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Items: 1 to 50 of 88

1.

Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors.

Kutil Z, Mikešová J, Zessin M, Meleshin M, Nováková Z, Alquicer G, Kozikowski A, Sippl W, Bařinka C, Schutkowski M.

ACS Omega. 2019 Nov 15;4(22):19895-19904. doi: 10.1021/acsomega.9b02808. eCollection 2019 Nov 26.

2.

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.

Zessin M, Kutil Z, Meleshin M, Nováková Z, Ghazy E, Kalbas D, Marek M, Romier C, Sippl W, Bařinka C, Schutkowski M.

Biochemistry. 2019 Dec 3;58(48):4777-4789. doi: 10.1021/acs.biochem.9b00786. Epub 2019 Nov 14.

PMID:
31682411
3.

The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries.

Kutil Z, Skultetyova L, Rauh D, Meleshin M, Snajdr I, Novakova Z, Mikesova J, Pavlicek J, Hadzima M, Baranova P, Havlinova B, Majer P, Schutkowski M, Barinka C.

FASEB J. 2019 Mar;33(3):4035-4045. doi: 10.1096/fj.201801680R. Epub 2018 Nov 29.

PMID:
30496698
4.

Regulation of the Minichromosome Maintenance Protein 3 (MCM3) Chromatin Binding by the Prolyl Isomerase Pin1.

Schumann M, Malešević M, Hinze E, Mathea S, Meleshin M, Schutkowski M, Haehnel W, Schiene-Fischer C.

J Mol Biol. 2018 Dec 7;430(24):5169-5181. doi: 10.1016/j.jmb.2018.10.002. Epub 2018 Oct 11.

PMID:
30316783
5.

Analysis of Toxoplasma gondii clonal type-specific antibody reactions in experimentally infected turkeys and chickens.

Maksimov P, Basso W, Zerweck J, Schutkowski M, Reimer U, Maksimov A, Conraths FJ, Schares G.

Int J Parasitol. 2018 Sep;48(11):845-856. doi: 10.1016/j.ijpara.2018.04.004. Epub 2018 Jun 30.

PMID:
29969590
6.

Potent and Selective Inhibitors of Human Sirtuin 5.

Kalbas D, Liebscher S, Nowak T, Meleshin M, Pannek M, Popp C, Alhalabi Z, Bordusa F, Sippl W, Steegborn C, Schutkowski M.

J Med Chem. 2018 Mar 22;61(6):2460-2471. doi: 10.1021/acs.jmedchem.7b01648. Epub 2018 Mar 12.

PMID:
29494161
7.

Histone Deacetylase 11 Is a Fatty-Acid Deacylase.

Kutil Z, Novakova Z, Meleshin M, Mikesova J, Schutkowski M, Barinka C.

ACS Chem Biol. 2018 Mar 16;13(3):685-693. doi: 10.1021/acschembio.7b00942. Epub 2018 Jan 30.

PMID:
29336543
8.

A 1-phytase type III effector interferes with plant hormone signaling.

Blüher D, Laha D, Thieme S, Hofer A, Eschen-Lippold L, Masch A, Balcke G, Pavlovic I, Nagel O, Schonsky A, Hinkelmann R, Wörner J, Parvin N, Greiner R, Weber S, Tissier A, Schutkowski M, Lee J, Jessen H, Schaaf G, Bonas U.

Nat Commun. 2017 Dec 18;8(1):2159. doi: 10.1038/s41467-017-02195-8.

9.

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.

Pannek M, Simic Z, Fuszard M, Meleshin M, Rotili D, Mai A, Schutkowski M, Steegborn C.

Nat Commun. 2017 Nov 15;8(1):1513. doi: 10.1038/s41467-017-01701-2.

10.

Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2.

Ruhs S, Strätz N, Quarch K, Masch A, Schutkowski M, Gekle M, Grossmann C.

Sci Rep. 2017 Nov 10;7(1):15340. doi: 10.1038/s41598-017-15418-1.

11.

Identification of sortase substrates by specificity profiling.

Schmohl L, Bierlmeier J, von Kügelgen N, Kurz L, Reis P, Barthels F, Mach P, Schutkowski M, Freund C, Schwarzer D.

