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Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study.

Robba C, Hemmes SNT, Serpa Neto A, Bluth T, Canet J, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Putensen C, Jaber S, Schmid W, Severgnini P, Wrigge H, Battaglini D, Ball L, Gama de Abreu M, Schultz MJ, Pelosi P; FERS for the LAS VEGAS investigators; PROtective VEntilation Network and the Clinical Trial Network of the European Society of Anaesthesiology.

BMC Anesthesiol. 2020 Apr 2;20(1):73. doi: 10.1186/s12871-020-00988-x.


Nebulized Heparin in Burn Patients with Inhalation Trauma-Safety and Feasibility.

Glas GJ, Horn J, Binnekade JM, Hollmann MW, Muller J, Cleffken B, Colpaert K, Dixon B, Juffermans NP, Knape P, Levi MM, Loef BG, Mackie DP, Malbrain MLNG, Preckel B, Reidinga AC, van der Sluijs KF, Schultz MJ.

J Clin Med. 2020 Mar 25;9(4). pii: E894. doi: 10.3390/jcm9040894.


Changes in Attitudes and Actual Practice of Oxygen Therapy in ICUs after Implementation of a Conservative Oxygenation Guideline.

Grim CC, Helmerhorst HJ, Schultz MJ, Winters T, van der Voort PH, van Westerloo DJ, de Jonge E.

Respir Care. 2020 Mar 24. pii: respcare.07527. doi: 10.4187/respcare.07527. [Epub ahead of print]


ERS International Congress, Madrid, 2019: highlights from the Respiratory Intensive Care Assembly.

Satici C, López-Padilla D, Schreiber A, Kharat A, Swingwood E, Pisani L, Patout M, Bos LD, Scala R, Schultz MJ, Heunks L.

ERJ Open Res. 2020 Mar 9;6(1). pii: 00331-2019. doi: 10.1183/23120541.00331-2019. eCollection 2020 Jan.


Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill.

Boshuizen M, Binnekade JM, Nota B, van de Groep K, Cremer OL, Horn J, Schultz MJ, van Bruggen R, Juffermans NP.

Transfus Med Hemother. 2020 Feb;47(1):61-67. doi: 10.1159/000497123. Epub 2019 May 3.


Infection Management in Patients with Sepsis and Septic Shock in Resource-Limited Settings.

Thwaites CL, Lundeg G, Dondorp AM, Adhikari NKJ, Nakibuuka J, Jawa R, Mer M, Murthy S, Schultz MJ, Thien BN, Kwizera A.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 8.
2019 Feb 9.


Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings.

Papali A, Adhikari NKJ, Diaz JV, Dondorp AM, Dünser MW, Jacob ST, Phua J, Romain M, Schultz MJ.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 3.
2019 Feb 9.


Hemodynamic Assessment and Support in Sepsis and Septic Shock in Resource-Limited Settings.

Misango D, Pattnaik R, Baker T, Dünser MW, Dondorp AM, Schultz MJ.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 7.
2019 Feb 9.


Development of the Guidelines: Focus on Availability, Feasibility, Affordability, and Safety of Interventions in Resource-Limited Settings.

Schultz MJ, Dünser MW, Dondorp AM.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 2.
2019 Feb 9.


Ventilatory Support of Patients with Sepsis or Septic Shock in Resource-Limited Settings.

Neto AS, Schultz MJ, Festic E, Adhikari NKJ, Dondorp AM, Pattnaik R, Pisani L, Povoa P, Martin-Loeches I, Thwaites CL.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 6.
2019 Feb 9.


Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future.

Schultz MJ, Dünser MW, Dondorp AM, Adhikari NKJ, Iyer S, Kwizera A, Lubell Y, Papali A, Pisani L, Riviello ED, Angus DC, Azevedo LC, Baker T, Diaz JV, Festic E, Haniffa R, Jawa R, Jacob ST, Kissoon N, Lodha R, Martin-Loeches I, Lundeg G, Misango D, Mer M, Mohanty S, Murthy S, Musa N, Nakibuuka J, Neto AS, Mai NTH, Thien BN, Pattnaik R, Phua J, Preller J, Povoa P, Ranjit S, Talmor D, Thevanayagam J, Thwaites CL.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 1.
2019 Feb 9.


Core Elements of General Supportive Care for Patients with Sepsis and Septic Shock in Resource-Limited Settings.

