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Simultaneous Extraction of RNA and Metabolites from Single Kidney Tissue Specimens for Combined Transcriptomic and Metabolomic Profiling.

Leuthold P, Schwab M, Hofmann U, Winter S, Rausch S, Pollak MN, Hennenlotter J, Bedke J, Schaeffeler E, Haag M.

J Proteome Res. 2018 Aug 9. doi: 10.1021/acs.jproteome.8b00199. [Epub ahead of print]


Pro- and antiangiogenic therapies: current status and clinical implications.

Rust R, Gantner C, Schwab ME.

FASEB J. 2018 Aug 7:fj201800640RR. doi: 10.1096/fj.201800640RR. [Epub ahead of print]


Characterization of the Breast Cancer Resistance Protein (BCRP/ABCG2) in clear cell renal cell carcinoma.

Reustle A, Fisel P, Renner O, Büttner F, Winter S, Rausch S, Kruck S, Nies AT, Hennenlotter J, Scharpf M, Fend F, Stenzl A, Bedke J, Schwab M, Schaeffeler E.

Int J Cancer. 2018 Aug 2. doi: 10.1002/ijc.31741. [Epub ahead of print]


Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn's Disease.

Jaeger SU, Schaeffeler E, Winter S, Tremmel R, Schölmerich J, Malek N, Stange EF, Schwab M, Wehkamp J.

Front Pharmacol. 2018 Jul 16;9:764. doi: 10.3389/fphar.2018.00764. eCollection 2018.


Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic Properties.

Bergonzi C, Schwab M, Naik T, Daudé D, Chabrière E, Elias M.

Sci Rep. 2018 Jul 26;8(1):11262. doi: 10.1038/s41598-018-28988-5.


Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits.

Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J.

PLoS One. 2018 Jul 24;13(7):e0200896. doi: 10.1371/journal.pone.0200896. eCollection 2018.


The perfluorinated alcohols c-C6F11OH, c-C6F10-1,1-(OH)2 and c-C6F10-1-(CF3)OH.

Schaab J, Schwab M, Kratzert D, Schwabedissen J, Stammler HG, Mitzel NW, Krossing I.

Chem Commun (Camb). 2018 Aug 16;54(67):9294-9297. doi: 10.1039/c8cc05148h.


Changes of motor corticobulbar projections following different lesion types affecting the central nervous system in adult macaque monkeys.

Fregosi M, Contestabile A, Badoud S, Borgognon S, Cottet J, Brunet JF, Bloch J, Schwab ME, Rouiller EM.

Eur J Neurosci. 2018 Jul 18. doi: 10.1111/ejn.14074. [Epub ahead of print]


Thermoresponsive Alignment Media in NMR spectroscopy: Helix Reversal of a Copolyaspartate at Ambient Temperatures.

Schwab M, Schmidts V, Thiele C.

Chemistry. 2018 Jul 12. doi: 10.1002/chem.201803540. [Epub ahead of print]


Personalized laboratory medicine: a patient-centered future approach.

Prodan Žitnik I, Černe D, Mancini I, Simi L, Pazzagli M, Di Resta C, Podgornik H, Repič Lampret B, Trebušak Podkrajšek K, Sipeky C, van Schaik R, Brandslund I, Vermeersch P, Schwab M, Marc J; behalf of EFLM/ESPT working group of Personalised Laboratory Medicine on.

Clin Chem Lab Med. 2018 Jul 10. pii: /j/cclm.ahead-of-print/cclm-2018-0181/cclm-2018-0181.xml. doi: 10.1515/cclm-2018-0181. [Epub ahead of print] Review.


Study protocol of the RaPS study: novel risk adapted prevention strategies for people with a family history of colorectal cancer.

Tikk K, Weigl K, Hoffmeister M, Igel S, Schwab M, Hampe J, Klug SJ, Mansmann U, Kolligs F, Brenner H.

BMC Cancer. 2018 Jul 6;18(1):720. doi: 10.1186/s12885-018-4646-5.


Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma.

Büttner F, Winter S, Rausch S, Hennenlotter J, Kruck S, Stenzl A, Scharpf M, Fend F, Agaimy A, Hartmann A, Bedke J, Schwab M, Schaeffeler E.

BMC Med. 2018 Jul 5;16(1):108. doi: 10.1186/s12916-018-1088-5.


Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.

