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Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption.

Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD.

Int J Mol Sci. 2020 Jan 7;21(2). pii: E373. doi: 10.3390/ijms21020373.


Tricellulin Effect on Paracellular Water Transport.

Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R, Fromm M.

Int J Mol Sci. 2019 Nov 14;20(22). pii: E5700. doi: 10.3390/ijms20225700.


Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment.

Hering NA, Fromm A, Bücker R, Gorkiewicz G, Zechner E, Högenauer C, Fromm M, Schulzke JD, Troeger H.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5595. doi: 10.3390/ijms20225595.


Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni.

Lobo de Sá FD, Butkevych E, Nattramilarasu PK, Fromm A, Mousavi S, Moos V, Golz JC, Stingl K, Kittler S, Seinige D, Kehrenberg C, Heimesaat MM, Bereswill S, Schulzke JD, Bücker R.

Int J Mol Sci. 2019 Sep 28;20(19). pii: E4830. doi: 10.3390/ijms20194830.


Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Campylobacter jejuni Induced Enterocolitis Model.

Mousavi S, Lobo de Sá FD, Schulzke JD, Bücker R, Bereswill S, Heimesaat MM.

Front Immunol. 2019 Sep 3;10:2094. doi: 10.3389/fimmu.2019.02094. eCollection 2019.


Phospholipid effects on SGLT1-mediated glucose transport in rabbit ileum brush border membrane vesicles.

Ebel H, Fromm A, Günzel D, Fromm M, Schulzke JD.

Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182985. doi: 10.1016/j.bbamem.2019.05.007. Epub 2019 May 11.


Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA.

Harrer A, Bücker R, Boehm M, Zarzecka U, Tegtmeyer N, Sticht H, Schulzke JD, Backert S.

Gut Pathog. 2019 Feb 13;11:4. doi: 10.1186/s13099-019-0283-z. eCollection 2019.


Epithelial barrier dysfunction as permissive pathomechanism in human intestinal graft-versus-host disease.

Troeger H, Hering NA, Bojarski C, Fromm A, Barmeyer C, Uharek L, Siegmund B, Fromm M, Rieger K, Schulzke JD.

Bone Marrow Transplant. 2018 Aug;53(8):1083-1086. doi: 10.1038/s41409-018-0144-2. Epub 2018 Mar 9. No abstract available.


Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain.

Neuhaus W, Piontek A, Protze J, Eichner M, Mahringer A, Subileau EA, Lee IM, Schulzke JD, Krause G, Piontek J.

Biomaterials. 2018 Apr;161:129-143. doi: 10.1016/j.biomaterials.2018.01.028. Epub 2018 Feb 2.


[Drug therapy in coeliac disease - "from bench to bedside"].

Stein J, Schulzke JD, Schuppan D.

Z Gastroenterol. 2018 Feb;56(2):151-164. doi: 10.1055/s-0043-121345. Epub 2017 Nov 7. Review. German.


Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon.

Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD.

Mucosal Immunol. 2018 Mar;11(2):575-577. doi: 10.1038/mi.2017.78. Epub 2017 Nov 1.


Giardia's Epithelial Cell Interaction In Vitro: Mimicking Asymptomatic Infection?

Kraft MR, Klotz C, Bücker R, Schulzke JD, Aebischer T.

Front Cell Infect Microbiol. 2017 Sep 26;7:421. doi: 10.3389/fcimb.2017.00421. eCollection 2017. Review.


In Colon Epithelia, Clostridium perfringens Enterotoxin Causes Focal Leaks by Targeting Claudins Which are Apically Accessible Due to Tight Junction Derangement.

Eichner M, Augustin C, Fromm A, Piontek A, Walther W, Bücker R, Fromm M, Krause G, Schulzke JD, Günzel D, Piontek J.

J Infect Dis. 2017 Dec 27;217(1):147-157. doi: 10.1093/infdis/jix485.


Gastrointestinal Tract As Entry Route for Hantavirus Infection.

Witkowski PT, Perley CC, Brocato RL, Hooper JW, Jürgensen C, Schulzke JD, Krüger DH, Bücker R.