Mer M, Schultz MJ, Adhikari NKJ, Kwizera A, Mohanty S, Dondorp AM, Neto AS, Preller J.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 5.
2019 Feb 9.


Management of Severe Malaria and Severe Dengue in Resource-Limited Settings.

Dondorp AM, Hoang MNT, Mer M, Dünser MW, Mohanty S, Nakibuuka J, Schultz MJ, Thwaites CL, Wills B.

In: Dondorp AM, Dünser MW, Schultz MJ, editors. Sepsis Management in Resource-limited Settings [Internet]. Cham (CH): Springer; 2019. Chapter 9.
2019 Feb 9.


Myocardial Function during Low versus Intermediate Tidal Volume Ventilation in Patients without Acute Respiratory Distress Syndrome.

Cherpanath TGV, Simonis FD, Bouma BJ, de Bruin-Bon RH, Determann RM, Juffermans NP, Gama de Abreu M, Pelosi P, Serpa Neto A, Groeneveld JAB, Schultz MJ, Lagrand WK.

Anesthesiology. 2020 Feb 11. doi: 10.1097/ALN.0000000000003175. [Epub ahead of print]


Microbiological profile of nosocomial infections following cardiac arrest: Insights from the targeted temperature management (TTM) trial.

Harmon MBA, Hodiamont CJ, Dankiewicz J, Nielsen N, Schultz MJ, Horn J, Friberg H, Juffermans NP.

Resuscitation. 2020 Mar 1;148:227-233. doi: 10.1016/j.resuscitation.2019.11.033. Epub 2020 Feb 4.


Associations between changes in oxygenation, dead space and driving pressure induced by the first prone position session and mortality in patients with acute respiratory distress syndrome.

van Meenen DM, Roozeman JP, Serpa Neto A, Pelosi P, Gama de Abreu M, Horn J, Cremer OL, Paulus F, Schultz MJ; MARS Consortium.

J Thorac Dis. 2019 Dec;11(12):5004-5013. doi: 10.21037/jtd.2019.12.38.


Intraabdominal Pressure Targeted Positive End-expiratory Pressure during Laparoscopic Surgery: An Open-label, Nonrandomized, Crossover, Clinical Trial.

Mazzinari G, Diaz-Cambronero O, Alonso-Iñigo JM, Garcia-Gregorio N, Ayas-Montero B, Ibañez JL, Serpa Neto A, Ball L, Gama de Abreu M, Pelosi P, Maupoey J, Argente Navarro MP, Schultz MJ.

Anesthesiology. 2020 Apr;132(4):667-677. doi: 10.1097/ALN.0000000000003146.


Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients.

Dickson RP, Schultz MJ, van der Poll T, Schouten LR, Falkowski NR, Luth JE, Sjoding MW, Brown CA, Chanderraj R, Huffnagle GB, Bos LDJ; Biomarker Analysis in Septic ICU Patients (BASIC) Consortium.

Am J Respir Crit Care Med. 2020 Mar 1;201(5):555-563. doi: 10.1164/rccm.201907-1487OC.


Re-evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery -Protocol and statistical analysis plan for an individual patient data meta-analysis of PROVHILO, iPROVE and PROBESE.

Campos NS, Bluth T, Hemmes SNT, Librero J, Pozo N, Ferrando C, Ball L, Mazzinari G, Pelosi P, Gama de Abreu M, Schultz MJ, Neto AS; para el Comité de en Redacción nombre de The Reevaluation of PEEP in Anesthesia Meta-Analysis los investigadores en nombre red de PROVHILO, iPROVE y PROBESE Investigadores e Investigadores de la Red PROVE.

Rev Esp Anestesiol Reanim. 2020 Feb;67(2):76-89. doi: 10.1016/j.redar.2019.08.002. Epub 2020 Jan 16. English, Spanish. No abstract available.


Correction to: An individualised versus a conventional pneumoperitoneum pressure strategy during colorectal laparoscopic surgery: rationale and study protocol for a multicentre randomised clinical study.

Diaz-Cambronero O, Mazzinari G, Errando CL, Schultz MJ, Lorente BF, García-Gregorio N, Montañés MV, Robles-Hernández D, Arnal LEO, Martín-De-Pablos A, Marí AM, Navarro MPA.

Trials. 2020 Jan 13;21(1):70. doi: 10.1186/s13063-020-4055-3.


