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[EXPRESS] Signaling Pathways and Gene Co-Expression Modules Associated with Cytoskeleton and Axon Morphology in Breast Cancer Survivors with Chronic Paclitaxel-Induced Peripheral Neuropathy.

Kober K, Schumacher MA, Conley YP, Topp K, Mazor M, Hammer M, Paul S, Levine J, Miaskowski C.

Mol Pain. 2019 Sep 5:1744806919878088. doi: 10.1177/1744806919878088. [Epub ahead of print]


Infrared Spectroscopic Observation of a G-C+ Hoogsteen Base Pair in the DNA:TATA-Box Binding Protein Complex Under Solution Conditions.

Stelling AL, Liu AY, Zeng W, Salinas R, Schumacher MA, Al-Hashimi HM.

Angew Chem Int Ed Engl. 2019 Aug 26;58(35):12010-12013. doi: 10.1002/anie.201902693. Epub 2019 Jul 25.


Structures of maintenance of carboxysome distribution Walker-box McdA and McdB adaptor homologs.

Schumacher MA, Henderson M, Zhang H.

Nucleic Acids Res. 2019 Jun 20;47(11):5950-5962. doi: 10.1093/nar/gkz314.


Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors.

Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C.

Support Care Cancer. 2019 Oct;27(10):3905-3912. doi: 10.1007/s00520-019-04695-3. Epub 2019 Feb 15.


The RRM of the kRNA-editing protein TbRGG2 uses multiple surfaces to bind and remodel RNA.

Travis B, Shaw PLR, Liu B, Ravindra K, Iliff H, Al-Hashimi HM, Schumacher MA.

Nucleic Acids Res. 2019 Feb 28;47(4):2130-2142. doi: 10.1093/nar/gky1259.


A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication.

Guo MS, Haakonsen DL, Zeng W, Schumacher MA, Laub MT.

Cell. 2018 Oct 4;175(2):583-597.e23. doi: 10.1016/j.cell.2018.08.029. Epub 2018 Sep 13.


A potentially abundant junctional RNA motif stabilized by m6A and Mg2.

Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM.

Nat Commun. 2018 Jul 17;9(1):2761. doi: 10.1038/s41467-018-05243-z.


The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor.

Schumacher MA, Bush MJ, Bibb MJ, Ramos-León F, Chandra G, Zeng W, Buttner MJ.

Nucleic Acids Res. 2018 Aug 21;46(14):7467-7468. doi: 10.1093/nar/gky616. No abstract available.


The crystal structure of the RsbN-σBldN complex from Streptomyces venezuelae defines a new structural class of anti-σ factor.

Schumacher MA, Bush MJ, Bibb MJ, Ramos-León F, Chandra G, Zeng W, Buttner MJ.

Nucleic Acids Res. 2018 Aug 21;46(14):7405-7417. doi: 10.1093/nar/gky493. Erratum in: Nucleic Acids Res. 2018 Aug 21;46(14):7467-7468.


Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins.

Toleman CA, Schumacher MA, Yu SH, Zeng W, Cox NJ, Smith TJ, Soderblom EJ, Wands AM, Kohler JJ, Boyce M.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5956-5961. doi: 10.1073/pnas.1722437115. Epub 2018 May 21.


The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.

Schumacher MA, den Hengst CD, Bush MJ, Le TBK, Tran NT, Chandra G, Zeng W, Travis B, Brennan RG, Buttner MJ.

Nat Commun. 2018 Mar 19;9(1):1139. doi: 10.1038/s41467-018-03576-3.


America's Opioid Epidemic: Supply and Demand Considerations.

Clark DJ, Schumacher MA.

Anesth Analg. 2017 Nov;125(5):1667-1674. doi: 10.1213/ANE.0000000000002388. Review.


Dissection of the molecular circuitry controlling virulence in Francisella tularensis.

Cuthbert BJ, Ross W, Rohlfing AE, Dove SL, Gourse RL, Brennan RG, Schumacher MA.

Genes Dev. 2017 Aug 1;31(15):1549-1560. doi: 10.1101/gad.303701.117. Epub 2017 Sep 1.


Bacterial Nucleoid Occlusion: Multiple Mechanisms for Preventing Chromosome Bisection During Cell Division.

Schumacher MA.

Subcell Biochem. 2017;84:267-298. doi: 10.1007/978-3-319-53047-5_9. Review.


The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.

Schumacher MA, Zeng W, Findlay KC, Buttner MJ, Brennan RG, Tschowri N.

