Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 504

1.

Small molecule stimulators of NRF1 transcriptional activity.

Iaconelli J, Chen E, Hull M, Schultz PG, Bollong M.

Chembiochem. 2019 Oct 9. doi: 10.1002/cbic.201900487. [Epub ahead of print]

PMID:
31596542
2.

A General Strategy for Engineering Noncanonical Amino Acid Dependent Bacterial Growth.

Koh M, Yao A, Gleason PR, Mills JH, Schultz PG.

J Am Chem Soc. 2019 Oct 4. doi: 10.1021/jacs.9b08491. [Epub ahead of print]

PMID:
31580059
3.

Toward a Synthetic Yeast Endosymbiont with a Minimal Genome.

Mehta AP, Ko Y, Supekova L, Pestonjamasp K, Li J, Schultz PG.

J Am Chem Soc. 2019 Sep 4;141(35):13799-13802. doi: 10.1021/jacs.9b08290. Epub 2019 Aug 26.

PMID:
31419116
4.

A tumor-targeted immune checkpoint blocker.

Zhang Y, Fang C, Wang RE, Wang Y, Guo H, Guo C, Zhao L, Li S, Li X, Schultz PG, Cao YJ, Wang F.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15889-15894. doi: 10.1073/pnas.1905646116. Epub 2019 Jul 22.

PMID:
31332018
5.

Site-Specific Incorporation of a Dithiolane Containing Amino Acid into Proteins.

Koh M, Cho HY, Yu C, Choi S, Lee KB, Schultz PG.

Bioconjug Chem. 2019 Aug 21;30(8):2102-2105. doi: 10.1021/acs.bioconjchem.9b00413. Epub 2019 Jul 23.

PMID:
31319026
6.

A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.

Li JC, Nastertorabi F, Xuan W, Han GW, Stevens RC, Schultz PG.

ACS Chem Biol. 2019 Jun 21;14(6):1150-1153. doi: 10.1021/acschembio.9b00002. Epub 2019 Jun 4.

PMID:
31181898
7.

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, Frohberger SJ, Sjoberg H, Pionnier N, Murphy E, Archer J, Steven A, Chunda VC, Fombad FF, Chounna PW, Njouendou AJ, Metuge HM, Ndzeshang BL, Gandjui NV, Akumtoh DN, Kwenti TDB, Woods AK, Joseph SB, Hull MV, Xiong W, Kuhen KL, Taylor MJ, Wanji S, Turner JD, Hübner MP, Hoerauf A, Chatterjee AK, Roland J, Tremblay MS, Schultz PG, Sullivan W, Chu XJ, Petrassi HM, McNamara CW.

Sci Transl Med. 2019 May 8;11(491). pii: eaav3523. doi: 10.1126/scitranslmed.aav3523.

PMID:
31068442
8.

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.

Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, Schultz PG, Mischel PS, Lairson LL.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440. doi: 10.1073/pnas.1816626116. Epub 2019 Mar 7.

9.

Enhancing Protein Stability with Genetically Encoded Noncanonical Amino Acids.

Li JC, Liu T, Wang Y, Mehta AP, Schultz PG.

J Am Chem Soc. 2018 Nov 28;140(47):15997-16000. doi: 10.1021/jacs.8b07157. Epub 2018 Nov 15.

10.

Visualization of the Delivery and Release of Small RNAs Using Genetic Code Expansion and Unnatural RNA-Binding Proteins.

Ahmed N, De Graaf JF, Ahmed N, Foss DV, Delcorde J, Schultz PG, Pezacki JP.

Bioconjug Chem. 2018 Dec 19;29(12):3982-3986. doi: 10.1021/acs.bioconjchem.8b00649. Epub 2018 Nov 13.

PMID:
30408949
11.

Engineering yeast endosymbionts as a step toward the evolution of mitochondria.

Mehta AP, Supekova L, Chen JH, Pestonjamasp K, Webster P, Ko Y, Henderson SC, McDermott G, Supek F, Schultz PG.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11796-11801. doi: 10.1073/pnas.1813143115. Epub 2018 Oct 29.

12.

A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.

Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE.

