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Items: 37

1.

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity.

Cozier GE, Schwager SL, Sharma RK, Chibale K, Sturrock ED, Acharya KR.

FEBS J. 2018 Apr;285(8):1477-1490. doi: 10.1111/febs.14421. Epub 2018 Mar 8.

2.

Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme.

Abrie JA, Moolman WJA, Cozier GE, Schwager SL, Acharya KR, Sturrock ED.

Mol Pharmacol. 2018 Apr;93(4):344-354. doi: 10.1124/mol.117.110866. Epub 2018 Jan 25. Erratum in: Mol Pharmacol. 2018 May;93(5):416.

PMID:
29371233
3.

Therapeutic drug monitoring of amlodipine and the Z-FHL/HHL ratio: Adherence tools in patients referred for apparent treatment-resistant hypertension.

Jones ESW, Lesosky M, Blockman M, Castel S, Decloedt EH, Schwager SLU, Sturrock ED, Wiesner L, Rayner BL.

S Afr Med J. 2017 Sep 22;107(10):887-891. doi: 10.7196/SAMJ.2017.v107i10.12268.

4.

The effect of structural motifs on the ectodomain shedding of human angiotensin-converting enzyme.

Conrad N, Schwager SL, Carmona AK, Sturrock ED.

Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):111-116. doi: 10.1016/j.bbrc.2016.10.155. Epub 2016 Nov 3.

PMID:
27818199
5.

Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.

Larmuth KM, Masuyer G, Douglas RG, Schwager SL, Acharya KR, Sturrock ED.

FEBS J. 2016 Mar;283(6):1060-76. doi: 10.1111/febs.13647. Epub 2016 Feb 9.

6.

Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.

Kramer GJ, Mohd A, Schwager SL, Masuyer G, Acharya KR, Sturrock ED, Bachmann BO.

ACS Med Chem Lett. 2014 Feb 4;5(4):346-51. doi: 10.1021/ml4004588. eCollection 2014 Apr 10.

7.

Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor.

Denti P, Sharp SK, Kröger WL, Schwager SL, Mahajan A, Njoroge M, Gibhard L, Smit I, Chibale K, Wiesner L, Sturrock ED, Davies NH.

Eur J Pharm Sci. 2014 Jun 2;56:113-9. doi: 10.1016/j.ejps.2014.01.012. Epub 2014 Feb 20.

PMID:
24561703
8.

A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.

Danilov SM, Wade MS, Schwager SL, Douglas RG, Nesterovitch AB, Popova IA, Hogarth KD, Bhardwaj N, Schwartz DE, Sturrock ED, Garcia JG.

PLoS One. 2014 Feb 4;9(2):e88001. doi: 10.1371/journal.pone.0088001. eCollection 2014.

9.

Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE).

Yates CJ, Masuyer G, Schwager SL, Akif M, Sturrock ED, Acharya KR.

J Biol Chem. 2014 Jan 17;289(3):1798-814. doi: 10.1074/jbc.M113.512335. Epub 2013 Dec 2.

10.

Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme.

Masuyer G, Akif M, Czarny B, Beau F, Schwager SL, Sturrock ED, Isaac RE, Dive V, Acharya KR.

FEBS J. 2014 Feb;281(3):943-56. doi: 10.1111/febs.12660. Epub 2013 Dec 24.

11.

Association of B2 receptor polymorphisms and ACE activity with ACE inhibitor-induced angioedema in black and mixed-race South Africans.

Moholisa RR, Rayner BR, Patricia Owen E, Schwager SL, Stark JS, Badri M, Cupido CL, Sturrock ED.

J Clin Hypertens (Greenwich). 2013 Jun;15(6):413-9. doi: 10.1111/jch.12104. Epub 2013 Apr 11.

12.

Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides.

Masuyer G, Schwager SL, Sturrock ED, Isaac RE, Acharya KR.

Sci Rep. 2012;2:717. doi: 10.1038/srep00717. Epub 2012 Oct 9.

13.

Shedding the load of hypertension: the proteolytic processing of angiotensin-converting enzyme.

Ehlers MR, Gordon K, Schwager SL, Sturrock ED.

S Afr Med J. 2012 Mar 2;102(6):461-4. Review.

PMID:
22668937
14.

Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril.

Akif M, Masuyer G, Schwager SL, Bhuyan BJ, Mugesh G, Isaac RE, Sturrock ED, Acharya KR.

FEBS J. 2011 Oct;278(19):3644-50. doi: 10.1111/j.1742-4658.2011.08276.x. Epub 2011 Sep 8.

15.

Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide.

Akif M, Schwager SL, Anthony CS, Czarny B, Beau F, Dive V, Sturrock ED, Acharya KR.

Biochem J. 2011 May 15;436(1):53-9. doi: 10.1042/BJ20102123.

16.

The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407.

Anthony CS, Corradi HR, Schwager SL, Redelinghuys P, Georgiadis D, Dive V, Acharya KR, Sturrock ED.

J Biol Chem. 2010 Nov 12;285(46):35685-93. doi: 10.1074/jbc.M110.167866. Epub 2010 Sep 8.

17.

The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme.

O'Neill HG, Redelinghuys P, Schwager SL, Sturrock ED.

