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Items: 1 to 50 of 493

1.

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.

Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE.

Nature. 2018 Oct 15. doi: 10.1038/s41586-018-0622-0. [Epub ahead of print]

PMID:
30323285
2.

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.

Janes J, Young ME, Chen E, Rogers NH, Burgstaller-Muehlbacher S, Hughes LD, Love MS, Hull MV, Kuhen KL, Woods AK, Joseph SB, Petrassi HM, McNamara CW, Tremblay MS, Su AI, Schultz PG, Chatterjee AK.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10750-10755. doi: 10.1073/pnas.1810137115. Epub 2018 Oct 3.

3.

Bacterial Genome Containing Chimeric DNA-RNA Sequences.

Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG.

J Am Chem Soc. 2018 Sep 12;140(36):11464-11473. doi: 10.1021/jacs.8b07046. Epub 2018 Aug 30.

PMID:
30160955
4.

Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).

Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose AJ, Park Y, Schultz PG, Horwich AL, Hoang QQ, Chapman E, Johnson SM.

J Med Chem. 2018 Aug 23;61(16):7345-7357. doi: 10.1021/acs.jmedchem.8b00989. Epub 2018 Aug 14.

PMID:
30060666
5.

Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.

Miglianico M, Eldering M, Slater H, Ferguson N, Ambrose P, Lees RS, Koolen KMJ, Pruzinova K, Jancarova M, Volf P, Koenraadt CJM, Duerr HP, Trevitt G, Yang B, Chatterjee AK, Wisler J, Sturm A, Bousema T, Sauerwein RW, Schultz PG, Tremblay MS, Dechering KJ.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6920-E6926. doi: 10.1073/pnas.1801338115. Epub 2018 Jul 2.

6.

A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction.

Zhong L, Tran T, Baguley TD, Lee SJ, Henke A, To A, Li S, Yu S, Grieco FA, Roland J, Schultz PG, Eizirik DL, Rogers N, Chartterjee AK, Tremblay MS, Shen W.

Br J Pharmacol. 2018 Sep;175(17):3470-3485. doi: 10.1111/bph.14388. Epub 2018 Jul 14.

PMID:
29888783
7.

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors.

Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, Chatterjee AK, McNamara CW, Young TS, Schultz PG, Meredith TC, Kahne D.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6834-6839. doi: 10.1073/pnas.1804670115. Epub 2018 May 7.

PMID:
29735709
8.

Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity.

Crnovcic I, Gan F, Yang D, Dong LB, Schultz PG, Shen B.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2670-2674. doi: 10.1016/j.bmcl.2018.04.065. Epub 2018 Apr 30.

PMID:
29730026
9.

Mechanistic studies of a small-molecule modulator of SMN2 splicing.

Wang J, Schultz PG, Johnson KA.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4604-E4612. doi: 10.1073/pnas.1800260115. Epub 2018 Apr 30.

PMID:
29712837
10.

The genetic incorporation of p-azidomethyl-l-phenylalanine into proteins in yeast.

Supekova L, Zambaldo C, Choi S, Lim R, Luo X, Kazane SA, Young TS, Schultz PG.

Bioorg Med Chem Lett. 2018 May 15;28(9):1570-1573. doi: 10.1016/j.bmcl.2018.03.055. Epub 2018 Mar 22.

PMID:
29625824
11.

Progress toward a reduced phage genetic code.

Yao A, Reed SA, Koh M, Yu C, Luo X, Mehta AP, Schultz PG.

Bioorg Med Chem. 2018 Mar 26. pii: S0968-0896(18)30377-8. doi: 10.1016/j.bmc.2018.03.035. [Epub ahead of print]

PMID:
29609949
12.

Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models.

Yang PY, Zou H, Lee C, Muppidi A, Chao E, Fu Q, Luo X, Wang D, Schultz PG, Shen W.

