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Items: 1 to 50 of 135

1.

How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics.

Fonkeu Y, Kraynyukova N, Hafner AS, Kochen L, Sartori F, Schuman EM, Tchumatchenko T.

Neuron. 2019 Jul 23. pii: S0896-6273(19)30572-0. doi: 10.1016/j.neuron.2019.06.022. [Epub ahead of print]

PMID:
31350097
2.

A genetically encodable cell-type-specific protein synthesis inhibitor.

Heumüller M, Glock C, Rangaraju V, Biever A, Schuman EM.

Nat Methods. 2019 Aug;16(8):699-702. doi: 10.1038/s41592-019-0468-x. Epub 2019 Jul 15.

PMID:
31308551
3.

Local translation in neurons: visualization and function.

Holt CE, Martin KC, Schuman EM.

Nat Struct Mol Biol. 2019 Jul;26(7):557-566. doi: 10.1038/s41594-019-0263-5. Epub 2019 Jul 3. Review.

PMID:
31270476
4.

Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge.

Langebeck-Jensen K, Shahar OD, Schuman EM, Langer JD, Ryu S.

Proteomics. 2019 Jul;19(14):e1900028. doi: 10.1002/pmic.201900028.

PMID:
31168896
5.

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments.

Hafner AS, Donlin-Asp PG, Leitch B, Herzog E, Schuman EM.

Science. 2019 May 17;364(6441). pii: eaau3644. doi: 10.1126/science.aau3644.

PMID:
31097639
6.

Local translation in neuronal processes.

Biever A, Donlin-Asp PG, Schuman EM.

Curr Opin Neurobiol. 2019 Aug;57:141-148. doi: 10.1016/j.conb.2019.02.008. Epub 2019 Mar 9. Review.

PMID:
30861464
7.

ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.

Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ.

Nat Commun. 2019 Jan 30;10(1):486. doi: 10.1038/s41467-019-08420-w.

8.

Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity.

Rangaraju V, Lauterbach M, Schuman EM.

Cell. 2019 Jan 10;176(1-2):73-84.e15. doi: 10.1016/j.cell.2018.12.013. Epub 2019 Jan 3.

PMID:
30612742
9.

Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo.

Alvarez-Castelao B, Schanzenbächer CT, Langer JD, Schuman EM.

Nat Protoc. 2019 Feb;14(2):556-575. doi: 10.1038/s41596-018-0106-6.

PMID:
30610240
10.

A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons.

Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman EM, Schwalbe H.

Chembiochem. 2018 Dec 4;19(23):2458-2464. doi: 10.1002/cbic.201800408. Epub 2018 Nov 8.

PMID:
30311996
11.

Local and global influences on protein turnover in neurons and glia.

Dörrbaum AR, Kochen L, Langer JD, Schuman EM.

Elife. 2018 Jun 19;7. pii: e34202. doi: 10.7554/eLife.34202.

12.

Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments.

Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM.

Neuron. 2018 May 2;98(3):495-511.e6. doi: 10.1016/j.neuron.2018.03.030. Epub 2018 Apr 12.

13.

Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses.

Schanzenbächer CT, Langer JD, Schuman EM.

Elife. 2018 Feb 15;7. pii: e33322. doi: 10.7554/eLife.33322.

14.

Cell-type-specific metabolic labeling of nascent proteomes in vivo.

Alvarez-Castelao B, Schanzenbächer CT, Hanus C, Glock C, Tom Dieck S, Dörrbaum AR, Bartnik I, Nassim-Assir B, Ciirdaeva E, Mueller A, Dieterich DC, Tirrell DA, Langer JD, Schuman EM.

Nat Biotechnol. 2017 Dec;35(12):1196-1201. doi: 10.1038/nbt.4016. Epub 2017 Nov 6.

PMID:
29106408
15.

mRNA transport & local translation in neurons.

Glock C, Heumüller M, Schuman EM.

Curr Opin Neurobiol. 2017 Aug;45:169-177. doi: 10.1016/j.conb.2017.05.005. Epub 2017 Jun 17. Review.

PMID:
28633045
16.

Local translation in neuronal compartments: how local is local?

Rangaraju V, Tom Dieck S, Schuman EM.

EMBO Rep. 2017 May;18(5):693-711. doi: 10.15252/embr.201744045. Epub 2017 Apr 12. Review.

17.

Activity-dependent spatially localized miRNA maturation in neuronal dendrites.

Sambandan S, Akbalik G, Kochen L, Rinne J, Kahlstatt J, Glock C, Tushev G, Alvarez-Castelao B, Heckel A, Schuman EM.

Science. 2017 Feb 10;355(6325):634-637. doi: 10.1126/science.aaf8995.

PMID:
28183980
18.

Visualization of newly synthesized neuronal RNA in vitro and in vivo using click-chemistry.

