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Items: 1 to 50 of 564

1.

Investigating fibrosis and inflammation in an ex vivo NASH murine model.

Gore E, Bigaeva E, Oldenburger A, Jansen YJM, Schuppan D, Boersema M, Rippmann JF, Broermann A, Olinga P.

Am J Physiol Gastrointest Liver Physiol. 2020 Jan 6. doi: 10.1152/ajpgi.00209.2019. [Epub ahead of print]

PMID:
31905025
2.

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis.

Harrison SA, Goodman Z, Jabbar A, Vemulapalli R, Younes ZH, Freilich B, Sheikh MY, Schattenberg JM, Kayali Z, Zivony A, Sheikh A, Garcia-Samaniego J, Satapathy SK, Therapondos G, Mena E, Schuppan D, Robinson J, Chan JL, Hagerty DT, Sanyal AJ.

J Hepatol. 2019 Dec 27. pii: S0168-8278(19)30758-5. doi: 10.1016/j.jhep.2019.11.024. [Epub ahead of print]

PMID:
31887369
3.

The enemy within the gut: bacterial pathogens in celiac autoimmunity.

Verdu EF, Schuppan D.

Nat Struct Mol Biol. 2020 Jan;27(1):5-7. doi: 10.1038/s41594-019-0360-5. No abstract available.

PMID:
31873302
4.

Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease.

Ashfaq-Khan M, Aslam M, Qureshi MA, Senkowski MS, Yen-Weng S, Strand S, Kim YO, Pickert G, Schattenberg JM, Schuppan D.

Sci Rep. 2019 Nov 25;9(1):17463. doi: 10.1038/s41598-019-53323-x.

5.

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension.

Helmstädter J, Frenis K, Filippou K, Grill A, Dib M, Kalinovic S, Pawelke F, Kus K, Kröller-Schön S, Oelze M, Chlopicki S, Schuppan D, Wenzel P, Ruf W, Drucker DJ, Münzel T, Daiber A, Steven S.

Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):145-158. doi: 10.1161/atv.0000615456.97862.30. Epub 2019 Nov 21.

PMID:
31747801
6.

Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices.

Bigaeva E, Gore E, Mutsaers HAM, Oosterhuis D, Kim YO, Schuppan D, Bank RA, Boersema M, Olinga P.

Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165582. doi: 10.1016/j.bbadis.2019.165582. Epub 2019 Oct 30.

7.

Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer.

Wei G, An P, Vaid KA, Nasser I, Huang P, Tan L, Zhao S, Schuppan D, Popov YV.

Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G174-G188. doi: 10.1152/ajpgi.00041.2019. Epub 2019 Oct 21.

8.

Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients.

Nielsen MJ, Villesen IF, Gudmann NS, Leeming DJ, Krag A, Karsdal MA, Zimmermann T, Schuppan D.

Sci Rep. 2019 Oct 16;9(1):14857. doi: 10.1038/s41598-019-51394-4.

9.

Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?

Karsdal MA, Detlefsen S, Daniels SJ, Nielsen MJ, Krag A, Schuppan D.

Hepatology. 2020 Jan;71(1):346-351. doi: 10.1002/hep.30969. Epub 2019 Dec 18. Review. No abstract available.

PMID:
31553813
10.

PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices.

Gore E, Bigaeva E, Oldenburger A, Kim YO, Rippmann JF, Schuppan D, Boersema M, Olinga P.

Biochem Pharmacol. 2019 Nov;169:113633. doi: 10.1016/j.bcp.2019.113633. Epub 2019 Sep 5.

11.

Deletion of organic cation transporter Oct3 promotes hepatic fibrosis via upregulation of TGFβ.

Vollmar J, Kim YO, Marquardt JU, Becker D, Galle PR, Schuppan D, Zimmermann T.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G195-G202. doi: 10.1152/ajpgi.00088.2019. Epub 2019 Jun 26.

PMID:
31241979
12.

α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages.

Leber N, Kaps L, Yang A, Aslam M, Giardino M, Klefenz A, Choteschovsky N, Rosigkeit S, Mostafa A, Nuhn L, Schuppan D, Zentel R.

Macromol Biosci. 2019 Jul;19(7):e1900162. doi: 10.1002/mabi.201900162. Epub 2019 Jun 7.

PMID:
31173461
13.

Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E.

Fritscher-Ravens A, Pflaum T, Mösinger M, Ruchay Z, Röcken C, Milla PJ, Das M, Böttner M, Wedel T, Schuppan D.

Gastroenterology. 2019 Jul;157(1):109-118.e5. doi: 10.1053/j.gastro.2019.03.046. Epub 2019 May 15.

PMID:
31100380
14.

Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo.

Darwish G, Helmerhorst EJ, Schuppan D, Oppenheim FG, Wei G.

