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Items: 1 to 50 of 81

1.

Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors.

Bijvelds MJC, Tresadern G, Hellemans A, Smans K, Nieuwenhuijze NDA, Meijsen KF, Bongartz JP, Ver Donck L, de Jonge HR, Schuurkes JAJ, De Maeyer JH.

J Biol Chem. 2018 May 25;293(21):8173-8181. doi: 10.1074/jbc.RA118.002835. Epub 2018 Apr 13.

2.

Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist.

Conlon K, De Maeyer JH, Bruce C, Schuurkes JAJ, Christie L, McRedmond J, Derakhchan K, Wade PR.

J Pharmacol Exp Ther. 2018 Feb;364(2):156-169. doi: 10.1124/jpet.117.244079. Epub 2017 Nov 27.

PMID:
29180358
3.

Inhibition of Heat-Stable Toxin-Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors.

Bijvelds MJ, Loos M, Bronsveld I, Hellemans A, Bongartz JP, Ver Donck L, Cox E, de Jonge HR, Schuurkes JA, De Maeyer JH.

J Infect Dis. 2015 Dec 1;212(11):1806-15. doi: 10.1093/infdis/jiv300. Epub 2015 May 21.

PMID:
25999056
4.

SSP-002392, a new 5-HT4 receptor agonist, dose-dependently reverses scopolamine-induced learning and memory impairments in C57Bl/6 mice.

Lo AC, De Maeyer JH, Vermaercke B, Callaerts-Vegh Z, Schuurkes JA, D'Hooge R.

Neuropharmacology. 2014 Oct;85:178-89. doi: 10.1016/j.neuropharm.2014.05.013. Epub 2014 May 23.

PMID:
24863046
5.

Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor.

Buiter HJ, Windhorst AD, Huisman MC, De Maeyer JH, Schuurkes JA, Lammertsma AA, Leysen JE.

EJNMMI Res. 2013 Apr 4;3(1):24. doi: 10.1186/2191-219X-3-24.

6.

Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.

Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B.

Neurobiol Aging. 2013 Jul;34(7):1779-89. doi: 10.1016/j.neurobiolaging.2013.01.020. Epub 2013 Mar 6.

PMID:
23474291
7.

Inotropic effects of prokinetic agents with 5-HT(4) receptor agonist actions on human isolated myocardial trabeculae.

Chai W, Chan KY, de Vries R, van den Bogeardt AJ, de Maeyer JH, Schuurkes JA, Villalón CM, Saxena PR, Danser AH, MaassenVanDenBrink A.

Life Sci. 2012 Apr 9;90(13-14):538-44. doi: 10.1016/j.lfs.2012.01.009. Epub 2012 Feb 1.

PMID:
22326501
8.

Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system.

Lammers WJ, Ver Donck L, Stephen B, Smets D, Schuurkes JA.

Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1200-10. doi: 10.1152/ajpgi.90581.2008. Epub 2009 Apr 9.

9.

Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in stomach.

De Maeyer JH, Schuurkes JA, Lefebvre RA.

Br J Pharmacol. 2009 Jan;156(2):362-76. doi: 10.1111/j.1476-5381.2008.00007.x. Epub 2009 Jan 13.

10.

Focal activities and re-entrant propagations as mechanisms of gastric tachyarrhythmias.

Lammers WJ, Ver Donck L, Stephen B, Smets D, Schuurkes JA.

Gastroenterology. 2008 Nov;135(5):1601-11. doi: 10.1053/j.gastro.2008.07.020. Epub 2008 Jul 22.

PMID:
18713627
11.

Mapping slow waves and spikes in chronically instrumented conscious dogs: automated on-line electrogram analysis.

Lammers WJ, Michiels B, Voeten J, Ver Donck L, Schuurkes JA.

Med Biol Eng Comput. 2008 Feb;46(2):121-9. doi: 10.1007/s11517-007-0294-7. Epub 2008 Jan 17.

PMID:
18200451
12.

5-HT4 receptor agonists: similar but not the same.

De Maeyer JH, Lefebvre RA, Schuurkes JA.

Neurogastroenterol Motil. 2008 Feb;20(2):99-112. doi: 10.1111/j.1365-2982.2007.01059.x. Review.

PMID:
18199093
13.

The effects of cholinergic stimulation and of nucleoside transport inhibition on spikes and spike patches in the canine small intestine in vivo.

Lammers WJ, Ver Donck L, Schuurkes JA, Smets D, Stephen B.

