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Temporal Dynamics of Reactive Oxygen and Nitrogen Species and NF-κB Activation During Acute and Chronic T Cell-Driven Inflammation.

Schwenck J, Mehling R, Thaiss WM, Kramer D, Menendez IG, Öz HH, Hartl D, Schulze-Osthoff K, Hailfinger S, Ghoreschi K, Quintanilla-Martinez L, Carlsen H, Röcken M, Pichler BJ, Kneilling M.

Mol Imaging Biol. 2019 Sep 3. doi: 10.1007/s11307-019-01412-8. [Epub ahead of print]


Multicenter Validation Study of a Diagnostic Algorithm to Detect NASH and Fibrosis in NAFLD Patients With Low NAFLD Fibrosis Score or Liver Stiffness.

Liebig S, Stoeckmann N, Geier A, Rau M, Schattenberg JM, Bahr MJ, Manns MP, Jaeckel E, Schulze-Osthoff K, Bantel H.

Clin Transl Gastroenterol. 2019 Aug;10(8):e00066. doi: 10.14309/ctg.0000000000000066.


Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis.

Heimer S, Knoll G, Schulze-Osthoff K, Ehrenschwender M.

Cell Death Dis. 2019 Jul 19;10(8):556. doi: 10.1038/s41419-019-1790-z.


Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.

Nasri M, Mir P, Dannenmann B, Amend D, Skroblyn T, Xu Y, Schulze-Osthoff K, Klimiankou M, Welte K, Skokowa J.

Blood Adv. 2019 Jan 8;3(1):63-71. doi: 10.1182/bloodadvances.2017015511.


Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.

Dannenmann B, Zahabi A, Mir P, Oswald B, Bernhard R, Klimiankou M, Morishima T, Schulze-Osthoff K, Zeidler C, Kanz L, Lachmann N, Moritz T, Welte K, Skokowa J.

Exp Hematol. 2019 Mar;71:51-60. doi: 10.1016/j.exphem.2018.12.006. Epub 2019 Jan 4.


German Cancer Consortium (DKTK) - A national consortium for translational cancer research.

Joos S, Nettelbeck DM, Reil-Held A, Engelmann K, Moosmann A, Eggert A, Hiddemann W, Krause M, Peters C, Schuler M, Schulze-Osthoff K, Serve H, Wick W, Puchta J, Baumann M.

Mol Oncol. 2019 Mar;13(3):535-542. doi: 10.1002/1878-0261.12430. Epub 2019 Jan 9. Review.


IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes.

Müller A, Hennig A, Lorscheid S, Grondona P, Schulze-Osthoff K, Hailfinger S, Kramer D.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10088-10093. doi: 10.1073/pnas.1801377115. Epub 2018 Sep 17.


Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax.

Stehle D, Grimm M, Einsele-Scholz S, Ladwig F, Johänning J, Fischer G, Gillissen B, Schulze-Osthoff K, Essmann F.

Sci Rep. 2018 Aug 20;8(1):12434. doi: 10.1038/s41598-018-30603-6.


Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection.

Wandrer F, Han B, Liebig S, Schlue J, Manns MP, Schulze-Osthoff K, Bantel H.

Aliment Pharmacol Ther. 2018 Aug;48(3):270-280. doi: 10.1111/apt.14802. Epub 2018 Jun 4.


Assessment of UV-C-induced water disinfection by differential PCR-based quantification of bacterial DNA damage.

Nocker A, Shah M, Dannenmann B, Schulze-Osthoff K, Wingender J, Probst AJ.

J Microbiol Methods. 2018 Jun;149:89-95. doi: 10.1016/j.mimet.2018.03.007. Epub 2018 Mar 31. No abstract available.


NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy.

Grondona P, Bucher P, Schulze-Osthoff K, Hailfinger S, Schmitt A.

Biomedicines. 2018 Mar 26;6(2). pii: E38. doi: 10.3390/biomedicines6020038. Review.


Correspondence: T cells are compromised in tetracycline transactivator transgenic mice.

Schmitt A, Schulze-Osthoff K, Hailfinger S.

Cell Death Differ. 2018 Mar;25(3):634-636. doi: 10.1038/s41418-017-0042-y. Epub 2018 Jan 19. No abstract available.