Akbalik G, Langebeck-Jensen K, Tushev G, Sambandan S, Rinne J, Epstein I, Cajigas I, Vlatkovic I, Schuman EM.

RNA Biol. 2017 Jan 2;14(1):20-28. doi: 10.1080/15476286.2016.1251541. Epub 2016 Nov 1.

19.

Unconventional secretory processing diversifies neuronal ion channel properties.

Hanus C, Geptin H, Tushev G, Garg S, Alvarez-Castelao B, Sambandan S, Kochen L, Hafner AS, Langer JD, Schuman EM.

Elife. 2016 Sep 28;5. pii: e20609. doi: 10.7554/eLife.20609.

20.

Nascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses.

Schanzenbächer CT, Sambandan S, Langer JD, Schuman EM.

Neuron. 2016 Oct 19;92(2):358-371. doi: 10.1016/j.neuron.2016.09.058.

21.

Engineered Aminoacyl-tRNA Synthetase for Cell-Selective Analysis of Mammalian Protein Synthesis.

Mahdavi A, Hamblin GD, Jindal GA, Bagert JD, Dong C, Sweredoski MJ, Hess S, Schuman EM, Tirrell DA.

J Am Chem Soc. 2016 Apr 6;138(13):4278-81. doi: 10.1021/jacs.5b08980. Epub 2016 Mar 25.

22.

Rethinking Functional Segregation: Gradients of Gene Expression in Area CA1.

Tushev G, Schuman EM.

Neuron. 2016 Jan 20;89(2):242-3. doi: 10.1016/j.neuron.2016.01.002.

23.

NEUROSCIENCE. Opting in or out of the network.

Martin KC, Schuman EM.

Science. 2015 Dec 18;350(6267):1477-8. doi: 10.1126/science.aad9467. No abstract available.

24.

The Regulation of Synaptic Protein Turnover.

Alvarez-Castelao B, Schuman EM.

J Biol Chem. 2015 Nov 27;290(48):28623-30. doi: 10.1074/jbc.R115.657130. Epub 2015 Oct 9. Review.

25.

Direct visualization of newly synthesized target proteins in situ.

tom Dieck S, Kochen L, Hanus C, Heumüller M, Bartnik I, Nassim-Assir B, Merk K, Mosler T, Garg S, Bunse S, Tirrell DA, Schuman EM.

Nat Methods. 2015 May;12(5):411-4. doi: 10.1038/nmeth.3319. Epub 2015 Mar 16.

26.

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.

You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W.

Nat Neurosci. 2015 Apr;18(4):603-610. doi: 10.1038/nn.3975. Epub 2015 Feb 25.

27.

Cell-specific proteomic analysis in Caenorhabditis elegans.

Yuet KP, Doma MK, Ngo JT, Sweredoski MJ, Graham RL, Moradian A, Hess S, Schuman EM, Sternberg PW, Tirrell DA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2705-10. doi: 10.1073/pnas.1421567112. Epub 2015 Feb 17.

28.

Design of photocaged puromycin for nascent polypeptide release and spatiotemporal monitoring of translation.

Buhr F, Kohl-Landgraf J, tom Dieck S, Hanus C, Chatterjee D, Hegelein A, Schuman EM, Wachtveitl J, Schwalbe H.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3717-21. doi: 10.1002/anie.201410940. Epub 2015 Feb 4.

PMID:
25656536
29.

Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions.

Garg S, Fischer SC, Schuman EM, Stelzer EH.

J R Soc Interface. 2015 Mar 6;12(104):20141055. doi: 10.1098/rsif.2014.1055.

30.

BONCAT: metabolic labeling, click chemistry, and affinity purification of newly synthesized proteomes.

Landgraf P, Antileo ER, Schuman EM, Dieterich DC.

Methods Mol Biol. 2015;1266:199-215. doi: 10.1007/978-1-4939-2272-7_14.

PMID:
25560077
31.

Synaptic control of secretory trafficking in dendrites.

Hanus C, Kochen L, Tom Dieck S, Racine V, Sibarita JB, Schuman EM, Ehlers MD.

Cell Rep. 2014 Jun 26;7(6):1771-8. doi: 10.1016/j.celrep.2014.05.028. Epub 2014 Jun 12.

32.

Correlative light- and electron microscopy with chemical tags.

Perkovic M, Kunz M, Endesfelder U, Bunse S, Wigge C, Yu Z, Hodirnau VV, Scheffer MP, Seybert A, Malkusch S, Schuman EM, Heilemann M, Frangakis AS.

J Struct Biol. 2014 May;186(2):205-13. doi: 10.1016/j.jsb.2014.03.018. Epub 2014 Mar 31.

33.

Quantitative, time-resolved proteomic analysis by combining bioorthogonal noncanonical amino acid tagging and pulsed stable isotope labeling by amino acids in cell culture.