Biol Chem. 2008 Sep;389(9):1153-61. doi: 10.1515/BC.2008.131.

PMID:
18713002
18.

A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay.

Carmona AK, Schwager SL, Juliano MA, Juliano L, Sturrock ED.

Nat Protoc. 2006;1(4):1971-6.

PMID:
17487185
19.

A high-throughput fluorimetric assay for angiotensin I-converting enzyme.

Schwager SL, Carmona AK, Sturrock ED.

Nat Protoc. 2006;1(4):1961-4. Epub 2006 Nov 30.

PMID:
17487183
21.

Structure of testis ACE glycosylation mutants and evidence for conserved domain movement.

Watermeyer JM, Sewell BT, Schwager SL, Natesh R, Corradi HR, Acharya KR, Sturrock ED.

Biochemistry. 2006 Oct 24;45(42):12654-63.

22.

Homologous substitution of ACE C-domain regions with N-domain sequences: effect on processing, shedding, and catalytic properties.

Woodman ZL, Schwager SL, Redelinghuys P, Chubb AJ, van der Merwe EL, Ehlers MR, Sturrock ED.

Biol Chem. 2006 Aug;387(8):1043-51.

PMID:
16895474
23.

Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.

Corradi HR, Schwager SL, Nchinda AT, Sturrock ED, Acharya KR.

J Mol Biol. 2006 Mar 31;357(3):964-74. Epub 2006 Jan 31.

PMID:
16476442
24.

The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity.

Woodman ZL, Schwager SL, Redelinghuys P, Carmona AK, Ehlers MR, Sturrock ED.

Biochem J. 2005 Aug 1;389(Pt 3):739-44.

25.

Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.

Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR.

Biochemistry. 2004 Jul 13;43(27):8718-24.

PMID:
15236580
26.

The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.

Allinson TM, Parkin ET, Condon TP, Schwager SL, Sturrock ED, Turner AJ, Hooper NM.

Eur J Biochem. 2004 Jun;271(12):2539-47.

27.

Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme.

Chubb AJ, Schwager SL, van der Merwe E, Ehlers MR, Sturrock ED.

Biochem Biophys Res Commun. 2004 Feb 20;314(4):971-5.

PMID:
14751227
28.

Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.

Gordon K, Redelinghuys P, Schwager SL, Ehlers MR, Papageorgiou AC, Natesh R, Acharya KR, Sturrock ED.

Biochem J. 2003 Apr 15;371(Pt 2):437-42.

29.

Crystal structure of the human angiotensin-converting enzyme-lisinopril complex.

Natesh R, Schwager SL, Sturrock ED, Acharya KR.

Nature. 2003 Jan 30;421(6922):551-4. Epub 2003 Jan 19.

PMID:
12540854
30.

Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain.

Chubb AJ, Schwager SL, Woodman ZL, Ehlers MR, Sturrock ED.

Biochem Biophys Res Commun. 2002 Oct 11;297(5):1225-30.

PMID:
12372418
31.

Cleavage of disulfide-bridged stalk domains during shedding of angiotensin-converting enzyme occurs at multiple juxtamembrane sites.

Schwager SL, Chubb AJ, Woodman ZL, Yan L, Mentele R, Ehlers MR, Sturrock ED.

Biochemistry. 2001 Dec 25;40(51):15624-30.

PMID:
11747437
32.

Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding.

Pang S, Chubb AJ, Schwager SL, Ehlers MR, Sturrock ED, Hooper NM.

Biochem J. 2001 Aug 15;358(Pt 1):185-92.

33.

Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.

Woodman ZL, Oppong SY, Cook S, Hooper NM, Schwager SL, Brandt WF, Ehlers MR, Sturrock ED.

Biochem J. 2000 May 1;347 Pt 3:711-8.

34.

Modulation of juxtamembrane cleavage ("shedding") of angiotensin-converting enzyme by stalk glycosylation: evidence for an alternative shedding protease.

Schwager SL, Chubb AJ, Scholle RR, Brandt WF, Mentele R, Riordan JF, Sturrock ED, Ehlers MR.

Biochemistry. 1999 Aug 10;38(32):10388-97.

PMID:
10441133
35.

Phorbol ester-induced juxtamembrane cleavage of angiotensin-converting enzyme is not inhibited by a stalk containing intrachain disulfides.

Schwager SL, Chubb AJ, Scholle RR, Brandt WF, Eckerskorn C, Sturrock ED, Ehlers MR.

Biochemistry. 1998 Nov 3;37(44):15449-56.

PMID:
9799507
36.

Proteolytic release of membrane proteins: studies on a membrane-protein-solubilizing activity in CHO cells.

Ehlers MR, Schwager SL, Chubb AJ, Scholle RR, Brandt WF, Riordan JF.

Immunopharmacology. 1997 Jun;36(2-3):271-8.

PMID:
9228557
37.

Proteolytic release of membrane-bound angiotensin-converting enzyme: role of the juxtamembrane stalk sequence.

Ehlers MR, Schwager SL, Scholle RR, Manji GA, Brandt WF, Riordan JF.

Biochemistry. 1996 Jul 23;35(29):9549-59.

PMID:
8755736

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