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Items: 1 to 50 of 1476

1.

Pharmacogene Variation Consortium Gene Introduction: NUDT15.

Yang JJ, Whirl-Carrillo M, Scott SA, Turner AJ, Schwab M, Tanaka Y, Suarez-Kurtz G, Schaeffeler E, Klein TE, Miller NA, Gaedigk A.

Clin Pharmacol Ther. 2018 Dec 4. doi: 10.1002/cpt.1268. [Epub ahead of print] No abstract available.

PMID:
30515762
2.

Adherence to Subcutaneous IFN β-1a in Multiple Sclerosis: Final Analysis of the Non-Interventional Study READOUTsmart Using the Dosing Log and Readout Function of RebiSmart®.

Rieckmann P, Schwab M, Pöhlau D, Penner IK, Wagner T, Schel E, Bayas A.

Adv Ther. 2018 Nov 28. doi: 10.1007/s12325-018-0839-1. [Epub ahead of print]

PMID:
30488338
3.

Enhanced axonal Neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model.

Scapin C, Ferri C, Pettinato E, Zambroni D, Bianchi F, Del Carro U, Belin S, Caruso D, Mitro N, Pellegatta M, Taveggia C, Schwab MH, Nave KA, Laura Feltri M, Wrabetz L, D'Antonio M.

Hum Mol Genet. 2018 Nov 27. doi: 10.1093/hmg/ddy411. [Epub ahead of print]

PMID:
30481294
4.

Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis.

Seyedsadr MS, Weinmann O, Amorim A, Ineichen BV, Egger M, Mirnajafi-Zadeh J, Becher B, Javan M, Schwab ME.

Neurobiol Dis. 2018 Nov 22;124:189-201. doi: 10.1016/j.nbd.2018.11.018. [Epub ahead of print]

PMID:
30468865
5.

Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon.

Ramharter M, Schwab M, Mombo-Ngoma G, Zoleko Manego R, Akerey-Diop D, Basra A, Mackanga JR, Würbel H, Wojtyniak JG, Gonzalez R, Hofmann U, Geditz M, Matsiegui PB, Kremsner PG, Menendez C, Kerb R, Lehr T.

Antimicrob Agents Chemother. 2018 Nov 19. pii: AAC.01113-18. doi: 10.1128/AAC.01113-18. [Epub ahead of print]

PMID:
30455233
6.

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update.

Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui CH, Stein CM, Moyer AM, Evans WE, Klein TE, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.

Clin Pharmacol Ther. 2018 Nov 17. doi: 10.1002/cpt.1304. [Epub ahead of print]

PMID:
30447069
7.

Controlling the Self-Injection Threshold in Laser Wakefield Accelerators.

Kuschel S, Schwab MB, Yeung M, Hollatz D, Seidel A, Ziegler W, Sävert A, Kaluza MC, Zepf M.

Phys Rev Lett. 2018 Oct 12;121(15):154801. doi: 10.1103/PhysRevLett.121.154801.

PMID:
30362794
8.

Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I.

Deakin IH, Godlewska BR, Walker MA, Huang GJ, Schwab MH, Nave KA, Law AJ, Harrison PJ.

Transl Psychiatry. 2018 Oct 22;8(1):229. doi: 10.1038/s41398-018-0288-2.

9.

mRCC Outcome in the Treatment of Metastatic Renal Cell Carcinoma - A German Single-center Real-world Experience.

Schwab M, Hofmann R, Heers H, Hegele A.

In Vivo. 2018 Nov-Dec;32(6):1617-1622. doi: 10.21873/invivo.11422.

PMID:
30348724
10.

Phase I Study of Domatinostat (4SC-202), a class I Histone Deacetylase Inhibitor in Patients with Advanced Hematological Malignancies.

von Tresckow B, Sayehli C, Aulitzky WE, Goebeler ME, Schwab M, Braz E, Krauss B, Krauss R, Hermann F, Bartz R, Engert A.

