity of flavonoids from the stem bark of Oroxylum indicum.

Tran TV, Malainer C, Schwaiger S, Hung T, Atanasov AG, Heiss EH, Dirsch VM, Stuppner H.

J Ethnopharmacol. 2015 Jan 15;159:36-42. doi: 10.1016/j.jep.2014.10.012. Epub 2014 Oct 31.


Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.

Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH, Schuster D, Kopp B, Bauer R, Stuppner H, Dirsch VM, Atanasov AG.

Biochem Pharmacol. 2014 Nov 1;92(1):73-89. doi: 10.1016/j.bcp.2014.07.018. Epub 2014 Jul 30. Review.


Lignan formation in hairy root cultures of Edelweiss (Leontopodium nivale ssp. alpinum (Cass.) Greuter).

Wawrosch C, Schwaiger S, Stuppner H, Kopp B.

Fitoterapia. 2014 Sep;97:219-23. doi: 10.1016/j.fitote.2014.06.008. Epub 2014 Jun 14.


Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata.

Heiss EH, Tran TV, Zimmermann K, Schwaiger S, Vouk C, Mayerhofer B, Malainer C, Atanasov AG, Stuppner H, Dirsch VM.

J Nat Prod. 2014 Mar 28;77(3):503-8. doi: 10.1021/np400778m. Epub 2014 Jan 29.


NF-κB inhibitors from Eurycoma longifolia.

Tran TV, Malainer C, Schwaiger S, Atanasov AG, Heiss EH, Dirsch VM, Stuppner H.

J Nat Prod. 2014 Mar 28;77(3):483-8. doi: 10.1021/np400701k. Epub 2014 Jan 27.


Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.

Temml V, Kuehnl S, Schuster D, Schwaiger S, Stuppner H, Fuchs D.

FEBS Open Bio. 2013 Sep 7;3:450-2. doi: 10.1016/j.fob.2013.08.008. eCollection 2013.


Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.

Enthammer M, Papadakis ES, Salomé Gachet M, Deutsch M, Schwaiger S, Koziel K, Ashraf MI, Khalid S, Wolber G, Packham G, Cutress RI, Stuppner H, Troppmair J.

Mol Cancer Ther. 2013 Nov;12(11):2400-14. doi: 10.1158/1535-7163.MCT-13-0142. Epub 2013 Sep 18.


Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.

Kuehnl S, Schroecksnadel S, Temml V, Gostner JM, Schennach H, Schuster D, Schwaiger S, Rollinger JM, Fuchs D, Stuppner H.

Phytomedicine. 2013 Oct 15;20(13):1190-5. doi: 10.1016/j.phymed.2013.06.006. Epub 2013 Jul 15.


Honokiol: a non-adipogenic PPARγ agonist from nature.

Atanasov AG, Wang JN, Gu SP, Bu J, Kramer MP, Baumgartner L, Fakhrudin N, Ladurner A, Malainer C, Vuorinen A, Noha SM, Schwaiger S, Rollinger JM, Schuster D, Stuppner H, Dirsch VM, Heiss EH.

Biochim Biophys Acta. 2013 Oct;1830(10):4813-9. doi: 10.1016/j.bbagen.2013.06.021. Epub 2013 Jun 27.


5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo.

Messner B, Kern J, Wiedemann D, Schwaiger S, Türkcan A, Ploner C, Trockenbacher A, Aumayr K, Bonaros N, Laufer G, Stuppner H, Untergasser G, Bernhard D.

PLoS One. 2013;8(3):e58342. doi: 10.1371/journal.pone.0058342. Epub 2013 Mar 12.


Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death.

Messner B, Frotschnig S, Steinacher-Nigisch A, Winter B, Eichmair E, Gebetsberger J, Schwaiger S, Ploner C, Laufer G, Bernhard D.

Cell Death Dis. 2012 Nov 15;3:e424. doi: 10.1038/cddis.2012.162.


Chemical profiling of Edelweiss (Leontopodium alpinum Cass.) extracts by micellar electrokinetic capillary chromatography.