Eur J Pharmacol. 2007 Jul 30;568(1-3):234-41. Epub 2007 Apr 20.

PMID:
17531971
14.

Determination of lactate concentrations in blood plasma and peritoneal fluid in horses with colic by an Accusport analyzer.

Delesalle C, Dewulf J, Lefebvre RA, Schuurkes JA, Proot J, Lefere L, Deprez P.

J Vet Intern Med. 2007 Mar-Apr;21(2):293-301.

15.

Mapping slow waves and spikes in chronically instrumented conscious dogs: implantation techniques and recordings.

Ver Donck L, Lammers WJ, Moreaux B, Smets D, Voeten J, Vekemans J, Schuurkes JA, Coulie B.

Med Biol Eng Comput. 2006 Mar;44(3):170-8. Epub 2006 Feb 11.

PMID:
16937158
16.

Serotonergic modulation of murine fundic tone.

Xue L, Camilleri M, Locke GR 3rd, Schuurkes JA, Meulemans A, Coulie BJ, Szurszewski JH, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2006 Dec;291(6):G1180-6. Epub 2006 Jul 27.

17.

Electrical activity in the rectum of anaesthetized dogs.

Lammers WJ, Abazer FA, Ver Donck L, Smets D, Schuurkes JA, Coulie B.

Neurogastroenterol Motil. 2006 Jul;18(7):569-77.

PMID:
16771772
18.
19.

Use of plasma ionized calcium levels and Ca2+ substitution response patterns as prognostic parameters for ileus and survival in colic horses.

Delesalle C, Dewulf J, Lefebvre RA, Schuurkes JA, Van Vlierbergen B, Deprez P.

Vet Q. 2005 Dec;27(4):157-72.

PMID:
16402513
20.

Peripheral pacemakers and patterns of slow wave propagation in the canine small intestine in vivo.

Lammers WJ, Ver Donck L, Schuurkes JA, Stephen B.

Can J Physiol Pharmacol. 2005 Nov;83(11):1031-43.

PMID:
16391712
21.

Porcine left atrial and sinoatrial 5-HT(4) receptor-induced responses: fading of the response and influence of development.

De Maeyer JH, Straetemans R, Schuurkes JA, Lefebvre RA.

Br J Pharmacol. 2006 Jan;147(2):140-57.

22.

Contractile effects of 5-hydroxytryptamine and 5-carboxamidotryptamine in the equine jejunum.

Delesalle C, Deprez P, Schuurkes JA, Lefebvre RA.

Br J Pharmacol. 2006 Jan;147(1):23-35.

23.

Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry.

Xue L, Locke GR, Camilleri M, Schuurkes JA, Meulemans A, Coulie BJ, Szurszewski JH, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2006 Jan;290(1):G74-82. Epub 2005 Sep 15.

24.

5-HT4 receptors located on cholinergic nerves in human colon circular muscle.

Leclere PG, Prins NH, Schuurkes JA, Lefebvre RA.

Neurogastroenterol Motil. 2005 Jun;17(3):366-75.

PMID:
15916624
25.

Spatial determination of successive spikes in the isolated cat duodenum.

Lammers WJ, Faes C, Stephen B, Bijnens L, Ver Donck L, Schuurkes JA.

Neurogastroenterol Motil. 2004 Dec;16(6):775-83.

PMID:
15601428
26.

Longitudinal and circumferential spike patches in the canine small intestine in vivo.

Lammers WJ, Donck LV, Schuurkes JA, Stephen B.

Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G1014-27. Epub 2003 Jul 3.

27.

Use of plasma ionized calcium levels and Ca(2+) substitution response patterns as prognostic parameters for ileus and survival in colic horses.

Delesalle C, Dewulf J, Lefebvre RA, Schuurkes JA, Van Vlierbergen B, Deprez P.

Vet Q. 2002 Dec;27(4):157-172.

PMID:
22070378
28.

Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle.

Prins NH, Akkermans LM, Lefebvre RA, Schuurkes JA.

Br J Pharmacol. 2001 Nov;134(6):1351-9.

29.

Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs.

Briejer MR, Prins NH, Schuurkes JA.

Neurogastroenterol Motil. 2001 Oct;13(5):465-72.

PMID:
11696108
30.

The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

Briejer MR, Bosmans JP, Van Daele P, Jurzak M, Heylen L, Leysen JE, Prins NH, Schuurkes JA.

Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

PMID:
11438309
31.

5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study.

Prins NH, van Der Grijn A, Lefebvre RA, Akkermans LM, Schuurkes JA.

