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Items: 1 to 50 of 204

1.

Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.

Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ.

Nat Neurosci. 2020 Feb;23(2):293. doi: 10.1038/s41593-019-0583-0.

PMID:
31911656
2.

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.

Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ.

Nat Neurosci. 2020 Jan;23(1):15-20. doi: 10.1038/s41593-019-0556-3. Epub 2019 Dec 16. Erratum in: Nat Neurosci. 2020 Feb;23(2):293.

PMID:
31844313
3.

Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context.

Waypa GB, Schumacker PT.

Eur Respir J. 2019 Dec 12;54(6). pii: 1901929. doi: 10.1183/13993003.01929-2019. Print 2019 Dec. No abstract available.

PMID:
31831673
4.

Happy 30th Anniversary to the Red Journal!

Schumacker PT.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):1-2. doi: 10.1165/rcmb.2019-0180ED. No abstract available.

5.

Mitochondrial complex III is essential for suppressive function of regulatory T cells.

Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS.

Nature. 2019 Jan;565(7740):495-499. doi: 10.1038/s41586-018-0846-z. Epub 2019 Jan 9.

6.

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.

Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Yvan-Charvet L, Chandel NS, Schumacker PT, Thorp EB.

Cell Metab. 2019 Feb 5;29(2):443-456.e5. doi: 10.1016/j.cmet.2018.12.004. Epub 2018 Dec 27.

7.

The Phillip Morris Foundation for a Smoke-Free World. A Cause for Concern.

Goldberg DS, Lederer DJ, MacKenzie EJ, Moss M, Samet JM, Schumacker PT, Wedzicha JA, Wynia MK.

Ann Am Thorac Soc. 2018 Nov;15(11):1269-1272. doi: 10.1513/AnnalsATS.201806-414GH. No abstract available.

8.

Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction.

Smith KA, Schumacker PT.

J Physiol. 2019 Feb;597(4):1033-1043. doi: 10.1113/JP275852. Epub 2018 Aug 28.

9.

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.

Sato T, Chang HC, Bayeva M, Shapiro JS, Ramos-Alonso L, Kouzu H, Jiang X, Liu T, Yar S, Sawicki KT, Chen C, Martínez-Pastor MT, Stumpo DJ, Schumacker PT, Blackshear PJ, Ben-Sahra I, Puig S, Ardehali H.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6291-E6300. doi: 10.1073/pnas.1804701115. Epub 2018 Jun 18.

10.

Rescuing Decrepit Soluble Guanylate Cyclase: A Therapy for Sickle Cell Disease?

Schumacker PT.

Am J Respir Cell Mol Biol. 2018 May;58(5):553-554. doi: 10.1165/rcmb.2018-0003ED. No abstract available.

11.

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress.

Guzman JN, Ilijic E, Yang B, Sanchez-Padilla J, Wokosin D, Galtieri D, Kondapalli J, Schumacker PT, Surmeier DJ.

J Clin Invest. 2018 Jun 1;128(6):2266-2280. doi: 10.1172/JCI95898. Epub 2018 Apr 30.

12.

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension.

Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J.

J Biol Chem. 2018 Jan 5;293(1):271-284. doi: 10.1074/jbc.RA117.000440. Epub 2017 Nov 8.

13.

Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H.

Nat Commun. 2017 Aug 30;8:16155. doi: 10.1038/ncomms16155.

14.

Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy.

Galvan DL, Badal SS, Long J, Chang BH, Schumacker PT, Overbeek PA, Danesh FR.

Kidney Int. 2017 Nov;92(5):1282-1287. doi: 10.1016/j.kint.2017.05.015. Epub 2017 Jul 26.

15.

Redox signaling during hypoxia in mammalian cells.

Smith KA, Waypa GB, Schumacker PT.

Redox Biol. 2017 Oct;13:228-234. doi: 10.1016/j.redox.2017.05.020. Epub 2017 May 31. Review.

16.

The mitochondrial respiratory chain is essential for haematopoietic stem cell function.

Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS.

Nat Cell Biol. 2017 Jun;19(6):614-625. doi: 10.1038/ncb3529. Epub 2017 May 15.