Sci Rep. 2019 May 16;9(1):7505. doi: 10.1038/s41598-019-43837-9.

15.

Clinical Guide and Update on Porphyrias.

Stölzel U, Doss MO, Schuppan D.

Gastroenterology. 2019 Aug;157(2):365-381.e4. doi: 10.1053/j.gastro.2019.04.050. Epub 2019 May 11. Review.

PMID:
31085196
16.

Nanoscale distribution of TLR4 on primary human macrophages stimulated with LPS and ATI.

Neumann J, Ziegler K, Gelléri M, Fröhlich-Nowoisky J, Liu F, Bellinghausen I, Schuppan D, Birk U, Pöschl U, Cremer C, Lucas K.

Nanoscale. 2019 May 16;11(19):9769-9779. doi: 10.1039/c9nr00943d.

PMID:
31066732
17.

Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma.

Terryberry J, Tuomi J, Perampalam S, Peloquin R, Brouwer E, Schuppan D, Guandalini S.

Clin Chem Lab Med. 2019 Jul 26;57(8):1207-1217. doi: 10.1515/cclm-2019-0088.

PMID:
30903755
18.

Cirrhosis risk score of the donor organ predicts early fibrosis progression after liver transplantation.

Zimmermann A, Darstein F, Hoppe-Lotichius M, Toenges G, Lautem A, Abel F, Schad A, Mittler J, Vollmar J, Grimm D, Lang H, Galle PR, Zimmermann T, Schuppan D.

J Gastrointestin Liver Dis. 2019 Mar;28(1):53-61. doi: 10.15403/jgld.2014.1121.281.crr.

19.

Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins.

Caminero A, McCarville JL, Zevallos VF, Pigrau M, Yu XB, Jury J, Galipeau HJ, Clarizio AV, Casqueiro J, Murray JA, Collins SM, Alaedini A, Bercik P, Schuppan D, Verdu EF.

Gastroenterology. 2019 Jun;156(8):2266-2280. doi: 10.1053/j.gastro.2019.02.028. Epub 2019 Feb 22.

PMID:
30802444
20.

Nitration of Wheat Amylase Trypsin Inhibitors Increases Their Innate and Adaptive Immunostimulatory Potential in vitro.

Ziegler K, Neumann J, Liu F, Fröhlich-Nowoisky J, Cremer C, Saloga J, Reinmuth-Selzle K, Pöschl U, Schuppan D, Bellinghausen I, Lucas K.

Front Immunol. 2019 Jan 21;9:3174. doi: 10.3389/fimmu.2018.03174. eCollection 2018.

21.

The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor.

van Dijk F, Teekamp N, Post E, Schuppan D, Kim YO, Zuidema J, Steendam R, Klose MHM, Meier-Menches SM, Casini A, Horvatovich PL, Sijbrandi NJ, Frijlink HW, Hinrichs WLJ, Poelstra K, Beljaars L, Olinga P.

J Control Release. 2019 Feb 28;296:250-257. doi: 10.1016/j.jconrel.2018.12.039. Epub 2019 Jan 22.

22.

Histamine causes influx via T-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions.

Pfanzagl B, Zevallos VF, Schuppan D, Pfragner R, Jensen-Jarolim E.

Am J Physiol Gastrointest Liver Physiol. 2019 Feb 1;316(2):G291-G303. doi: 10.1152/ajpgi.00261.2018. Epub 2018 Dec 12.

23.

Management of celiac disease in daily clinical practice.

Elli L, Ferretti F, Orlando S, Vecchi M, Monguzzi E, Roncoroni L, Schuppan D.

Eur J Intern Med. 2019 Mar;61:15-24. doi: 10.1016/j.ejim.2018.11.012. Epub 2018 Dec 5. Review.

PMID:
30528262
24.

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

Kazankov K, Jørgensen SMD, Thomsen KL, Møller HJ, Vilstrup H, George J, Schuppan D, Grønbæk H.

Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):145-159. doi: 10.1038/s41575-018-0082-x. Review.

PMID:
30482910
25.

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways.

Schink A, Naumoska K, Kitanovski Z, Kampf CJ, Fröhlich-Nowoisky J, Thines E, Pöschl U, Schuppan D, Lucas K.

Food Funct. 2018 Nov 14;9(11):5950-5964. doi: 10.1039/c8fo01286e.

PMID:
30379176
26.

Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis.

Farrell G, Schattenberg JM, Leclercq I, Yeh MM, Goldin R, Teoh N, Schuppan D.

Hepatology. 2019 May;69(5):2241-2257. doi: 10.1002/hep.30333. Review.

27.

Celiac disease and endocrine autoimmunity - the genetic link.

Kahaly GJ, Frommer L, Schuppan D.