Bioorg Med Chem. 2017 Sep 15;25(18):5002-5007. doi: 10.1016/j.bmc.2017.06.033. Epub 2017 Jun 22.

PMID:
28684010
12.

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases.

Palma A, Tinti M, Paoluzi S, Santonico E, Brandt BW, Hooft van Huijsduijnen R, Masch A, Heringa J, Schutkowski M, Castagnoli L, Cesareni G.

J Biol Chem. 2017 Mar 24;292(12):4942-4952. doi: 10.1074/jbc.M116.757518. Epub 2017 Feb 3.

13.

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, Chua KF, Mai A, Steegborn C.

Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011. doi: 10.1002/anie.201610082. Epub 2016 Dec 19.

PMID:
27990725
14.

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions.

Schuster S, Roessler C, Meleshin M, Zimmermann P, Simic Z, Kambach C, Schiene-Fischer C, Steegborn C, Hottiger MO, Schutkowski M.

Sci Rep. 2016 Mar 4;6:22643. doi: 10.1038/srep22643.

15.

PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation.

McCuaig RD, Dunn J, Li J, Masch A, Knaute T, Schutkowski M, Zerweck J, Rao S.

Front Immunol. 2015 Nov 5;6:562. doi: 10.3389/fimmu.2015.00562. eCollection 2015.

16.

The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters.

Simic Z, Weiwad M, Schierhorn A, Steegborn C, Schutkowski M.

Chembiochem. 2015 Nov 2;16(16):2337-47. doi: 10.1002/cbic.201500364. Epub 2015 Sep 18.

PMID:
26382620
17.

A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases.

Roessler C, Tüting C, Meleshin M, Steegborn C, Schutkowski M.

J Med Chem. 2015 Sep 24;58(18):7217-23. doi: 10.1021/acs.jmedchem.5b00293. Epub 2015 Sep 8.

PMID:
26308971
18.

Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays.

Rohe A, Platzer C, Masch A, Greiner S, Henze C, Ihling C, Erdmann F, Schutkowski M, Sippl W, Schmidt M.

Bioorg Med Chem. 2015 Aug 1;23(15):4936-42. doi: 10.1016/j.bmc.2015.05.021. Epub 2015 May 19.

PMID:
26059593
19.

SIRT5 regulation of ammonia-induced autophagy and mitophagy.

Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M.

Autophagy. 2015;11(2):253-70. doi: 10.1080/15548627.2015.1009778.

20.

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M.

Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263.

21.

The peptide microarray "ChloroPhos1.0" identifies new phosphorylation targets of plastid casein kinase II (pCKII) in Arabidopsis thaliana.

Schönberg A, Bergner E, Helm S, Agne B, Dünschede B, Schünemann D, Schutkowski M, Baginsky S.

PLoS One. 2014 Oct 8;9(10):e108344. doi: 10.1371/journal.pone.0108344. eCollection 2014.

22.

Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.

Roessler C, Nowak T, Pannek M, Gertz M, Nguyen GT, Scharfe M, Born I, Sippl W, Steegborn C, Schutkowski M.

Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10728-32. doi: 10.1002/anie.201402679. Epub 2014 Aug 11.

PMID:
25111069
23.

Whole CMV proteome pattern recognition analysis after HSCT identifies unique epitope targets associated with the CMV status.

Pérez-Bercoff L, Valentini D, Gaseitsiwe S, Mahdavifar S, Schutkowski M, Poiret T, Pérez-Bercoff Å, Ljungman P, Maeurer MJ.

PLoS One. 2014 Apr 16;9(4):e89648. doi: 10.1371/journal.pone.0089648. eCollection 2014.

24.

New assays and approaches for discovery and design of Sirtuin modulators.

Schutkowski M, Fischer F, Roessler C, Steegborn C.

Expert Opin Drug Discov. 2014 Feb;9(2):183-99. doi: 10.1517/17460441.2014.875526. Epub 2014 Jan 2. Review.

PMID:
24382304
25.

Serotyping of Toxoplasma gondii in cats (Felis domesticus) reveals predominance of type II infections in Germany.