Eur J Haematol. 2018 Oct 22. doi: 10.1111/ejh.13188. [Epub ahead of print]

PMID:
30347469
11.

Covert Stuttering: Investigation of the Paradigm Shift From Covertly Stuttering to Overtly Stuttering.

Douglass JE, Schwab M, Alvarado J.

Am J Speech Lang Pathol. 2018 Oct 19;27(3S):1235-1243. doi: 10.1044/2018_AJSLP-ODC11-17-0190.

PMID:
30347066
12.

Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions.

Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Krumbholz M, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl UK, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C; NEMOS (Neuromyelitis Optica Study Group).

Neurol Neuroimmunol Neuroinflamm. 2018 Sep 26;5(6):e504. doi: 10.1212/NXI.0000000000000504. eCollection 2018 Nov.

13.

Inflammation after Stroke: A Local Rather Than Systemic Response?

Rust R, Grönnert L, Schwab ME.

Trends Neurosci. 2018 Dec;41(12):877-879. doi: 10.1016/j.tins.2018.09.011. Epub 2018 Oct 13.

PMID:
30327142
14.

Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer.

Todenhöfer T, Seiler R, Stewart C, Moskalev I, Gao J, Ladhar S, Kamjabi A, Al Nakouzi N, Hayashi T, Choi S, Wang Y, Frees S, Daugaard M, Oo HZ, Fisel P, Schwab M, Schaeffeler E, Douglas J, Hennenlotter J, Bedke J, Gibb EA, Fazli L, Stenzl A, Black PC.

Mol Cancer Ther. 2018 Dec;17(12):2746-2755. doi: 10.1158/1535-7163.MCT-18-0107. Epub 2018 Sep 27.

PMID:
30262589
15.

Weather, Weather Changes and the Risk of Bell's Palsy: A Multicenter Case-Crossover Study.

Franzke P, Bitsch A, Walther M, Schiffner R, Rupprecht S, Rasche M, Volk GF, Witte OW, Schlattmann P, Guntinas-Lichius O, Hagemann G, Schwab M, Rakers F.

Neuroepidemiology. 2018;51(3-4):207-215. doi: 10.1159/000492671. Epub 2018 Sep 11.

PMID:
30205396
16.

A Web-based survey among adults aged 40-54 years was time effective and yielded stable response patterns.

Weigl K, Tikk K, Hoffmeister M, De Toni EN, Hampe J, Kolligs F, Klug SJ, Mansmann U, Nasseh D, Radlovic J, Schwab M, Schweigler D, Stephan AM, Brenner H.

J Clin Epidemiol. 2019 Jan;105:10-18. doi: 10.1016/j.jclinepi.2018.08.021. Epub 2018 Sep 6.

PMID:
30196128
17.

From hype to reality: data science enabling personalized medicine.

Fröhlich H, Balling R, Beerenwinkel N, Kohlbacher O, Kumar S, Lengauer T, Maathuis MH, Moreau Y, Murphy SA, Przytycka TM, Rebhan M, Röst H, Schuppert A, Schwab M, Spang R, Stekhoven D, Sun J, Weber A, Ziemek D, Zupan B.

BMC Med. 2018 Aug 27;16(1):150. doi: 10.1186/s12916-018-1122-7.

18.

Simultaneous Extraction of RNA and Metabolites from Single Kidney Tissue Specimens for Combined Transcriptomic and Metabolomic Profiling.

Leuthold P, Schwab M, Hofmann U, Winter S, Rausch S, Pollak MN, Hennenlotter J, Bedke J, Schaeffeler E, Haag M.

J Proteome Res. 2018 Sep 7;17(9):3039-3049. doi: 10.1021/acs.jproteome.8b00199. Epub 2018 Aug 23.

PMID:
30091608
19.

Pro- and antiangiogenic therapies: current status and clinical implications.

Rust R, Gantner C, Schwab ME.

FASEB J. 2018 Aug 7:fj201800640RR. doi: 10.1096/fj.201800640RR. [Epub ahead of print]

PMID:
30085886
20.