Nature. 2018 Oct;562(7728):600-604. doi: 10.1038/s41586-018-0622-0. Epub 2018 Oct 15.

13.

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.

Janes J, Young ME, Chen E, Rogers NH, Burgstaller-Muehlbacher S, Hughes LD, Love MS, Hull MV, Kuhen KL, Woods AK, Joseph SB, Petrassi HM, McNamara CW, Tremblay MS, Su AI, Schultz PG, Chatterjee AK.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10750-10755. doi: 10.1073/pnas.1810137115. Epub 2018 Oct 3.

14.

Bacterial Genome Containing Chimeric DNA-RNA Sequences.

Mehta AP, Wang Y, Reed SA, Supekova L, Javahishvili T, Chaput JC, Schultz PG.

J Am Chem Soc. 2018 Sep 12;140(36):11464-11473. doi: 10.1021/jacs.8b07046. Epub 2018 Aug 30.

PMID:
30160955
15.

Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).

Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose AJ, Park Y, Schultz PG, Horwich AL, Hoang QQ, Chapman E, Johnson SM.

J Med Chem. 2018 Aug 23;61(16):7345-7357. doi: 10.1021/acs.jmedchem.8b00989. Epub 2018 Aug 14.

16.

Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.

Miglianico M, Eldering M, Slater H, Ferguson N, Ambrose P, Lees RS, Koolen KMJ, Pruzinova K, Jancarova M, Volf P, Koenraadt CJM, Duerr HP, Trevitt G, Yang B, Chatterjee AK, Wisler J, Sturm A, Bousema T, Sauerwein RW, Schultz PG, Tremblay MS, Dechering KJ.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6920-E6926. doi: 10.1073/pnas.1801338115. Epub 2018 Jul 2.

17.

A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction.

Zhong L, Tran T, Baguley TD, Lee SJ, Henke A, To A, Li S, Yu S, Grieco FA, Roland J, Schultz PG, Eizirik DL, Rogers N, Chartterjee AK, Tremblay MS, Shen W.

Br J Pharmacol. 2018 Sep;175(17):3470-3485. doi: 10.1111/bph.14388. Epub 2018 Jul 14.

18.

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors.

Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, Chatterjee AK, McNamara CW, Young TS, Schultz PG, Meredith TC, Kahne D.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6834-6839. doi: 10.1073/pnas.1804670115. Epub 2018 May 7.

19.

Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity.

Crnovcic I, Gan F, Yang D, Dong LB, Schultz PG, Shen B.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2670-2674. doi: 10.1016/j.bmcl.2018.04.065. Epub 2018 Apr 30.

PMID:
29730026
20.

Mechanistic studies of a small-molecule modulator of SMN2 splicing.

Wang J, Schultz PG, Johnson KA.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4604-E4612. doi: 10.1073/pnas.1800260115. Epub 2018 Apr 30.

21.

The genetic incorporation of p-azidomethyl-l-phenylalanine into proteins in yeast.

Supekova L, Zambaldo C, Choi S, Lim R, Luo X, Kazane SA, Young TS, Schultz PG.

Bioorg Med Chem Lett. 2018 May 15;28(9):1570-1573. doi: 10.1016/j.bmcl.2018.03.055. Epub 2018 Mar 22.

PMID:
29625824
22.

Progress toward a reduced phage genetic code.

Yao A, Reed SA, Koh M, Yu C, Luo X, Mehta AP, Schultz PG.

Bioorg Med Chem. 2018 Oct 15;26(19):5247-5252. doi: 10.1016/j.bmc.2018.03.035. Epub 2018 Mar 26.

PMID:
29609949
23.

Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate Induced Mouse Colitis Models.

Yang PY, Zou H, Lee C, Muppidi A, Chao E, Fu Q, Luo X, Wang D, Schultz PG, Shen W.

J Med Chem. 2018 Apr 12;61(7):3218-3223. doi: 10.1021/acs.jmedchem.7b00768. Epub 2018 Mar 23.

PMID:
29528634
24.

Functional Replacement of Histidine in Proteins To Generate Noncanonical Amino Acid Dependent Organisms.

Gan F, Liu R, Wang F, Schultz PG.