Br J Pharmacol. 2001 Apr;132(8):1941-7.

32.

5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle.

Prins NH, Akkermans LM, Lefebvre RA, Schuurkes JA.

Br J Pharmacol. 2000 Nov;131(5):927-32.

33.

An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle.

Prins NH, Shankley NP, Welsh NJ, Briejer MR, Lefebvre RA, Akkermans LM, Schuurkes JA.

Br J Pharmacol. 2000 Apr;129(8):1601-8.

34.

Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle.

Prins NH, Briejer MR, Van Bergen PJ, Akkermans LM, Schuurkes JA.

Br J Pharmacol. 1999 Oct;128(4):849-52.

35.

Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.

De Winter BY, Boeckxstaens GE, De Man JG, Moreels TG, Schuurkes JA, Peeters TL, Herman AG, Pelckmans PA.

Gut. 1999 Nov;45(5):713-8.

36.

Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle.

Prins NH, Van Haselen JF, Lefebvre RA, Briejer MR, Akkermans LM, Schuurkes JA.

Br J Pharmacol. 1999 Jul;127(6):1431-7.

37.

Idiopathic constipation: too few stools and too little knowledge.

Briejer MR, Schuurkes JA, Sarna SK.

Trends Pharmacol Sci. 1999 Jan;20(1):1-3. Review.

PMID:
10101952
38.

5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction.

Briejer MR, Mathis C, Schuurkes JA.

Neurogastroenterol Motil. 1997 Dec;9(4):231-7.

PMID:
9430791
39.

Gastric secretion but not nitric oxide is involved in pentagastrin-induced gastric relaxation in conscious dogs.

Meulemans AL, Wellens AL, Schuurkes JA.

Neurogastroenterol Motil. 1997 Mar;9(1):49-54.

PMID:
9058392
40.

Characterization of the contraction to 5-HT in the canine colon longitudinal muscle.

Prins NH, Briejer MR, Schuurkes JA.

Br J Pharmacol. 1997 Feb;120(4):714-20.

41.

Neurokinetic and myokinetic effects of the peptide xenin on the motility of the small and large intestine of guinea pig.

Feurle GE, Klein A, Hamscher G, Metzger JW, Schuurkes JA.

J Pharmacol Exp Ther. 1996 Aug;278(2):654-61.

PMID:
8768716
42.
43.

Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility.

Briejer MR, Akkermans LM, Schuurkes JA.

Pharmacol Rev. 1995 Dec;47(4):631-51. Review. No abstract available.

PMID:
8746557
44.

NO mediates gastric relaxation after brief vagal stimulation in anesthetized dogs.

Meulemans AL, Eelen JG, Schuurkes JA.

Am J Physiol. 1995 Aug;269(2 Pt 1):G255-61.

PMID:
7653566
45.

Cisapride and structural analogs selectively enhance 5-hydroxytryptamine (5-HT)-induced purinergic neurotransmission in the guinea pig proximal colon.

Briejer MR, Veen GJ, Akkermans LM, Lefebvre RA, Schuurkes JA.

J Pharmacol Exp Ther. 1995 Aug;274(2):641-8.

PMID:
7636723
46.

Novel 5-HT2-like receptor mediates neurogenic relaxation of the guinea-pig proximal colon.

Briejer MR, Akkermans LM, Lefebvre RA, Schuurkes JA.

Eur J Pharmacol. 1995 Jun 12;279(2-3):123-33.

PMID:
7556392
47.

5-HT-induced neurogenic relaxations of the guinea-pig proximal colon: investigation into the role of ATP and VIP in addition to nitric oxide.

Briejer MR, Akkermans LM, Meulemans AL, Lefebvre RA, Schuurkes JA.

Naunyn Schmiedebergs Arch Pharmacol. 1995 Feb;351(2):126-35.

PMID:
7770095
48.

Interactions of serotonin with multiple receptors and neurotransmitters in the guinea-pig isolated colon.

Briejer MR, Akkermans LM, Schuurkes JA.

Arch Int Pharmacodyn Ther. 1995 Jan-Feb;329(1):121-33. Review.

PMID:
7639614
49.

Nitric oxide and gastric relaxation.

Schuurkes JA, Meulemans AL.

Dig Dis Sci. 1994 Dec;39(12 Suppl):79S-81S.

PMID:
7995223
50.

Pharmacotherapy of gastrointestinal motor disorders.

Schuurkes JA.

Rev Gastroenterol Mex. 1994 Apr-Jun;59(2):165-70. Review.

PMID:
7991970

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