Characterization of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma.

Reustle A, Fisel P, Renner O, Büttner F, Winter S, Rausch S, Kruck S, Nies AT, Hennenlotter J, Scharpf M, Fend F, Stenzl A, Bedke J, Schwab M, Schaeffeler E.

Int J Cancer. 2018 Dec 15;143(12):3181-3193. doi: 10.1002/ijc.31741. Epub 2018 Sep 25.

PMID:
30070687
21.

Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn's Disease.

Jaeger SU, Schaeffeler E, Winter S, Tremmel R, Schölmerich J, Malek N, Stange EF, Schwab M, Wehkamp J.

Front Pharmacol. 2018 Jul 16;9:764. doi: 10.3389/fphar.2018.00764. eCollection 2018.

22.

Structural and Biochemical Characterization of AaL, a Quorum Quenching Lactonase with Unusual Kinetic Properties.

Bergonzi C, Schwab M, Naik T, Daudé D, Chabrière E, Elias M.

Sci Rep. 2018 Jul 26;8(1):11262. doi: 10.1038/s41598-018-28988-5.

23.

Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits.

Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J.

PLoS One. 2018 Jul 24;13(7):e0200896. doi: 10.1371/journal.pone.0200896. eCollection 2018.

24.

The perfluorinated alcohols c-C6F11OH, c-C6F10-1,1-(OH)2 and c-C6F10-1-(CF3)OH.

Schaab J, Schwab M, Kratzert D, Schwabedissen J, Stammler HG, Mitzel NW, Krossing I.

Chem Commun (Camb). 2018 Aug 16;54(67):9294-9297. doi: 10.1039/c8cc05148h.

PMID:
30033461
25.

Changes of motor corticobulbar projections following different lesion types affecting the central nervous system in adult macaque monkeys.

Fregosi M, Contestabile A, Badoud S, Borgognon S, Cottet J, Brunet JF, Bloch J, Schwab ME, Rouiller EM.

Eur J Neurosci. 2018 Aug;48(4):2050-2070. doi: 10.1111/ejn.14074. Epub 2018 Aug 16.

26.

Thermoresponsive Alignment Media in NMR Spectroscopy: Helix Reversal of a Copolyaspartate at Ambient Temperatures.

Schwab M, Schmidts V, Thiele CM.

Chemistry. 2018 Sep 25;24(54):14373-14377. doi: 10.1002/chem.201803540. Epub 2018 Aug 30.

PMID:
29999196
27.

Personalized laboratory medicine: a patient-centered future approach.

Prodan Žitnik I, Černe D, Mancini I, Simi L, Pazzagli M, Di Resta C, Podgornik H, Repič Lampret B, Trebušak Podkrajšek K, Sipeky C, van Schaik R, Brandslund I, Vermeersch P, Schwab M, Marc J; behalf of EFLM/ESPT working group of Personalised Laboratory Medicine on.

Clin Chem Lab Med. 2018 Nov 27;56(12):1981-1991. doi: 10.1515/cclm-2018-0181. Review.

PMID:
29990304
28.

Study protocol of the RaPS study: novel risk adapted prevention strategies for people with a family history of colorectal cancer.

Tikk K, Weigl K, Hoffmeister M, Igel S, Schwab M, Hampe J, Klug SJ, Mansmann U, Kolligs F, Brenner H.

BMC Cancer. 2018 Jul 6;18(1):720. doi: 10.1186/s12885-018-4646-5.

29.

Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma.

Büttner F, Winter S, Rausch S, Hennenlotter J, Kruck S, Stenzl A, Scharpf M, Fend F, Agaimy A, Hartmann A, Bedke J, Schwab M, Schaeffeler E.

BMC Med. 2018 Jul 5;16(1):108. doi: 10.1186/s12916-018-1088-5.

30.

Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.

Dickens D, Rädisch S, Chiduza GN, Giannoudis A, Cross MJ, Malik H, Schaeffeler E, Sison-Young RL, Wilkinson EL, Goldring CE, Schwab M, Pirmohamed M, Nies AT.