Simultaneous quantification of DNA damage and mitochondrial copy number by long-run DNA-damage quantification (LORD-Q).

Dannenmann B, Lehle S, Lorscheid S, Huber SM, Essmann F, Schulze-Osthoff K.

Oncotarget. 2017 Aug 10;8(68):112417-112425. doi: 10.18632/oncotarget.20112. eCollection 2017 Dec 22.


Macrophage p38 kinase inhibition for liver regeneration.

Schulze-Osthoff K, Bantel H.

FEBS J. 2017 Dec;284(24):4196-4199. doi: 10.1111/febs.14330.


Increased apoptosis of regulatory T cells in patients with active autoimmune hepatitis.

John K, Hardtke-Wolenski M, Jaeckel E, Manns MP, Schulze-Osthoff K, Bantel H.

Cell Death Dis. 2017 Dec 14;8(12):3219. doi: 10.1038/s41419-017-0010-y. No abstract available.


Prominent Oncogenic Roles of EVI1 in Breast Carcinoma.

Wang H, Schaefer T, Konantz M, Braun M, Varga Z, Paczulla AM, Reich S, Jacob F, Perner S, Moch H, Fehm TN, Kanz L, Schulze-Osthoff K, Lengerke C.

Cancer Res. 2017 Apr 15;77(8):2148-2160. doi: 10.1158/0008-5472.CAN-16-0593. Epub 2017 Feb 16.


Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma.

Gillissen B, Richter A, Richter A, Preissner R, Schulze-Osthoff K, Essmann F, Daniel PT.

J Biol Chem. 2017 Apr 21;292(16):6478-6492. doi: 10.1074/jbc.M116.754184. Epub 2017 Feb 1.


c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity.

Plaza-Sirvent C, Schuster M, Neumann Y, Heise U, Pils MC, Schulze-Osthoff K, Schmitz I.

Cell Rep. 2017 Jan 3;18(1):12-22. doi: 10.1016/j.celrep.2016.12.022.


CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.

Van Nuffel E, Schmitt A, Afonina IS, Schulze-Osthoff K, Beyaert R, Hailfinger S.

J Invest Dermatol. 2017 Mar;137(3):569-575. doi: 10.1016/j.jid.2016.09.031. Epub 2016 Dec 8. Review.


Letter: cytokeratin-18 as a biomarker of hepatocellular carcinoma regression after transarterial chemoembolization. Authors' reply.

Bantel H, Wandrer F, Bock B, Kirstein MM, Schulze-Osthoff K.

Aliment Pharmacol Ther. 2017 Jan;45(1):184-185. doi: 10.1111/apt.13826. No abstract available.


Nuclear delivery of recombinant OCT4 by chitosan nanoparticles for transgene-free generation of protein-induced pluripotent stem cells.

Tammam S, Malak P, Correa D, Rothfuss O, Azzazy HM, Lamprecht A, Schulze-Osthoff K.

Oncotarget. 2016 Jun 21;7(25):37728-37739. doi: 10.18632/oncotarget.9276.


Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak.

Einsele-Scholz S, Malmsheimer S, Bertram K, Stehle D, Johänning J, Manz M, Daniel PT, Gillissen BF, Schulze-Osthoff K, Essmann F.

J Cell Sci. 2016 Aug 1;129(15):3054. doi: 10.1242/jcs.193946. No abstract available.


Serum cell death biomarker mirrors liver cancer regression after transarterial chemoembolisation.

Bock B, Hasdemir D, Wandrer F, Rodt T, Manns MP, Schulze-Osthoff K, Bantel H.

Aliment Pharmacol Ther. 2016 Oct;44(7):747-54. doi: 10.1111/apt.13758. Epub 2016 Aug 3.


Genome surveillance in pluripotent stem cells: Low apoptosis threshold and efficient antioxidant defense.

Dannenmann B, Lehle S, Essmann F, Schulze-Osthoff K.

Mol Cell Oncol. 2015 Jun 23;3(2):e1052183. doi: 10.1080/23723556.2015.1052183. eCollection 2016 Mar.


The Atypical Inhibitor of NF-κB, IκBζ, Controls Macrophage Interleukin-10 Expression.

