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Items: 1 to 50 of 255

1.

Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression.

Koch S, Damas M, Freise A, Hage E, Dhingra A, Rückert J, Gallo A, Kremmer E, Tegge W, Brönstrup M, Brune W, Schulz TF.

PLoS Pathog. 2019 May 6;15(5):e1007743. doi: 10.1371/journal.ppat.1007743. eCollection 2019 May.

2.

Human Cytomegalovirus Genomes Sequenced Directly from Clinical Material: Variation, Multiple-Strain Infection, Recombination and Gene Loss.

Suárez NM, Wilkie GS, Hage E, Camiolo S, Holton M, Hughes J, Maabar MD, Sreenu VB, Dhingra A, Gompels UA, Wilkinson GWG, Baldanti F, Furione M, Lilleri D, Arossa A, Ganzenmueller T, Gerna G, Hubáček P, Schulz TF, Wolf D, Zavattoni M, Davison AJ.

J Infect Dis. 2019 May 2. pii: jiz208. doi: 10.1093/infdis/jiz208. [Epub ahead of print]

PMID:
31050742
3.

Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8.

Kirsch P, Jakob V, Oberhausen K, Stein SC, Cucarro I, Schulz TF, Empting M.

J Med Chem. 2019 Apr 25;62(8):3924-3939. doi: 10.1021/acs.jmedchem.8b01827. Epub 2019 Apr 12.

PMID:
30888817
4.

An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in vivo.

Dubich T, Lieske A, Santag S, Beauclair G, Rückert J, Herrmann J, Gorges J, Büsche G, Kazmaier U, Hauser H, Stadler M, Schulz TF, Wirth D.

J Mol Med (Berl). 2019 Mar;97(3):311-324. doi: 10.1007/s00109-018-01733-1. Epub 2019 Jan 4.

PMID:
30610257
5.

Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2α To Activate Productive Viral Replication.

Abere B, Samarina N, Gramolelli S, Rückert J, Gerold G, Pich A, Schulz TF.

J Virol. 2018 Aug 16;92(17). pii: e00544-18. doi: 10.1128/JVI.00544-18. Print 2018 Sep 1.

6.

Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease.

Baier C, Haid S, Beilken A, Behnert A, Wetzke M, Brown RJP, Schmitt C, Ebadi E, Hansen G, Schulz TF, Pietschmann T, Bange FC.

Antimicrob Resist Infect Control. 2018 Feb 13;7:21. doi: 10.1186/s13756-018-0316-2. eCollection 2018.

7.

Editorial overview: Viruses and cancer: How tumor viruses affect the cellular genome.

Schulz TF, Cesarman E.

Curr Opin Virol. 2017 Oct;26:vi-vii. doi: 10.1016/j.coviro.2017.10.005. No abstract available.

PMID:
29107266
8.

The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target.

Abere B, Mamo TM, Hartmann S, Samarina N, Hage E, Rückert J, Hotop SK, Büsche G, Schulz TF.

PLoS Pathog. 2017 Sep 22;13(9):e1006639. doi: 10.1371/journal.ppat.1006639. eCollection 2017 Sep.

9.

Kaposi sarcoma herpesvirus pathogenesis.

Mariggiò G, Koch S, Schulz TF.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732). pii: 20160275. doi: 10.1098/rstb.2016.0275. Review.

10.

Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression.

McHugh D, Caduff N, Barros MHM, Rämer PC, Raykova A, Murer A, Landtwing V, Quast I, Styles CT, Spohn M, Fowotade A, Delecluse HJ, Papoudou-Bai A, Lee YM, Kim JM, Middeldorp J, Schulz TF, Cesarman E, Zbinden A, Capaul R, White RE, Allday MJ, Niedobitek G, Blackbourn DJ, Grundhoff A, Münz C.

Cell Host Microbe. 2017 Jul 12;22(1):61-73.e7. doi: 10.1016/j.chom.2017.06.009.

11.

The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion.

Zischke J, Mamareli P, Pokoyski C, Gabaev I, Buyny S, Jacobs R, Falk CS, Lochner M, Sparwasser T, Schulz TF, Kay-Fedorov PC.

PLoS Pathog. 2017 Jun 19;13(6):e1006454. doi: 10.1371/journal.ppat.1006454. eCollection 2017 Jun.

12.

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration.

González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Lenac Rovis T, Jonjic S, Verjans GMGM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A.

PLoS Pathog. 2017 May 25;13(5):e1006346. doi: 10.1371/journal.ppat.1006346. eCollection 2017 May.