Nucleic Acids Res. 2017 Jun 20;45(11):6923-6933. doi: 10.1093/nar/gkx287.


The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.

Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR.

Cell Death Differ. 2017 May;24(5):855-865. doi: 10.1038/cdd.2017.27. Epub 2017 Mar 17.


ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.

Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR.

Cell Death Dis. 2017 Feb 23;8(2):e2622. doi: 10.1038/cddis.2017.42.


Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking.

Schumacher MA, Huang KH, Zeng W, Janakiraman A.

J Biol Chem. 2017 Mar 3;292(9):3740-3750. doi: 10.1074/jbc.M116.773192. Epub 2017 Jan 18.


A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation.

McLeod BN, Allison-Gamble GE, Barge MT, Tonthat NK, Schumacher MA, Hayes F, Barillà D.

Nucleic Acids Res. 2017 Apr 7;45(6):3158-3171. doi: 10.1093/nar/gkw1302.


Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding.

Schumacher MA, Zeng W.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10067-72. doi: 10.1073/pnas.1607503113. Epub 2016 Aug 22.


Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.

Miao Y, Tenor JL, Toffaletti DL, Washington EJ, Liu J, Shadrick WR, Schumacher MA, Lee RE, Perfect JR, Brennan RG.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7148-53. doi: 10.1073/pnas.1601774113. Epub 2016 Jun 15.


Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells.

Bertaux-Skeirik N, Centeno J, Feng R, Schumacher MA, Shivdasani RA, Zavros Y.

Methods Mol Biol. 2016;1422:23-31. doi: 10.1007/978-1-4939-3603-8_3.


Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA.

MBio. 2016 Apr 26;7(2):e00492-16. doi: 10.1128/mBio.00492-16.


Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ.

Schumacher MA, Zeng W.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4988-93. doi: 10.1073/pnas.1602327113. Epub 2016 Apr 18.


Molecular insights into DNA binding and anchoring by the Bacillus subtilis sporulation kinetochore-like RacA protein.

Schumacher MA, Lee J, Zeng W.

Nucleic Acids Res. 2016 Jun 20;44(11):5438-49. doi: 10.1093/nar/gkw248. Epub 2016 Apr 16.


Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC.

Schumacher MA, Zeng W, Huang KH, Tchorzewski L, Janakiraman A.

J Biol Chem. 2016 Jan 29;291(5):2485-98. doi: 10.1074/jbc.M115.697037. Epub 2015 Dec 10.


Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.

Aihara E, Mahe MM, Schumacher MA, Matthis AL, Feng R, Ren W, Noah TK, Matsu-ura T, Moore SR, Hong CI, Zavros Y, Herness S, Shroyer NF, Iwatsuki K, Jiang P, Helmrath MA, Montrose MH.

Sci Rep. 2015 Nov 24;5:17185. doi: 10.1038/srep17185.


Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages.

Schumacher MA, Tonthat NK, Lee J, Rodriguez-Castañeda FA, Chinnam NB, Kalliomaa-Sanford AK, Ng IW, Barge MT, Shaw PL, Barillà D.

Science. 2015 Sep 4;349(6252):1120-4. doi: 10.1126/science.aaa9046. Erratum in: Science. 2016 Aug 26;353(6302). pii: aai8230. doi: 10.1126/science.aai8230.


HipBA-promoter structures reveal the basis of heritable multidrug tolerance.

Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG.

Nature. 2015 Aug 6;524(7563):59-64. doi: 10.1038/nature14662. Epub 2015 Jul 29.


Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA).

Cuthbert BJ, Brennan RG, Schumacher MA.

PLoS One. 2015 Jun 29;10(6):e0128225. doi: 10.1371/journal.pone.0128225. eCollection 2015.


Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold.

Shaw PL, McAdams NM, Hast MA, Ammerman ML, Read LK, Schumacher MA.

Nucleic Acids Res. 2015 Aug 18;43(14):7096-109. doi: 10.1093/nar/gkv647. Epub 2015 Jun 27.


Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.

Lee SC, Li A, Calo S, Inoue M, Tonthat NK, Bain JM, Louw J, Shinohara ML, Erwig LP, Schumacher MA, Ko DC, Heitman J.

Mol Microbiol. 2015 Sep;97(5):844-65. doi: 10.1111/mmi.13071. Epub 2015 Jun 17.


Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis.

