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Accreditation, setting and experience as indicators to assure quality in oncology biomarker testing laboratories.

Tack V, Schuuring E, Keppens C, Hart N', Pauwels P, van Krieken H, Dequeker EMC.

Br J Cancer. 2018 Aug 24. doi: 10.1038/s41416-018-0204-9. [Epub ahead of print]


International pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA.

Keppens C, Dequeker EMC, Patton SJ, Normanno N, Fenizia F, Butler R, Cheetham M, Fairley JA, Williams H, Hall JA, Schuuring E, Deans ZC; IQN Path ASBL.

BMC Cancer. 2018 Aug 9;18(1):804. doi: 10.1186/s12885-018-4694-x.


Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer.

Verlaat W, Van Leeuwen RW, Novianti PW, Schuuring E, Meijer CJLM, Van Der Zee AGJ, Snijders PJF, Heideman DAM, Steenbergen RDM, Wisman GBA.

Epigenetics. 2018 Aug 24:1-10. doi: 10.1080/15592294.2018.1507197. [Epub ahead of print]


Describing the Reportable Range Is Important for Reliable Treatment Decisions: A Multiple Laboratory Study for Molecular Tumor Profiling Using Next-Generation Sequencing.

Tack V, Spans L, Schuuring E, Keppens C, Zwaenepoel K, Pauwels P, Van Houdt J, Dequeker EMC.

J Mol Diagn. 2018 Jul 26. pii: S1525-1578(17)30624-4. doi: 10.1016/j.jmoldx.2018.06.006. [Epub ahead of print]


Response to HER2 Inhibition in a Patient With Brain Metastasis With EGFR TKI Acquired Resistance and an HER2 Amplification.

Meedendorp AD, Ter Elst A, 't Hart NA, Groen HJM, Schuuring E, van der Wekken AJ.

Front Oncol. 2018 May 22;8:176. doi: 10.3389/fonc.2018.00176. eCollection 2018.


A stitch in time saves nine: external quality assessment rounds demonstrate improved quality of biomarker analysis in lung cancer.

Keppens C, Tack V, Hart N', Tembuyser L, Ryska A, Pauwels P, Zwaenepoel K, Schuuring E, Cabillic F, Tornillo L, Warth A, Weichert W, Dequeker E; EQA assessors expert group.

Oncotarget. 2018 Apr 17;9(29):20524-20538. doi: 10.18632/oncotarget.24980. eCollection 2018 Apr 17.


Data-Driven prioritisation of antibody-drug conjugate targets in head and neck squamous cell carcinoma.

Hanemaaijer SH, van Gijn SE, Oosting SF, Plaat BEC, Moek KL, Schuuring EM, van der Laan BFAM, Roodenburg JLN, van Vugt MATM, van der Vegt B, Fehrmann RSN.

Oral Oncol. 2018 May;80:33-39. doi: 10.1016/j.oraloncology.2018.03.005. Epub 2018 Mar 27.


Detection of EGFR Variants in Plasma: A Multilaboratory Comparison of a Real-Time PCR EGFR Mutation Test in Europe.

Keppens C, Palma JF, Das PM, Scudder S, Wen W, Normanno N, van Krieken JH, Sacco A, Fenizia F, Gonzalez de Castro D, Hönigschnabl S, Kern I, Lopez-Rios F, Lozano MD, Marchetti A, Halfon P, Schuuring E, Setinek U, Sorensen B, Taniere P, Tiemann M, Vosmikova H, Dequeker EMC.

J Mol Diagn. 2018 Jul;20(4):483-494. doi: 10.1016/j.jmoldx.2018.03.006. Epub 2018 Apr 26.


High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands.

Boeve K, Schepman KP, Schuuring E, Roodenburg JLN, Halmos GB, van Dijk BAC, Boorsma RAC, de Visscher JGAM, Brouwers AH, van der Vegt B, Witjes MJH.

Clin Otolaryngol. 2018 Mar 25. doi: 10.1111/coa.13107. [Epub ahead of print]


A single digital droplet PCR assay to detect multiple KIT exon 11 mutations in tumor and plasma from patients with gastrointestinal stromal tumors.

Boonstra PA, Ter Elst A, Tibbesma M, Bosman LJ, Mathijssen R, Atrafi F, van Coevorden F, Steeghs N, Farag S, Gelderblom H, van der Graaf WTA, Desar IME, Maier J, Overbosch J, Suurmeijer AJH, Gietema J, Schuuring E, Reyners AKL.

