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Items: 1 to 50 of 107

1.

A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice.

Wang X, Sommerfeld MR, Jahn-Hofmann K, Cai B, Filliol A, Remotti HE, Schwabe RF, Kannt A, Tabas I.

Hepatol Commun. 2019 Jul 23;3(9):1221-1234. doi: 10.1002/hep4.1405. eCollection 2019 Sep.

2.

Contributions of Fibroblasts, Extracellular Matrix, Stiffness, and Mechanosensing to Hepatocarcinogenesis.

Filliol A, Schwabe RF.

Semin Liver Dis. 2019 Jul;39(3):315-333. doi: 10.1055/s-0039-1685539. Epub 2019 Jun 21.

PMID:
31226725
3.

Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.

Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaat9284. doi: 10.1126/scitranslmed.aat9284.

PMID:
31189722
4.

Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice.

Yan J, Tung HC, Li S, Niu Y, Garbacz WG, Lu P, Bi Y, Li Y, He J, Xu M, Ren S, Monga SP, Schwabe RF, Yang D, Xie W.

Gastroenterology. 2019 Sep;157(3):793-806.e14. doi: 10.1053/j.gastro.2019.05.066. Epub 2019 Jun 3.

PMID:
31170413
5.

HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis.

Hernandez C, Huebener P, Pradere JP, Antoine DJ, Friedman RA, Schwabe RF.

J Clin Invest. 2019 Apr 1;129(4):1803. doi: 10.1172/JCI128262. Epub 2019 Apr 1. No abstract available.

6.

HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis.

Hernandez C, Huebener P, Pradere JP, Antoine DJ, Friedman RA, Schwabe RF.

J Clin Invest. 2019 Apr 1;129(4):1803. doi: 10.1172/JCI128261. Epub 2019 Apr 1. No abstract available.

7.

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.

Huebener P, Pradere JP, Hernandez C, Gwak GY, Caviglia JM, Mu X, Loike JD, Jenkins RE, Antoine DJ, Schwabe RF.

J Clin Invest. 2019 Mar 4;130:1802. doi: 10.1172/JCI126976. eCollection 2019 Mar 4. No abstract available.

8.

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.

Huebener P, Pradere JP, Hernandez C, Gwak GY, Caviglia JM, Mu X, Loike JD, Jenkins RE, Antoine DJ, Schwabe RF.

J Clin Invest. 2019 Mar 4;130:1802. doi: 10.1172/JCI126975. eCollection 2019 Mar 4. No abstract available.

9.

Soluble Fibers Improve Metabolic Syndrome but May Cause Liver Disease and Hepatocellular Carcinoma.

Wen W, Schwabe RF.

Hepatology. 2019 Aug;70(2):739-741. doi: 10.1002/hep.30565. Epub 2019 Apr 11. No abstract available.

PMID:
30762890
10.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.

Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB.

Sci Transl Med. 2018 Nov 21;10(468). pii: eaat0344. doi: 10.1126/scitranslmed.aat0344.

PMID:
30463916
11.

Apoptosis and necroptosis in the liver: a matter of life and death.

Schwabe RF, Luedde T.

Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):738-752. doi: 10.1038/s41575-018-0065-y. Review.

12.

HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis.

Hernandez C, Huebener P, Pradere JP, Antoine DJ, Friedman RA, Schwabe RF.

J Clin Invest. 2018 Jun 1;128(6):2436-2451. doi: 10.1172/JCI91786. Epub 2018 May 7. Erratum in: J Clin Invest. 2019 Apr 1;129(4):1803.

13.

Animal models of HCC - When injury meets mutation.

Yan J, Caviglia JM, Schwabe RF.

J Hepatol. 2017 Nov 16. pii: S0168-8278(17)32197-9. doi: 10.1016/j.jhep.2017.07.023. [Epub ahead of print] No abstract available.

PMID:
29153595
14.

MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis.

Caviglia JM, Yan J, Jang MK, Gwak GY, Affo S, Yu L, Olinga P, Friedman RA, Chen X, Schwabe RF.

Hepatology. 2018 Jun;67(6):2414-2429. doi: 10.1002/hep.29627. Epub 2018 Jan 18.

15.

The gut microbiome and liver cancer: mechanisms and clinical translation.

Yu LX, Schwabe RF.

Nat Rev Gastroenterol Hepatol. 2017 Sep;14(9):527-539. doi: 10.1038/nrgastro.2017.72. Epub 2017 Jul 5. Review.

16.

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells.

Tummala KS, Brandt M, Teijeiro A, Graña O, Schwabe RF, Perna C, Djouder N.

Cell Rep. 2017 Apr 18;19(3):584-600. doi: 10.1016/j.celrep.2017.03.059.

17.

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis.

