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Vitamin K Antagonists, Non-Vitamin K Antagonist Oral Anticoagulants, and Vascular Calcification in Patients with Atrial Fibrillation.

Peeters FECM, Dudink EAMP, Kimenai DM, Weijs B, Altintas S, Heckman LIB, Mihl C, Schurgers LJ, Wildberger JE, Meex SJR, Kietselaer BLJH, Crijns HJGM.

TH Open. 2018 Nov 10;2(4):e391-e398. doi: 10.1055/s-0038-1675578. eCollection 2018 Oct.


Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice.

Posthuma JJ, Posma JJN, van Oerle R, Leenders P, van Gorp RH, Jaminon AMG, Mackman N, Heitmeier S, Schurgers LJ, Ten Cate H, Spronk HMH.

Sci Rep. 2019 Mar 7;9(1):3909. doi: 10.1038/s41598-019-40602-w.


The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K.

Wasilewski GB, Vervloet MG, Schurgers LJ.

Front Cardiovasc Med. 2019 Feb 5;6:6. doi: 10.3389/fcvm.2019.00006. eCollection 2019. Review.


Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.

Gussenhoven R, Klein L, Ophelders DRMG, Habets DHJ, Giebel B, Kramer BW, Schurgers LJ, Reutelingsperger CPM, Wolfs TGAM.

J Clin Med. 2019 Jan 24;8(2). pii: E137. doi: 10.3390/jcm8020137.


Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults.

van Ballegooijen AJ, Beulens JWJ, Schurgers LJ, de Koning EJ, Lips P, van Schoor NM, Vervloet MG.

Nutrients. 2019 Jan 22;11(2). pii: E231. doi: 10.3390/nu11020231.


Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon.

Bucerius J, Dijkgraaf I, Mottaghy FM, Schurgers LJ.

Eur J Nucl Med Mol Imaging. 2019 Jan;46(1):251-265. doi: 10.1007/s00259-018-4176-z. Epub 2018 Oct 9.


Missense mutation of VKORC1 leads to medial arterial calcification in rats.

Michaux A, Matagrin B, Debaux JV, Schurgers LJ, Benoit E, Lattard V.

Sci Rep. 2018 Sep 13;8(1):13733. doi: 10.1038/s41598-018-31788-6.


The role of kidney transplantation and phosphate binder use in vitamin K status.

Jansz TT, Neradova A, van Ballegooijen AJ, Verhaar MC, Vervloet MG, Schurgers LJ, van Jaarsveld BC.

PLoS One. 2018 Aug 30;13(8):e0203157. doi: 10.1371/journal.pone.0203157. eCollection 2018.


Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome.

Miyata KN, Nast CC, Dai T, Dukkipati R, LaPage JA, Troost JP, Schurgers LJ, Kretzler M, Adler SG.

Exp Mol Pathol. 2018 Aug;105(1):120-129. doi: 10.1016/j.yexmp.2018.07.001. Epub 2018 Jul 6.


A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers.

Eersels K, Diliën H, Lowdon JW, Steen Redeker E, Rogosic R, Heidt B, Peeters M, Cornelis P, Lux P, Reutelingsperger CP, Schurgers LJ, Cleij TJ, van Grinsven B.

Nutrients. 2018 Jun 11;10(6). pii: E751. doi: 10.3390/nu10060751.


Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study.

Popko J, Karpiński M, Chojnowska S, Maresz K, Milewski R, Badmaev V, Schurgers LJ.

Nutrients. 2018 Jun 6;10(6). pii: E734. doi: 10.3390/nu10060734.


Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles.

Schurgers LJ, Akbulut AC, Kaczor DM, Halder M, Koenen RR, Kramann R.

Front Cardiovasc Med. 2018 Apr 6;5:36. doi: 10.3389/fcvm.2018.00036. eCollection 2018.


Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling.

Willems BA, Furmanik M, Caron MMJ, Chatrou MLL, Kusters DHM, Welting TJM, Stock M, Rafael MS, Viegas CSB, Simes DC, Vermeer C, Reutelingsperger CPM, Schurgers LJ.