Dickens D, Rädisch S, Chiduza GN, Giannoudis A, Cross MJ, Malik H, Schaeffeler E, Sison-Young RL, Wilkinson EL, Goldring CE, Schwab M, Pirmohamed M, Nies AT.

Mol Pharm. 2018 Aug 6;15(8):3557-3572. doi: 10.1021/acs.molpharmaceut.8b00547. Epub 2018 Jul 10.


The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy.

Wang Y, Moussian B, Schaeffeler E, Schwab M, Nies AT.

Drug Discov Today. 2018 Jun 8. pii: S1359-6446(18)30080-1. doi: 10.1016/j.drudis.2018.06.002. [Epub ahead of print] Review.


First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury.

Kucher K, Johns D, Maier D, Abel R, Badke A, Baron H, Thietje R, Casha S, Meindl R, Gomez-Mancilla B, Pfister C, Rupp R, Weidner N, Mir A, Schwab ME, Curt A.

Neurorehabil Neural Repair. 2018 Jun;32(6-7):578-589. doi: 10.1177/1545968318776371. Epub 2018 Jun 5.


Variants of PEAR1 Are Associated With Outcome in Patients With ACS and Stable CAD Undergoing PCI.

Stimpfle F, Bauer M, Rath D, Schaeffeler E, Schwab M, Gawaz M, Winter S, Geisler T.

Front Pharmacol. 2018 May 15;9:490. doi: 10.3389/fphar.2018.00490. eCollection 2018.


Changing flood frequencies under opposing late Pleistocene eastern Mediterranean climates.

Ben Dor Y, Armon M, Ahlborn M, Morin E, Erel Y, Brauer A, Schwab MJ, Tjallingii R, Enzel Y.

Sci Rep. 2018 May 31;8(1):8445. doi: 10.1038/s41598-018-25969-6.


Underlying mechanism of subcortical brain protection during hypoxia and reoxygenation in a sheep model - Influence of α1-adrenergic signalling.

Schiffner R, Bischoff SJ, Lehmann T, Rakers F, Rupprecht S, Matziolis G, Schubert H, Schwab M, Huber O, Lemke C, Schmidt M.

PLoS One. 2018 May 29;13(5):e0196363. doi: 10.1371/journal.pone.0196363. eCollection 2018.


Early reduced behavioral activity induced by large strokes affects the efficiency of enriched environment in rats.

Wahl AS, Erlebach E, Brattoli B, Büchler U, Kaiser J, Ineichen BV, Mosberger AC, Schneeberger S, Imobersteg S, Wieckhorst M, Stirn M, Schroeter A, Ommer B, Schwab ME.

J Cereb Blood Flow Metab. 2018 May 17:271678X18777661. doi: 10.1177/0271678X18777661. [Epub ahead of print]


Stroke Promotes Systemic Endothelial Inflammation and Atherosclerosis.

Rust R, Hofer AS, Schwab ME.

Trends Mol Med. 2018 Jul;24(7):593-595. doi: 10.1016/j.molmed.2018.04.008. Epub 2018 May 7.


Adverse Drug Reactions (ADR) and Emergencies.

Schurig AM, Böhme M, Just KS, Scholl C, Dormann H, Plank-Kiegele B, Seufferlein T, Gräff I, Schwab M, Stingl JC.

Dtsch Arztebl Int. 2018 Apr 13;115(15):251-258. doi: 10.3238/arztebl.2018.0251.


Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy.

Fisel P, Schaeffeler E, Schwab M.

Clin Transl Sci. 2018 Jul;11(4):352-364. doi: 10.1111/cts.12551. Epub 2018 Apr 16. Review.


Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators.

Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17.


Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Gazzaz M, Kinzig M, Schaeffeler E, Jübner M, Hsin CH, Li X, Taubert M, Trueck C, Iltgen-Breburda J, Kraus D, Queckenberg C, Stoffel M, Schwab M, Sörgel F, Fuhr U.

Clin Pharmacol Ther. 2018 Apr 6. doi: 10.1002/cpt.1083. [Epub ahead of print]


Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair.

Holm MM, Kaiser J, Schwab ME.

Trends Neurosci. 2018 Jun;41(6):360-372. doi: 10.1016/j.tins.2018.03.006. Epub 2018 Mar 28. Review.


Reply to the letter 'Is a rapid increase in nitrogen oxides really associated with an acute myocardial infarction?'

Rakers F, Rasche M, Schwab M.