J Am Chem Soc. 2018 Mar 21;140(11):3829-3832. doi: 10.1021/jacs.7b13452. Epub 2018 Mar 12.

PMID:
29509426
25.

Retraction of "Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity".

Sun SB, Sen S, Kim NJ, Magliery TJ, Schultz PG, Wang F.

J Am Chem Soc. 2018 Feb 7;140(5):1976. doi: 10.1021/jacs.7b08106. Epub 2018 Jan 29. No abstract available.

26.

Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins.

Xuan W, Collins D, Koh M, Shao S, Yao A, Xiao H, Garner P, Schultz PG.

ACS Chem Biol. 2018 Mar 16;13(3):578-581. doi: 10.1021/acschembio.7b00998. Epub 2018 Feb 9.

27.

Playing with the Molecules of Life.

Young DD, Schultz PG.

ACS Chem Biol. 2018 Apr 20;13(4):854-870. doi: 10.1021/acschembio.7b00974. Epub 2018 Mar 2. Review.

28.

Engineering Bifunctional Antibodies with Constant Region Fusion Architectures.

Du J, Cao Y, Liu Y, Wang Y, Zhang Y, Fu G, Zhang Y, Lu L, Luo X, Kim CH, Schultz PG, Wang F.

J Am Chem Soc. 2017 Dec 27;139(51):18607-18615. doi: 10.1021/jacs.7b09641. Epub 2017 Dec 14.

PMID:
29186655
29.

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30.

30.

Development of A Chimeric Antigen Receptor Targeting C-Type Lectin-Like Molecule-1 for Human Acute Myeloid Leukemia.

Laborda E, Mazagova M, Shao S, Wang X, Quirino H, Woods AK, Hampton EN, Rodgers DT, Kim CH, Schultz PG, Young TS.

Int J Mol Sci. 2017 Oct 27;18(11). pii: E2259. doi: 10.3390/ijms18112259.

31.

Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.

Choi SH, Mahankali M, Lee SJ, Hull M, Petrassi HM, Chatterjee AK, Schultz PG, Jones KA, Shen W.

ACS Chem Biol. 2017 Nov 17;12(11):2715-2719. doi: 10.1021/acschembio.7b00799. Epub 2017 Oct 11.

PMID:
28976731
32.

Genetically Encoded Fluorescent Probe for Detecting Sirtuins in Living Cells.

Xuan W, Yao A, Schultz PG.

J Am Chem Soc. 2017 Sep 13;139(36):12350-12353. doi: 10.1021/jacs.7b05725. Epub 2017 Aug 31.

33.

Recombinant Macrocyclic Lanthipeptides Incorporating Non-Canonical Amino Acids.

Zambaldo C, Luo X, Mehta AP, Schultz PG.

J Am Chem Soc. 2017 Aug 30;139(34):11646-11649. doi: 10.1021/jacs.7b04159. Epub 2017 Aug 15.

34.

A Novel Role for RARα Agonists as Apolipoprotein CIII Inhibitors Identified from High Throughput Screening.

Lee SJ, Mahankali M, Bitar A, Zou H, Chao E, Nguyen H, Gonzalez J, Caballero D, Hull M, Wang D, Schultz PG, Shen W.

Sci Rep. 2017 Jul 19;7(1):5824. doi: 10.1038/s41598-017-05163-w.

35.

Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.

Luo X, Fu G, Wang RE, Zhu X, Zambaldo C, Liu R, Liu T, Lyu X, Du J, Xuan W, Yao A, Reed SA, Kang M, Zhang Y, Guo H, Huang C, Yang PY, Wilson IA, Schultz PG, Wang F.

Nat Chem Biol. 2017 Aug;13(8):845-849. doi: 10.1038/nchembio.2405. Epub 2017 Jun 12.

36.

Construction and Screening of a Lentiviral Secretome Library.

Liu T, Jia P, Ma H, Reed SA, Luo X, Larman HB, Schultz PG.

Cell Chem Biol. 2017 Jun 22;24(6):767-771.e3. doi: 10.1016/j.chembiol.2017.05.017. Epub 2017 Jun 9.

37.

A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids.

Xuan W, Schultz PG.