Sci Rep. 2018 Mar 21;8(1):4961. doi: 10.1038/s41598-018-23353-y.


Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design.

Peeters FECM, van Mourik MJW, Meex SJR, Bucerius J, Schalla SM, Gerretsen SC, Mihl C, Dweck MR, Schurgers LJ, Wildberger JE, Crijns HJGM, Kietselaer BLJH.

Nutrients. 2018 Mar 21;10(4). pii: E386. doi: 10.3390/nu10040386.


Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study.

Schumacher SP, Schurgers LJ, Vervloet MG, Neradova A.

Nephrology (Carlton). 2019 Feb;24(2):221-226. doi: 10.1111/nep.13245. Epub 2018 Apr 6.


Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging.

Hendrikx G, Hackeng TM, van Gorp R, Bauwens M, Schurgers LJ, Mottaghy FM, Post MJ, Dijkgraaf I.

Contrast Media Mol Imaging. 2017 Oct 24;2017:8638549. doi: 10.1155/2017/8638549. eCollection 2017.


Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment.

Peeters FECM, Meex SJR, Dweck MR, Aikawa E, Crijns HJGM, Schurgers LJ, Kietselaer BLJH.

Eur Heart J. 2018 Jul 21;39(28):2618-2624. doi: 10.1093/eurheartj/ehx653.


Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype.

Vajen T, Benedikter BJ, Heinzmann ACA, Vasina EM, Henskens Y, Parsons M, Maguire PB, Stassen FR, Heemskerk JWM, Schurgers LJ, Koenen RR.

J Extracell Vesicles. 2017 May 16;6(1):1322454. doi: 10.1080/20013078.2017.1322454. eCollection 2017.


Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.

Brandenburg VM, Reinartz S, Kaesler N, Krüger T, Dirrichs T, Kramann R, Peeters F, Floege J, Keszei A, Marx N, Schurgers LJ, Koos R.

Circulation. 2017 May 23;135(21):2081-2083. doi: 10.1161/CIRCULATIONAHA.116.027011. No abstract available.


Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study.

Neradova A, Schumacher SP, Hubeek I, Lux P, Schurgers LJ, Vervloet MG.

BMC Nephrol. 2017 May 2;18(1):149. doi: 10.1186/s12882-017-0560-3.


The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification: a systematic review.

Houben E, Neradova A, Schurgers LJ, Vervloet M.

G Ital Nefrol. 2016 Nov-Dec;33(6). pii: gin/33.6.5. Review.


Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification.

Kapustin AN, Schoppet M, Schurgers LJ, Reynolds JL, McNair R, Heiss A, Jahnen-Dechent W, Hackeng TM, Schlieper G, Harrison P, Shanahan CM.

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):e22-e32. doi: 10.1161/ATVBAHA.116.308886. Epub 2017 Jan 19.


Does statins promote vascular calcification in chronic kidney disease?

Chen Z, Qureshi AR, Parini P, Hurt-Camejo E, Ripsweden J, Brismar TB, Barany P, Jaminon AM, Schurgers LJ, Heimbürger O, Lindholm B, Stenvinkel P.

Eur J Clin Invest. 2017 Feb;47(2):137-148. doi: 10.1111/eci.12718.


Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice.

Donners MM, Bai L, Lutgens SP, Wijnands E, Johnson J, Schurgers LJ, Liu CL, Daemen MJ, Cleutjens KB, Shi GP, Biessen EA, Heeneman S.

PLoS One. 2016 Sep 16;11(9):e0162595. doi: 10.1371/journal.pone.0162595. eCollection 2016.


Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis?

Brandenburg VM, Evenepoel P, Floege J, Goldsmith D, Kramann R, Massy Z, Mazzaferro S, Schurgers LJ, Sinha S, Torregrosa V, Ureña-Torres P, Vervloet M, Cozzolino M; ERA-EDTA Working Group on CKD-MBD and EUCALNET.

Nephrol Dial Transplant. 2016 Aug;31(8):1211-9. doi: 10.1093/ndt/gfw025. Epub 2016 Mar 22.