Oncotarget. 2018 Feb 14;9(17):13870-13883. doi: 10.18632/oncotarget.24493. eCollection 2018 Mar 2.


Viable tumor in salvage neck dissections in head and neck cancer: Relation with initial treatment, change of lymph node size and human papillomavirus.

van den Bovenkamp K, Dorgelo B, Noordhuis MG, van der Laan BFAM, van der Vegt B, Bijl HP, Roodenburg JL, van Dijk BAC, Oosting SF, Schuuring EMD, Langendijk JA, Halmos GB, Plaat BEC.

Oral Oncol. 2018 Feb;77:131-136. doi: 10.1016/j.oraloncology.2017.12.017. Epub 2018 Jan 8.


Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature.

Boonstra PA, Gietema JA, Suurmeijer AJH, Groves MR, de Assis Batista F, Schuuring E, Reyners AKL.

Oncotarget. 2017 Nov 26;8(65):109836-109847. doi: 10.18632/oncotarget.22663. eCollection 2017 Dec 12.


Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers.

Wei J, van der Wekken AJ, Saber A, Terpstra MM, Schuuring E, Timens W, Hiltermann TJN, Groen HJM, van den Berg A, Kok K.

Cancers (Basel). 2018 Jan 4;10(1). pii: E10. doi: 10.3390/cancers10010010.


Rapid BRAF mutation tests in patients with advanced melanoma: comparison of immunohistochemistry, Droplet Digital PCR, and the Idylla Mutation Platform.

Bisschop C, Ter Elst A, Bosman LJ, Platteel I, Jalving M, van den Berg A, Diepstra A, van Hemel B, Diercks GFH, Hospers GAP, Schuuring E.

Melanoma Res. 2018 Apr;28(2):96-104. doi: 10.1097/CMR.0000000000000421.


Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression.

van der Wekken AJ, Kuiper JL, Saber A, Terpstra MM, Wei J, Hiltermann TJN, Thunnissen E, Heideman DAM, Timens W, Schuuring E, Kok K, Smit EF, van den Berg A, Groen HJM.

PLoS One. 2017 Aug 30;12(8):e0182885. doi: 10.1371/journal.pone.0182885. eCollection 2017.


Review of the implementation of plasma ctDNA testing on behalf of IQN Path ASBL: a perspective from an EQA providers' survey.

Deans ZC, Williams H, Dequeker EMC, Keppens C, Normanno N, Schuuring E, Patton SJ, Cheetham M, Butler R, Hall JA; IQN Path ASBL.

Virchows Arch. 2017 Dec;471(6):809-813. doi: 10.1007/s00428-017-2222-z. Epub 2017 Aug 25. No abstract available.


Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer.

Tomar T, Alkema NG, Schreuder L, Meersma GJ, de Meyer T, van Criekinge W, Klip HG, Fiegl H, van Nieuwenhuysen E, Vergote I, Widschwendter M, Schuuring E, van der Zee AGJ, de Jong S, Wisman GBA.

BMC Med. 2017 Jun 23;15(1):116. doi: 10.1186/s12916-017-0870-0.


Phosphorylated FADD is not prognostic for local control in T1-T2 supraglottic laryngeal carcinoma treated with radiotherapy.

Wachters JE, Schrijvers ML, Slagter-Menkema L, Mastik M, Langendijk JA, de Bock GH, Roodenburg JL, van der Laan BFAM, van der Wal JE, Schuuring E.

Laryngoscope. 2017 Sep;127(9):E301-E307. doi: 10.1002/lary.26563. Epub 2017 Mar 17.


Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non-Small Cell Lung Cancer.

van der Wekken AJ, Pelgrim R, 't Hart N, Werner N, Mastik MF, Hendriks L, van der Heijden EHFM, Looijen-Salamon M, de Langen AJ, Staal-van den Brekel J, Riemersma S, van den Borne BE, Speel EJM, Dingemans AC, Hiltermann TJN, van den Berg A, Timens W, Schuuring E, Groen HJM.

Clin Cancer Res. 2017 Aug 1;23(15):4251-4258. doi: 10.1158/1078-0432.CCR-16-1631. Epub 2017 Feb 9.


Lymphatic drainage patterns of oral maxillary tumors: Approachable locations of sentinel lymph nodes mainly at the cervical neck level.

