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Items: 1 to 50 of 116

1.

Heme binding to human CLOCK affects interactions with the E-box.

Freeman SL, Kwon H, Portolano N, Parkin G, Venkatraman Girija U, Basran J, Fielding AJ, Fairall L, Svistunenko DA, Moody PCE, Schwabe JWR, Kyriacou CP, Raven EL.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19911-19916. doi: 10.1073/pnas.1905216116. Epub 2019 Sep 16.

PMID:
31527239
2.

Cognitive Behaviour Therapy Complemented with Emotion Regulation Training for Patients with Persistent Physical Symptoms: A Randomised Clinical Trial.

Kleinstäuber M, Allwang C, Bailer J, Berking M, Brünahl C, Erkic M, Gitzen H, Gollwitzer M, Gottschalk JM, Heider J, Hermann A, Lahmann C, Löwe B, Martin A, Rau J, Schröder A, Schwabe J, Schwarz J, Stark R, Weiss FD, Rief W.

Psychother Psychosom. 2019;88(5):287-299. doi: 10.1159/000501621. Epub 2019 Aug 20.

PMID:
31430755
3.

A de novo substitution in BCL11B leads to loss of interaction with transcriptional complexes and craniosynostosis.

Goos JAC, Vogel WK, Mlcochova H, Millard CJ, Esfandiari E, Selman WH, Calpena E, Koelling N, Carpenter EL, Swagemakers SMA, van der Spek PJ, Filtz TM, Schwabe JWR, Iwaniec UT, Mathijssen IMJ, Leid M, Twigg SRF.

Hum Mol Genet. 2019 Apr 3. pii: ddz072. doi: 10.1093/hmg/ddz072. [Epub ahead of print]

4.

Synthesis of HDAC Substrate Peptidomimetic Inhibitors Using Fmoc Amino Acids Incorporating Zinc-Binding Groups.

Mahindra A, Millard CJ, Black I, Archibald LJ, Schwabe JWR, Jamieson AG.

Org Lett. 2019 May 3;21(9):3178-3182. doi: 10.1021/acs.orglett.9b00885. Epub 2019 Apr 18.

5.

Tailoring Hexagonal Gibbsite Single Crystal Nanoplatelets for Ethylene Polymerization and Nanocomposite Formation on MAO-Free Heterogeneous Bis(imino)pyridine Iron(II) Catalyst.

Zhong F, Schwabe J, Thomann R, Mülhaupt R.

Macromol Rapid Commun. 2019 Jun;40(11):e1900015. doi: 10.1002/marc.201900015. Epub 2019 Mar 20.

PMID:
30892758
6.

Quantitative and Microstructural Changes of the Blood-Nerve Barrier in Peripheral Neuropathy.

Reinhold AK, Schwabe J, Lux TJ, Salvador E, Rittner HL.

Front Neurosci. 2018 Dec 18;12:936. doi: 10.3389/fnins.2018.00936. eCollection 2018.

7.

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.

Kelly RDW, Chandru A, Watson PJ, Song Y, Blades M, Robertson NS, Jamieson AG, Schwabe JWR, Cowley SM.

Sci Rep. 2018 Oct 2;8(1):14690. doi: 10.1038/s41598-018-32927-9.

8.

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

Zhang T, Wei G, Millard CJ, Fischer R, Konietzny R, Kessler BM, Schwabe JWR, Brockdorff N.

Nat Commun. 2018 Sep 18;9(1):3798. doi: 10.1038/s41467-018-06235-9.

9.

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.

Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13.

10.

Contrast-Enhanced Ultrasound (CEUS) and Quantitative Perfusion Analysis in Patients with Suspicion for Prostate Cancer.

Maxeiner A, Fischer T, Schwabe J, Baur ADJ, Stephan C, Peters R, Slowinski T, von Laffert M, Marticorena Garcia SR, Hamm B, Jung EM.

Ultraschall Med. 2019 Jun;40(3):340-348. doi: 10.1055/a-0594-2093. Epub 2018 Jun 6.

PMID:
29874683
11.

Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex.

Wu M, Hayward D, Kalin JH, Song Y, Schwabe JW, Cole PA.

Elife. 2018 Jun 5;7. pii: e37231. doi: 10.7554/eLife.37231.

12.

A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations.