Mol Pharm. 2018 Aug 6;15(8):3557-3572. doi: 10.1021/acs.molpharmaceut.8b00547. Epub 2018 Jul 10.

PMID:
29944835
31.

The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy.

Wang Y, Moussian B, Schaeffeler E, Schwab M, Nies AT.

Drug Discov Today. 2018 Oct;23(10):1746-1760. doi: 10.1016/j.drudis.2018.06.002. Epub 2018 Jun 8. Review.

PMID:
29890226
32.

First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury.

Kucher K, Johns D, Maier D, Abel R, Badke A, Baron H, Thietje R, Casha S, Meindl R, Gomez-Mancilla B, Pfister C, Rupp R, Weidner N, Mir A, Schwab ME, Curt A.

Neurorehabil Neural Repair. 2018 Jun;32(6-7):578-589. doi: 10.1177/1545968318776371. Epub 2018 Jun 5.

PMID:
29869587
33.

Variants of PEAR1 Are Associated With Outcome in Patients With ACS and Stable CAD Undergoing PCI.

Stimpfle F, Bauer M, Rath D, Schaeffeler E, Schwab M, Gawaz M, Winter S, Geisler T.

Front Pharmacol. 2018 May 15;9:490. doi: 10.3389/fphar.2018.00490. eCollection 2018.

34.

Changing flood frequencies under opposing late Pleistocene eastern Mediterranean climates.

Ben Dor Y, Armon M, Ahlborn M, Morin E, Erel Y, Brauer A, Schwab MJ, Tjallingii R, Enzel Y.

Sci Rep. 2018 May 31;8(1):8445. doi: 10.1038/s41598-018-25969-6.

35.

Underlying mechanism of subcortical brain protection during hypoxia and reoxygenation in a sheep model - Influence of α1-adrenergic signalling.

Schiffner R, Bischoff SJ, Lehmann T, Rakers F, Rupprecht S, Matziolis G, Schubert H, Schwab M, Huber O, Lemke C, Schmidt M.

PLoS One. 2018 May 29;13(5):e0196363. doi: 10.1371/journal.pone.0196363. eCollection 2018.

36.

Early reduced behavioral activity induced by large strokes affects the efficiency of enriched environment in rats.

Wahl AS, Erlebach E, Brattoli B, Büchler U, Kaiser J, Ineichen BV, Mosberger AC, Schneeberger S, Imobersteg S, Wieckhorst M, Stirn M, Schroeter A, Ommer B, Schwab ME.

J Cereb Blood Flow Metab. 2018 May 17:271678X18777661. doi: 10.1177/0271678X18777661. [Epub ahead of print]

PMID:
29768943
37.

Stroke Promotes Systemic Endothelial Inflammation and Atherosclerosis.

Rust R, Hofer AS, Schwab ME.

Trends Mol Med. 2018 Jul;24(7):593-595. doi: 10.1016/j.molmed.2018.04.008. Epub 2018 May 7.

PMID:
29747910
38.

Adverse Drug Reactions (ADR) and Emergencies.

Schurig AM, Böhme M, Just KS, Scholl C, Dormann H, Plank-Kiegele B, Seufferlein T, Gräff I, Schwab M, Stingl JC.

Dtsch Arztebl Int. 2018 Apr 13;115(15):251-258. doi: 10.3238/arztebl.2018.0251.

39.

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy.

Fisel P, Schaeffeler E, Schwab M.

Clin Transl Sci. 2018 Jul;11(4):352-364. doi: 10.1111/cts.12551. Epub 2018 Apr 16. Review.

40.

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators.

Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17.

PMID:
29653637
41.

Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Gazzaz M, Kinzig M, Schaeffeler E, Jübner M, Hsin CH, Li X, Taubert M, Trueck C, Iltgen-Breburda J, Kraus D, Queckenberg C, Stoffel M, Schwab M, Sörgel F, Fuhr U.