Wang X, Zheng Z, Caviglia JM, Corey KE, Herfel TM, Cai B, Masia R, Chung RT, Lefkowitch JH, Schwabe RF, Tabas I.

Cell Metab. 2016 Dec 13;24(6):848-862. doi: 10.1016/j.cmet.2016.09.016. Epub 2016 Oct 27.

18.

The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer.

Affo S, Yu LX, Schwabe RF.

Annu Rev Pathol. 2017 Jan 24;12:153-186. doi: 10.1146/annurev-pathol-052016-100322. Epub 2016 Dec 5. Review.

19.

Gut microbiota and Toll-like receptors set the stage for cytokine-mediated failure of antibacterial responses in the fibrotic liver.

Kuntzen C, Schwabe RF.

Gut. 2017 Mar;66(3):396-398. doi: 10.1136/gutjnl-2016-312486. Epub 2016 Sep 21. No abstract available.

PMID:
27654586
20.

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation.

Pradère JP, Hernandez C, Koppe C, Friedman RA, Luedde T, Schwabe RF.

Sci Signal. 2016 Aug 23;9(442):ra85. doi: 10.1126/scisignal.aab2820.

21.

TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.

Weber SN, Bohner A, Dapito DH, Schwabe RF, Lammert F.

PLoS One. 2016 Jul 8;11(7):e0158819. doi: 10.1371/journal.pone.0158819. eCollection 2016.

22.

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.

Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Corvera CU, Grimm D, Willenbring H.

Cell Stem Cell. 2016 Jun 2;18(6):809-16. doi: 10.1016/j.stem.2016.05.005.

23.

Opposite roles of cannabinoid receptors 1 and 2 in hepatocarcinogenesis.

Suk KT, Mederacke I, Gwak GY, Cho SW, Adeyemi A, Friedman R, Schwabe RF.

Gut. 2016 Oct;65(10):1721-32. doi: 10.1136/gutjnl-2015-310212. Epub 2016 May 11. Erratum in: Gut. 2019 Jul;68(7):1342.

24.

Damage-associated molecular patterns in cancer: a double-edged sword.

Hernandez C, Huebener P, Schwabe RF.

Oncogene. 2016 Nov 17;35(46):5931-5941. doi: 10.1038/onc.2016.104. Epub 2016 Apr 18. Review.

25.

Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.

Siegmund SV, Schlosser M, Schildberg FA, Seki E, De Minicis S, Uchinami H, Kuntzen C, Knolle PA, Strassburg CP, Schwabe RF.

PLoS One. 2016 Mar 3;11(3):e0150893. doi: 10.1371/journal.pone.0150893. eCollection 2016.

26.

Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer BM, Araúzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M, Sharma AD.

Cell Stem Cell. 2016 Jun 2;18(6):797-808. doi: 10.1016/j.stem.2016.01.010. Epub 2016 Feb 25.

27.

Contribution of Underlying Connective Tissue Cells to Taste Buds in Mouse Tongue and Soft Palate.

Boggs K, Venkatesan N, Mederacke I, Komatsu Y, Stice S, Schwabe RF, Mistretta CM, Mishina Y, Liu HX.

PLoS One. 2016 Jan 7;11(1):e0146475. doi: 10.1371/journal.pone.0146475. eCollection 2016.

28.

Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.

Mu X, Pradere JP, Affò S, Dapito DH, Friedman R, Lefkovitch JH, Schwabe RF.

Gastroenterology. 2016 Mar;150(3):720-33. doi: 10.1053/j.gastro.2015.11.039. Epub 2015 Nov 26.

29.

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance.

Fischer KR, Durrans A, Lee S, Sheng J, Li F, Wong ST, Choi H, El Rayes T, Ryu S, Troeger J, Schwabe RF, Vahdat LT, Altorki NK, Mittal V, Gao D.

Nature. 2015 Nov 26;527(7579):472-6. doi: 10.1038/nature15748. Epub 2015 Nov 11.

30.

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

Mu X, Español-Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, Lemaigre FP, Adili A, Yuan D, Weber A, Unger K, Heikenwälder M, Leclercq IA, Schwabe RF.

J Clin Invest. 2015 Oct 1;125(10):3891-903. doi: 10.1172/JCI77995. Epub 2015 Sep 8.

31.

HMGB1 and injury amplification.

Huebener P, Hernandez C, Schwabe RF.

Oncotarget. 2015 Sep 15;6(27):23048-9. No abstract available.

32.

Comment on: HMGB1-dependent and -independent autophagy.

Huebener P, Gwak GY, Schwabe RF.

Autophagy. 2015;11(7):1187-8. doi: 10.1080/15548627.2015.1054593.

33.

Origin and function of myofibroblasts in the liver.

Wells RG, Schwabe RF.