17.

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress.

Shi H, Deng HX, Gius D, Schumacker PT, Surmeier DJ, Ma YC.

Hum Mol Genet. 2017 May 15;26(10):1915-1926. doi: 10.1093/hmg/ddx100.

18.

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H.

Nat Commun. 2017 Jan 24;8:14095. doi: 10.1038/ncomms14095. Erratum in: Nat Commun. 2017 Aug 30;8:16155.

19.

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.

Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P.

Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. Epub 2016 Mar 21.

20.

A New Beginning for the Red Journal.

Schumacker PT.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):v-vi. No abstract available.

PMID:
27689797
21.

Calcium and Parkinson's disease.

Surmeier DJ, Schumacker PT, Guzman JD, Ilijic E, Yang B, Zampese E.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):1013-1019. doi: 10.1016/j.bbrc.2016.08.168. Epub 2016 Aug 30. Review.

22.

MITOCHONDRIAL FUNCTION IN SEPSIS.

Arulkumaran N, Deutschman CS, Pinsky MR, Zuckerbraun B, Schumacker PT, Gomez H, Gomez A, Murray P, Kellum JA; ADQI XIV Workgroup.

Shock. 2016 Mar;45(3):271-81. doi: 10.1097/SHK.0000000000000463. Review.

23.

Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy.

Ayanga BA, Badal SS, Wang Y, Galvan DL, Chang BH, Schumacker PT, Danesh FR.

J Am Soc Nephrol. 2016 Sep;27(9):2733-47. doi: 10.1681/ASN.2015101096. Epub 2016 Jan 29.

24.

O2 sensing, mitochondria and ROS signaling: The fog is lifting.

Waypa GB, Smith KA, Schumacker PT.

Mol Aspects Med. 2016 Feb-Mar;47-48:76-89. doi: 10.1016/j.mam.2016.01.002. Epub 2016 Jan 14. Review.

25.

MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on "miR-223 reverses experimental pulmonary arterial hypertension".

Smith KA, Yuan JX, Schumacker PT.

Am J Physiol Cell Physiol. 2015 Sep 15;309(6):C361-2. doi: 10.1152/ajpcell.00209.2015. Epub 2015 Jul 22. No abstract available.

26.

Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent.

Datta A, Kim GA, Taylor JM, Gugino SF, Farrow KN, Schumacker PT, Berkelhamer SK.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L369-77. doi: 10.1152/ajplung.00176.2014. Epub 2015 Jun 19.

27.

Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells.

Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L196-203. doi: 10.1152/ajplung.00097.2014. Epub 2015 May 29.

28.

Corrigendum: Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker PT, Surmeier DJ.

Nature. 2015 May 21;521(7552):380. doi: 10.1038/nature14487. No abstract available.

PMID:
25993967
29.

Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn.

Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH.

Front Pharmacol. 2015 Mar 11;6:47. doi: 10.3389/fphar.2015.00047. eCollection 2015.

30.

Reactive oxygen species in cancer: a dance with the devil.

Schumacker PT.

Cancer Cell. 2015 Feb 9;27(2):156-7. doi: 10.1016/j.ccell.2015.01.007.

31.

Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity.

Takeuchi T, Schumacker PT, Kozmin SA.

J Am Chem Soc. 2015 Jan 21;137(2):564-7. doi: 10.1021/ja5101257. Epub 2015 Jan 5.

32.

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Sabharwal SS, Schumacker PT.

Nat Rev Cancer. 2014 Nov;14(11):709-21. doi: 10.1038/nrc3803. Review.

33.

The 'mitoflash' probe cpYFP does not respond to superoxide.

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP.

Nature. 2014 Oct 23;514(7523):E12-4. doi: 10.1038/nature13858. No abstract available.

34.

Update in pulmonary vascular diseases 2013.

Hassoun PM, Schumacker PT.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):738-43. doi: 10.1164/rccm.201405-0871UP. Review. No abstract available.

35.

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice.