Autoimmun Rev. 2018 Dec;17(12):1169-1175. doi: 10.1016/j.autrev.2018.05.013. Epub 2018 Oct 12. Review.

PMID:
30316996
28.

Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects.

Schink A, Neumann J, Leifke AL, Ziegler K, Fröhlich-Nowoisky J, Cremer C, Thines E, Weber B, Pöschl U, Schuppan D, Lucas K.

PLoS One. 2018 Oct 11;13(10):e0203907. doi: 10.1371/journal.pone.0203907. eCollection 2018.

29.

Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany.

Labenz C, Huber Y, Kalliga E, Nagel M, Ruckes C, Straub BK, Galle PR, Wörns MA, Anstee QM, Schuppan D, Schattenberg JM.

Aliment Pharmacol Ther. 2018 Nov;48(10):1109-1116. doi: 10.1111/apt.14976. Epub 2018 Oct 4.

PMID:
30288767
30.

Assessment of liver fibrosis progression and regression by a serological collagen turnover profile.

Karsdal MA, Hjuler ST, Luo Y, Rasmussen DGK, Nielsen MJ, Holm Nielsen S, Leeming DJ, Goodman Z, Arch RH, Patel K, Schuppan D.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G25-G31. doi: 10.1152/ajpgi.00158.2018. Epub 2018 Aug 30.

31.

Monitoring Translation Activity of mRNA-Loaded Nanoparticles in Mice.

Rosigkeit S, Meng M, Grunwitz C, Gomes P, Kreft A, Hayduk N, Heck R, Pickert G, Ziegler K, Abassi Y, Röder J, Kaps L, Vascotto F, Beissert T, Witzel S, Kuhn A, Diken M, Schuppan D, Sahin U, Haas H, Bockamp E.

Mol Pharm. 2018 Sep 4;15(9):3909-3919. doi: 10.1021/acs.molpharmaceut.8b00370. Epub 2018 Aug 9.

PMID:
30028629
32.

Celiac Disease and Glandular Autoimmunity.

Kahaly GJ, Frommer L, Schuppan D.

Nutrients. 2018 Jun 25;10(7). pii: E814. doi: 10.3390/nu10070814. Review.

33.

Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice.

Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, Christen U.

J Autoimmun. 2018 Jul;91:83-96. doi: 10.1016/j.jaut.2018.05.001. Epub 2018 May 9.

PMID:
29753567
34.

Liver fibrosis: Direct antifibrotic agents and targeted therapies.

Schuppan D, Ashfaq-Khan M, Yang AT, Kim YO.

Matrix Biol. 2018 Aug;68-69:435-451. doi: 10.1016/j.matbio.2018.04.006. Epub 2018 Apr 12. Review.

PMID:
29656147
35.

Influence of low FODMAP and gluten-free diets on disease activity and intestinal microbiota in patients with non-celiac gluten sensitivity.

Dieterich W, Schuppan D, Schink M, Schwappacher R, Wirtz S, Agaimy A, Neurath MF, Zopf Y.

Clin Nutr. 2019 Apr;38(2):697-707. doi: 10.1016/j.clnu.2018.03.017. Epub 2018 Apr 4.

PMID:
29653862
36.

Enhanced protection of C57 BL/6 vs Balb/c mice to melanoma liver metastasis is mediated by NK cells.

Foerster F, Boegel S, Heck R, Pickert G, Rüssel N, Rosigkeit S, Bros M, Strobl S, Kaps L, Aslam M, Diken M, Castle J, Sahin U, Tuettenberg A, Bockamp E, Schuppan D.

Oncoimmunology. 2017 Dec 26;7(4):e1409929. doi: 10.1080/2162402X.2017.1409929. eCollection 2018.

37.

Dietary wheat amylase trypsin inhibitors exacerbate murine allergic airway inflammation.

Zevallos VF, Raker VK, Maxeiner J, Scholtes P, Steinbrink K, Schuppan D.

Eur J Nutr. 2019 Jun;58(4):1507-1514. doi: 10.1007/s00394-018-1681-6. Epub 2018 Mar 29.

PMID:
29600329
38.

The immune contexture of hepatocellular carcinoma predicts clinical outcome.

Foerster F, Hess M, Gerhold-Ay A, Marquardt JU, Becker D, Galle PR, Schuppan D, Binder H, Bockamp E.

Sci Rep. 2018 Mar 29;8(1):5351. doi: 10.1038/s41598-018-21937-2.

39.

Wheat amylase-trypsin inhibitors exacerbate intestinal and airway allergic immune responses in humanized mice.

Bellinghausen I, Weigmann B, Zevallos V, Maxeiner J, Reißig S, Waisman A, Schuppan D, Saloga J.