Effects of Protective Mechanical Ventilation With Different PEEP Levels on Alveolar Damage and Inflammation in a Model of Open Abdominal Surgery: A Randomized Study in Obese Versus Non-obese Rats.

Maia LA, Fernandes MVS, Santos RS, Agra LC, Carvalho AC, Rocha NN, Oliveira MV, Santos CL, Morales MM, Capelozzi VL, Souza SAL, Gutfilen B, Schultz MJ, Gama de Abreu M, Pelosi P, Silva PL, Rocco PRM.

Front Physiol. 2019 Dec 17;10:1513. doi: 10.3389/fphys.2019.01513. eCollection 2019.


Characterization of a cryptic PML-RARA fusion by mate-pair sequencing in a case of acute promyelocytic leukemia with a normal karyotype and negative RARA FISH studies.

Schultz MJ, Blackburn PR, Cogbill CH, Pitel BA, Smadbeck JB, Johnson SH, Vasmatzis G, Rech KL, Sukov WR, Greipp PT, Hoppman NL, Baughn LB, Ketterling RP, Peterson JF.

Leuk Lymphoma. 2020 Apr;61(4):975-978. doi: 10.1080/10428194.2019.1699081. Epub 2019 Dec 6. No abstract available.


The Effects of Escalation of Respiratory Support and Prolonged Invasive Ventilation on Outcomes of Cardiac Surgical Patients: A Retrospective Cohort Study.

Zochios V, Chandan JS, Schultz MJ, Morris AC, Parhar KK, Giménez-Milà M, Gerrard C, Vuylsteke A, Klein AA.

J Cardiothorac Vasc Anesth. 2020 May;34(5):1226-1234. doi: 10.1053/j.jvca.2019.10.052. Epub 2019 Nov 8.


Pulmonary levels of biomarkers for inflammation and lung injury in protective versus conventional one-lung ventilation for oesophagectomy: A randomised clinical trial.

van der Woude MC, Bormans L, van der Horst RP, Sosef MN, Belgers HJ, Hemmes SN, Tuip-de Boer A, Gama de Abreu M, Pelosi P, Spronk PE, Neto AS, Schultz MJ.

Eur J Anaesthesiol. 2019 Dec 4. doi: 10.1097/EJA.0000000000001126. [Epub ahead of print]


Tenascin C Plasma Levels in Critically Ill Patients with or Without Sepsis: A Multicentre Observational Study.

Meijer MT, Uhel F, Cremer OL, Schultz MJ, van der Poll T; MARS consortium.

Shock. 2019 Nov 19. doi: 10.1097/SHK.0000000000001481. [Epub ahead of print]


Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS.

Morales-Quinteros L, Schultz MJ, Bringué J, Calfee CS, Camprubí M, Cremer OL, Horn J, van der Poll T, Sinha P, Artigas A, Bos LD; MARS Consortium.

Ann Intensive Care. 2019 Nov 21;9(1):128. doi: 10.1186/s13613-019-0601-0.


Reduced cardiac index reserve and hypovolemia in severe falciparum malaria.

Kingston HWF, Ghose A, Rungpradubvong V, Satitthummanid S, Herdman MT, Plewes K, Leopold SJ, Ishioka H, Mohanty S, Maude RJ, Schultz MJ, Lagrand WK, Hossain MA, Day NPJ, White NJ, Anstey NM, Dondorp AM.

J Infect Dis. 2019 Nov 6. pii: jiz568. doi: 10.1093/infdis/jiz568. [Epub ahead of print]


Cumulative fluid balance predicts mortality and increases time on mechanical ventilation in ARDS patients: An observational cohort study.

van Mourik N, Metske HA, Hofstra JJ, Binnekade JM, Geerts BF, Schultz MJ, Vlaar APJ.

PLoS One. 2019 Oct 30;14(10):e0224563. doi: 10.1371/journal.pone.0224563. eCollection 2019.


Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response.

Schouten LRA, Bos LDJ, Serpa Neto A, van Vught LA, Wiewel MA, Hoogendijk AJ, Bonten MJM, Cremer OL, Horn J, van der Poll T, Schultz MJ, Wösten-van Asperen RM; MARS consortium.

Intensive Care Med Exp. 2019 Oct 29;7(1):58. doi: 10.1186/s40635-019-0270-1.


Is gender inequity in ventilator management a "women's issue"?

Schultz MJ, Karagiannidis C.

