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Items: 13


ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models.

Brooks DL, Schwab LP, Krutilina R, Parke DN, Sethuraman A, Hoogewijs D, Schörg A, Gotwald L, Fan M, Wenger RH, Seagroves TN.

Mol Cancer. 2016 Mar 22;15:26. doi: 10.1186/s12943-016-0510-x.


mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.

Sodi VL, Khaku S, Krutilina R, Schwab LP, Vocadlo DJ, Seagroves TN, Reginato MJ.

Mol Cancer Res. 2015 May;13(5):923-33. doi: 10.1158/1541-7786.MCR-14-0536. Epub 2015 Jan 30.


Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like properties.

Chen J, Wang J, Schwab LP, Park KT, Seagroves TN, Jennings LK, Miller DD, Li W.

Anticancer Res. 2014 Aug;34(8):3891-904.


The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.

Slominski A, Kim TK, Brożyna AA, Janjetovic Z, Brooks DL, Schwab LP, Skobowiat C, Jóźwicki W, Seagroves TN.

Arch Biochem Biophys. 2014 Dec 1;563:79-93. doi: 10.1016/ Epub 2014 Jul 2.


O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL, Vocadlo DJ, Seagroves TN, Reginato MJ.

Mol Cell. 2014 Jun 5;54(5):820-31. doi: 10.1016/j.molcel.2014.04.026. Epub 2014 May 22.


The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.

Whelan KA, Schwab LP, Karakashev SV, Franchetti L, Johannes GJ, Seagroves TN, Reginato MJ.

J Biol Chem. 2013 May 31;288(22):15865-77. doi: 10.1074/jbc.M112.426999. Epub 2013 Apr 12.


Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer.

Wang C, Schwab LP, Fan M, Seagroves TN, Buolamwini JK.

Cancer Prev Res (Phila). 2013 May;6(5):437-47. doi: 10.1158/1940-6207.CAPR-12-0345. Epub 2013 Feb 27.


Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer.

Hallett MA, Teng B, Hasegawa H, Schwab LP, Seagroves TN, Pourmotabbed T.

Breast Cancer Res. 2013 Feb 13;15(1):R12. doi: 10.1186/bcr3385.


Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer.

Schwab LP, Peacock DL, Majumdar D, Ingels JF, Jensen LC, Smith KD, Cushing RC, Seagroves TN.

Breast Cancer Res. 2012 Jan 7;14(1):R6.


Macrophage response to high number of titanium particles is cytotoxic and COX-2 mediated and it is not affected by the particle's endotoxin content or the cleaning treatment.

Schwab LP, Marlar J, Hasty KA, Smith RA.

J Biomed Mater Res A. 2011 Dec 15;99(4):630-7. doi: 10.1002/jbm.a.33222. Epub 2011 Sep 27.


VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.

Seagroves TN, Peacock DL, Liao D, Schwab LP, Krueger R, Handorf CR, Haase VH, Johnson RS.

Am J Pathol. 2010 May;176(5):2269-82. doi: 10.2353/ajpath.2010.090310. Epub 2010 Apr 9.


Titanium particles that have undergone phagocytosis by macrophages lose the ability to activate other macrophages.

Xing Z, Schwab LP, Alley CF, Hasty KA, Smith RA.

J Biomed Mater Res B Appl Biomater. 2008 Apr;85(1):37-41.


Titanium particles and surface-bound LPS activate different pathways in IC-21 macrophages.

Schwab LP, Xing Z, Hasty KA, Smith RA.

J Biomed Mater Res B Appl Biomater. 2006 Oct;79(1):66-73.


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