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Items: 1 to 50 of 314

1.

Discovery of novel lead in the group of N-substituted piperazine ether derivatives with potential histamine H3 receptor activity.

Kuder KJ, Stachnik M, Schunack W, Szymańska E, Kieć-Kononowicz K.

Med Chem. 2014;10(6):588-99.

PMID:
24047214
2.

N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands.

Więcek M, Kottke T, Ligneau X, Schunack W, Seifert R, Stark H, Handzlik J, Kieć-Kononowicz K.

Bioorg Med Chem. 2011 May 1;19(9):2850-8. doi: 10.1016/j.bmc.2011.03.046. Epub 2011 Mar 24.

PMID:
21498080
3.

Histamine elevates free intracellular calcium in mouse retinal dopaminergic cells via H1-receptors.

Frazão R, McMahon DG, Schunack W, Datta P, Heidelberger R, Marshak DW.

Invest Ophthalmol Vis Sci. 2011 May 10;52(6):3083-8. doi: 10.1167/iovs.10-6160.

4.

Antihistaminic drugs modify casein-induced inflammation in the rat.

Rzodkiewicz P, Wojtecka-Lukasik E, Szukiewicz D, Schunack W, Maslinski S.

Inflamm Res. 2010 Mar;59 Suppl 2:S187-8. doi: 10.1007/s00011-009-0124-5.

PMID:
20012883
5.

Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.

Łazewska D, Wiecek M, Ligneau X, Kottke T, Weizel L, Seifert R, Schunack W, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6682-5. doi: 10.1016/j.bmcl.2009.10.005. Epub 2009 Oct 6.

PMID:
19846299
6.

Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands.

Łazewska D, Kuder K, Ligneau X, Camelin JC, Schunack W, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2009 Apr 15;17(8):3037-42. doi: 10.1016/j.bmc.2009.03.014. Epub 2009 Mar 14.

PMID:
19329325
7.

Histamine chloramine modifies casein-induced inflammation.

Wojtecka-Lukasik E, Rzodkiewicz P, Maslinska D, Szukiewicz D, Schunack W, Maslinski S.

Inflamm Res. 2009 Apr;58 Suppl 1:20-1. doi: 10.1007/s00011-009-0648-8. No abstract available.

PMID:
19271131
8.

Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands.

Kuder KJ, Ligneau X, Camelin JC, Lazewska D, Schwartz JC, Schunack W, Stark H, Kieć-Kononowicz K.

Inflamm Res. 2009 Apr;58 Suppl 1:47-8. doi: 10.1007/s00011-009-2002-6. No abstract available.

PMID:
19266264
9.

Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives.

Weis R, Schweiger K, Faist J, Rajkovic E, Kungl AJ, Fabian WM, Schunack W, Seebacher W.

Bioorg Med Chem. 2008 Dec 15;16(24):10326-31. doi: 10.1016/j.bmc.2008.10.042. Epub 2008 Oct 22.

PMID:
18977145
10.

[Not smoking, essential for healthy lungs].

Schunack W.

Pharm Unserer Zeit. 2008;37(6):494-9. doi: 10.1002/pauz.200800289. Review. German. No abstract available.

PMID:
18956365
11.

Refined docking as a valuable tool for lead optimization: application to histamine H3 receptor antagonists.

Levoin N, Calmels T, Poupardin-Olivier O, Labeeuw O, Danvy D, Robert P, Berrebi-Bertrand I, Ganellin CR, Schunack W, Stark H, Capet M.

Arch Pharm (Weinheim). 2008 Oct;341(10):610-23. doi: 10.1002/ardp.200800042.

PMID:
18816585
12.

Piperidine variations in search for non-imidazole histamine H(3) receptor ligands.

Łazewska D, Kuder K, Ligneau X, Schwartz JC, Schunack W, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2008 Sep 15;16(18):8729-36. doi: 10.1016/j.bmc.2008.07.071. Epub 2008 Jul 29.

PMID:
18774720
13.

Effect of histamine chloramine on luminol-dependent chemiluminescence of granulocytes.

Wojtecka-Lukasik E, Grzybowska-Kowalczyk A, Maslinska D, Szukiewicz D, Schunack W, Maslinski S.

Inflamm Res. 2008;57 Suppl 1:S19-20. doi: 10.1007/s00011-007-0609-z. No abstract available.

PMID:
18345508
14.

Influence of (R)-alpha-methylhistamine on the histamine H3 receptor in the rat gastrointestinal tract.