Semin Liver Dis. 2015 May;35(2):e1. doi: 10.1055/s-0035-1554915. Epub 2015 May 23. No abstract available.

PMID:
26008640
34.

Origin and function of myofibroblasts in the liver.

Wells RG, Schwabe RF.

Semin Liver Dis. 2015 May;35(2):97-106. doi: 10.1055/s-0035-1550061. Epub 2015 May 14. Review. Erratum in: Semin Liver Dis. 2015 May;35(2):e1. Schwabe, Robert [corrected to Schwabe, Robert F].

PMID:
25974896
35.

Mouse models of liver cancer.

Caviglia JM, Schwabe RF.

Methods Mol Biol. 2015;1267:165-83. doi: 10.1007/978-1-4939-2297-0_8.

PMID:
25636469
36.

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers.

Mederacke I, Dapito DH, Affò S, Uchinami H, Schwabe RF.

Nat Protoc. 2015 Feb;10(2):305-15. doi: 10.1038/nprot.2015.017. Epub 2015 Jan 22.

37.

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC.

Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042.

38.

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.

Huebener P, Pradere JP, Hernandez C, Gwak GY, Caviglia JM, Mu X, Loike JD, Schwabe RF.

J Clin Invest. 2015 Feb;125(2):539-50. doi: 10.1172/JCI76887. Epub 2014 Dec 22. Erratum in: J Clin Invest. 2019 Mar 4;130:1802.

39.

NAD(+) supplementation as a novel approach to cURIng HCC?

Mederacke I, Schwabe RF.

Cancer Cell. 2014 Dec 8;26(6):777-778. doi: 10.1016/j.ccell.2014.11.011.

40.

Hepatic inflammation and fibrosis: functional links and key pathways.

Seki E, Schwabe RF.

Hepatology. 2015 Mar;61(3):1066-79. doi: 10.1002/hep.27332. Epub 2015 Jan 28. Review.

41.

Cell death and cell death responses in liver disease: mechanisms and clinical relevance.

Luedde T, Kaplowitz N, Schwabe RF.

Gastroenterology. 2014 Oct;147(4):765-783.e4. doi: 10.1053/j.gastro.2014.07.018. Epub 2014 Jul 18. Review.

42.

High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo.

Huebener P, Gwak GY, Pradere JP, Quinzii CM, Friedman R, Lin CS, Trent CM, Mederacke I, Zhao E, Dapito DH, Lin Y, Goldberg IJ, Czaja MJ, Schwabe RF.

Cell Metab. 2014 Mar 4;19(3):539-47. doi: 10.1016/j.cmet.2014.01.014.

43.

CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis.

Affò S, Morales-Ibanez O, Rodrigo-Torres D, Altamirano J, Blaya D, Dapito DH, Millán C, Coll M, Caviglia JM, Arroyo V, Caballería J, Schwabe RF, Ginès P, Bataller R, Sancho-Bru P.

Gut. 2014 Nov;63(11):1782-92. doi: 10.1136/gutjnl-2013-306098. Epub 2014 Jan 10.

44.

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology.

Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, Pradere JP, Schwabe RF.

Nat Commun. 2013;4:2823. doi: 10.1038/ncomms3823.

45.

Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue.

Wongsiriroj N, Jiang H, Piantedosi R, Yang KJ, Kluwe J, Schwabe RF, Ginsberg H, Goldberg IJ, Blaner WS.

J Lipid Res. 2014 Jan;55(1):104-14. doi: 10.1194/jlr.M043844. Epub 2013 Nov 1.

46.

The microbiome and cancer.

Schwabe RF, Jobin C.

Nat Rev Cancer. 2013 Nov;13(11):800-12. doi: 10.1038/nrc3610. Epub 2013 Oct 17. Review.

47.

The Yin and Yang of Toll-like receptors in cancer.

Pradere JP, Dapito DH, Schwabe RF.

Oncogene. 2014 Jul 3;33(27):3485-95. doi: 10.1038/onc.2013.302. Epub 2013 Aug 12. Review.

48.

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice.

Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, Jang MK, Guenther ND, Mederacke I, Friedman R, Dragomir AC, Aloman C, Schwabe RF.

Hepatology. 2013 Oct;58(4):1461-73. doi: 10.1002/hep.26429. Epub 2013 Aug 9.

49.

Regulation of wound healing and organ fibrosis by toll-like receptors.

Huebener P, Schwabe RF.

Biochim Biophys Acta. 2013 Jul;1832(7):1005-17. doi: 10.1016/j.bbadis.2012.11.017. Epub 2012 Dec 4. Review.

50.

Cancer. Bacteria deliver a genotoxic hit.

Schwabe RF, Wang TC.

Science. 2012 Oct 5;338(6103):52-3. doi: 10.1126/science.1229905. No abstract available.

PMID:
23042875

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