Boeve K, Schepman KP, Vegt BV, Schuuring E, Roodenburg JL, Brouwers AH, Witjes MJ.

Head Neck. 2017 Mar;39(3):486-491. doi: 10.1002/hed.24628. Epub 2016 Dec 22.


Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma.

Wang R, van Leeuwen RW, Boers A, Klip HG, de Meyer T, Steenbergen RD, van Criekinge W, van der Zee AG, Schuuring E, Wisman GB.

Oncotarget. 2016 Dec 6;7(49):80735-80750. doi: 10.18632/oncotarget.12598.


Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL.

Deans ZC, Costa JL, Cree I, Dequeker E, Edsjö A, Henderson S, Hummel M, Ligtenberg MJ, Loddo M, Machado JC, Marchetti A, Marquis K, Mason J, Normanno N, Rouleau E, Schuuring E, Snelson KM, Thunnissen E, Tops B, Williams G, van Krieken H, Hall JA; IQN Path ASBL.

Virchows Arch. 2017 Jan;470(1):5-20. doi: 10.1007/s00428-016-2025-7. Epub 2016 Sep 27. Review.


Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer.

Noorlag R, Boeve K, Witjes MJ, Koole R, Peeters TL, Schuuring E, Willems SM, van Es RJ.

Head Neck. 2017 Feb;39(2):326-333. doi: 10.1002/hed.24584. Epub 2016 Sep 21.


RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis.

Clausen MJ, Melchers LJ, Mastik MF, Slagter-Menkema L, Groen HJ, Laan BF, van Criekinge W, de Meyer T, Denil S, van der Vegt B, Wisman GB, Roodenburg JL, Schuuring E.

Epigenetics. 2016 Sep;11(9):653-663. Epub 2016 Jul 5.


FGFR Family Members Protein Expression as Prognostic Markers in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma.

Koole K, Clausen MJ, van Es RJ, van Kempen PM, Melchers LJ, Koole R, Langendijk JA, van Diest PJ, Roodenburg JL, Schuuring E, Willems SM.

Mol Diagn Ther. 2016 Aug;20(4):363-74. doi: 10.1007/s40291-016-0204-5.


Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis.

Tjon Pian Gi RE, San Giorgi MR, Pawlita M, Michel A, van Hemel BM, Schuuring EM, van den Heuvel ER, van der Laan BF, Dikkers FG.

Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3231-6. doi: 10.1007/s00405-016-4085-3. Epub 2016 May 17.


Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing.

Saber A, van der Wekken AJ, Kok K, Terpstra MM, Bosman LJ, Mastik MF, Timens W, Schuuring E, Hiltermann TJ, Groen HJ, van den Berg A.

PLoS One. 2016 Apr 5;11(4):e0153065. doi: 10.1371/journal.pone.0153065. eCollection 2016.


Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer.

Saber A, van der Wekken AJ, Kerner GS, van den Berge M, Timens W, Schuuring E, ter Elst A, van den Berg A, Hiltermann TJ, Groen HJ.

PLoS One. 2016 Mar 23;11(3):e0152317. doi: 10.1371/journal.pone.0152317. eCollection 2016.


Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3.

Boers A, Wang R, van Leeuwen RW, Klip HG, de Bock GH, Hollema H, van Criekinge W, de Meyer T, Denil S, van der Zee AGJ, Schuuring E, Wisman GBA.

Clin Epigenetics. 2016 Mar 9;8:29. doi: 10.1186/s13148-016-0196-3. eCollection 2016.


Re-expression of Selected Epigenetically Silenced Candidate Tumor Suppressor Genes in Cervical Cancer by TET2-directed Demethylation.

Huisman C, van der Wijst MG, Schokker M, Blancafort P, Terpstra MM, Kok K, van der Zee AG, Schuuring E, Wisman GB, Rots MG.

Mol Ther. 2016 Mar;24(3):536-47. doi: 10.1038/mt.2015.226. Epub 2015 Dec 21.


Identification and validation of WISP1 as an epigenetic regulator of metastasis in oral squamous cell carcinoma.

Clausen MJ, Melchers LJ, Mastik MF, Slagter-Menkema L, Groen HJ, van der Laan BF, van Criekinge W, de Meyer T, Denil S, Wisman GB, Roodenburg JL, Schuuring E.