13.

Rhadinoviral interferon regulatory factor homologues.

Koch S, Schulz TF.

Biol Chem. 2017 Jul 26;398(8):857-870. doi: 10.1515/hsz-2017-0111. Review.

PMID:
28455950
14.

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence.

Weidner-Glunde M, Mariggiò G, Schulz TF.

J Virol. 2017 Jun 26;91(14). pii: e01083-16. doi: 10.1128/JVI.01083-16. Print 2017 Jul 15. Review.

15.

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency.

Mariggiò G, Koch S, Zhang G, Weidner-Glunde M, Rückert J, Kati S, Santag S, Schulz TF.

PLoS Pathog. 2017 Apr 21;13(4):e1006335. doi: 10.1371/journal.ppat.1006335. eCollection 2017 Apr.

16.

Characterization of Human Cytomegalovirus Genome Diversity in Immunocompromised Hosts by Whole-Genome Sequencing Directly From Clinical Specimens.

Hage E, Wilkie GS, Linnenweber-Held S, Dhingra A, Suárez NM, Schmidt JJ, Kay-Fedorov PC, Mischak-Weissinger E, Heim A, Schwarz A, Schulz TF, Davison AJ, Ganzenmueller T.

J Infect Dis. 2017 Jun 1;215(11):1673-1683. doi: 10.1093/infdis/jix157.

PMID:
28368496
17.

Viral mouse models of multiple sclerosis and epilepsy: Marked differences in neuropathogenesis following infection with two naturally occurring variants of Theiler's virus BeAn strain.

Bröer S, Hage E, Käufer C, Gerhauser I, Anjum M, Li L, Baumgärtner W, Schulz TF, Löscher W.

Neurobiol Dis. 2017 Mar;99:121-132. doi: 10.1016/j.nbd.2016.12.020. Epub 2016 Dec 22.

PMID:
28017800
18.

Proliferation status defines functional properties of endothelial cells.

Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Köster M, May T, Schulz TF, Hauser H, Wirth D.

Cell Mol Life Sci. 2017 Apr;74(7):1319-1333. doi: 10.1007/s00018-016-2417-5. Epub 2016 Nov 16.

PMID:
27853834
19.

Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules.

Kampers J, Orjuela-Grimm M, Schober T, Schulz TF, Stiefel M, Klein C, Körholz D, Mauz-Körholz C, Kreipe H, Beier R, Maecker-Kolhoff B.

Leuk Lymphoma. 2017 Mar;58(3):633-638. doi: 10.1080/10428194.2016.1205742. Epub 2016 Aug 11.

PMID:
27685149
20.

KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.

Abere B, Schulz TF.

Curr Opin Virol. 2016 Oct;20:11-19. doi: 10.1016/j.coviro.2016.07.008. Epub 2016 Aug 9. Review.

PMID:
27518127
21.

Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori.

Bubendorfer S, Krebes J, Yang I, Hage E, Schulz TF, Bahlawane C, Didelot X, Suerbaum S.

Nat Commun. 2016 Jun 22;7:11995. doi: 10.1038/ncomms11995.

22.

Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens.

Zannetti C, Roblot G, Charrier E, Ainouze M, Tout I, Briat F, Isorce N, Faure-Dupuy S, Michelet M, Marotel M, Kati S, Schulz TF, Rivoire M, Traverse-Glehen A, Luangsay S, Alatiff O, Henry T, Walzer T, Durantel D, Hasan U.

J Immunol. 2016 Jul 1;197(1):356-67. doi: 10.4049/jimmunol.1502301. Epub 2016 May 25.

23.

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS.

Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1034-43. doi: 10.1073/pnas.1516812113. Epub 2016 Jan 25.

24.

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4(+) T Cells.

Gogol-Döring A, Ammar I, Gupta S, Bunse M, Miskey C, Chen W, Uckert W, Schulz TF, Izsvák Z, Ivics Z.

Mol Ther. 2016 Mar;24(3):592-606. doi: 10.1038/mt.2016.11. Epub 2016 Jan 12.

25.

The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1.

Castillo-Gomez E, Kästner A, Steiner J, Schneider A, Hettling B, Poggi G, Ostehr K, Uhr M, Asif AR, Matzke M, Schmidt U, Pfander V, Hammer C, Schulz TF, Binder L, Stöcker W, Weber F, Ehrenreich H.

Ann Neurol. 2016 Jan;79(1):144-51. doi: 10.1002/ana.24545. Epub 2015 Dec 2.