Maksimov P, Zerweck J, Dubey JP, Pantchev N, Frey CF, Maksimov A, Reimer U, Schutkowski M, Hosseininejad M, Ziller M, Conraths FJ, Schares G.

PLoS One. 2013 Nov 7;8(11):e80213. doi: 10.1371/journal.pone.0080213. eCollection 2013.

26.

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F, Kambach C, Becker CF, Zerweck J, Schutkowski M, Steegborn C.

Nat Commun. 2013;4:2327. doi: 10.1038/ncomms3327.

PMID:
23995836
27.

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.

Gertz M, Fischer F, Nguyen GT, Lakshminarasimhan M, Schutkowski M, Weyand M, Steegborn C.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81. doi: 10.1073/pnas.1303628110. Epub 2013 Jul 9.

28.

The SH2 domain interaction landscape.

Tinti M, Kiemer L, Costa S, Miller ML, Sacco F, Olsen JV, Carducci M, Paoluzi S, Langone F, Workman CT, Blom N, Machida K, Thompson CM, Schutkowski M, Brunak S, Mann M, Mayer BJ, Castagnoli L, Cesareni G.

Cell Rep. 2013 Apr 25;3(4):1293-305. doi: 10.1016/j.celrep.2013.03.001. Epub 2013 Mar 28.

29.

Sirt1 activation by resveratrol is substrate sequence-selective.

Lakshminarasimhan M, Rauh D, Schutkowski M, Steegborn C.

Aging (Albany NY). 2013 Mar;5(3):151-4.

30.

Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts.

Rentzsch A, Kahlert V, Jahreis G, Schlott B, Schutkowski M, Malešević M, Fischer G.

Biol Chem. 2013 Aug;394(8):1057-67. doi: 10.1515/hsz-2013-0125.

PMID:
23492557
31.

Crystal structure analysis of human Sirt2 and its ADP-ribose complex.

Moniot S, Schutkowski M, Steegborn C.

J Struct Biol. 2013 May;182(2):136-43. doi: 10.1016/j.jsb.2013.02.012. Epub 2013 Feb 26.

PMID:
23454361
32.

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.

Wolf A, Rietscher K, Glaß M, Hüttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M.

J Cell Sci. 2013 Apr 15;126(Pt 8):1832-44. doi: 10.1242/jcs.118992. Epub 2013 Feb 26.

33.

Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.

Funkner A, Parthier C, Schutkowski M, Zerweck J, Lilie H, Gyrych N, Fischer G, Stubbs MT, Ferrari DM.

J Mol Biol. 2013 Apr 26;425(8):1340-62. doi: 10.1016/j.jmb.2013.01.029. Epub 2013 Jan 30.

PMID:
23376096
34.

Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.

Fischer F, Gertz M, Suenkel B, Lakshminarasimhan M, Schutkowski M, Steegborn C.

PLoS One. 2012;7(9):e45098. doi: 10.1371/journal.pone.0045098. Epub 2012 Sep 19.

35.

Type III restriction endonuclease EcoP15I is a heterotrimeric complex containing one Res subunit with several DNA-binding regions and ATPase activity.

Wyszomirski KH, Curth U, Alves J, Mackeldanz P, Möncke-Buchner E, Schutkowski M, Krüger DH, Reuter M.

Nucleic Acids Res. 2012 Apr;40(8):3610-22. doi: 10.1093/nar/gkr1239. Epub 2011 Dec 23.

36.

Parvulin 17 promotes microtubule assembly by its peptidyl-prolyl cis/trans isomerase activity.

Thiele A, Krentzlin K, Erdmann F, Rauh D, Hause G, Zerweck J, Kilka S, Pösel S, Fischer G, Schutkowski M, Weiwad M.

J Mol Biol. 2011 Aug 26;411(4):896-909. doi: 10.1016/j.jmb.2011.06.040. Epub 2011 Jun 25.

PMID:
21756916
37.

The protein interaction network mediated by human SH3 domains.

Carducci M, Perfetto L, Briganti L, Paoluzi S, Costa S, Zerweck J, Schutkowski M, Castagnoli L, Cesareni G.

Biotechnol Adv. 2012 Jan-Feb;30(1):4-15. doi: 10.1016/j.biotechadv.2011.06.012. Epub 2011 Jun 29.

