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Items: 1 to 50 of 163

1.

Gsα stimulation of mammalian adenylate cyclases regulated by their hexahelical membrane anchors.

Seth A, Finkbeiner M, Grischin J, Schultz JE.

Cell Signal. 2020 Jan 10;68:109538. doi: 10.1016/j.cellsig.2020.109538. [Epub ahead of print]

2.

Development of Chemo- and Enantioselective Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of α-Nitroesters.

Trost BM, Schultz JE, Bai Y.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11820-11825. doi: 10.1002/anie.201904034. Epub 2019 Jul 16.

PMID:
31231880
3.

Chemo-, Regio-, Diastereo-, and Enantioselective Palladium Allylic Alkylation of 1,3-Dioxaboroles as Synthetic Equivalents of α-Hydroxyketones.

Trost BM, Schultz JE, Chang T, Maduabum MR.

J Am Chem Soc. 2019 Jun 19;141(24):9521-9526. doi: 10.1021/jacs.9b04658. Epub 2019 Jun 10.

PMID:
31180647
4.

In search of a function for the membrane anchors of class IIIa adenylate cyclases.

Finkbeiner M, Grischin J, Seth A, Schultz JE.

Int J Med Microbiol. 2019 May - Jun;309(3-4):245-251. doi: 10.1016/j.ijmm.2019.03.006. Epub 2019 Mar 22. Review.

PMID:
30954381
5.

CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a quinone responsive diheme-B membrane anchor domain.

Wissig J, Grischin J, Bassler J, Schubert C, Friedrich T, Bähre H, Schultz JE, Unden G.

Mol Microbiol. 2019 Jul;112(1):16-28. doi: 10.1111/mmi.14251. Epub 2019 Apr 10.

PMID:
30901498
6.

Enantioselective Divergent Synthesis of C19-Oxo Eburnane Alkaloids via Palladium-Catalyzed Asymmetric Allylic Alkylation of an N-Alkyl-α,β-unsaturated Lactam.

Trost BM, Bai Y, Bai WJ, Schultz JE.

J Am Chem Soc. 2019 Mar 27;141(12):4811-4814. doi: 10.1021/jacs.9b00788. Epub 2019 Mar 15.

PMID:
30848892
7.

Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium.

Chung JH, Martin BL, Canan BD, Elnakish MT, Milani-Nejad N, Saad NS, Repas SJ, Schultz JEJ, Murray JD, Slabaugh JL, Gearinger RL, Conkle J, Karaze T, Rastogi N, Chen MP, Crecelius W, Peczkowski KK, Ziolo MT, Fedorov VV, Kilic A, Whitson BA, Higgins RSD, Smith SA, Mohler PJ, Binkley PF, Janssen PML.

J Mol Cell Cardiol. 2018 Aug;121:81-93. doi: 10.1016/j.yjmcc.2018.07.005. Epub 2018 Jul 5.

8.

Adenylate cyclases: Receivers, transducers, and generators of signals.

Bassler J, Schultz JE, Lupas AN.

Cell Signal. 2018 Jun;46:135-144. doi: 10.1016/j.cellsig.2018.03.002. Epub 2018 Mar 18. Review.

9.

A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration.

Huang C, Liu Y, Beenken A, Jiang L, Gao X, Huang Z, Hsu A, Gross GJ, Wang YG, Mohammadi M, Schultz JEJ.

Cardiovasc Res. 2017 Nov 1;113(13):1585-1602. doi: 10.1093/cvr/cvx165.

10.

Characterization of a novel signal transducer element intrinsic to class IIIa/b adenylate cyclases and guanylate cyclases.

Ziegler M, Bassler J, Beltz S, Schultz A, Lupas AN, Schultz JE.

FEBS J. 2017 Apr;284(8):1204-1217. doi: 10.1111/febs.14047. Epub 2017 Mar 20.

11.

Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases.

Beltz S, Bassler J, Schultz JE.

Elife. 2016 Feb 27;5. pii: e13098. doi: 10.7554/eLife.13098.

12.

The bacterial cell envelope: structure, function, and infection interface.

Braun V, Götz F, Schultz JE, Wohlleben W.

Int J Med Microbiol. 2015 Feb;305(2):175-7. doi: 10.1016/j.ijmm.2014.12.003. Epub 2014 Dec 23. No abstract available.