PMID:
26505629
26.

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.

Hammer C, Begemann M, McLaren PJ, Bartha I, Michel A, Klose B, Schmitt C, Waterboer T, Pawlita M, Schulz TF, Ehrenreich H, Fellay J.

Am J Hum Genet. 2015 Nov 5;97(5):738-43. doi: 10.1016/j.ajhg.2015.09.008. Epub 2015 Oct 8.

27.

Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.

Schulz TF, Cesarman E.

Curr Opin Virol. 2015 Oct;14:116-28. doi: 10.1016/j.coviro.2015.08.016. Epub 2015 Sep 29. Review.

PMID:
26431609
28.

Inhibiting the Recruitment of PLCγ1 to Kaposi's Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells.

Gramolelli S, Weidner-Glunde M, Abere B, Viejo-Borbolla A, Bala K, Rückert J, Kremmer E, Schulz TF.

PLoS Pathog. 2015 Aug 21;11(8):e1005105. doi: 10.1371/journal.ppat.1005105. eCollection 2015 Aug.

29.

K1 and K15 of Kaposi's Sarcoma-Associated Herpesvirus Are Partial Functional Homologues of Latent Membrane Protein 2A of Epstein-Barr Virus.

Steinbrück L, Gustems M, Medele S, Schulz TF, Lutter D, Hammerschmidt W.

J Virol. 2015 Jul;89(14):7248-61. doi: 10.1128/JVI.00839-15. Epub 2015 May 6.

30.

The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA.

Hellert J, Weidner-Glunde M, Krausze J, Lünsdorf H, Ritter C, Schulz TF, Lührs T.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6694-9. doi: 10.1073/pnas.1421804112. Epub 2015 May 6.

31.

Generation of high-titre virus stocks using BrK.219, a B-cell line infected stably with recombinant Kaposi's sarcoma-associated herpesvirus.

Kati S, Hage E, Mynarek M, Ganzenmueller T, Indenbirken D, Grundhoff A, Schulz TF.

J Virol Methods. 2015 Jun 1;217:79-86. doi: 10.1016/j.jviromet.2015.02.022. Epub 2015 Feb 28.

PMID:
25736227
32.

A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity.

Hammer C, Wanitchakool P, Sirianant L, Papiol S, Monnheimer M, Faria D, Ousingsawat J, Schramek N, Schmitt C, Margos G, Michel A, Kraiczy P, Pawlita M, Schreiber R, Schulz TF, Fingerle V, Tumani H, Ehrenreich H, Kunzelmann K.

Mol Med. 2015 Feb 23;21:26-37. doi: 10.2119/molmed.2014.00219.

33.

ORF57 overcomes the detrimental sequence bias of Kaposi's sarcoma-associated herpesvirus lytic genes.

Vogt C, Hackmann C, Rabner A, Koste L, Santag S, Kati S, Mandel-Gutfreund Y, Schulz TF, Bohne J.

J Virol. 2015 May;89(9):5097-109. doi: 10.1128/JVI.03264-14. Epub 2015 Feb 18.

34.

A rolling circle amplification screen for polyomaviruses other than BKPyV in renal transplant recipients confirms high prevalence of urinary JCPyV shedding.

Kluba J, Linnenweber-Held S, Heim A, Ang AM, Raggub L, Broecker V, Becker JU, Schulz TF, Schwarz A, Ganzenmueller T.

Intervirology. 2015;58(2):88-94. doi: 10.1159/000369210. Epub 2015 Feb 13.

35.

Crystallization, room-temperature X-ray diffraction and preliminary analysis of Kaposi's sarcoma herpesvirus LANA bound to DNA.

Hellert J, Krausze J, Schulz TF, Lührs T.

Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1570-4. doi: 10.1107/S2053230X14019906. Epub 2014 Oct 25.

36.

The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma.

Gramolelli S, Schulz TF.

J Pathol. 2015 Jan;235(2):368-80. doi: 10.1002/path.4441. Review.

PMID:
25212381
37.

High-level human herpesvirus-8 viremia and multicentric Castleman's disease following initiation of highly active antiretroviral therapy.

Lumley S, Madge S, Nugent D, Ainsworth J, Dervisevic S, Schmitt C, Schulz TF, Johnson MA, Cwynarski K, Webster DP.

AIDS. 2014 Jul 17;28(11):1698-700. doi: 10.1097/QAD.0000000000000287. No abstract available.

PMID:
25197975
38.

Activation of NF-κB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-κB-inducing kinase, IκB kinases, and phosphorylation of p65.