Front Microbiol. 2017 Sep 8;8:1721. doi: 10.3389/fmicb.2017.01721. eCollection 2017.


Zinc strengthens the jejunal barrier by reversibly tightening the paracellular route.

Zakrzewski SS, Fromm M, Schulzke JD, Günzel D.

Am J Physiol Gastrointest Liver Physiol. 2017 Dec 1;313(6):G537-G548. doi: 10.1152/ajpgi.00355.2016. Epub 2017 Sep 1.


Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon.

Bücker R, Krug SM, Moos V, Bojarski C, Schweiger MR, Kerick M, Fromm A, Janßen S, Fromm M, Hering NA, Siegmund B, Schneider T, Barmeyer C, Schulzke JD.

Mucosal Immunol. 2018 Mar;11(2):474-485. doi: 10.1038/mi.2017.66. Epub 2017 Aug 2. Erratum in: Mucosal Immunol. 2017 Nov 01;:.


Campylobacter fetus impairs barrier function in HT-29/B6 cells through focal tight junction alterations and leaks.

Bücker R, Krug SM, Fromm A, Nielsen HL, Fromm M, Nielsen H, Schulzke JD.

Ann N Y Acad Sci. 2017 Oct;1405(1):189-201. doi: 10.1111/nyas.13406. Epub 2017 Jun 29.


Water channels and barriers formed by claudins.

Rosenthal R, Günzel D, Theune D, Czichos C, Schulzke JD, Fromm M.

Ann N Y Acad Sci. 2017 Jun;1397(1):100-109. doi: 10.1111/nyas.13383. Review.


Lactoferrin protects against intestinal inflammation and bacteria-induced barrier dysfunction in vitro.

Hering NA, Luettig J, Krug SM, Wiegand S, Gross G, van Tol EA, Schulzke JD, Rosenthal R.

Ann N Y Acad Sci. 2017 Oct;1405(1):177-188. doi: 10.1111/nyas.13405. Epub 2017 Jun 14.


Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis.

Krug SM, Bojarski C, Fromm A, Lee IM, Dames P, Richter JF, Turner JR, Fromm M, Schulzke JD.

Mucosal Immunol. 2018 Mar;11(2):345-356. doi: 10.1038/mi.2017.52. Epub 2017 Jun 14.


Zinc treatment is efficient against Escherichia coli α-haemolysin-induced intestinal leakage in mice.

Wiegand S, Zakrzewski SS, Eichner M, Schulz E, Günzel D, Pieper R, Rosenthal R, Barmeyer C, Bleich A, Dobrindt U, Schulzke JD, Bücker R.

Sci Rep. 2017 Mar 31;7:45649. doi: 10.1038/srep45649.


Celiac Disease: Role of the Epithelial Barrier.

Schumann M, Siegmund B, Schulzke JD, Fromm M.

Cell Mol Gastroenterol Hepatol. 2017 Jan 14;3(2):150-162. doi: 10.1016/j.jcmgh.2016.12.006. eCollection 2017 Mar. Review.


Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease.

Epple HJ, Friebel J, Moos V, Troeger H, Krug SM, Allers K, Schinnerling K, Fromm A, Siegmund B, Fromm M, Schulzke JD, Schneider T.

Mucosal Immunol. 2017 Nov;10(6):1542-1552. doi: 10.1038/mi.2017.6. Epub 2017 Feb 8.


Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8.

Barmeyer C, Erko I, Awad K, Fromm A, Bojarski C, Meissner S, Loddenkemper C, Kerick M, Siegmund B, Fromm M, Schweiger MR, Schulzke JD.

J Gastroenterol. 2017 Oct;52(10):1090-1100. doi: 10.1007/s00535-017-1309-2. Epub 2017 Jan 30.


Myrrh exerts barrier-stabilising and -protective effects in HT-29/B6 and Caco-2 intestinal epithelial cells.

Rosenthal R, Luettig J, Hering NA, Krug SM, Albrecht U, Fromm M, Schulzke JD.