Eur J Prev Cardiol. 2018 Jun;25(9):997-998. doi: 10.1177/2047487318768324. Epub 2018 Mar 29. No abstract available.


Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.

Nishii R, Moriyama T, Janke LJ, Yang W, Suiter CC, Lin TN, Li L, Kihira K, Toyoda H, Hofmann U, Schwab M, Takagi M, Morio T, Manabe A, Kham S, Jiang N, Rabin KR, Kato M, Koh K, Yeoh AE, Hori H, Yang JJ.

Blood. 2018 May 31;131(22):2466-2474. doi: 10.1182/blood-2017-11-815506. Epub 2018 Mar 23.


Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.

Sahm A, Bens M, Szafranski K, Holtze S, Groth M, Görlach M, Calkhoven C, Müller C, Schwab M, Kraus J, Kestler HA, Cellerino A, Burda H, Hildebrandt T, Dammann P, Platzer M.

PLoS Genet. 2018 Mar 23;14(3):e1007272. doi: 10.1371/journal.pgen.1007272. eCollection 2018 Mar.


Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs.

Mintzer S, Wechsler RT, Rogin JB, Gidal BE, Schwab M, Ben-Menachem E, Carreño M, da Silva PS, Moreira J, Li Y, Blum D, Grinnell T.

Epilepsy Res. 2018 Mar;141:83-89. doi: 10.1016/j.eplepsyres.2018.02.001. Epub 2018 Feb 9.


Is Mistletoe Treatment Beneficial in Invasive Breast Cancer? A New Approach to an Unresolved Problem.

Fritz P, Dippon J, Müller S, Goletz S, Trautmann C, Pappas X, Ott G, Brauch H, Schwab M, Winter S, Mürdter T, Brinkmann F, Faisst S, Rössle S, Gerteis A, Friedel G.

Anticancer Res. 2018 Mar;38(3):1585-1593.


Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons.

Kuo AH, Li C, Mattern V, Huber HF, Comuzzie A, Cox L, Schwab M, Nathanielsz PW, Clarke GD.

Int J Obes (Lond). 2018 Jun;42(5):1092-1096. doi: 10.1038/s41366-018-0008-2. Epub 2018 Jan 30.


Metabolic and Lipidomic Reprogramming in Renal Cell Carcinoma Subtypes Reflects Regions of Tumor Origin.

Schaeffeler E, Büttner F, Reustle A, Klumpp V, Winter S, Rausch S, Fisel P, Hennenlotter J, Kruck S, Stenzl A, Wahrheit J, Sonntag D, Scharpf M, Fend F, Agaimy A, Hartmann A, Bedke J, Schwab M.

Eur Urol Focus. 2018 Feb 13. pii: S2405-4569(18)30017-8. doi: 10.1016/j.euf.2018.01.016. [Epub ahead of print]


Rapid increases in nitrogen oxides are associated with acute myocardial infarction: A case-crossover study.

Rasche M, Walther M, Schiffner R, Kroegel N, Rupprecht S, Schlattmann P, Schulze PC, Franzke P, Witte OW, Schwab M, Rakers F.

Eur J Prev Cardiol. 2018 Jan 1:2047487318755804. doi: 10.1177/2047487318755804. [Epub ahead of print]


Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.

Goetz MP, Sangkuhl K, Guchelaar HJ, Schwab M, Province M, Whirl-Carrillo M, Symmans WF, McLeod HL, Ratain MJ, Zembutsu H, Gaedigk A, van Schaik RH, Ingle JN, Caudle KE, Klein TE.

Clin Pharmacol Ther. 2018 May;103(5):770-777. doi: 10.1002/cpt.1007. Epub 2018 Jan 31.


Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B.

Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22.


Electromagnetic-radiation absorption by water.

Lunkenheimer P, Emmert S, Gulich R, Köhler M, Wolf M, Schwab M, Loidl A.

Phys Rev E. 2017 Dec;96(6-1):062607. doi: 10.1103/PhysRevE.96.062607. Epub 2017 Dec 11.


Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia.

Bassler D, Shinwell ES, Hallman M, Jarreau PH, Plavka R, Carnielli V, Meisner C, Engel C, Koch A, Kreutzer K, van den Anker JN, Schwab M, Halliday HL, Poets CF; Neonatal European Study of Inhaled Steroids Trial Group.

N Engl J Med. 2018 Jan 11;378(2):148-157. doi: 10.1056/NEJMoa1708831.


The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.