Hover BM, Tonthat NK, Schumacher MA, Yokoyama K.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6347-52. doi: 10.1073/pnas.1500697112. Epub 2015 May 4.


Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.

Schumacher MA, Chinnam NB, Cuthbert B, Tonthat NK, Whitfill T.

Genes Dev. 2015 Feb 15;29(4):451-64. doi: 10.1101/gad.254714.114.


CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.

Bertaux-Skeirik N, Feng R, Schumacher MA, Li J, Mahe MM, Engevik AC, Javier JE, Peek RM Jr, Ottemann K, Orian-Rousseau V, Boivin GP, Helmrath MA, Zavros Y.

PLoS Pathog. 2015 Feb 6;11(2):e1004663. doi: 10.1371/journal.ppat.1004663. eCollection 2015 Feb.


The use of murine-derived fundic organoids in studies of gastric physiology.

Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y.

J Physiol. 2015 Apr 15;593(8):1809-27. doi: 10.1113/jphysiol.2014.283028. Epub 2015 Feb 19.


Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NFκB pathway activation: the use of a novel in vitro model to study epithelial response to infection.

Schumacher MA, Feng R, Aihara E, Engevik AC, Montrose MH, Ottemann KM, Zavros Y.

Helicobacter. 2015 Feb;20(1):19-28. doi: 10.1111/hel.12152. Epub 2014 Dec 11.


Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model.

Marwaha S, Schumacher MA, Zavros Y, Eghbalnia HR.

PLoS One. 2014 Nov 3;9(11):e111338. doi: 10.1371/journal.pone.0111338. eCollection 2014.


Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.

Tschowri N, Schumacher MA, Schlimpert S, Chinnam NB, Findlay KC, Brennan RG, Buttner MJ.

Cell. 2014 Aug 28;158(5):1136-1147. doi: 10.1016/j.cell.2014.07.022.


Establishment of Gastrointestinal Epithelial Organoids.

Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, Sato T, Shroyer NF.

Curr Protoc Mouse Biol. 2013 Dec 19;3(4):217-40. doi: 10.1002/9780470942390.mo130179.


Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori.

Aihara E, Closson C, Matthis AL, Schumacher MA, Engevik AC, Zavros Y, Ottemann KM, Montrose MH.

PLoS Pathog. 2014 Jul 17;10(7):e1004275. doi: 10.1371/journal.ppat.1004275. eCollection 2014 Jul.


Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.

Emptage RP, Tonthat NK, York JD, Schumacher MA, Zhou P.

J Biol Chem. 2014 Aug 29;289(35):24059-68. doi: 10.1074/jbc.M114.589986. Epub 2014 Jul 14.


Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein.

Schumacher MA, Tonthat NK, Kwong SM, Chinnam NB, Liu MA, Skurray RA, Firth N.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9121-6. doi: 10.1073/pnas.1406065111. Epub 2014 Jun 9.


The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons.

Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA.

Neurosci Lett. 2014 Aug 22;578:211-6. doi: 10.1016/j.neulet.2014.01.021. Epub 2014 Jan 25.


Ligand concentration regulates the pathways of coupled protein folding and binding.

Daniels KG, Tonthat NK, McClure DR, Chang YC, Liu X, Schumacher MA, Fierke CA, Schmidler SC, Oas TG.

J Am Chem Soc. 2014 Jan 22;136(3):822-5. doi: 10.1021/ja4086726. Epub 2014 Jan 9.


Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell.

Donnelly JM, Engevik AC, Engevik M, Schumacher MA, Xiao C, Yang L, Worrell RT, Zavros Y.

Dig Dis Sci. 2014 Mar;59(3):569-82. doi: 10.1007/s10620-013-2927-z. Epub 2013 Nov 8.


Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism.

Murray DS, Chinnam N, Tonthat NK, Whitfill T, Wray LV Jr, Fisher SH, Schumacher MA.

J Biol Chem. 2013 Dec 13;288(50):35801-11. doi: 10.1074/jbc.M113.519496. Epub 2013 Oct 24.


The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation.

Schumacher MA, Chinnam N, Ohashi T, Shah RS, Erickson HP.

J Biol Chem. 2013 Nov 22;288(47):33738-44. doi: 10.1074/jbc.M113.516641. Epub 2013 Oct 10.


SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid.

Tonthat NK, Milam SL, Chinnam N, Whitfill T, Margolin W, Schumacher MA.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10586-91. doi: 10.1073/pnas.1221036110. Epub 2013 Jun 10. Erratum in: Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15163.

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