Ganzera M, Greifeneder V, Schwaiger S, Stuppner H.

Fitoterapia. 2012 Dec;83(8):1680-6. doi: 10.1016/j.fitote.2012.09.023. Epub 2012 Oct 4.


2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells.

Ladurner A, Atanasov AG, Heiss EH, Baumgartner L, Schwaiger S, Rollinger JM, Stuppner H, Dirsch VM.

Biochem Pharmacol. 2012 Sep 15;84(6):804-12. doi: 10.1016/j.bcp.2012.06.029. Epub 2012 Jul 6.


Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats.

Zeller I, Wiedemann D, Schwaiger S, Stelzmüller M, Kreutmayer S, Leberfing O, Stuppner H, Bernhard D.

Eur J Cardiothorac Surg. 2012 Nov;42(5):878-84. doi: 10.1093/ejcts/ezs128. Epub 2012 May 2.


Ratanhiaphenol III from Ratanhiae radix is a PTP1B inhibitor.

Heiss EH, Baumgartner L, Schwaiger S, Heredia RJ, Atanasov AG, Rollinger JM, Stuppner H, Dirsch VM.

Planta Med. 2012 May;78(7):678-81. doi: 10.1055/s-0031-1298242. Epub 2012 Feb 3.


Characterization of an UV- and VIS-absorbing, purpurogallin-derived secondary pigment new to algae and highly abundant in Mesotaenium berggrenii (Zygnematophyceae, Chlorophyta), an extremophyte living on glaciers.

Remias D, Schwaiger S, Aigner S, Leya T, Stuppner H, Lütz C.

FEMS Microbiol Ecol. 2012 Mar;79(3):638-48. doi: 10.1111/j.1574-6941.2011.01245.x. Epub 2011 Nov 30.


Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein.

Duwensee K, Schwaiger S, Tancevski I, Eller K, van Eck M, Markt P, Linder T, Stanzl U, Ritsch A, Patsch JR, Schuster D, Stuppner H, Bernhard D, Eller P.

Atherosclerosis. 2011 Nov;219(1):109-15. doi: 10.1016/j.atherosclerosis.2011.07.023. Epub 2011 Jul 21.


Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.

Baumgartner L, Sosa S, Atanasov AG, Bodensieck A, Fakhrudin N, Bauer J, Favero GD, Ponti C, Heiss EH, Schwaiger S, Ladurner A, Widowitz U, Loggia RD, Rollinger JM, Werz O, Bauer R, Dirsch VM, Tubaro A, Stuppner H.

J Nat Prod. 2011 Aug 26;74(8):1779-86. doi: 10.1021/np200343t. Epub 2011 Jul 29.


Quantitative analysis of anti-inflammatory lignan derivatives in Ratanhiae radix and its tincture by HPLC-PDA and HPLC-MS.

Baumgartner L, Schwaiger S, Stuppner H.

J Pharm Biomed Anal. 2011 Nov 1;56(3):546-52. doi: 10.1016/j.jpba.2011.06.016. Epub 2011 Jun 28.


Metabolic fingerprinting of Leontopodium species (Asteraceae) by means of ¹H NMR and HPLC-ESI-MS.

Safer S, Cicek SS, Pieri V, Schwaiger S, Schneider P, Wissemann V, Stuppner H.

Phytochemistry. 2011 Aug;72(11-12):1379-89. doi: 10.1016/j.phytochem.2011.04.006.


Tailoring of high-Q-factor surface plasmon modes on silver microtubes.

Rottler A, Bröll M, Schwaiger S, Heitmann D, Mendach S.

Opt Lett. 2011 Apr 1;36(7):1240-2. doi: 10.1364/OL.36.001240.


Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).

Schwaiger S, Zeller I, Pölzelbauer P, Frotschnig S, Laufer G, Messner B, Pieri V, Stuppner H, Bernhard D.

J Ethnopharmacol. 2011 Jan 27;133(2):704-9. doi: 10.1016/j.jep.2010.10.049. Epub 2010 Oct 30.

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