Hörber S, Hildebrand DG, Lieb WS, Lorscheid S, Hailfinger S, Schulze-Osthoff K, Essmann F.

J Biol Chem. 2016 Jun 10;291(24):12851-61. doi: 10.1074/jbc.M116.718825. Epub 2016 Apr 18.


Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak.

Einsele-Scholz S, Malmsheimer S, Bertram K, Stehle D, Johänning J, Manz M, Daniel PT, Gillissen BF, Schulze-Osthoff K, Essmann F.

J Cell Sci. 2016 Jun 1;129(11):2213-23. doi: 10.1242/jcs.181727. Epub 2016 Apr 13. Erratum in: J Cell Sci. 2016 Aug 1;129(15):3054.


The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells.

Ruiz-Magaña MJ, Martínez-Aguilar R, Lucendo E, Campillo-Davo D, Schulze-Osthoff K, Ruiz-Ruiz C.

Oncotarget. 2016 Apr 19;7(16):21875-86. doi: 10.18632/oncotarget.7871.


Decrease of Store-Operated Ca2+ Entry and Increase of Na+/Ca2+ Exchange by Pharmacological JAK2 Inhibition.

Yan J, Hosseinzadeh Z, Zhang B, Froeschl M, Schulze-Osthoff K, Stournaras C, Lang F.

Cell Physiol Biochem. 2016;38(2):683-95. doi: 10.1159/000443126. Epub 2016 Feb 8.


MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation.

Schmitt A, Grondona P, Maier T, Brändle M, Schönfeld C, Jäger G, Kosnopfel C, Eberle FC, Schittek B, Schulze-Osthoff K, Yazdi AS, Hailfinger S.

J Invest Dermatol. 2016 Apr;136(4):788-797. doi: 10.1016/j.jid.2015.12.027. Epub 2016 Jan 6.


The paracaspase MALT1 dampens NF-κB signalling by cleaving the LUBAC subunit HOIL-1.

Hailfinger S, Schmitt A, Schulze-Osthoff K.

FEBS J. 2016 Feb;283(3):400-2. doi: 10.1111/febs.13639. Epub 2016 Jan 25. No abstract available.


Interrogating Substrate Selectivity and Composition of Endogenous Histone Deacetylase Complexes with Chemical Probes.

Dose A, Sindlinger J, Bierlmeier J, Bakirbas A, Schulze-Osthoff K, Einsele-Scholz S, Hartl M, Essmann F, Finkemeier I, Schwarzer D.

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1192-5. doi: 10.1002/anie.201508174. Epub 2015 Dec 14.


Novel AKT phosphorylation sites identified in the pluripotency factors OCT4, SOX2 and KLF4.

Malak PN, Dannenmann B, Hirth A, Rothfuss OC, Schulze-Osthoff K.

Cell Cycle. 2015;14(23):3748-54. doi: 10.1080/15384101.2015.1104444.


Interferon-Mediated Cytokine Induction Determines Sustained Virus Control in Chronic Hepatitis C Virus Infection.

Wandrer F, Falk CS, John K, Skawran B, Manns MP, Schulze-Osthoff K, Bantel H.

J Infect Dis. 2016 Mar 1;213(5):746-54. doi: 10.1093/infdis/jiv505. Epub 2015 Oct 26.


Molecular and functional interactions between AKT and SOX2 in breast carcinoma.

Schaefer T, Wang H, Mir P, Konantz M, Pereboom TC, Paczulla AM, Merz B, Fehm T, Perner S, Rothfuss OC, Kanz L, Schulze-Osthoff K, Lengerke C.

Oncotarget. 2015 Dec 22;6(41):43540-56. doi: 10.18632/oncotarget.6183.


IκBζ is a key driver in the development of psoriasis.

Johansen C, Mose M, Ommen P, Bertelsen T, Vinter H, Hailfinger S, Lorscheid S, Schulze-Osthoff K, Iversen L.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5825-33. doi: 10.1073/pnas.1509971112. Epub 2015 Oct 12.


Platelets induce apoptosis via membrane-bound FasL.

Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF.

Blood. 2015 Sep 17;126(12):1483-93. doi: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Erratum in: Blood. 2016 Jan 14;127(2):270. Blood. 2016 Jan 14;127(2):270.