New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs).

van Gorp RH, Schurgers LJ.

Nutrients. 2015 Nov 17;7(11):9538-57. doi: 10.3390/nu7115479. Review.


Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis.

Chatrou ML, Cleutjens JP, van der Vusse GJ, Roijers RB, Mutsaers PH, Schurgers LJ.

PLoS One. 2015 Nov 10;10(11):e0142335. doi: 10.1371/journal.pone.0142335. eCollection 2015.


Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).

Vossen LM, Schurgers LJ, van Varik BJ, Kietselaer BL, Vermeer C, Meeder JG, Rahel BM, van Cauteren YJ, Hoffland GA, Rennenberg RJ, Reesink KD, de Leeuw PW, Kroon AA.

Nutrients. 2015 Oct 28;7(11):8905-15. doi: 10.3390/nu7115443.


What's in a name? The pharmacy of vitamin K.

Card DJ, Shearer MJ, Schurgers LJ, Gomez K, Harrington DJ.

Br J Haematol. 2016 Sep;174(6):989-90. doi: 10.1111/bjh.13828. Epub 2015 Oct 22. No abstract available.


Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?

Zaragatski E, Grommes J, Schurgers LJ, Langer S, Kennes L, Tamm M, Koeppel TA, Kranz J, Hackhofer T, Arakelyan K, Jacobs MJ, Kokozidou M.

Kidney Int. 2016 Mar;89(3):601-11.


Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells.

van Niel G, Bergam P, Di Cicco A, Hurbain I, Lo Cicero A, Dingli F, Palmulli R, Fort C, Potier MC, Schurgers LJ, Loew D, Levy D, Raposo G.

Cell Rep. 2015 Oct 6;13(1):43-51. doi: 10.1016/j.celrep.2015.08.057. Epub 2015 Sep 17.


High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification.

Scheiber D, Veulemans V, Horn P, Chatrou ML, Potthoff SA, Kelm M, Schurgers LJ, Westenfeld R.

Nutrients. 2015 Aug 18;7(8):6991-7011. doi: 10.3390/nu7085318.


Circulating annexin A5 predicts mortality in patients with heart failure.

Schurgers LJ, Burgmaier M, Ueland T, Schutters K, Aakhus S, Hofstra L, Gullestad L, Aukrust P, Hellmich M, Narula J, Reutelingsperger CP.

J Intern Med. 2016 Jan;279(1):89-97. doi: 10.1111/joim.12396. Epub 2015 Jul 30.


Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet.

Kusters DH, Chatrou ML, Willems BA, De Saint-Hubert M, Bauwens M, van der Vorst E, Bena S, Biessen EA, Perretti M, Schurgers LJ, Reutelingsperger CP.

PLoS One. 2015 Jun 19;10(6):e0130484. doi: 10.1371/journal.pone.0130484. eCollection 2015.


Prevention of vasculopathy by vitamin K supplementation: can we turn fiction into fact?

Brandenburg VM, Schurgers LJ, Kaesler N, Püsche K, van Gorp RH, Leftheriotis G, Reinartz S, Koos R, Krüger T.

Atherosclerosis. 2015 May;240(1):10-6. doi: 10.1016/j.atherosclerosis.2015.02.040. Epub 2015 Feb 24. Review.


Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.

Kapustin AN, Chatrou ML, Drozdov I, Zheng Y, Davidson SM, Soong D, Furmanik M, Sanchis P, De Rosales RT, Alvarez-Hernandez D, Shroff R, Yin X, Muller K, Skepper JN, Mayr M, Reutelingsperger CP, Chester A, Bertazzo S, Schurgers LJ, Shanahan CM.

Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.


Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis.

Schurgers LJ, Spronk HM.

Thromb Haemost. 2014 Nov;112(5):909-17. doi: 10.1160/TH14-03-0268. Epub 2014 Oct 9. Review.


AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice.

Burgmaier M, Schutters K, Willems B, van der Vorst EP, Kusters D, Chatrou M, Norling L, Biessen EA, Cleutjens J, Perretti M, Schurgers LJ, Reutelingsperger CP.