Hävemeier A, Gramolelli S, Pietrek M, Jochmann R, Stürzl M, Schulz TF.

J Virol. 2014 Nov;88(22):13161-72. doi: 10.1128/JVI.01766-14. Epub 2014 Sep 3.

39.

A human adenovirus species B subtype 21a associated with severe pneumonia.

Hage E, Huzly D, Ganzenmueller T, Beck R, Schulz TF, Heim A.

J Infect. 2014 Nov;69(5):490-9. doi: 10.1016/j.jinf.2014.06.015. Epub 2014 Jun 27.

PMID:
24975176
40.

Manipulation of endothelial cells by KSHV: implications for angiogenesis and aberrant vascular differentiation.

Ojala PM, Schulz TF.

Semin Cancer Biol. 2014 Jun;26:69-77. doi: 10.1016/j.semcancer.2014.01.008. Epub 2014 Jan 28. Review.

PMID:
24486643
41.

The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.

Haas DA, Bala K, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF.

PLoS Pathog. 2013;9(11):e1003737. doi: 10.1371/journal.ppat.1003737. Epub 2013 Nov 7.

42.

A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.

Hellert J, Weidner-Glunde M, Krausze J, Richter U, Adler H, Fedorov R, Pietrek M, Rückert J, Ritter C, Schulz TF, Lührs T.

PLoS Pathog. 2013;9(10):e1003640. doi: 10.1371/journal.ppat.1003640. Epub 2013 Oct 17.

43.

No human virus sequences detected by next-generation sequencing in benign verrucous skin tumors occurring in BRAF-inhibitor-treated patients.

Ganzenmueller T, Hage E, Yakushko Y, Kluba J, Woltemate S, Schacht V, Schulz TF, Gutzmer R.

Exp Dermatol. 2013 Nov;22(11):725-9. doi: 10.1111/exd.12249.

PMID:
24112647
44.

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.

Gupta SS, Maetzig T, Maertens GN, Sharif A, Rothe M, Weidner-Glunde M, Galla M, Schambach A, Cherepanov P, Schulz TF.

J Virol. 2013 Dec;87(23):12721-36. doi: 10.1128/JVI.01942-13. Epub 2013 Sep 18.

45.

Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H.

Mol Psychiatry. 2014 Oct;19(10):1143-9. doi: 10.1038/mp.2013.110. Epub 2013 Sep 3.

PMID:
23999527
46.

Delayed seroconversion and rapid onset of lymphoproliferative disease after transmission of human T-cell lymphotropic virus type 1 from a multiorgan donor.

Glowacka I, Korn K, Potthoff SA, Lehmann U, Kreipe HH, Ivens K, Barg-Hock H, Schulz TF, Heim A.

Clin Infect Dis. 2013 Nov;57(10):1417-24. doi: 10.1093/cid/cit545. Epub 2013 Aug 15.

PMID:
23956168
47.

A peptide inhibitor of cytomegalovirus infection from human hemofiltrate.

Borst EM, Ständker L, Wagner K, Schulz TF, Forssmann WG, Messerle M.

Antimicrob Agents Chemother. 2013 Oct;57(10):4751-60. doi: 10.1128/AAC.00854-13. Epub 2013 Jul 15.

48.

Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.

Scholz BA, Harth-Hertle ML, Malterer G, Haas J, Ellwart J, Schulz TF, Kempkes B.

PLoS Pathog. 2013;9(5):e1003336. doi: 10.1371/journal.ppat.1003336. Epub 2013 May 16.

49.

Activation of the B cell antigen receptor triggers reactivation of latent Kaposi's sarcoma-associated herpesvirus in B cells.

Kati S, Tsao EH, Günther T, Weidner-Glunde M, Rothämel T, Grundhoff A, Kellam P, Schulz TF.

J Virol. 2013 Jul;87(14):8004-16. doi: 10.1128/JVI.00506-13. Epub 2013 May 15.

50.

EBV-specific T-cell immunity in pediatric solid organ graft recipients with posttransplantation lymphoproliferative disease.

Wilsdorf N, Eiz-Vesper B, Henke-Gendo C, Diestelhorst J, Oschlies I, Hussein K, Pape L, Baumann U, Tönshoff B, Pohl M, Höcker B, Wingen AM, Klapper W, Kreipe H, Schulz TF, Klein C, Maecker-Kolhoff B.

Transplantation. 2013 Jan 15;95(1):247-55. doi: 10.1097/TP.0b013e318279968d.

PMID:
23222899

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