Int J Colorectal Dis. 2017 May;32(5):623-634. doi: 10.1007/s00384-016-2736-x. Epub 2016 Dec 15.


Active and passive involvement of claudins in the pathophysiology of intestinal inflammatory diseases.

Barmeyer C, Fromm M, Schulzke JD.

Pflugers Arch. 2017 Jan;469(1):15-26. doi: 10.1007/s00424-016-1914-6. Epub 2016 Nov 30. Review.


Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome.

Barmeyer C, Schumann M, Meyer T, Zielinski C, Zuberbier T, Siegmund B, Schulzke JD, Daum S, Ullrich R.

Int J Colorectal Dis. 2017 Jan;32(1):29-39. doi: 10.1007/s00384-016-2663-x. Epub 2016 Sep 30.


The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling.

Luettig J, Rosenthal R, Lee IM, Krug SM, Schulzke JD.

Mol Nutr Food Res. 2016 Dec;60(12):2576-2586. doi: 10.1002/mnfr.201600274. Epub 2016 Sep 16.


Claudin-2-mediated cation and water transport share a common pore.

Rosenthal R, Günzel D, Krug SM, Schulzke JD, Fromm M, Yu AS.

Acta Physiol (Oxf). 2017 Feb;219(2):521-536. doi: 10.1111/apha.12742. Epub 2016 Jul 20.


Bortezomib treatment diminishes hazelnut-induced intestinal anaphylaxis in mice.

Mudnakudu Nagaraju KK, Babina M, Weise C, Kühl A, Schulzke J, Worm M.

Eur J Immunol. 2016 Jul;46(7):1727-36. doi: 10.1002/eji.201545918. Epub 2016 May 11.


Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation.

Demehri FR, Krug SM, Feng Y, Lee IF, Schulzke JD, Teitelbaum DH.

Dig Dis Sci. 2016 Jun;61(6):1524-33. doi: 10.1007/s10620-015-3991-3. Epub 2015 Dec 21.


ENaC Dysregulation Through Activation of MEK1/2 Contributes to Impaired Na+ Absorption in Lymphocytic Colitis.

Barmeyer C, Erko I, Fromm A, Bojarski C, Loddenkemper C, Dames P, Kerick M, Siegmund B, Fromm M, Schweiger MR, Schulzke JD.

Inflamm Bowel Dis. 2016 Mar;22(3):539-47. doi: 10.1097/MIB.0000000000000646.


Yersinia enterocolitica Affects Intestinal Barrier Function in the Colon.

Hering NA, Fromm A, Kikhney J, Lee IF, Moter A, Schulzke JD, Bücker R.

J Infect Dis. 2016 Apr 1;213(7):1157-62. doi: 10.1093/infdis/jiv571. Epub 2015 Nov 29.


Arcobacter butzleri isolates exhibit pathogenic potential in intestinal epithelial cell models.

Karadas G, Bücker R, Sharbati S, Schulzke JD, Alter T, Gölz G.

J Appl Microbiol. 2016 Jan;120(1):218-25. doi: 10.1111/jam.12979. Epub 2015 Dec 8.


Interleukin-13 affects the epithelial sodium channel in the intestine by coordinated modulation of STAT6 and p38 MAPK activity.

Dames P, Bergann T, Fromm A, Bücker R, Barmeyer C, Krug SM, Fromm M, Schulzke JD.

J Physiol. 2015 Dec 15;593(24):5269-82. doi: 10.1113/JP271156. Epub 2015 Oct 28.


Claudin-related intestinal diseases.

Barmeyer C, Schulzke JD, Fromm M.

Semin Cell Dev Biol. 2015 Jun;42:30-8. doi: 10.1016/j.semcdb.2015.05.006. Epub 2015 May 19. Review.


Low Recent Protein Intake Predicts Cancer-Related Fatigue and Increased Mortality in Patients with Advanced Tumor Disease Undergoing Chemotherapy.

Stobäus N, Müller MJ, Küpferling S, Schulzke JD, Norman K.

Nutr Cancer. 2015;67(5):818-24. doi: 10.1080/01635581.2015.1040520. Epub 2015 May 21.


