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Items: 24


A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways.

Campino S, Marin-Menendez A, Kemp A, Cross N, Drought L, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A, Rayner JC.

PLoS Pathog. 2018 Nov 29;14(11):e1007436. doi: 10.1371/journal.ppat.1007436. eCollection 2018 Nov.


Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.

Bushell E, Gomes AR, Sanderson T, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O.

Cell. 2017 Jul 13;170(2):260-272.e8. doi: 10.1016/j.cell.2017.06.030.


A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite.

Gomes AR, Bushell E, Schwach F, Girling G, Anar B, Quail MA, Herd C, Pfander C, Modrzynska K, Rayner JC, Billker O.

Cell Host Microbe. 2015 Mar 11;17(3):404-413. doi: 10.1016/j.chom.2015.01.014. Epub 2015 Feb 26.


PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites.

Schwach F, Bushell E, Gomes AR, Anar B, Girling G, Herd C, Rayner JC, Billker O.

Nucleic Acids Res. 2015 Jan;43(Database issue):D1176-82. doi: 10.1093/nar/gku1143.


Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites.

Brochet M, Collins MO, Smith TK, Thompson E, Sebastian S, Volkmann K, Schwach F, Chappell L, Gomes AR, Berriman M, Rayner JC, Baker DA, Choudhary J, Billker O.

PLoS Biol. 2014 Mar 4;12(3):e1001806. doi: 10.1371/journal.pbio.1001806. eCollection 2014 Mar.


Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates.

Ning J, Otto TD, Pfander C, Schwach F, Brochet M, Bushell E, Goulding D, Sanders M, Lefebvre PA, Pei J, Grishin NV, Vanderlaan G, Billker O, Snell WJ.

Genes Dev. 2013 May 15;27(10):1198-215. doi: 10.1101/gad.212746.112.


A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs.

Sebastian S, Brochet M, Collins MO, Schwach F, Jones ML, Goulding D, Rayner JC, Choudhary JS, Billker O.

Cell Host Microbe. 2012 Jul 19;12(1):9-19. doi: 10.1016/j.chom.2012.05.014.


The UEA sRNA workbench: a suite of tools for analysing and visualizing next generation sequencing microRNA and small RNA datasets.

Stocks MB, Moxon S, Mapleson D, Woolfenden HC, Mohorianu I, Folkes L, Schwach F, Dalmay T, Moulton V.

Bioinformatics. 2012 Aug 1;28(15):2059-61. doi: 10.1093/bioinformatics/bts311. Epub 2012 May 24.


PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division.

Volz JC, Bártfai R, Petter M, Langer C, Josling GA, Tsuboi T, Schwach F, Baum J, Rayner JC, Stunnenberg HG, Duffy MF, Cowman AF.

Cell Host Microbe. 2012 Jan 19;11(1):7-18. doi: 10.1016/j.chom.2011.11.011.


A scalable pipeline for highly effective genetic modification of a malaria parasite.

Pfander C, Anar B, Schwach F, Otto TD, Brochet M, Volkmann K, Quail MA, Pain A, Rosen B, Skarnes W, Rayner JC, Billker O.

Nat Methods. 2011 Oct 23;8(12):1078-82. doi: 10.1038/nmeth.1742.


mRNA expression profiling reveals conserved and non-conserved miR-140 targets.

Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V, Dalmay T.

RNA Biol. 2011 Jul-Aug;8(4):607-15. doi: 10.4161/rna.8.4.15390. Epub 2011 Jul 1.


Profiling of short RNAs during fleshy fruit development reveals stage-specific sRNAome expression patterns.

Mohorianu I, Schwach F, Jing R, Lopez-Gomollon S, Moxon S, Szittya G, Sorefan K, Moulton V, Dalmay T.

Plant J. 2011 Jul;67(2):232-46. doi: 10.1111/j.1365-313X.2011.04586.x. Epub 2011 May 9.


The Arabidopsis RNA-directed DNA methylation argonautes functionally diverge based on their expression and interaction with target loci.

Havecker ER, Wallbridge LM, Hardcastle TJ, Bush MS, Kelly KA, Dunn RM, Schwach F, Doonan JH, Baulcombe DC.

Plant Cell. 2010 Feb;22(2):321-34. doi: 10.1105/tpc.109.072199. Epub 2010 Feb 19.


Deciphering the diversity of small RNAs in plants: the long and short of it.

Schwach F, Moxon S, Moulton V, Dalmay T.

Brief Funct Genomic Proteomic. 2009 Nov;8(6):472-81. doi: 10.1093/bfgp/elp024. Epub 2009 Jul 29. Review.


Highly specific gene silencing by artificial microRNAs in the unicellular alga Chlamydomonas reinhardtii.

Molnar A, Bassett A, Thuenemann E, Schwach F, Karkare S, Ossowski S, Weigel D, Baulcombe D.

Plant J. 2009 Apr;58(1):165-74. doi: 10.1111/j.1365-313X.2008.03767.x. Epub 2009 Jan 19.


Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140.

Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V, Dalmay T.

RNA. 2008 Dec;14(12):2513-20. doi: 10.1261/rna.1221108. Epub 2008 Oct 22.


A toolkit for analysing large-scale plant small RNA datasets.

Moxon S, Schwach F, Dalmay T, Maclean D, Studholme DJ, Moulton V.

Bioinformatics. 2008 Oct 1;24(19):2252-3. doi: 10.1093/bioinformatics/btn428. Epub 2008 Aug 19.


Deep sequencing of tomato short RNAs identifies microRNAs targeting genes involved in fruit ripening.

Moxon S, Jing R, Szittya G, Schwach F, Rusholme Pilcher RL, Moulton V, Dalmay T.

Genome Res. 2008 Oct;18(10):1602-9. doi: 10.1101/gr.080127.108. Epub 2008 Jul 24.


PolIVb influences RNA-directed DNA methylation independently of its role in siRNA biogenesis.

Mosher RA, Schwach F, Studholme D, Baulcombe DC.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3145-50. doi: 10.1073/pnas.0709632105. Epub 2008 Feb 19.


miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii.

Molnár A, Schwach F, Studholme DJ, Thuenemann EC, Baulcombe DC.

Nature. 2007 Jun 28;447(7148):1126-9. Epub 2007 May 30.


SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans-acting endogenous siRNA.

Hernandez-Pinzon I, Yelina NE, Schwach F, Studholme DJ, Baulcombe D, Dalmay T.

Plant J. 2007 Apr;50(1):140-8.


An unusual large intergenic region in the S-RNA of a Bulgarian tomato spotted wilt virus isolate.

Heinze C, Willingmann P, Schwach F, Adam G.

Arch Virol. 2003 Jan;148(1):199-205.


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