J Cell Mol Med. 2014 Oct;18(10):2117-24. doi: 10.1111/jcmm.12374. Epub 2014 Sep 12.


The realm of vitamin K dependent proteins: shifting from coagulation toward calcification.

Willems BA, Vermeer C, Reutelingsperger CP, Schurgers LJ.

Mol Nutr Food Res. 2014 Aug;58(8):1620-35. doi: 10.1002/mnfr.201300743. Epub 2014 Feb 17. Review.


Warfarin induces cardiovascular damage in mice.

Krüger T, Oelenberg S, Kaesler N, Schurgers LJ, van de Sandt AM, Boor P, Schlieper G, Brandenburg VM, Fekete BC, Veulemans V, Ketteler M, Vermeer C, Jahnen-Dechent W, Floege J, Westenfeld R.

Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2618-24. doi: 10.1161/ATVBAHA.113.302244. Epub 2013 Aug 29.


Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease.

Schurgers LJ.

Kidney Int. 2013 May;83(5):782-4. doi: 10.1038/ki.2013.26.


Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers.

Theuwissen E, Teunissen KJ, Spronk HM, Hamulyák K, Ten Cate H, Shearer MJ, Vermeer C, Schurgers LJ.

J Thromb Haemost. 2013 Jun;11(6):1085-92. doi: 10.1111/jth.12203.


Warfarin accelerates ectopic mineralization in Abcc6(-/-) mice: clinical relevance to pseudoxanthoma elasticum.

Li Q, Guo H, Chou DW, Harrington DJ, Schurgers LJ, Terry SF, Uitto J.

Am J Pathol. 2013 Apr;182(4):1139-50. doi: 10.1016/j.ajpath.2012.12.037. Epub 2013 Feb 15.


Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization.

Schurgers LJ, Uitto J, Reutelingsperger CP.

Trends Mol Med. 2013 Apr;19(4):217-26. doi: 10.1016/j.molmed.2012.12.008. Epub 2013 Jan 30. Review.


Mechanisms of arterial remodeling: lessons from genetic diseases.

van Varik BJ, Rennenberg RJ, Reutelingsperger CP, Kroon AA, de Leeuw PW, Schurgers LJ.

Front Genet. 2012 Dec 13;3:290. doi: 10.3389/fgene.2012.00290. eCollection 2012.


Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy.

Kramann R, Brandenburg VM, Schurgers LJ, Ketteler M, Westphal S, Leisten I, Bovi M, Jahnen-Dechent W, Knüchel R, Floege J, Schneider RK.

Nephrol Dial Transplant. 2013 Apr;28(4):856-68. doi: 10.1093/ndt/gfs466. Epub 2012 Dec 6.


Matrix gla protein and alkaline phosphatase are differently modulated in human dermal fibroblasts from PXE patients and controls.

Boraldi F, Annovi G, Vermeer C, Schurgers LJ, Trenti T, Tiozzo R, Guerra D, Quaglino D.

J Invest Dermatol. 2013 Apr;133(4):946-54. doi: 10.1038/jid.2012.460. Epub 2012 Dec 6.


Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.

Sato T, Schurgers LJ, Uenishi K.

Nutr J. 2012 Nov 12;11:93. doi: 10.1186/1475-2891-11-93.


Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients.

Boxma PY, van den Berg E, Geleijnse JM, Laverman GD, Schurgers LJ, Vermeer C, Kema IP, Muskiet FA, Navis G, Bakker SJ, de Borst MH.

PLoS One. 2012;7(10):e47991. doi: 10.1371/journal.pone.0047991. Epub 2012 Oct 31.


Calcification inhibitors in vascular calciphylaxis associated with normal renal function.

Brandenburg V, Al-Fakhri N, Nemeth K, Goettsch C, Schurgers LJ, Vermeer C, Hofbauer LC, Schoppet M.

Thromb Haemost. 2012 Dec;108(6):1241-3. doi: 10.1160/TH12-07-0484. Epub 2012 Oct 23. No abstract available.


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