Cheresh P, Morales-Nebreda L, Kim SJ, Yeldandi A, Williams DB, Cheng Y, Mutlu GM, Budinger GR, Ridge K, Schumacker PT, Bohr VA, Kamp DW.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):25-36. doi: 10.1165/rcmb.2014-0038OC.

36.

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase.

Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker PT, Surmeier DJ.

Nat Neurosci. 2014 Jun;17(6):832-40. doi: 10.1038/nn.3717. Epub 2014 May 11.

37.

Mitochondria in lung biology and pathology: more than just a powerhouse.

Schumacker PT, Gillespie MN, Nakahira K, Choi AM, Crouser ED, Piantadosi CA, Bhattacharya J.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L962-74. doi: 10.1152/ajplung.00073.2014. Epub 2014 Apr 18. Review.

38.

Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.

Kim SJ, Cheresh P, Williams D, Cheng Y, Ridge K, Schumacker PT, Weitzman S, Bohr VA, Kamp DW.

J Biol Chem. 2014 Feb 28;289(9):6165-76. doi: 10.1074/jbc.M113.515130. Epub 2014 Jan 15.

39.

Paradoxical regulation of hypoxia inducible factor-1α (HIF-1α) by histone deacetylase inhibitor in diffuse large B-cell lymphoma.

Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI.

PLoS One. 2013 Nov 27;8(11):e81333. doi: 10.1371/journal.pone.0081333. eCollection 2013.

40.

Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.

Ball MK, Waypa GB, Mungai PT, Nielsen JM, Czech L, Dudley VJ, Beussink L, Dettman RW, Berkelhamer SK, Steinhorn RH, Shah SJ, Schumacker PT.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):314-24. doi: 10.1164/rccm.201302-0302OC.

41.

Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension.

Waypa GB, Osborne SW, Marks JD, Berkelhamer SK, Kondapalli J, Schumacker PT.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):885-91. doi: 10.1165/rcmb.2013-0191OC.

42.

Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling.

Sabharwal SS, Waypa GB, Marks JD, Schumacker PT.

Biochem J. 2013 Dec 15;456(3):337-46. doi: 10.1042/BJ20130740.

43.

Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis.

Hanna C, Hubchak SC, Liang X, Rozen-Zvi B, Schumacker PT, Hayashida T, Schnaper HW.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1323-31. doi: 10.1152/ajprenal.00155.2013. Epub 2013 Aug 14.

44.

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons.

Dryanovski DI, Guzman JN, Xie Z, Galteri DJ, Volpicelli-Daley LA, Lee VM, Miller RJ, Schumacker PT, Surmeier DJ.

J Neurosci. 2013 Jun 12;33(24):10154-64. doi: 10.1523/JNEUROSCI.5311-12.2013.

45.

Nitric oxide quenches the fire in heart mitochondria.

Schumacker PT.

Nat Med. 2013 Jun;19(6):666-7. doi: 10.1038/nm.3224. No abstract available.

PMID:
23744141
46.

ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion.

Schriewer JM, Peek CB, Bass J, Schumacker PT.

J Am Heart Assoc. 2013 Apr 18;2(2):e000159. doi: 10.1161/JAHA.113.000159.

47.

Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung.

Berkelhamer SK, Kim GA, Radder JE, Wedgwood S, Czech L, Steinhorn RH, Schumacker PT.

Free Radic Biol Med. 2013 Aug;61:51-60. doi: 10.1016/j.freeradbiomed.2013.03.003. Epub 2013 Mar 14.

48.

Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells.

Shah MR, Wedgwood S, Czech L, Kim GA, Lakshminrusimha S, Schumacker PT, Steinhorn RH, Farrow KN.

Int J Mol Sci. 2013 Feb 21;14(2):4334-48. doi: 10.3390/ijms14024334.

49.

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS.

Immunity. 2013 Feb 21;38(2):225-36. doi: 10.1016/j.immuni.2012.10.020. Epub 2013 Feb 15.

50.

Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.

Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT.

Am J Respir Crit Care Med. 2013 Feb 15;187(4):424-32. doi: 10.1164/rccm.201207-1294OC. Epub 2013 Jan 17.

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