J Allergy Clin Immunol. 2019 Jan;143(1):201-212.e4. doi: 10.1016/j.jaci.2018.02.041. Epub 2018 Mar 21.

PMID:
29574077
40.

Niemann-Pick type C2 protein supplementation in experimental non-alcoholic fatty liver disease.

Christensen CU, Glavind E, Thomsen KL, Kim YO, Heebøll S, Schuppan D, Hamilton-Dutoit S, Würtz Heegaard C, Grønbæk H.

PLoS One. 2018 Mar 9;13(3):e0192728. doi: 10.1371/journal.pone.0192728. eCollection 2018.

41.

IL10 promoter haplotypes may contribute to altered cytokine expression and systemic inflammation in celiac disease.

Hofmann SR, Laass MW, Fehrs A, Schuppan D, Zevallos VF, Salminger D, Mäbert K, Hedrich CM.

Clin Immunol. 2018 May;190:15-21. doi: 10.1016/j.clim.2018.02.010. Epub 2018 Feb 24.

PMID:
29481982
42.

IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal.

Weng SY, Wang X, Vijayan S, Tang Y, Kim YO, Padberg K, Regen T, Molokanova O, Chen T, Bopp T, Schild H, Brombacher F, Crosby JR, McCaleb ML, Waisman A, Bockamp E, Schuppan D.

EBioMedicine. 2018 Mar;29:92-103. doi: 10.1016/j.ebiom.2018.01.028. Epub 2018 Feb 17.

43.

Outcome measures in coeliac disease trials: the Tampere recommendations.

Ludvigsson JF, Ciacci C, Green PH, Kaukinen K, Korponay-Szabo IR, Kurppa K, Murray JA, Lundin KEA, Maki MJ, Popp A, Reilly NR, Rodriguez-Herrera A, Sanders DS, Schuppan D, Sleet S, Taavela J, Voorhees K, Walker MM, Leffler DA.

Gut. 2018 Aug;67(8):1410-1424. doi: 10.1136/gutjnl-2017-314853. Epub 2018 Feb 13.

44.

Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.

Vollmar J, Lautem A, Closs E, Schuppan D, Kim YO, Grimm D, Marquardt JU, Fuchs P, Straub BK, Schad A, Gründemann D, Schattenberg JM, Gehrke N, Wörns MA, Baumgart J, Galle PR, Zimmermann T.

Oncotarget. 2017 Dec 18;8(70):115667-115680. doi: 10.18632/oncotarget.23372. eCollection 2017 Dec 29.

45.

Self-reported dietary adherence, disease-specific symptoms, and quality of life are associated with healthcare provider follow-up in celiac disease.

Hughey JJ, Ray BK, Lee AR, Voorhees KN, Kelly CP, Schuppan D.

BMC Gastroenterol. 2017 Dec 11;17(1):156. doi: 10.1186/s12876-017-0713-7.

46.

Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver.

van Dijk F, Teekamp N, Beljaars L, Post E, Zuidema J, Steendam R, Kim YO, Frijlink HW, Schuppan D, Poelstra K, Hinrichs WLJ, Olinga P.

J Control Release. 2018 Jan 10;269:258-265. doi: 10.1016/j.jconrel.2017.11.029. Epub 2017 Nov 21.

47.

The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update.

Catassi C, Alaedini A, Bojarski C, Bonaz B, Bouma G, Carroccio A, Castillejo G, De Magistris L, Dieterich W, Di Liberto D, Elli L, Fasano A, Hadjivassiliou M, Kurien M, Lionetti E, Mulder CJ, Rostami K, Sapone A, Scherf K, Schuppan D, Trott N, Volta U, Zevallos V, Zopf Y, Sanders DS.

Nutrients. 2017 Nov 21;9(11). pii: E1268. doi: 10.3390/nu9111268. Review.

48.

Determinants of fibrosis progression and regression in NASH.

Schuppan D, Surabattula R, Wang XY.

J Hepatol. 2018 Feb;68(2):238-250. doi: 10.1016/j.jhep.2017.11.012. Epub 2017 Nov 14. Review.

PMID:
29154966
49.

Targeting myeloid cells in the tumor sustaining microenvironment.

Schupp J, Krebs FK, Zimmer N, Trzeciak E, Schuppan D, Tuettenberg A.

Cell Immunol. 2019 Sep;343:103713. doi: 10.1016/j.cellimm.2017.10.013. Epub 2017 Nov 2. Review.

PMID:
29129292
50.

Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation.

Molokanova O, Schönig K, Weng SY, Wang X, Bros M, Diken M, Ohngemach S, Karsdal M, Strand D, Nikolaev A, Eshkind L, Schuppan D.

Matrix Biol. 2018 Mar;66:34-49. doi: 10.1016/j.matbio.2017.11.002. Epub 2017 Nov 6.

PMID:
29122677

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