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Items: 1 to 50 of 217

1.

Epigenetic reprogramming of immune cells in injury, repair, and resolution.

Placek K, Schultze JL, Aschenbrenner AC.

J Clin Invest. 2019 Jul 22;129(8):2994-3005. doi: 10.1172/JCI124619. eCollection 2019 Jul 22. Review.

2.

Shiny-Seq: advanced guided transcriptome analysis.

Sundararajan Z, Knoll R, Hombach P, Becker M, Schultze JL, Ulas T.

BMC Res Notes. 2019 Jul 18;12(1):432. doi: 10.1186/s13104-019-4471-1.

3.

Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration.

Sloot YJE, Rabold K, Ulas T, De Graaf DM, Heinhuis B, Händler K, Schultze JL, Netea MG, Smit JWA, Joosten LAB, Netea-Maier RT.

Cell Oncol (Dordr). 2019 Oct;42(5):691-703. doi: 10.1007/s13402-019-00457-9. Epub 2019 Jun 14.

PMID:
31201646
4.

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

Schmidleithner L, Thabet Y, Schönfeld E, Köhne M, Sommer D, Abdullah Z, Sadlon T, Osei-Sarpong C, Subbaramaiah K, Copperi F, Haendler K, Varga T, Schanz O, Bourry S, Bassler K, Krebs W, Peters AE, Baumgart AK, Schneeweiss M, Klee K, Schmidt SV, Nüssing S, Sander J, Ohkura N, Waha A, Sparwasser T, Wunderlich FT, Förster I, Ulas T, Weighardt H, Sakaguchi S, Pfeifer A, Blüher M, Dannenberg AJ, Ferreirós N, Muglia LJ, Wickenhauser C, Barry SC, Schultze JL, Beyer M.

Immunity. 2019 May 21;50(5):1232-1248.e14. doi: 10.1016/j.immuni.2019.03.014. Epub 2019 Apr 23.

PMID:
31027998
5.

Immune memory characteristics of innate lymphoid cells.

Placek K, Schultze JL, Netea MG.

Curr Opin Infect Dis. 2019 Jun;32(3):196-203. doi: 10.1097/QCO.0000000000000540.

PMID:
31021952
6.

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression.

Goossens P, Rodriguez-Vita J, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O, Van Eck M, Auphan-Anezin N, Bebien M, Verthuy C, Vu Manh TP, Turner M, Dalod M, Schultze JL, Lawrence T.

Cell Metab. 2019 Jun 4;29(6):1376-1389.e4. doi: 10.1016/j.cmet.2019.02.016. Epub 2019 Mar 28.

PMID:
30930171
7.

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.

Salvagno C, Ciampricotti M, Tuit S, Hau CS, van Weverwijk A, Coffelt SB, Kersten K, Vrijland K, Kos K, Ulas T, Song JY, Ooi CH, Rüttinger D, Cassier PA, Jonkers J, Schultze JL, Ries CH, de Visser KE.

Nat Cell Biol. 2019 Apr;21(4):511-521. doi: 10.1038/s41556-019-0298-1. Epub 2019 Mar 18.

8.

Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes.

van der Poel M, Ulas T, Mizee MR, Hsiao CC, Miedema SSM, Adelia, Schuurman KG, Helder B, Tas SW, Schultze JL, Hamann J, Huitinga I.

Nat Commun. 2019 Mar 13;10(1):1139. doi: 10.1038/s41467-019-08976-7.

9.

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.

Zwick M, Ulas T, Cho YL, Ried C, Grosse L, Simon C, Bernhard C, Busch DH, Schultze JL, Buchholz VR, Stutte S, Brocker T.

Front Immunol. 2019 Feb 12;10:222. doi: 10.3389/fimmu.2019.00222. eCollection 2019.

10.

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation.

Schultze JL, Mass E, Schlitzer A.

Immunity. 2019 Feb 19;50(2):288-301. doi: 10.1016/j.immuni.2019.01.019. Review.

PMID:
30784577
11.

The Myeloid Cell Compartment-Cell by Cell.

Bassler K, Schulte-Schrepping J, Warnat-Herresthal S, Aschenbrenner AC, Schultze JL.

Annu Rev Immunol. 2019 Apr 26;37:269-293. doi: 10.1146/annurev-immunol-042718-041728. Epub 2019 Jan 16.