Bagert JD, Xie YJ, Sweredoski MJ, Qi Y, Hess S, Schuman EM, Tirrell DA.

Mol Cell Proteomics. 2014 May;13(5):1352-8. doi: 10.1074/mcp.M113.031914. Epub 2014 Feb 21.

34.

SnapShot: local protein translation in dendrites.

Tom Dieck S, Hanus C, Schuman EM.

Neuron. 2014 Feb 19;81(4):958-958.e1. doi: 10.1016/j.neuron.2014.02.009. Review. No abstract available.

35.

Molecular biology. mRNA, live and unmasked.

Akbalik G, Schuman EM.

Science. 2014 Jan 24;343(6169):375-6. doi: 10.1126/science.1249623. No abstract available.

PMID:
24458628
36.

Deep sequencing and high-resolution imaging reveal compartment-specific localization of Bdnf mRNA in hippocampal neurons.

Will TJ, Tushev G, Kochen L, Nassim-Assir B, Cajigas IJ, Tom Dieck S, Schuman EM.

Sci Signal. 2013 Dec 17;6(306):rs16. doi: 10.1126/scisignal.2004520.

37.

Alternative polyadenylation and differential expression of Shank mRNAs in the synaptic neuropil.

Epstein I, Tushev G, Will TJ, Vlatkovic I, Cajigas IJ, Schuman EM.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130137. doi: 10.1098/rstb.2013.0137. Print 2014 Jan 5.

38.

The central dogma decentralized: new perspectives on RNA function and local translation in neurons.

Holt CE, Schuman EM.

Neuron. 2013 Oct 30;80(3):648-57. doi: 10.1016/j.neuron.2013.10.036. Review.

39.

Protein synthesis-dependent associative long-term memory in larval zebrafish.

Hinz FI, Aizenberg M, Tushev G, Schuman EM.

J Neurosci. 2013 Sep 25;33(39):15382-7. doi: 10.1523/JNEUROSCI.0560-13.2013.

40.

Teaching old NCATs new tricks: using non-canonical amino acid tagging to study neuronal plasticity.

Hinz FI, Dieterich DC, Schuman EM.

Curr Opin Chem Biol. 2013 Oct;17(5):738-46. doi: 10.1016/j.cbpa.2013.07.021. Epub 2013 Aug 9. Review.

41.

Proteostasis in complex dendrites.

Hanus C, Schuman EM.

Nat Rev Neurosci. 2013 Sep;14(9):638-48. doi: 10.1038/nrn3546. Epub 2013 Jul 31. Review.

PMID:
23900412
42.

Axonal translation of β-catenin regulates synaptic vesicle dynamics.

Taylor AM, Wu J, Tai HC, Schuman EM.

J Neurosci. 2013 Mar 27;33(13):5584-9. doi: 10.1523/JNEUROSCI.2944-12.2013.

43.

Mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells.

Ngo JT, Schuman EM, Tirrell DA.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4992-7. doi: 10.1073/pnas.1216375110. Epub 2013 Mar 11.

44.

Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging.

Tom Dieck S, Müller A, Nehring A, Hinz FI, Bartnik I, Schuman EM, Dieterich DC.

Curr Protoc Cell Biol. 2012 Sep;Chapter 7:Unit7.11. doi: 10.1002/0471143030.cb0711s56.

45.

Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT).

Hodas JJ, Nehring A, Höche N, Sweredoski MJ, Pielot R, Hess S, Tirrell DA, Dieterich DC, Schuman EM.

Proteomics. 2012 Aug;12(15-16):2464-76. doi: 10.1002/pmic.201200112.

46.

State-selective metabolic labeling of cellular proteins.

Ngo JT, Babin BM, Champion JA, Schuman EM, Tirrell DA.

ACS Chem Biol. 2012 Aug 17;7(8):1326-30. doi: 10.1021/cb300238w. Epub 2012 Jun 12.

47.

The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging.

Cajigas IJ, Tushev G, Will TJ, tom Dieck S, Fuerst N, Schuman EM.

Neuron. 2012 May 10;74(3):453-66. doi: 10.1016/j.neuron.2012.02.036.

48.

Non-canonical amino acid labeling in vivo to visualize and affinity purify newly synthesized proteins in larval zebrafish.

Hinz FI, Dieterich DC, Tirrell DA, Schuman EM.

ACS Chem Neurosci. 2012 Jan 18;3(1):40-49.

49.

Cerebellar-dependent learning in larval zebrafish.

Aizenberg M, Schuman EM.

J Neurosci. 2011 Jun 15;31(24):8708-12. doi: 10.1523/JNEUROSCI.6565-10.2011.

50.

Calcium-dependent dynamics of cadherin interactions at cell-cell junctions.

Kim SA, Tai CY, Mok LP, Mosser EA, Schuman EM.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9857-62. doi: 10.1073/pnas.1019003108. Epub 2011 May 25.

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