Chazot P, Shenton F, Schunack W, Grandi D, Morini G.

Inflamm Res. 2007 Apr;56 Suppl 1:S19-20. No abstract available.

PMID:
17806162
15.

Contractile properties of various histaprodifen derivatives in guinea pig isolated ileum and trachea.

Christophe B, Carlier B, Schunack W, Chatelain P, Peck M, Massingham R.

Pharmacology. 2007;79(2):104-13. Epub 2006 Dec 12.

PMID:
17164592
16.

BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.

Ligneau X, Perrin D, Landais L, Camelin JC, Calmels TP, Berrebi-Bertrand I, Lecomte JM, Parmentier R, Anaclet C, Lin JS, Bertaina-Anglade V, la Rochelle CD, d'Aniello F, Rouleau A, Gbahou F, Arrang JM, Ganellin CR, Stark H, Schunack W, Schwartz JC.

J Pharmacol Exp Ther. 2007 Jan;320(1):365-75. Epub 2006 Sep 27.

PMID:
17005916
17.

Histamine-induced ion secretion across rat distal colon: involvement of histamine H1 and H2 receptors.

Schultheiss G, Hennig B, Schunack W, Prinz G, Diener M.

Eur J Pharmacol. 2006 Sep 28;546(1-3):161-70. Epub 2006 Aug 1.

PMID:
16919622
18.

[Vitamin D3--a prodrug of different D3-hormones].

Schunack W.

Med Klin (Munich). 2006 Jun;101 Suppl 1:20-4. German.

PMID:
16826365
19.
20.

Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists.

Łazewska D, Ligneau X, Schwartz JC, Schunack W, Stark H, Kieć-Kononowicz K.

Bioorg Med Chem. 2006 May 15;14(10):3522-9. Epub 2006 Feb 8.

PMID:
16466921
21.

Piperidine-containing histamine H3 receptor antagonists of the carbamate series: the alkyl derivatives.

Lazewska D, Kieć-Kononowicz K, Elz S, Pertz HH, Stark H, Schunack W.

Pharmazie. 2005 Jun;60(6):403-10.

PMID:
15997826
22.

Effect of H3 receptor ligands on ethanol-induced damage in rat gastric mucosal cells.

Uberti L, Silvotti L, Schunack W, Morini G.

Inflamm Res. 2005 Apr;54 Suppl 1:S64-5. No abstract available.

PMID:
15928838
23.

Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives.

Apelt J, Grassmann S, Ligneau X, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H.

Pharmazie. 2005 Feb;60(2):97-106.

PMID:
15739896
24.

The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat.

Baldi E, Bucherelli C, Schunack W, Cenni G, Blandina P, Passani MB.

Neuropharmacology. 2005 Feb;48(2):246-51.

PMID:
15695163
25.
26.

Medicinal chemical and pharmacological aspects of imidazole-containing histamine H3 receptor antagonists.

Stark H, Kathmann M, Schlicker E, Schunack W, Schlegel B, Sippl W.

Mini Rev Med Chem. 2004 Nov;4(9):965-77. Review.

PMID:
15544557
27.

Structure-activity relationships of histamine H1-receptor agonists.

Pertz HH, Elz S, Schunack W.

Mini Rev Med Chem. 2004 Nov;4(9):935-40. Review.

PMID:
15544554
28.

Protective effect of BP 2-94, a histamine H3-receptor agonist prodrug, in a model of carbon tetrachloride-induced hepatotoxicity in rats.

Valcheva-Kuzmanova SV, Popova PB, Krasnaliev IJ, Galunska BT, Belcheva A, Schunack W.

Folia Med (Plovdiv). 2004;46(2):36-41.

PMID:
15506549
29.

Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives.

Grassmann S, Apelt J, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H.

Arch Pharm (Weinheim). 2004 Oct;337(10):533-45.

PMID:
15476285
30.

Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain.

Sadek B, Elz S, Pertz HH, Stark H, Schunack W.

Inflamm Res. 2004 Aug;53 Suppl 2:S109-15. Epub 2004 Aug 10.

PMID:
15338060
31.

H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.

Galeotti N, Malmberg-Aiello P, Bartolini A, Schunack W, Ghelardini C.

Neuropharmacology. 2004 Aug;47(2):295-303.

PMID:
15223308
32.

Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain.

Pelloux-Léon N, Fkyerat A, Piripitsi A, Tertiuk W, Schunack W, Stark H, Garbarg M, Ligneau X, Arrang JM, Schwartz JC, Ganellin CR.