PMID:
30649988
12.

Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens.

Netea MG, Schlitzer A, Placek K, Joosten LAB, Schultze JL.

Cell Host Microbe. 2019 Jan 9;25(1):13-26. doi: 10.1016/j.chom.2018.12.006. Review.

PMID:
30629914
13.

Stroke target identification guided by astrocyte transcriptome analysis.

Rakers C, Schleif M, Blank N, Matušková H, Ulas T, Händler K, Torres SV, Schumacher T, Tai K, Schultze JL, Jackson WS, Petzold GC.

Glia. 2019 Apr;67(4):619-633. doi: 10.1002/glia.23544. Epub 2018 Dec 26.

PMID:
30585358
14.

Myocardial infarction cell by cell.

Schultze JL.

Nat Immunol. 2019 Jan;20(1):7-9. doi: 10.1038/s41590-018-0277-x. No abstract available.

PMID:
30538327
15.

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.

Kabrani E, Chu VT, Tasouri E, Sommermann T, Baßler K, Ulas T, Zenz T, Bullinger L, Schultze JL, Rajewsky K, Sander S.

Blood. 2018 Dec 20;132(25):2670-2683. doi: 10.1182/blood-2018-06-856203. Epub 2018 Oct 17.

PMID:
30333121
16.

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD.

Cell Rep. 2018 Jul 31;24(5):1085-1092.e6. doi: 10.1016/j.celrep.2018.06.112.

17.

Systematic evaluation of error rates and causes in short samples in next-generation sequencing.

Pfeiffer F, Gröber C, Blank M, Händler K, Beyer M, Schultze JL, Mayer G.

Sci Rep. 2018 Jul 19;8(1):10950. doi: 10.1038/s41598-018-29325-6.

18.

CD83 expression is essential for Treg cell differentiation and stability.

Doebbeler M, Koenig C, Krzyzak L, Seitz C, Wild A, Ulas T, Baßler K, Kopelyanskiy D, Butterhof A, Kuhnt C, Kreiser S, Stich L, Zinser E, Knippertz I, Wirtz S, Riegel C, Hoffmann P, Edinger M, Nitschke L, Winkler T, Schultze JL, Steinkasserer A, Lechmann M.

JCI Insight. 2018 Jun 7;3(11). pii: 99712. doi: 10.1172/jci.insight.99712. eCollection 2018 Jun 7.

19.

Dysregulated Functions of Lung Macrophage Populations in COPD.

Kapellos TS, Bassler K, Aschenbrenner AC, Fujii W, Schultze JL.

J Immunol Res. 2018 Feb 18;2018:2349045. doi: 10.1155/2018/2349045. eCollection 2018. Review.

20.

Systems Medicine in Chronic Inflammatory Diseases.

Schultze JL; SYSCID consortium, Rosenstiel P.

Immunity. 2018 Apr 17;48(4):608-613. doi: 10.1016/j.immuni.2018.03.022.

21.

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P.

Genome Med. 2018 Apr 13;10(1):27. doi: 10.1186/s13073-018-0534-5.

22.

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.

Bickert A, Kern P, van Uelft M, Herresthal S, Ulas T, Gutbrod K, Breiden B, Degen J, Sandhoff K, Schultze JL, Dörmann P, Hartmann D, Bauer R, Willecke K.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):734-749. doi: 10.1016/j.bbalip.2018.04.006. Epub 2018 Apr 10.

PMID:
29653252
23.

Innate immune memory in the brain shapes neurological disease hallmarks.

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze JL, Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ.

Nature. 2018 Apr;556(7701):332-338. doi: 10.1038/s41586-018-0023-4. Epub 2018 Apr 11.

24.

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J.

J Clin Invest. 2018 May 1;128(5):1852-1866. doi: 10.1172/JCI89867. Epub 2018 Apr 3.

25.

Systems immunology allows a new view on human dendritic cells.

Schultze JL, Aschenbrenner AC.

Semin Cell Dev Biol. 2019 Feb;86:15-23. doi: 10.1016/j.semcdb.2018.02.017. Epub 2018 Feb 24. Review.

PMID:
29448068
26.

Exosomes-Small Players, Big Sound.

Gulei D, Irimie AI, Cojocneanu-Petric R, Schultze JL, Berindan-Neagoe I.