PMID:
21740962
38.

Deciphering enzyme function using peptide arrays.

Thiele A, Stangl GI, Schutkowski M.

Mol Biotechnol. 2011 Nov;49(3):283-305. doi: 10.1007/s12033-011-9402-x. Review.

PMID:
21604200
39.

Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain.

Kuhfahl S, Hauburger A, Thieme T, Groppe J, Ihling C, Tomic S, Schutkowski M, Sinz A, Schwarz E.

Biochem Biophys Res Commun. 2011 May 6;408(2):300-5. doi: 10.1016/j.bbrc.2011.04.021. Epub 2011 Apr 9.

PMID:
21510924
40.

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.

Papadopoulos C, Arato K, Lilienthal E, Zerweck J, Schutkowski M, Chatain N, Müller-Newen G, Becker W, de la Luna S.

J Biol Chem. 2011 Feb 18;286(7):5494-505. doi: 10.1074/jbc.M110.157909. Epub 2010 Dec 2.

41.

High density peptide microarrays for proteome-wide fingerprinting of kinase activities in cell lysates.

Thiele A, Weiwad M, Zerweck J, Fischer G, Schutkowski M.

Methods Mol Biol. 2010;669:173-81. doi: 10.1007/978-1-60761-845-4_14.

PMID:
20857366
42.

Antibody signatures defined by high-content peptide microarray analysis.

Masch A, Zerweck J, Reimer U, Wenschuh H, Schutkowski M.

Methods Mol Biol. 2010;669:161-72. doi: 10.1007/978-1-60761-845-4_13.

PMID:
20857365
43.

Synthetic peptide arrays for pathway-level protein monitoring by liquid chromatography-tandem mass spectrometry.

Hewel JA, Liu J, Onishi K, Fong V, Chandran S, Olsen JB, Pogoutse O, Schutkowski M, Wenschuh H, Winkler DF, Eckler L, Zandstra PW, Emili A.

Mol Cell Proteomics. 2010 Nov;9(11):2460-73. doi: 10.1074/mcp.M900456-MCP200. Epub 2010 May 13.

44.

High-density peptide microarrays for reliable identification of phosphorylation sites and upstream kinases.

Thiele A, Zerweck J, Weiwad M, Fischer G, Schutkowski M.

Methods Mol Biol. 2009;570:203-19. doi: 10.1007/978-1-60327-394-7_9. Review.

PMID:
19649595
45.

Peptide arrays for enzyme profiling.

Thiele A, Zerweck J, Schutkowski M.

Methods Mol Biol. 2009;570:19-65. doi: 10.1007/978-1-60327-394-7_2. Review.

PMID:
19649588
46.

Epitope mapping protocols. Preface.

Reineke U, Schutkowski M.

Methods Mol Biol. 2009;524:v-vi. No abstract available.

PMID:
19514158
47.

Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease.

Lorenz P, Kreutzer M, Zerweck J, Schutkowski M, Thiesen HJ.

Methods Mol Biol. 2009;524:247-58. doi: 10.1007/978-1-59745-450-6_18.

PMID:
19377950
48.

Peptide microarrays for profiling of modification state-specific antibodies.

Zerweck J, Masch A, Schutkowski M.

Methods Mol Biol. 2009;524:169-80. doi: 10.1007/978-1-59745-450-6_12.

PMID:
19377944
49.

Major histocompatibility complex class II molecule-human immunodeficiency virus peptide analysis using a microarray chip.

Gaseitsiwe S, Valentini D, Ahmed R, Mahdavifar S, Magalhaes I, Zerweck J, Schutkowski M, Gautherot E, Montero F, Ehrnst A, Reilly M, Maeurer M.

Clin Vaccine Immunol. 2009 Apr;16(4):567-73. doi: 10.1128/CVI.00441-08. Epub 2009 Feb 18.

50.

Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29.

Barak NN, Neumann P, Sevvana M, Schutkowski M, Naumann K, Malesević M, Reichardt H, Fischer G, Stubbs MT, Ferrari DM.

J Mol Biol. 2009 Feb 6;385(5):1630-42. doi: 10.1016/j.jmb.2008.11.052. Epub 2008 Dec 3.

PMID:
19084538

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