J Med Chem. 2018 Apr 12;61(7):3218-3223. doi: 10.1021/acs.jmedchem.7b00768. Epub 2018 Mar 23.

PMID:
29528634
13.

Functional Replacement of Histidine in Proteins To Generate Noncanonical Amino Acid Dependent Organisms.

Gan F, Liu R, Wang F, Schultz PG.

J Am Chem Soc. 2018 Mar 21;140(11):3829-3832. doi: 10.1021/jacs.7b13452. Epub 2018 Mar 12.

PMID:
29509426
14.

Retraction of "Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity".

Sun SB, Sen S, Kim NJ, Magliery TJ, Schultz PG, Wang F.

J Am Chem Soc. 2018 Feb 7;140(5):1976. doi: 10.1021/jacs.7b08106. Epub 2018 Jan 29. No abstract available.

15.

Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins.

Xuan W, Collins D, Koh M, Shao S, Yao A, Xiao H, Garner P, Schultz PG.

ACS Chem Biol. 2018 Mar 16;13(3):578-581. doi: 10.1021/acschembio.7b00998. Epub 2018 Feb 9.

16.

Playing with the Molecules of Life.

Young DD, Schultz PG.

ACS Chem Biol. 2018 Apr 20;13(4):854-870. doi: 10.1021/acschembio.7b00974. Epub 2018 Mar 2.

17.

Engineering Bifunctional Antibodies with Constant Region Fusion Architectures.

Du J, Cao Y, Liu Y, Wang Y, Zhang Y, Fu G, Zhang Y, Lu L, Luo X, Kim CH, Schultz PG, Wang F.

J Am Chem Soc. 2017 Dec 27;139(51):18607-18615. doi: 10.1021/jacs.7b09641. Epub 2017 Dec 14.

PMID:
29186655
18.

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30.

19.

Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia.

Laborda E, Mazagova M, Shao S, Wang X, Quirino H, Woods AK, Hampton EN, Rodgers DT, Kim CH, Schultz PG, Young TS.

Int J Mol Sci. 2017 Oct 27;18(11). pii: E2259. doi: 10.3390/ijms18112259.

20.

Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.

Choi SH, Mahankali M, Lee SJ, Hull M, Petrassi HM, Chatterjee AK, Schultz PG, Jones KA, Shen W.

ACS Chem Biol. 2017 Nov 17;12(11):2715-2719. doi: 10.1021/acschembio.7b00799. Epub 2017 Oct 11.

PMID:
28976731
21.

Genetically Encoded Fluorescent Probe for Detecting Sirtuins in Living Cells.

Xuan W, Yao A, Schultz PG.

J Am Chem Soc. 2017 Sep 13;139(36):12350-12353. doi: 10.1021/jacs.7b05725. Epub 2017 Aug 31.

22.

Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids.

Zambaldo C, Luo X, Mehta AP, Schultz PG.

J Am Chem Soc. 2017 Aug 30;139(34):11646-11649. doi: 10.1021/jacs.7b04159. Epub 2017 Aug 15.

23.

A Novel Role for RARα Agonists as Apolipoprotein CIII Inhibitors Identified from High Throughput Screening.

Lee SJ, Mahankali M, Bitar A, Zou H, Chao E, Nguyen H, Gonzalez J, Caballero D, Hull M, Wang D, Schultz PG, Shen W.

Sci Rep. 2017 Jul 19;7(1):5824. doi: 10.1038/s41598-017-05163-w.

24.

Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.

Luo X, Fu G, Wang RE, Zhu X, Zambaldo C, Liu R, Liu T, Lyu X, Du J, Xuan W, Yao A, Reed SA, Kang M, Zhang Y, Guo H, Huang C, Yang PY, Wilson IA, Schultz PG, Wang F.

Nat Chem Biol. 2017 Aug;13(8):845-849. doi: 10.1038/nchembio.2405. Epub 2017 Jun 12.

25.

Construction and Screening of a Lentiviral Secretome Library.