Monocyte and M1 Macrophage-induced Barrier Defect Contributes to Chronic Intestinal Inflammation in IBD.

Lissner D, Schumann M, Batra A, Kredel LI, Kühl AA, Erben U, May C, Schulzke JD, Siegmund B.

Inflamm Bowel Dis. 2015 Jun;21(6):1297-305. doi: 10.1097/MIB.0000000000000384.


Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3.

Milatz S, Piontek J, Schulzke JD, Blasig IE, Fromm M, Günzel D.

Biochem J. 2015 Jun 15;468(3):449-58. doi: 10.1042/BJ20150148. Epub 2015 Apr 7.


Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation.

Luettig J, Rosenthal R, Barmeyer C, Schulzke JD.

Tissue Barriers. 2015 Apr 3;3(1-2):e977176. doi: 10.4161/21688370.2014.977176. eCollection 2015.


A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion.

Aue A, Hinze C, Walentin K, Ruffert J, Yurtdas Y, Werth M, Chen W, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM.

J Am Soc Nephrol. 2015 Nov;26(11):2704-15. doi: 10.1681/ASN.2014080759. Epub 2015 Mar 18.


Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine.

Brandner JM, Schulzke JD.

Cell Tissue Res. 2015 Jun;360(3):723-48. doi: 10.1007/s00441-014-2096-1. Epub 2015 Feb 8. Review.


Intestinal permeability--a new target for disease prevention and therapy.

Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM.

BMC Gastroenterol. 2014 Nov 18;14:189. doi: 10.1186/s12876-014-0189-7. Review.


Imaging the leaky gut.

Wallace MB, Vazquez-Roque M, Bojarski C, Schulzke JD.

Gastroenterology. 2014 Nov;147(5):952-4. doi: 10.1053/j.gastro.2014.09.027. Epub 2014 Sep 27. No abstract available.


Tight junction, selective permeability, and related diseases.

Krug SM, Schulzke JD, Fromm M.

Semin Cell Dev Biol. 2014 Dec;36:166-76. doi: 10.1016/j.semcdb.2014.09.002. Epub 2014 Sep 16. Review.


A transgenic probiotic secreting a parasite immunomodulator for site-directed treatment of gut inflammation.

Whelan RA, Rausch S, Ebner F, Günzel D, Richter JF, Hering NA, Schulzke JD, Kühl AA, Keles A, Janczyk P, Nöckler K, Wieler LH, Hartmann S.

Mol Ther. 2014 Oct;22(10):1730-40. doi: 10.1038/mt.2014.125. Epub 2014 Jul 2.


Tick-borne encephalitis virus replication, intracellular trafficking, and pathogenicity in human intestinal Caco-2 cell monolayers.

Yu C, Achazi K, Möller L, Schulzke JD, Niedrig M, Bücker R.

PLoS One. 2014 May 12;9(5):e96957. doi: 10.1371/journal.pone.0096957. eCollection 2014.


Small intestinal permeability in older adults.

Valentini L, Ramminger S, Haas V, Postrach E, Werich M, Fischer A, Koller M, Swidsinski A, Bereswill S, Lochs H, Schulzke JD.

Physiol Rep. 2014 Apr 22;2(4):e00281. doi: 10.14814/phy2.281. Print 2014.


α-Haemolysin of Escherichia coli in IBD: a potentiator of inflammatory activity in the colon.

Bücker R, Schulz E, Günzel D, Bojarski C, Lee IF, John LJ, Wiegand S, Janßen T, Wieler LH, Dobrindt U, Beutin L, Ewers C, Fromm M, Siegmund B, Troeger H, Schulzke JD.

Gut. 2014 Dec;63(12):1893-901. doi: 10.1136/gutjnl-2013-306099. Epub 2014 Feb 17.


Effect of inflammation on handgrip strength in the non-critically ill is independent from age, gender and body composition.

Norman K, Stobäus N, Kulka K, Schulzke J.

Eur J Clin Nutr. 2014 Feb;68(2):155-8. doi: 10.1038/ejcn.2013.261. Epub 2013 Dec 11.


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