Johänning J, Kröner P, Thomas M, Zanger UM, Nörenberg A, Eichelbaum M, Schwab M, Brauch H, Schroth W, Mürdter TE.

Arch Toxicol. 2018 Mar;92(3):1099-1112. doi: 10.1007/s00204-017-2147-y. Epub 2017 Dec 28.


Genetic variation in human drug-related genes.

Schärfe CPI, Tremmel R, Schwab M, Kohlbacher O, Marks DS.

Genome Med. 2017 Dec 22;9(1):117. doi: 10.1186/s13073-017-0502-5.


Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure.

Melkonyan MM, Hunanyan L, Lourhmati A, Layer N, Beer-Hammer S, Yenkoyan K, Schwab M, Danielyan L.

Int J Mol Sci. 2017 Dec 21;19(1). pii: E9. doi: 10.3390/ijms19010009.


Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate.

Rieger H, Schmidt P, Schaeffeler E, Abe M, Schiffhauer M, Schwab M, von Ahsen N, Zurek G, Kirchherr H, Shipkova M, Wieland E.

Clin Chem Lab Med. 2018 Apr 25;56(5):803-809. doi: 10.1515/cclm-2017-0670.


Synthesis, Characterisation and Reactions of Truly Cationic NiI -Phosphine Complexes.

Schwab MM, Himmel D, Kacprzak S, Radtke V, Kratzert D, Weis P, Wernet M, Peter A, Yassine Z, Schmitz D, Scheidt EW, Scherer W, Weber S, Feuerstein W, Breher F, Higelin A, Krossing I.

Chemistry. 2018 Jan 19;24(4):918-927. doi: 10.1002/chem.201704436. Epub 2017 Dec 13.


Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.

Amstutz U, Henricks LM, Offer SM, Barbarino J, Schellens JHM, Swen JJ, Klein TE, McLeod HL, Caudle KE, Diasio RB, Schwab M.

Clin Pharmacol Ther. 2018 Feb;103(2):210-216. doi: 10.1002/cpt.911. Epub 2017 Nov 20.


Information processing deficits as a driving force for memory impairment in MS: A cross--sectional study of memory functions and MRI in early and late stage MS.

Köhler W, Fischer M, Bublak P, Faiss JH, Hoffmann F, Kunkel A, Sailer M, Schwab M, Stadler E, Zettl UK, Penner IK; HIPPOCOMS Study Group.

Mult Scler Relat Disord. 2017 Nov;18:119-127. doi: 10.1016/j.msard.2017.09.026. Epub 2017 Sep 25.


Urodynamic measurements reflect physiological bladder function in rats.

Schneider MP, Sartori AM, Tampé J, Moors S, Engmann AK, Ineichen BV, Hofer AS, Schwab ME, Kessler TM.

Neurourol Urodyn. 2018 Apr;37(4):1266-1271. doi: 10.1002/nau.23455. Epub 2017 Nov 15.


[Metabolomics and Cancer].

Schwab M, Fisel P, Schäffeler E.

Pathologe. 2017 Nov;38(Suppl 2):202-204. doi: 10.1007/s00292-017-0374-x. German. No abstract available.


Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation.

Wahl AS, Büchler U, Brändli A, Brattoli B, Musall S, Kasper H, Ineichen BV, Helmchen F, Ommer B, Schwab ME.

Nat Commun. 2017 Oct 30;8(1):1187. doi: 10.1038/s41467-017-01090-6.


Effects of Late Gestational Fetal Exposure to Dexamethasone Administration on the Postnatal Hypothalamus-Pituitary-Adrenal Axis Response to Hypoglycemia in Pigs.

Schiffner R, Rodríguez-González GL, Rakers F, Nistor M, Nathanielsz PW, Daneva T, Schwab M, Lehmann T, Schmidt M.

Int J Mol Sci. 2017 Oct 27;18(11). pii: E2241. doi: 10.3390/ijms18112241.


Premature brain aging in humans exposed to maternal nutrient restriction during early gestation.

Franke K, Gaser C, Roseboom TJ, Schwab M, de Rooij SR.

Neuroimage. 2018 Jun;173:460-471. doi: 10.1016/j.neuroimage.2017.10.047. Epub 2017 Oct 23.


Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.

Fujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM, Schwab M.

Hepatology. 2018 Apr;67(4):1609-1619. doi: 10.1002/hep.29599. Epub 2018 Mar 2. Review.


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