Liu T, Jia P, Ma H, Reed SA, Luo X, Larman HB, Schultz PG.

Cell Chem Biol. 2017 Jun 22;24(6):767-771.e3. doi: 10.1016/j.chembiol.2017.05.017. Epub 2017 Jun 9.

26.

A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids.

Xuan W, Schultz PG.

Angew Chem Int Ed Engl. 2017 Jul 24;56(31):9170-9173. doi: 10.1002/anie.201703553. Epub 2017 Jun 27.

27.

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.

Bollong MJ, Yang B, Vergani N, Beyer BA, Chin EN, Zambaldo C, Wang D, Chatterjee AK, Lairson LL, Schultz PG.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4679-4684. doi: 10.1073/pnas.1702750114. Epub 2017 Apr 17.

28.

Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid.

Koh M, Nasertorabi F, Han GW, Stevens RC, Schultz PG.

J Am Chem Soc. 2017 Apr 26;139(16):5728-5731. doi: 10.1021/jacs.7b02273. Epub 2017 Apr 17.

PMID:
28413876
29.

Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Reactive Aryl Carbamate Side Chains.

Xuan W, Shao S, Schultz PG.

Angew Chem Int Ed Engl. 2017 Apr 24;56(18):5096-5100. doi: 10.1002/anie.201611841. Epub 2017 Apr 3.

30.

Small molecule selectively suppresses MYC transcription in cancer cells.

Bouvard C, Lim SM, Ludka J, Yazdani N, Woods AK, Chatterjee AK, Schultz PG, Zhu S.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502. doi: 10.1073/pnas.1702663114. Epub 2017 Mar 14.

31.

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis.

Love MS, Beasley FC, Jumani RS, Wright TM, Chatterjee AK, Huston CD, Schultz PG, McNamara CW.

PLoS Negl Trop Dis. 2017 Feb 3;11(2):e0005373. doi: 10.1371/journal.pntd.0005373. eCollection 2017 Feb.

32.

Replacement of 2'-Deoxycytidine by 2'-Deoxycytidine Analogues in the E. coli Genome.

Mehta AP, Li H, Reed SA, Supekova L, Javahishvili T, Schultz PG.

J Am Chem Soc. 2016 Nov 2;138(43):14230-14233. Epub 2016 Oct 20.

33.

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis.

Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG, Lavis LD, Revyakin A, Tjian R.

Genes Dev. 2016 Sep 15;30(18):2106-2118.

34.

Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.

Abdeen S, Salim N, Mammadova N, Summers CM, Goldsmith-Pestana K, McMahon-Pratt D, Schultz PG, Horwich AL, Chapman E, Johnson SM.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5247-5253. doi: 10.1016/j.bmcl.2016.09.051. Epub 2016 Sep 22.

PMID:
27720295
35.

Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody-drug Conjugate.

Yu S, Pearson AD, Lim RK, Rodgers DT, Li S, Parker HB, Weglarz M, Hampton EN, Bollong MJ, Shen J, Zambaldo C, Wang D, Woods AK, Wright TM, Schultz PG, Kazane SA, Young TS, Tremblay MS.

Mol Ther. 2016 Dec;24(12):2078-2089. doi: 10.1038/mt.2016.175. Epub 2016 Oct 12.

36.

Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones.

Liu Y, Wang Y, Zhang Y, Liu T, Jia H, Zou H, Fu Q, Zhang Y, Lu L, Chao E, Parker H, Nguyen-Tran V, Shen W, Wang D, Schultz PG, Wang F.

ACS Chem Biol. 2016 Nov 18;11(11):2991-2995. Epub 2016 Oct 5.

37.

Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.

Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11501-11506. Epub 2016 Sep 23.

38.

Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator.

Luo X, Wang TA, Zhang Y, Wang F, Schultz PG.

Cell Chem Biol. 2016 Sep 22;23(9):1098-1102. doi: 10.1016/j.chembiol.2016.08.007.

39.