Agostini M, Schoenmakers E, Beig J, Fairall L, Szatmari I, Rajanayagam O, Muskett FW, Adams C, Marais AD, O'Rahilly S, Semple RK, Nagy L, Majithia AR, Schwabe JWR, Blom DJ, Murphy R, Chatterjee K, Savage DB.

Diabetes. 2018 Jun;67(6):1086-1092. doi: 10.2337/db17-1236. Epub 2018 Apr 5.

13.

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.

14.

A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness.

Baur ADJ, Schwabe J, Rogasch J, Maxeiner A, Penzkofer T, Stephan C, Rudl M, Hamm B, Jung EM, Fischer T.

Eur Radiol. 2018 May;28(5):1949-1960. doi: 10.1007/s00330-017-5192-2. Epub 2017 Dec 13.

PMID:
29238867
15.

Expression and Purification of Protein Complexes Suitable for Structural Studies Using Mammalian HEK 293F Cells.

Nigi I, Fairall L, Schwabe JWR.

Curr Protoc Protein Sci. 2017 Nov 1;90:5.28.1-5.28.16. doi: 10.1002/cpps.44.

PMID:
29091272
16.

[Progressive encephalomyelitis with rigidity and myoclonus : Stiff tongue as initial symptom].

Niedernhöfer P, Schwabe J, Seidel G.

Nervenarzt. 2018 Feb;89(2):198-199. doi: 10.1007/s00115-017-0429-5. German. No abstract available.

PMID:
29038884
17.

Backbone resonance assignment of the BCL6-BTB/POZ domain.

Lin LY, Evans SE, Fairall L, Schwabe JWR, Wagner SD, Muskett FW.

Biomol NMR Assign. 2018 Apr;12(1):47-50. doi: 10.1007/s12104-017-9778-z. Epub 2017 Sep 19.

18.

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.

Moran C, Agostini M, McGowan A, Schoenmakers E, Fairall L, Lyons G, Rajanayagam O, Watson L, Offiah A, Barton J, Price S, Schwabe J, Chatterjee K.

Thyroid. 2017 Jul;27(7):973-982. doi: 10.1089/thy.2017.0157.

19.

Genetic disorders of nuclear receptors.

Achermann JC, Schwabe J, Fairall L, Chatterjee K.

J Clin Invest. 2017 Apr 3;127(4):1181-1192. doi: 10.1172/JCI88892. Epub 2017 Apr 3. Review.

20.

Targeting Class I Histone Deacetylases in a "Complex" Environment.

Millard CJ, Watson PJ, Fairall L, Schwabe JWR.

Trends Pharmacol Sci. 2017 Apr;38(4):363-377. doi: 10.1016/j.tips.2016.12.006. Epub 2017 Jan 28. Review.

PMID:
28139258
21.

Mutations in TBL1X Are Associated With Central Hypothyroidism.

Heinen CA, Losekoot M, Sun Y, Watson PJ, Fairall L, Joustra SD, Zwaveling-Soonawala N, Oostdijk W, van den Akker EL, Alders M, Santen GW, van Rijn RR, Dreschler WA, Surovtseva OV, Biermasz NR, Hennekam RC, Wit JM, Schwabe JW, Boelen A, Fliers E, van Trotsenburg AS.

J Clin Endocrinol Metab. 2016 Dec;101(12):4564-4573. Epub 2016 Sep 7.

22.

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, Bond ST, McEwen KA, Kerr-Bayles L, Ashton TD, Fleming C, Wu M, Pike Winer LS, Chen D, Hudson GM, Schwabe JWR, Baar K, Febbraio MA, Gregorevic P, Pfeffer FM, Walder KR, Hargreaves M, McGee SL.

Cell Rep. 2016 Sep 13;16(11):2802-2810. doi: 10.1016/j.celrep.2016.08.005.

23.

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.

Watson PJ, Millard CJ, Riley AM, Robertson NS, Wright LC, Godage HY, Cowley SM, Jamieson AG, Potter BV, Schwabe JW.

Nat Commun. 2016 Apr 25;7:11262. doi: 10.1038/ncomms11262.

24.

The structure of the core NuRD repression complex provides insights into its interaction with chromatin.

Millard CJ, Varma N, Saleh A, Morris K, Watson PJ, Bottrill AR, Fairall L, Smith CJ, Schwabe JW.

Elife. 2016 Apr 21;5:e13941. doi: 10.7554/eLife.13941.

25.

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate.

Hughes MA, Powley IR, Jukes-Jones R, Horn S, Feoktistova M, Fairall L, Schwabe JW, Leverkus M, Cain K, MacFarlane M.