High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells.

Dannenmann B, Lehle S, Hildebrand DG, Kübler A, Grondona P, Schmid V, Holzer K, Fröschl M, Essmann F, Rothfuss O, Schulze-Osthoff K.

Stem Cell Reports. 2015 May 12;4(5):886-98. doi: 10.1016/j.stemcr.2015.04.004. Epub 2015 Apr 30.


Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis.

Bou-Hanna C, Jarry A, Lode L, Schmitz I, Schulze-Osthoff K, Kury S, Bezieau S, Mosnier JF, Laboisse CL.

Cancer Lett. 2015 Apr 10;359(2):211-7. doi: 10.1016/j.canlet.2015.01.014. Epub 2015 Jan 21.


Controlled processing of a full-sized porcine liver to a decellularized matrix in 24 h.

Bühler NE, Schulze-Osthoff K, Königsrainer A, Schenk M.

J Biosci Bioeng. 2015 May;119(5):609-13. doi: 10.1016/j.jbiosc.2014.10.019. Epub 2014 Nov 21.


Reply: To PMID 24913549.

Bantel H, Thum T, Schulze-Osthoff K.

Hepatology. 2015 Apr;61(4):1440-1. doi: 10.1002/hep.27352. Epub 2015 Mar 9. No abstract available.


Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.

Effenberger T, von der Heyde J, Bartsch K, Garbers C, Schulze-Osthoff K, Chalaris A, Murphy G, Rose-John S, Rabe B.

FASEB J. 2014 Nov;28(11):4847-56. doi: 10.1096/fj.14-254565. Epub 2014 Jul 30.


Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis.

Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R.

Circ Res. 2014 Sep 12;115(7):662-7. doi: 10.1161/CIRCRESAHA.115.304634. Epub 2014 Jul 28.


MicroRNAs play a role in spontaneous recovery from acute liver failure.

John K, Hadem J, Krech T, Wahl K, Manns MP, Dooley S, Batkai S, Thum T, Schulze-Osthoff K, Bantel H.

Hepatology. 2014 Oct;60(4):1346-55. doi: 10.1002/hep.27250. Epub 2014 Aug 25.


Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells.

Geisel J, Brück J, Glocova I, Dengler K, Sinnberg T, Rothfuss O, Walter M, Schulze-Osthoff K, Röcken M, Ghoreschi K.

J Immunol. 2014 Apr 15;192(8):3530-9. doi: 10.4049/jimmunol.1300556. Epub 2014 Mar 17.


[Cytokeratin 18 as marker for non-invasive diagnosis and prognosis of acute and chronic liver diseases].

Canbay A, Feldstein A, Kronenberger B, Schulze-Osthoff K, Bantel H.

Z Gastroenterol. 2014 Mar;52(3):290-5. doi: 10.1055/s-0033-1356138. Epub 2014 Mar 12. Review. German.


Robust detection of liver steatosis and staging of NAFLD by an improved ELISA for serum cytokeratin-18 fragments.

Bantel H, John K, Schulze-Osthoff K.

Am J Gastroenterol. 2014 Jan;109(1):140-1. doi: 10.1038/ajg.2013.350. No abstract available.


LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.

Lehle S, Hildebrand DG, Merz B, Malak PN, Becker MS, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O.

Nucleic Acids Res. 2014 Apr;42(6):e41. doi: 10.1093/nar/gkt1349. Epub 2013 Dec 26.


Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome.

John K, Wielgosz S, Schulze-Osthoff K, Bantel H, Hass R.

Cell Death Dis. 2013 Oct 24;4:e886. doi: 10.1038/cddis.2013.408.


Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).

Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, Rose-John S, Essmann F, Schulze-Osthoff K, Piekorz RP, Scheller J.

Cell Cycle. 2013 Nov 1;12(21):3421-32. doi: 10.4161/cc.26431. Epub 2013 Sep 18.


A novel intronic promoter of the Crem gene induces small ICER (smICER) isoforms.

Seidl MD, Nunes F, Fels B, Hildebrandt I, Schmitz W, Schulze-Osthoff K, Müller FU.

FASEB J. 2014 Jan;28(1):143-52. doi: 10.1096/fj.13-231977. Epub 2013 Sep 10.


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