Genes Chromosomes Cancer. 2016 Jan;55(1):45-59. doi: 10.1002/gcc.22310. Epub 2015 Sep 22.


Assessment of hypoxic subvolumes in laryngeal cancer with (18)F-fluoroazomycinarabinoside ((18)F-FAZA)-PET/CT scanning and immunohistochemistry.

Bruine de Bruin L, Bollineni VR, Wachters JE, Schuuring E, van Hemel BM, van der Wal JE, Slagter-Menkema L, de Bock GH, Steenbakkers RJ, Langendijk JA, Pruim J, van der Laan BF, Halmos GB.

Radiother Oncol. 2015 Oct;117(1):106-12. doi: 10.1016/j.radonc.2015.07.012. Epub 2015 Aug 3.


Identification of methylation markers for the prediction of nodal metastasis in oral and oropharyngeal squamous cell carcinoma.

Melchers LJ, Clausen MJ, Mastik MF, Slagter-Menkema L, van der Wal JE, Wisman GB, Roodenburg JL, Schuuring E.

Epigenetics. 2015;10(9):850-60. doi: 10.1080/15592294.2015.1075689.


Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China.

Wang R, Guo XL, Wisman GB, Schuuring E, Wang WF, Zeng ZY, Zhu H, Wu SW.

BMC Infect Dis. 2015 Jul 4;15:257. doi: 10.1186/s12879-015-0998-5.


Erratum to: Quality assessment of estrogen receptor and progesterone receptor testing in breast cancer using a tissue microarray-based approach.

Dekker TJ, ter Borg S, Hooijer GK, Meijer SL, Wesseling J, Boers JE, Schuuring E, Bart J, van Gorp J, Bult P, Riemersma SA, van Deurzen CH, Sleddens HF, Mesker WE, Kroep JR, Smit VT, van de Vijver MJ.

Breast Cancer Res Treat. 2015 Jul;152(2):253. doi: 10.1007/s10549-015-3478-0. No abstract available.


Reproducibility and prognostic value of pattern of invasion scoring in low-stage oral squamous cell carcinoma.

Heerema MG, Melchers LJ, Roodenburg JL, Schuuring E, de Bock GH, van der Vegt B.

Histopathology. 2016 Feb;68(3):388-97. doi: 10.1111/his.12754. Epub 2015 Aug 3.


Quality assessment of estrogen receptor and progesterone receptor testing in breast cancer using a tissue microarray-based approach.

Dekker TJ, ter Borg S, Hooijer GK, Meijer SL, Wesseling J, Boers JE, Schuuring E, Bart J, van Gorp J, Bult P, Riemersma SA, van Deurzen CH, Sleddens HF, Mesker WE, Kroep JR, Smit VT, van de Vijver MJ.

Breast Cancer Res Treat. 2015 Jul;152(2):247-52. doi: 10.1007/s10549-015-3444-x. Epub 2015 Jun 4. Erratum in: Breast Cancer Res Treat. 2015 Jul;152(2):253.


Detection of HPV-associated oropharyngeal tumours in a 16-year cohort: more than meets the eye.

Melchers LJ, Mastik MF, Samaniego Cameron B, van Dijk BA, de Bock GH, van der Laan BF, van der Vegt B, Speel EJ, Roodenburg JL, Witjes MJ, Schuuring E.

Br J Cancer. 2015 Apr 14;112(8):1349-57. doi: 10.1038/bjc.2015.99. Epub 2015 Mar 17.


Fully automated fluorescent in situ hybridization (FISH) staining and digital analysis of HER2 in breast cancer: a validation study.

van der Logt EM, Kuperus DA, van Setten JW, van den Heuvel MC, Boers JE, Schuuring E, Kibbelaar RE.

PLoS One. 2015 Apr 6;10(4):e0123201. doi: 10.1371/journal.pone.0123201. eCollection 2015.


Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs.

Huisman C, van der Wijst MG, Falahi F, Overkamp J, Karsten G, Terpstra MM, Kok K, van der Zee AG, Schuuring E, Wisman GB, Rots MG.

Epigenetics. 2015;10(5):384-96. doi: 10.1080/15592294.2015.1034415. Epub 2015 Apr 1.


Paediatric nodal marginal zone B-cell lymphadenopathy of the neck: a Haemophilus influenzae-driven immune disorder?