Multifunctional Antibody Agonists Targeting Glucagon-like Peptide-1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide Receptors.

Wang Y, Du J, Zou H, Liu Y, Zhang Y, Gonzalez J, Chao E, Lu L, Yang P, Parker H, Nguyen-Tran V, Shen W, Wang D, Schultz PG, Wang F.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12475-8. doi: 10.1002/anie.201606321. Epub 2016 Sep 6.

PMID:
27595986
40.

Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins.

Xuan W, Li J, Luo X, Schultz PG.

Angew Chem Int Ed Engl. 2016 Aug 16;55(34):10065-8. doi: 10.1002/anie.201604891. Epub 2016 Jul 15.

PMID:
27418387
41.

At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code.

Xiao H, Schultz PG.

Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9). pii: a023945. doi: 10.1101/cshperspect.a023945. Review.

42.

Replacement of Thymidine by a Modified Base in the Escherichia coli Genome.

Mehta AP, Li H, Reed SA, Supekova L, Javahishvili T, Schultz PG.

J Am Chem Soc. 2016 Jun 15;138(23):7272-5. doi: 10.1021/jacs.6b03904. Epub 2016 Jun 3.

43.

GroEL/ES inhibitors as potential antibiotics.

Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3127-3134. doi: 10.1016/j.bmcl.2016.04.089. Epub 2016 May 4.

44.

Enhancing protein stability with extended disulfide bonds.

Liu T, Wang Y, Luo X, Li J, Reed SA, Xiao H, Young TS, Schultz PG.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):5910-5. doi: 10.1073/pnas.1605363113. Epub 2016 May 9.

45.

Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer.

Cao Y, Rodgers DT, Du J, Ahmad I, Hampton EN, Ma JS, Mazagova M, Choi SH, Yun HY, Xiao H, Yang P, Luo X, Lim RK, Pugh HM, Wang F, Kazane SA, Wright TM, Kim CH, Schultz PG, Young TS.

Angew Chem Int Ed Engl. 2016 Jun 20;55(26):7520-4. doi: 10.1002/anie.201601902. Epub 2016 May 4.

46.

Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding.

Lee TC, Kang M, Kim CH, Schultz PG, Chapman E, Deniz AA.

Chembiochem. 2016 Jun 2;17(11):981-4. doi: 10.1002/cbic.201500695. Epub 2016 Apr 26.

47.

Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery.

Yang PY, Zou H, Chao E, Sherwood L, Nunez V, Keeney M, Ghartey-Tagoe E, Ding Z, Quirino H, Luo X, Welzel G, Chen G, Singh P, Woods AK, Schultz PG, Shen W.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4140-5. doi: 10.1073/pnas.1601653113. Epub 2016 Mar 28.

48.

Recombinant thiopeptides containing noncanonical amino acids.

Luo X, Zambaldo C, Liu T, Zhang Y, Xuan W, Wang C, Reed SA, Yang PY, Wang RE, Javahishvili T, Schultz PG, Young TS.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3615-20. doi: 10.1073/pnas.1602733113. Epub 2016 Mar 14.

49.

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.

Rodgers DT, Mazagova M, Hampton EN, Cao Y, Ramadoss NS, Hardy IR, Schulman A, Du J, Wang F, Singer O, Ma J, Nunez V, Shen J, Woods AK, Wright TM, Schultz PG, Kim CH, Young TS.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E459-68. doi: 10.1073/pnas.1524155113. Epub 2016 Jan 12.

50.

Versatile strategy for controlling the specificity and activity of engineered T cells.

Ma JS, Kim JY, Kazane SA, Choi SH, Yun HY, Kim MS, Rodgers DT, Pugh HM, Singer O, Sun SB, Fonslow BR, Kochenderfer JN, Wright TM, Schultz PG, Young TS, Kim CH, Cao Y.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E450-8. doi: 10.1073/pnas.1524193113. Epub 2016 Jan 12.

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