Angew Chem Int Ed Engl. 2017 Jul 24;56(31):9170-9173. doi: 10.1002/anie.201703553. Epub 2017 Jun 27.

38.

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.

Bollong MJ, Yang B, Vergani N, Beyer BA, Chin EN, Zambaldo C, Wang D, Chatterjee AK, Lairson LL, Schultz PG.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4679-4684. doi: 10.1073/pnas.1702750114. Epub 2017 Apr 17.

39.

Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid.

Koh M, Nasertorabi F, Han GW, Stevens RC, Schultz PG.

J Am Chem Soc. 2017 Apr 26;139(16):5728-5731. doi: 10.1021/jacs.7b02273. Epub 2017 Apr 17.

PMID:
28413876
40.

Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Reactive Aryl Carbamate Side Chains.

Xuan W, Shao S, Schultz PG.

Angew Chem Int Ed Engl. 2017 Apr 24;56(18):5096-5100. doi: 10.1002/anie.201611841. Epub 2017 Apr 3.

41.

Small molecule selectively suppresses MYC transcription in cancer cells.

Bouvard C, Lim SM, Ludka J, Yazdani N, Woods AK, Chatterjee AK, Schultz PG, Zhu S.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502. doi: 10.1073/pnas.1702663114. Epub 2017 Mar 14.

42.

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis.

Love MS, Beasley FC, Jumani RS, Wright TM, Chatterjee AK, Huston CD, Schultz PG, McNamara CW.

PLoS Negl Trop Dis. 2017 Feb 3;11(2):e0005373. doi: 10.1371/journal.pntd.0005373. eCollection 2017 Feb.

43.

Replacement of 2'-Deoxycytidine by 2'-Deoxycytidine Analogues in the E. coli Genome.

Mehta AP, Li H, Reed SA, Supekova L, Javahishvili T, Schultz PG.

J Am Chem Soc. 2016 Nov 2;138(43):14230-14233. Epub 2016 Oct 20.

44.

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis.

Zhang Z, English BP, Grimm JB, Kazane SA, Hu W, Tsai A, Inouye C, You C, Piehler J, Schultz PG, Lavis LD, Revyakin A, Tjian R.

Genes Dev. 2016 Sep 15;30(18):2106-2118.

45.

Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.

Abdeen S, Salim N, Mammadova N, Summers CM, Goldsmith-Pestana K, McMahon-Pratt D, Schultz PG, Horwich AL, Chapman E, Johnson SM.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5247-5253. doi: 10.1016/j.bmcl.2016.09.051. Epub 2016 Sep 22.

PMID:
27720295
46.

Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody-drug Conjugate.

Yu S, Pearson AD, Lim RK, Rodgers DT, Li S, Parker HB, Weglarz M, Hampton EN, Bollong MJ, Shen J, Zambaldo C, Wang D, Woods AK, Wright TM, Schultz PG, Kazane SA, Young TS, Tremblay MS.

Mol Ther. 2016 Dec;24(12):2078-2089. doi: 10.1038/mt.2016.175. Epub 2016 Oct 12.

47.

Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones.

Liu Y, Wang Y, Zhang Y, Liu T, Jia H, Zou H, Fu Q, Zhang Y, Lu L, Chao E, Parker H, Nguyen-Tran V, Shen W, Wang D, Schultz PG, Wang F.

ACS Chem Biol. 2016 Nov 18;11(11):2991-2995. Epub 2016 Oct 5.

48.

Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.

Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11501-11506. Epub 2016 Sep 23.

49.

Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator.

Luo X, Wang TA, Zhang Y, Wang F, Schultz PG.

Cell Chem Biol. 2016 Sep 22;23(9):1098-1102. doi: 10.1016/j.chembiol.2016.08.007.

50.

Multifunctional Antibody Agonists Targeting Glucagon-like Peptide-1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide Receptors.

Wang Y, Du J, Zou H, Liu Y, Zhang Y, Gonzalez J, Chao E, Lu L, Yang P, Parker H, Nguyen-Tran V, Shen W, Wang D, Schultz PG, Wang F.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12475-8. doi: 10.1002/anie.201606321. Epub 2016 Sep 6.

PMID:
27595986

Supplemental Content

Loading ...
Support Center