Kluin PM, Langerak AW, Beverdam-Vincent J, Geurts-Giele WR, Visser L, Rutgers B, Schuuring E, Van Baarlen J, Lam KH, Seldenrijk K, Kibbelaar RE, de Wit P, Diepstra A, Rosati S, van Noesel MM, Zwaan CM, Hunting JC, Hoogendoorn M, van der Gaag EJ, van Esser JW, de Bont E, Kluin-Nelemans HC, Winter RH, Lo Ten Foe JR, van der Zanden AG.

J Pathol. 2015 Jul;236(3):302-14. doi: 10.1002/path.4524. Epub 2015 Apr 8.


Mining for viral fragments in methylation enriched sequencing data.

Mensaert K, Van Criekinge W, Thas O, Schuuring E, Steenbergen RD, Wisman GB, De Meyer T.

Front Genet. 2015 Feb 4;6:16. doi: 10.3389/fgene.2015.00016. eCollection 2015.


The relevance of external quality assessment for molecular testing for ALK positive non-small cell lung cancer: results from two pilot rounds show room for optimization.

Tembuyser L, Tack V, Zwaenepoel K, Pauwels P, Miller K, Bubendorf L, Kerr K, Schuuring E, Thunnissen E, Dequeker EM.

PLoS One. 2014 Nov 11;9(11):e112159. doi: 10.1371/journal.pone.0112159. eCollection 2014.


Head and neck squamous cell carcinomas do not express EGFRvIII.

Melchers LJ, Clausen MJ, Mastik MF, Slagter-Menkema L, Langendijk JA, van der Laan BF, van der Wal JE, van der Vegt B, Roodenburg JL, Schuuring E.

Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):454-62. doi: 10.1016/j.ijrobp.2014.06.035.


Clinical validation of the Cervista HPV HR test according to the international guidelines for human papillomavirus test requirements for cervical cancer screening.

Boers A, Wang R, Slagter-Menkema L, van Hemel BM, Ghyssaert H, van der Zee AG, Wisman GB, Schuuring E.

J Clin Microbiol. 2014 Dec;52(12):4391-3. doi: 10.1128/JCM.02716-14. Epub 2014 Oct 8.


Comparing the Cervista HPV HR test and Hybrid Capture 2 assay in a Dutch screening population: improved specificity of the Cervista HPV HR test by changing the cut-off.

Boers A, Slagter-Menkema L, van Hemel BM, Belinson JL, Ruitenbeek T, Buikema HJ, Klip H, Ghyssaert H, van der Zee AG, de Bock GH, Wisman GB, Schuuring E.

PLoS One. 2014 Jul 22;9(7):e101930. doi: 10.1371/journal.pone.0101930. eCollection 2014.


DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women.

Boers A, Bosgraaf RP, van Leeuwen RW, Schuuring E, Heideman DA, Massuger LF, Verhoef VM, Bulten J, Melchers WJ, van der Zee AG, Bekkers RL, Wisman GB.

Br J Cancer. 2014 Sep 9;111(6):1095-101. doi: 10.1038/bjc.2014.392. Epub 2014 Jul 17.


Guidance for laboratories performing molecular pathology for cancer patients.

Cree IA, Deans Z, Ligtenberg MJ, Normanno N, Edsjö A, Rouleau E, Solé F, Thunnissen E, Timens W, Schuuring E, Dequeker E, Murray S, Dietel M, Groenen P, Van Krieken JH; European Society of Pathology Task Force on Quality Assurance in Molecular Pathology; Royal College of Pathologists.

J Clin Pathol. 2014 Nov;67(11):923-31. doi: 10.1136/jclinpath-2014-202404. Epub 2014 Jul 10. Review.


Clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11.

Tjon Pian Gi RE, San Giorgi MR, Slagter-Menkema L, van Hemel BM, van der Laan BF, van den Heuvel ER, Dikkers FG, Schuuring EM.

Head Neck. 2015 Nov;37(11):1625-32. doi: 10.1002/hed.23808. Epub 2014 Sep 12.


An international interpretation study using the ALK IHC antibody D5F3 and a sensitive detection kit demonstrates high concordance between ALK IHC and ALK FISH and between evaluators.

Wynes MW, Sholl LM, Dietel M, Schuuring E, Tsao MS, Yatabe Y, Tubbs RR, Hirsch FR.

J Thorac Oncol. 2014 May;9(5):631-8. doi: 10.1097/JTO.0000000000000115.

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