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Items: 10


2-hydroxyglutarate inhibits MyoD-mediated differentiation by preventing H3K9 demethylation.

Schvartzman JM, Reuter VP, Koche RP, Thompson CB.

Proc Natl Acad Sci U S A. 2019 Jun 10. pii: 201817662. doi: 10.1073/pnas.1817662116. [Epub ahead of print]


Distinct histomorphological features are associated with IDH1 mutation in intrahepatic Cholangiocarcinoma.

Wang T, Drill E, Vakiani E, Pak LM, Boerner T, Askan G, Schvartzman JM, Simpson AL, Jarnagin WR, Sigel CS.

Hum Pathol. 2019 May 20. pii: S0046-8177(19)30087-5. doi: 10.1016/j.humpath.2019.05.002. [Epub ahead of print]


Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition.

Harding JJ, Lowery MA, Shih AH, Schvartzman JM, Hou S, Famulare C, Patel M, Roshal M, Do RK, Zehir A, You D, Selcuklu SD, Viale A, Tallman MS, Hyman DM, Reznik E, Finley LWS, Papaemmanuil E, Tosolini A, Frattini MG, MacBeth KJ, Liu G, Fan B, Choe S, Wu B, Janjigian YY, Mellinghoff IK, Diaz LA, Levine RL, Abou-Alfa GK, Stein EM, Intlekofer AM.

Cancer Discov. 2018 Dec;8(12):1540-1547. doi: 10.1158/2159-8290.CD-18-0877. Epub 2018 Oct 24.


Metabolic regulation of chromatin modifications and gene expression.

Schvartzman JM, Thompson CB, Finley LWS.

J Cell Biol. 2018 Jul 2;217(7):2247-2259. doi: 10.1083/jcb.201803061. Epub 2018 May 14. Review.


Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.

Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R.

Cancer Cell. 2011 Jun 14;19(6):701-14. doi: 10.1016/j.ccr.2011.04.017.


Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal.

Sotillo R, Schvartzman JM, Socci ND, Benezra R.

Nature. 2010 Mar 18;464(7287):436-40. doi: 10.1038/nature08803. Epub 2010 Feb 21.


Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Schvartzman JM, Sotillo R, Benezra R.

Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781. Review.


Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.

Sotillo R, Schvartzman JM, Benezra R.

Cancer Cell. 2009 Dec 8;16(6):451-2. doi: 10.1016/j.ccr.2009.11.014.


Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.

Diaz-Rodríguez E, Sotillo R, Schvartzman JM, Benezra R.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16719-24. doi: 10.1073/pnas.0803504105. Epub 2008 Oct 21.


How do we ask for money? A view of funding for basic research.

Schvartzman JM, Schvartzman JB.

EMBO Rep. 2008 Mar;9(3):216-20. doi: 10.1038/embor.2008.16. No abstract available.

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