Mol Cell. 2016 Mar 17;61(6):834-49. doi: 10.1016/j.molcel.2016.02.023.

26.

New Antarctic Gravity Anomaly Grid for Enhanced Geodetic and Geophysical Studies in Antarctica.

Scheinert M, Ferraccioli F, Schwabe J, Bell R, Studinger M, Damaske D, Jokat W, Aleshkova N, Jordan T, Leitchenkov G, Blankenship DD, Damiani TM, Young D, Cochran JR, Richter TD.

Geophys Res Lett. 2016 Jan 28;43(2):600-610. doi: 10.1002/2015GL067439. Epub 2016 Jan 21.

27.

A specific mutation in TBL1XR1 causes Pierpont syndrome.

Heinen CA, Jongejan A, Watson PJ, Redeker B, Boelen A, Boudzovitch-Surovtseva O, Forzano F, Hordijk R, Kelley R, Olney AH, Pierpont ME, Schaefer GB, Stewart F, van Trotsenburg AS, Fliers E, Schwabe JW, Hennekam RC.

J Med Genet. 2016 May;53(5):330-7. doi: 10.1136/jmedgenet-2015-103233. Epub 2016 Jan 14. Erratum in: J Med Genet. 2016 Jun;53(6):430.

28.

Histone deacetylase 3 indirectly modulates tubulin acetylation.

Bacon T, Seiler C, Wolny M, Hughes R, Watson P, Schwabe J, Grigg R, Peckham M.

Biochem J. 2015 Dec 15;472(3):367-77. doi: 10.1042/BJ20150660. Epub 2015 Oct 8.

29.

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex.

Hudson GM, Watson PJ, Fairall L, Jamieson AG, Schwabe JW.

J Biol Chem. 2015 Jul 17;290(29):18237-44. doi: 10.1074/jbc.M115.661058. Epub 2015 Jun 8.

30.

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.

Itoh T, Fairall L, Muskett FW, Milano CP, Watson PJ, Arnaudo N, Saleh A, Millard CJ, El-Mezgueldi M, Martino F, Schwabe JW.

Nucleic Acids Res. 2015 Feb 27;43(4):2033-44. doi: 10.1093/nar/gkv068. Epub 2015 Feb 4.

31.

Transient expression in HEK 293 cells: an alternative to E. coli for the production of secreted and intracellular mammalian proteins.

Nettleship JE, Watson PJ, Rahman-Huq N, Fairall L, Posner MG, Upadhyay A, Reddivari Y, Chamberlain JM, Kolstoe SE, Bagby S, Schwabe JW, Owens RJ.

Methods Mol Biol. 2015;1258:209-22. doi: 10.1007/978-1-4939-2205-5_11. Review.

PMID:
25447866
32.

Towards an understanding of the structure and function of MTA1.

Millard CJ, Fairall L, Schwabe JW.

Cancer Metastasis Rev. 2014 Dec;33(4):857-67. doi: 10.1007/s10555-014-9513-5. Review.

33.

Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach.

Portolano N, Watson PJ, Fairall L, Millard CJ, Milano CP, Song Y, Cowley SM, Schwabe JW.

J Vis Exp. 2014 Oct 16;(92):e51897. doi: 10.3791/51897.

34.

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells.

Jamaladdin S, Kelly RD, O'Regan L, Dovey OM, Hodson GE, Millard CJ, Portolano N, Fry AM, Schwabe JW, Cowley SM.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9840-5. doi: 10.1073/pnas.1321330111. Epub 2014 Jun 23.

35.

A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia.

Schoenmakers N, Moran C, Campi I, Agostini M, Bacon O, Rajanayagam O, Schwabe J, Bradbury S, Barrett T, Geoghegan F, Druce M, Beck-Peccoz P, O'Toole A, Clark P, Bignell M, Lyons G, Halsall D, Gurnell M, Chatterjee K.

J Clin Endocrinol Metab. 2014 Jul;99(7):E1381-6. doi: 10.1210/jc.2013-4077. Epub 2014 Mar 19. Erratum in: J Clin Endocrinol Metab. 2015 Apr;100(4):1709.

36.

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

Evans SE, Goult BT, Fairall L, Jamieson AG, Ko Ferrigno P, Ford R, Schwabe JW, Wagner SD.

PLoS One. 2014 Mar 4;9(3):e90889. doi: 10.1371/journal.pone.0090889. eCollection 2014.