Bioconjug Chem. 2018 Mar 21;29(3):635-648. doi: 10.1021/acs.bioconjchem.8b00003. Epub 2018 Feb 9. Review.

PMID:
29369619
27.

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.

28.

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T.

Cell. 2018 Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034.

29.

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner.

Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, Blecher R, Ulas T, Squarzoni P, Hoeffel G, Coulpier F, Siopi E, David FS, Scholz C, Shihui F, Lum J, Amoyo AA, Larbi A, Poidinger M, Buttgereit A, Lledo PM, Greter M, Chan JKY, Amit I, Beyer M, Schultze JL, Schlitzer A, Pettersson S, Ginhoux F, Garel S.

Cell. 2018 Jan 25;172(3):500-516.e16. doi: 10.1016/j.cell.2017.11.042. Epub 2017 Dec 21.

30.

Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.

Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL.

Immunity. 2017 Dec 19;47(6):1051-1066.e12. doi: 10.1016/j.immuni.2017.11.024.

31.

The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function.

Wischhof L, Maida S, Piazzesi A, Gioran A, Barragan Sanz K, Irsen S, Beyer M, Schultze JL, Dyer MJ, Salomoni P, Ehninger D, Nicotera P, Bano D.

Sci Rep. 2017 Dec 6;7(1):17055. doi: 10.1038/s41598-017-17284-3.

32.

Bioinformatic Assessment of Macrophage Activation by the Innate Immune System.

Ulas T, Schultze JL, Beyer M.

Methods Mol Biol. 2018;1714:19-40. doi: 10.1007/978-1-4939-7519-8_2.

PMID:
29177853
33.

RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo.

Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Haßel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Gröber C, Händler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Förster I.

Mol Ther. 2018 Jan 3;26(1):95-104. doi: 10.1016/j.ymthe.2017.10.005. Epub 2017 Oct 13.

34.

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.

Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD.

Nature. 2017 Oct 5;550(7674):119-123. doi: 10.1038/nature24022. Epub 2017 Sep 27.

35.

Corrigendum: S100-alarmin-induced innate immune programming protects newborn infants from sepsis.

Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schöning J, Schreek S, Pfeifer S, Reuner F, Völlger L, Stanulla M, von Köckritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173b. No abstract available.

PMID:
28926540
36.

Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.

Hösel M, Quasdorff M, Ringelhan M, Kashkar H, Debey-Pascher S, Sprinzl MF, Bockmann JH, Arzberger S, Webb D, von Olshausen G, Weber A, Schultze JL, Büning H, Heikenwalder M, Protzer U.

Cell Mol Gastroenterol Hepatol. 2017 Jul 19;4(3):339-363. doi: 10.1016/j.jcmgh.2017.07.003. eCollection 2017 Nov.

37.

Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.

Heidkamp GF, Sander J, Lehmann CHK, Heger L, Eissing N, Baranska A, Lühr JJ, Hoffmann A, Reimer KC, Lux A, Söder S, Hartmann A, Zenk J, Ulas T, McGovern N, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Forster A, Repp R, Fasching PA, Purbojo A, Cesnjevar R, Ullrich E, Ginhoux F, Schlitzer A, Nimmerjahn F, Schultze JL, Dudziak D.

Sci Immunol. 2016 Dec 16;1(6). pii: eaai7677. doi: 10.1126/sciimmunol.aai7677. Epub 2016 Dec 16.

PMID:
28783692
38.

A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a.

Aschenbrenner AC, Bassler K, Brondolin M, Bonaguro L, Carrera P, Klee K, Ulas T, Schultze JL, Hoch M.

Sci Rep. 2017 Jun 22;7(1):4056. doi: 10.1038/s41598-017-04370-9.

39.

Generation and functional characterization of MDSC-like cells.

Heine A, Held SAE, Schulte-Schrepping J, Wolff JFA, Klee K, Ulas T, Schmacke NA, Daecke SN, Riethausen K, Schultze JL, Brossart P.

Oncoimmunology. 2017 Feb 23;6(4):e1295203. doi: 10.1080/2162402X.2017.1295203. eCollection 2017.

40.

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice.

Bilkei-Gorzo A, Albayram O, Draffehn A, Michel K, Piyanova A, Oppenheimer H, Dvir-Ginzberg M, Rácz I, Ulas T, Imbeault S, Bab I, Schultze JL, Zimmer A.