Clin Pharmacol Ther. 2018 Dec;104(6):1249-1259. doi: 10.1002/cpt.1083. Epub 2018 May 10.

PMID:
29633238
42.

Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair.

Holm MM, Kaiser J, Schwab ME.

Trends Neurosci. 2018 Jun;41(6):360-372. doi: 10.1016/j.tins.2018.03.006. Epub 2018 Mar 28. Review.

PMID:
29605090
43.

Reply to the letter 'Is a rapid increase in nitrogen oxides really associated with an acute myocardial infarction?'

Rakers F, Rasche M, Schwab M.

Eur J Prev Cardiol. 2018 Jun;25(9):997-998. doi: 10.1177/2047487318768324. Epub 2018 Mar 29. No abstract available.

PMID:
29591535
44.

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.

Nishii R, Moriyama T, Janke LJ, Yang W, Suiter CC, Lin TN, Li L, Kihira K, Toyoda H, Hofmann U, Schwab M, Takagi M, Morio T, Manabe A, Kham S, Jiang N, Rabin KR, Kato M, Koh K, Yeoh AE, Hori H, Yang JJ.

Blood. 2018 May 31;131(22):2466-2474. doi: 10.1182/blood-2017-11-815506. Epub 2018 Mar 23.

PMID:
29572377
45.

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.

Sahm A, Bens M, Szafranski K, Holtze S, Groth M, Görlach M, Calkhoven C, Müller C, Schwab M, Kraus J, Kestler HA, Cellerino A, Burda H, Hildebrandt T, Dammann P, Platzer M.

PLoS Genet. 2018 Mar 23;14(3):e1007272. doi: 10.1371/journal.pgen.1007272. eCollection 2018 Mar.

46.

Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs.

Mintzer S, Wechsler RT, Rogin JB, Gidal BE, Schwab M, Ben-Menachem E, Carreño M, da Silva PS, Moreira J, Li Y, Blum D, Grinnell T.

Epilepsy Res. 2018 Mar;141:83-89. doi: 10.1016/j.eplepsyres.2018.02.001. Epub 2018 Feb 9.

47.

Is Mistletoe Treatment Beneficial in Invasive Breast Cancer? A New Approach to an Unresolved Problem.

Fritz P, Dippon J, Müller S, Goletz S, Trautmann C, Pappas X, Ott G, Brauch H, Schwab M, Winter S, Mürdter T, Brinkmann F, Faisst S, Rössle S, Gerteis A, Friedel G.

Anticancer Res. 2018 Mar;38(3):1585-1593.

PMID:
29491089
48.

Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons.

Kuo AH, Li C, Mattern V, Huber HF, Comuzzie A, Cox L, Schwab M, Nathanielsz PW, Clarke GD.

Int J Obes (Lond). 2018 Jun;42(5):1092-1096. doi: 10.1038/s41366-018-0008-2. Epub 2018 Jan 30.

49.

Metabolic and Lipidomic Reprogramming in Renal Cell Carcinoma Subtypes Reflects Regions of Tumor Origin.

Schaeffeler E, Büttner F, Reustle A, Klumpp V, Winter S, Rausch S, Fisel P, Hennenlotter J, Kruck S, Stenzl A, Wahrheit J, Sonntag D, Scharpf M, Fend F, Agaimy A, Hartmann A, Bedke J, Schwab M.

Eur Urol Focus. 2018 Feb 13. pii: S2405-4569(18)30017-8. doi: 10.1016/j.euf.2018.01.016. [Epub ahead of print]

PMID:
29452772
50.

Rapid increases in nitrogen oxides are associated with acute myocardial infarction: A case-crossover study.

Rasche M, Walther M, Schiffner R, Kroegel N, Rupprecht S, Schlattmann P, Schulze PC, Franzke P, Witte OW, Schwab M, Rakers F.

Eur J Prev Cardiol. 2018 Nov;25(16):1707-1716. doi: 10.1177/2047487318755804. Epub 2018 Feb 15.

PMID:
29446990

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