J Med Chem. 2004 Jun 3;47(12):3264-74.

PMID:
15163206
33.

4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists.

Meier G, Krause M, Hüls A, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H.

J Med Chem. 2004 May 6;47(10):2678-87.

PMID:
15115409
34.

Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists.

Mikó T, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H.

Bioorg Med Chem. 2004 May 15;12(10):2727-36.

PMID:
15110854
35.

Neuronal histamine H(3) receptors mediate antisecretory effects in the rat isolated gastric fundus.

Adami M, Coruzzi G, Guaita E, Schunack W, Kitbunnadaj R, Timmermann H.

Inflamm Res. 2004 Mar;53 Suppl 1:S25-6. Epub 2004 Mar 5. No abstract available.

PMID:
15054602
36.

Mutational analysis of the histamine H1-receptor binding pocket of histaprodifens.

Bruysters M, Pertz HH, Teunissen A, Bakker RA, Gillard M, Chatelain P, Schunack W, Timmerman H, Leurs R.

Eur J Pharmacol. 2004 Mar 8;487(1-3):55-63.

PMID:
15033376
37.

Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists.

Govoni M, Bakker RA, van de Wetering I, Smit MJ, Menge WM, Timmerman H, Elz S, Schunack W, Leurs R.

J Med Chem. 2003 Dec 18;46(26):5812-24.

PMID:
14667234
38.

[Regarding public health there is no doubt that in Germany and Europe that it is driven by economic considerations].

Schunack W, Schubert-Zsilavecz M.

Pharm Unserer Zeit. 2003;32(6):445. German. No abstract available.

PMID:
14651041
39.
40.

[Cardiovascular risk factor reduction. Cholesterol absorption inhibitors: a new action principle].

Schunack W.

Pharm Unserer Zeit. 2003;32(6):498-502. Review. German. No abstract available.

PMID:
14639831
41.

Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide.

Pierpaoli S, Marzocca C, Bello MG, Schunack W, Mannaioni PF, Masini E.

Inflamm Res. 2003 Sep;52(9):390-6.

PMID:
14504667
42.

Protean agonism at histamine H3 receptors in vitro and in vivo.

Gbahou F, Rouleau A, Morisset S, Parmentier R, Crochet S, Lin JS, Ligneau X, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11086-91. Epub 2003 Sep 5.

43.

Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor.

Schwartz JC, Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Arrang JM.

J Neural Transm Suppl. 2003;(64):1-16. Review.

PMID:
12830926
44.

Histamine H1-agonist properties of histaprodifen derivatives on guinea-pig isolated trachea and ileum.

Christophe B, Carlier B, Schunack W, Chatelain P, Peck MJ, Massingham R.

Inflamm Res. 2003 Apr;52 Suppl 1:S51-2. No abstract available.

PMID:
12755408
45.

Pro-cognitive effect of a selective histamine H1-receptor agonist, 2-(3-trifluoromethylphenyl)histamine, in the rat object recognition test.

Malmberg-Aiello P, Ipponi A, Blandina P, Bartolini L, Schunack W.

Inflamm Res. 2003 Apr;52 Suppl 1:S33-4. No abstract available.

PMID:
12755399
46.

Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities.

Grassmann S, Apelt J, Sippl W, Ligneau X, Pertz HH, Zhao YH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H.

Bioorg Med Chem. 2003 May 15;11(10):2163-74.

PMID:
12713826
47.

Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds.

Mikó T, Ligneau X, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H.

J Med Chem. 2003 Apr 10;46(8):1523-30.

PMID:
12672253
48.

Molecular characterization of specific H1-receptor agonists histaprodifen and its Nalpha-substituted analogues on bovine aortic H1-receptors.

Carman-Krzan M, Bavec A, Zorko M, Schunack W.

Naunyn Schmiedebergs Arch Pharmacol. 2003 May;367(5):538-46. Epub 2003 Mar 25.

PMID:
12669185
49.

Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor.

Seifert R, Wenzel-Seifert K, Burckstummer T, Pertz HH, Schunack W, Dove S, Buschauer A, Elz S.

J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.

PMID:
12626648
50.

Replacement of imidazole by a piperidine moiety differentially affects the potency of histamine H3-receptor antagonists.

Liedtke S, Flau K, Kathmann M, Schlicker E, Stark H, Meier G, Schunack W.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jan;367(1):43-50. Epub 2002 Nov 14.

PMID:
12616340

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