37.

An evolving understanding of nuclear receptor coregulator proteins.

Millard CJ, Watson PJ, Fairall L, Schwabe JW.

J Mol Endocrinol. 2013 Nov 7;51(3):T23-36. doi: 10.1530/JME-13-0227. Print 2013 Dec. Review.

38.

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis.

Weber K, Harper N, Schwabe J, Cohen GM.

Cell Rep. 2013 Oct 31;5(2):409-20. doi: 10.1016/j.celrep.2013.09.010. Epub 2013 Oct 10.

39.

Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).

Dhani DK, Goult BT, George GM, Rogerson DT, Bitton DA, Miller CJ, Schwabe JW, Tanaka K.

Mol Biol Cell. 2013 Nov;24(21):3337-49. doi: 10.1091/mbc.E13-05-0253. Epub 2013 Sep 4.

40.

Class I HDACs share a common mechanism of regulation by inositol phosphates.

Millard CJ, Watson PJ, Celardo I, Gordiyenko Y, Cowley SM, Robinson CV, Fairall L, Schwabe JW.

Mol Cell. 2013 Jul 11;51(1):57-67. doi: 10.1016/j.molcel.2013.05.020. Epub 2013 Jun 20.

41.

Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: prediction of multiple cultivation variables.

Clavaud M, Roggo Y, Von Daeniken R, Liebler A, Schwabe JO.

Talanta. 2013 Jul 15;111:28-38. doi: 10.1016/j.talanta.2013.03.044. Epub 2013 Mar 26.

PMID:
23622522
42.

A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death.

Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L, Schwabe JW, Cain K, Macfarlane M.

Mol Cell. 2012 Jul 27;47(2):291-305. doi: 10.1016/j.molcel.2012.05.004. Epub 2012 Jun 7.

43.

Novel fatty acid gentamicin salts as slow-release drug carrier systems for anti-infective protection of vascular biomaterials.

Obermeier A, Matl FD, Schwabe J, Zimmermann A, Kühn KD, Lakemeier S, von Eisenhart-Rothe R, Stemberger A, Burgkart R.

J Mater Sci Mater Med. 2012 Jul;23(7):1675-83. doi: 10.1007/s10856-012-4631-5. Epub 2012 Apr 3.

PMID:
22476651
44.

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1.

Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J, Ciechanover A, Cohen GM.

Cell Death Differ. 2012 Sep;19(9):1424-34. doi: 10.1038/cdd.2012.16. Epub 2012 Feb 24.

45.

Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.

Watson PJ, Fairall L, Santos GM, Schwabe JW.

Nature. 2012 Jan 9;481(7381):335-40. doi: 10.1038/nature10728.

46.

A mutation in the thyroid hormone receptor alpha gene.

Bochukova E, Schoenmakers N, Agostini M, Schoenmakers E, Rajanayagam O, Keogh JM, Henning E, Reinemund J, Gevers E, Sarri M, Downes K, Offiah A, Albanese A, Halsall D, Schwabe JW, Bain M, Lindley K, Muntoni F, Vargha-Khadem F, Dattani M, Farooqi IS, Gurnell M, Chatterjee K.

N Engl J Med. 2012 Jan 19;366(3):243-9. doi: 10.1056/NEJMoa1110296. Epub 2011 Dec 14. Erratum in: N Engl J Med. 2012 Oct 11;367(15):1474. Khadem, Faraneh Vargha [corrected to Vargha-Khadem, Faraneh].

47.

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

Calkin AC, Goult BT, Zhang L, Fairall L, Hong C, Schwabe JW, Tontonoz P.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20107-12. doi: 10.1073/pnas.1111589108. Epub 2011 Nov 22.

48.

Nuclear hormone receptor co-repressors: structure and function.

Watson PJ, Fairall L, Schwabe JW.

Mol Cell Endocrinol. 2012 Jan 30;348(2):440-9. doi: 10.1016/j.mce.2011.08.033. Epub 2011 Sep 8. Review.

49.

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

Zhang L, Fairall L, Goult BT, Calkin AC, Hong C, Millard CJ, Tontonoz P, Schwabe JW.

Genes Dev. 2011 Jun 15;25(12):1262-74. doi: 10.1101/gad.2056211.

50.

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.

Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW.

Nat Struct Mol Biol. 2011 Feb;18(2):177-84. doi: 10.1038/nsmb.1983. Epub 2011 Jan 16.

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