Nat Med. 2017 Jun;23(6):782-787. doi: 10.1038/nm.4311. Epub 2017 May 8.

PMID:
28481360
41.

Mapping the human DC lineage through the integration of high-dimensional techniques.

See P, Dutertre CA, Chen J, Günther P, McGovern N, Irac SE, Gunawan M, Beyer M, Händler K, Duan K, Sumatoh HRB, Ruffin N, Jouve M, Gea-Mallorquí E, Hennekam RCM, Lim T, Yip CC, Wen M, Malleret B, Low I, Shadan NB, Fen CFS, Tay A, Lum J, Zolezzi F, Larbi A, Poidinger M, Chan JKY, Chen Q, Rénia L, Haniffa M, Benaroch P, Schlitzer A, Schultze JL, Newell EW, Ginhoux F.

Science. 2017 Jun 9;356(6342). pii: eaag3009. doi: 10.1126/science.aag3009. Epub 2017 May 4.

PMID:
28473638
42.

S100-alarmin-induced innate immune programming protects newborn infants from sepsis.

Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schöning J, Schreek S, Pfeifer S, Reuner F, Völlger L, Stanulla M, von Köckritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D.

Nat Immunol. 2017 Jun;18(6):622-632. doi: 10.1038/ni.3745. Epub 2017 May 1. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.

PMID:
28459433
43.

New "programmers" in tissue macrophage activation.

Aschenbrenner AC, Schultze JL.

Pflugers Arch. 2017 Apr;469(3-4):375-383. doi: 10.1007/s00424-017-1943-9. Epub 2017 Feb 9. Review.

PMID:
28185067
44.

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.

Arts RJ, Plantinga TS, Tuit S, Ulas T, Heinhuis B, Tesselaar M, Sloot Y, Adema GJ, Joosten LA, Smit JW, Netea MG, Schultze JL, Netea-Maier RT.

Oncoimmunology. 2016 Sep 9;5(12):e1229725. doi: 10.1080/2162402X.2016.1229725. eCollection 2016.

45.

Chromatin Remodeling in Monocyte and Macrophage Activation.

Schultze JL.

Adv Protein Chem Struct Biol. 2017;106:1-15. doi: 10.1016/bs.apcsb.2016.09.001. Epub 2016 Oct 18. Review.

PMID:
28057208
46.

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development.

Durek P, Nordström K, Gasparoni G, Salhab A, Kressler C, de Almeida M, Bassler K, Ulas T, Schmidt F, Xiong J, Glažar P, Klironomos F, Sinha A, Kinkley S, Yang X, Arrigoni L, Amirabad AD, Ardakani FB, Feuerbach L, Gorka O, Ebert P, Müller F, Li N, Frischbutter S, Schlickeiser S, Cendon C, Fröhler S, Felder B, Gasparoni N, Imbusch CD, Hutter B, Zipprich G, Tauchmann Y, Reinke S, Wassilew G, Hoffmann U, Richter AS, Sieverling L; DEEP Consortium, Chang HD, Syrbe U, Kalus U, Eils J, Brors B, Manke T, Ruland J, Lengauer T, Rajewsky N, Chen W, Dong J, Sawitzki B, Chung HR, Rosenstiel P, Schulz MH, Schultze JL, Radbruch A, Walter J, Hamann A, Polansky JK.

Immunity. 2016 Nov 15;45(5):1148-1161. doi: 10.1016/j.immuni.2016.10.022.

47.

ImpulseDE: detection of differentially expressed genes in time series data using impulse models.

Sander J, Schultze JL, Yosef N.

Bioinformatics. 2017 Mar 1;33(5):757-759. doi: 10.1093/bioinformatics/btw665.

48.

The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS.

Tedeschi A, Dupraz S, Laskowski CJ, Xue J, Ulas T, Beyer M, Schultze JL, Bradke F.

Neuron. 2016 Oct 19;92(2):419-434. doi: 10.1016/j.neuron.2016.09.026. Epub 2016 Oct 6.

49.

Tissue-resident macrophages - how to humanize our knowledge.

Schlitzer A, Schultze JL.

Immunol Cell Biol. 2017 Feb;95(2):173-177. doi: 10.1038/icb.2016.82. Epub 2016 Oct 18. Review.

PMID:
27752049
50.

Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.

Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. Epub 2016 Sep 6.

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