Eur Respir J. 2019 Oct 17;54(4). pii: 1901588. doi: 10.1183/13993003.01588-2019. Print 2019 Oct. No abstract available.


Normalization of mechanical power to anthropometric indices: impact on its association with mortality in critically ill patients.

Serpa Neto A, Deliberato RO, Johnson AE, Pollard TJ, Celi LA, Pelosi P, Gama de Abreu M, Schultz MJ; PROVE Network Investigators.

Intensive Care Med. 2019 Dec;45(12):1835-1837. doi: 10.1007/s00134-019-05794-9. Epub 2019 Oct 8. No abstract available.


The tidal volume fix and more….

Simonis FD, Serpa Neto A, Schultz MJ.

J Thorac Dis. 2019 Aug;11(8):E117-E122. doi: 10.21037/jtd.2019.08.39. No abstract available.


The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients.

Pisani L, Vercesi V, van Tongeren PSI, Lagrand WK, Leopold SJ, Huson MAM, Henwood PC, Walden A, Smit MR, Riviello ED, Pelosi P, Dondorp AM, Schultz MJ; Lung Ultrasound Consortium.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):44. doi: 10.1186/s40635-019-0241-6.


Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury.

Juschten J, Ingelse SA, Maas MAW, Girbes ARJ, Juffermans NP, Schultz MJ, Tuinman PR.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):36. doi: 10.1186/s40635-019-0240-7.


Manipulation of the microbiome in critical illness-probiotics as a preventive measure against ventilator-associated pneumonia.

van Ruissen MCE, Bos LD, Dickson RP, Dondorp AM, Schultsz C, Schultz MJ.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):37. doi: 10.1186/s40635-019-0238-1. Review.


Pulmonary complement depositions in autopsy of critically ill patients have no relation with ARDS.

de Beer FM, Begieneman MPV, Roelofs JJTH, Horn J, Niessen HWM, Schultz MJ, Lagrand WK.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):35. doi: 10.1186/s40635-019-0237-2.


Development of a model for anemia of inflammation that is relevant to critical care.

Boshuizen M, van Bruggen R, Zaat SA, Schultz MJ, Aguilera E, Motos A, Senussi T, Idone FA, Pelosi P, Torres A, Bassi GL, Juffermans NP.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):47. doi: 10.1186/s40635-019-0261-2.


The role of hypercapnia in acute respiratory failure.

Morales-Quinteros L, Camprubí-Rimblas M, Bringué J, Bos LD, Schultz MJ, Artigas A.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):39. doi: 10.1186/s40635-019-0239-0. Review.


ERS statement on chest imaging in acute respiratory failure.

Chiumello D, Sferrazza Papa GF, Artigas A, Bouhemad B, Grgic A, Heunks L, Markstaller K, Pellegrino GM, Pisani L, Rigau D, Schultz MJ, Sotgiu G, Spieth P, Zompatori M, Navalesi P.

Eur Respir J. 2019 Sep 19;54(3). pii: 1900435. doi: 10.1183/13993003.00435-2019. Print 2019 Sep.


Opinions and Management of Hypothermic Sepsis: Results from an Online Survey.

Harmon MBA, Pelleboer I, Steiner AA, Wiewel M, Schultz MJ, Horn J, Juffermans NP.

Ther Hypothermia Temp Manag. 2019 Jun 24. doi: 10.1089/ther.2019.0002. [Epub ahead of print]


Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?

Uhel F, Scicluna BP, van Vught LA, Cremer OL, Bonten MJ, Schultz MJ, van der Poll T.

Crit Care. 2019 Jun 20;23(1):226. doi: 10.1186/s13054-019-2513-7. No abstract available.


Changes in ventilator settings and ventilation-induced lung injury in burn patients-A systematic review.

Glas GJ, Horn J, van der Hoeven SM, Hollmann MW, Cleffken B, Colpaert K, Juffermans NP, Knape P, Loef BG, Mackie DP, Malbrain M, Muller J, Reidinga AC, Preckel B, Schultz MJ.

Burns. 2019 Jun 12. pii: S0305-4179(18)31119-7. doi: 10.1016/j.burns.2019.05.015. [Epub ahead of print] Review.


Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial.

Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology, Bluth T, Serpa Neto A, Schultz MJ, Pelosi P, Gama de Abreu M; PROBESE Collaborative Group, Bluth T, Bobek I, Canet JC, Cinnella G, de Baerdemaeker L, Gama de Abreu M, Gregoretti C, Hedenstierna G, Hemmes SNT, Hiesmayr M, Hollmann MW, Jaber S, Laffey J, Licker MJ, Markstaller K, Matot I, Mills GH, Mulier JP, Pelosi P, Putensen C, Rossaint R, Schmitt J, Schultz MJ, Senturk M, Serpa Neto A, Severgnini P, Sprung J, Vidal Melo MF, Wrigge H.

JAMA. 2019 Jun 18;321(23):2292-2305. doi: 10.1001/jama.2019.7505. Erratum in: JAMA. 2019 Nov 12;322(18):1829-1830.


Mechanical Ventilation Management during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. An International Multicenter Prospective Cohort.

Schmidt M, Pham T, Arcadipane A, Agerstrand C, Ohshimo S, Pellegrino V, Vuylsteke A, Guervilly C, McGuinness S, Pierard S, Breeding J, Stewart C, Ching SSW, Camuso JM, Stephens RS, King B, Herr D, Schultz MJ, Neuville M, Zogheib E, Mira JP, Rozé H, Pierrot M, Tobin A, Hodgson C, Chevret S, Brodie D, Combes A.

Am J Respir Crit Care Med. 2019 Oct 15;200(8):1002-1012. doi: 10.1164/rccm.201806-1094OC.


Intraoperative immunomodulatory effects of sevoflurane versus total intravenous anesthesia with propofol in bariatric surgery (the OBESITA trial): study protocol for a randomized controlled pilot trial.

de Sousa GC, Cruz FF, Heil LB, Sobrinho CJS, Saddy F, Knibel FP, Pereira JB, Schultz MJ, Pelosi P, Gama de Abreu M, Silva PL, Rocco PRM.

Trials. 2019 May 28;20(1):300. doi: 10.1186/s13063-019-3399-z.


Electroencephalographic reactivity as predictor of neurological outcome in postanoxic coma: A multicenter prospective cohort study.

Admiraal MM, van Rootselaar AF, Hofmeijer J, Hoedemaekers CWE, van Kaam CR, Keijzer HM, van Putten MJAM, Schultz MJ, Horn J.

Ann Neurol. 2019 Jul;86(1):17-27. doi: 10.1002/ana.25507. Epub 2019 Jun 8.


Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study.

Schouten LR, van Kaam AH, Kohse F, Veltkamp F, Bos LD, de Beer FM, van Hooijdonk RT, Horn J, Straat M, Witteveen E, Glas GJ, Wieske L, van Vught LA, Wiewel MA, Ingelse SA, Cortjens B, van Woensel JB, Bos AP, Walther T, Schultz MJ, Wösten-van Asperen RM; MARS consortium.

Ann Intensive Care. 2019 May 14;9(1):55. doi: 10.1186/s13613-019-0529-4.


Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial.

Kiss T, Wittenstein J, Becker C, Birr K, Cinnella G, Cohen E, El Tahan MR, Falcão LF, Gregoretti C, Granell M, Hachenberg T, Hollmann MW, Jankovic R, Karzai W, Krassler J, Loop T, Licker MJ, Marczin N, Mills GH, Murrell MT, Neskovic V, Nisnevitch-Savarese Z, Pelosi P, Rossaint R, Schultz MJ, Neto AS, Severgnini P, Szegedi L, Vegh T, Voyagis G, Zhong J, de Abreu MG, Senturk M; PROTHOR investigators and the Research Workgroup PROtective VEntilation Network (PROVEnet) of the European Society of Anaesthesiology (ESA).

Trials. 2019 May 8;20(1):259. doi: 10.1186/s13063-019-3371-y.


Epidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection.

van de Groep K, Verhoeff TL, Verboom DM, Bos LD, Schultz MJ, Bonten MJM, Cremer OL; MARS consortium.

J Crit Care. 2019 Aug;52:258-264. doi: 10.1016/j.jcrc.2019.02.029. Epub 2019 May 1.


Detection of Invasive Aspergillosis in Critically Ill Patients with Influenza: The Role of Plasma Galactomannan.

van de Groep K, Verboom DM, van de Veerdonk FL, Haas PA, van der Poll T, Schultz MJ, Bonten MJM, Cremer OL.

Am J Respir Crit Care Med. 2019 Sep 1;200(5):636-638. doi: 10.1164/rccm.201903-0587LE. No abstract available.


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