PMID:
25660413
13.

Intraprotein signal transduction by HAMP domains: a balancing act.

Schultz JE, Kanchan K, Ziegler M.

Int J Med Microbiol. 2015 Feb;305(2):243-51. doi: 10.1016/j.ijmm.2014.12.007. Epub 2014 Dec 23. Review.

PMID:
25595022
14.

Biochemical characterization of the tandem HAMP domain from Natronomonas pharaonis as an intraprotein signal transducer.

Natarajan J, Schultz A, Kurz U, Schultz JE.

FEBS J. 2014 Jul;281(14):3218-27. doi: 10.1111/febs.12855. Epub 2014 Jun 17.

15.

Regulated unfolding: a basic principle of intraprotein signaling in modular proteins.

Schultz JE, Natarajan J.

Trends Biochem Sci. 2013 Nov;38(11):538-45. doi: 10.1016/j.tibs.2013.08.005. Epub 2013 Sep 16. Review.

PMID:
24051046
16.

The regulatory tandem domains of human phosphodiesterases 1 and 4 regulate a cyanobacterial adenylyl cyclase.

Banjac A, Kurz U, Schultz JE.

Cell Signal. 2012 Aug;24(8):1479-84. doi: 10.1016/j.cellsig.2012.03.019. Epub 2012 Mar 30.

PMID:
22484154
17.

The S-helix determines the signal in a Tsr receptor/adenylyl cyclase reporter.

Winkler K, Schultz A, Schultz JE.

J Biol Chem. 2012 May 4;287(19):15479-88. doi: 10.1074/jbc.M112.348409. Epub 2012 Mar 15.

18.

Mechanism of regulation of receptor histidine kinases.

Ferris HU, Dunin-Horkawicz S, Hornig N, Hulko M, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M.

Structure. 2012 Jan 11;20(1):56-66. doi: 10.1016/j.str.2011.11.014.

19.

HAMP domain-mediated signal transduction probed with a mycobacterial adenylyl cyclase as a reporter.

Mondéjar LG, Lupas A, Schultz A, Schultz JE.

J Biol Chem. 2012 Jan 6;287(2):1022-31. doi: 10.1074/jbc.M111.284067. Epub 2011 Nov 17.

20.

Intramolecular signaling in tandem-GAF domains from PDE5 and PDE10 studied with a cyanobacterial adenylyl cyclase reporter.

Banjac A, Zimmermann MO, Boeckler FM, Kurz U, Schultz A, Schultz JE.

Cell Signal. 2012 Mar;24(3):629-34. doi: 10.1016/j.cellsig.2011.10.013. Epub 2011 Nov 4.

PMID:
22080917
21.

The GAF-tandem domain of phosphodiesterase 5 as a potential drug target.

Schultz JE, Dunkern T, Gawlitta-Gorka E, Sorg G.

Handb Exp Pharmacol. 2011;(204):151-66. doi: 10.1007/978-3-642-17969-3_6. Review.

PMID:
21695639
22.

The mechanisms of HAMP-mediated signaling in transmembrane receptors.

Ferris HU, Dunin-Horkawicz S, Mondéjar LG, Hulko M, Hantke K, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M.

Structure. 2011 Mar 9;19(3):378-85. doi: 10.1016/j.str.2011.01.006.

23.

Fibroblast Growth Factor 2 Mediates Isoproterenol-induced Cardiac Hypertrophy through Activation of the Extracellular Regulated Kinase.

House SL, House BE, Glascock B, Kimball T, Nusayr E, Schultz JE, Doetschman T.

Mol Cell Pharmacol. 2010;2(4):143-154.

24.

Escherichia coli exports cyclic AMP via TolC.

Hantke K, Winkler K, Schultz JE.

J Bacteriol. 2011 Mar;193(5):1086-9. doi: 10.1128/JB.01399-10. Epub 2010 Dec 23. Retraction in: Hantke K, Winkler K, Schultz JE. J Bacteriol. 2015 Dec 15;197(24):3849.

25.

Transmembrane receptor chimeras to probe HAMP domain function.

Linder JU, Schultz JE.

Methods Enzymol. 2010;471:115-23. doi: 10.1016/S0076-6879(10)71007-7. Epub 2010 Mar 1.

PMID:
20946845
26.

Transmembrane signaling in chimeras of the Escherichia coli aspartate and serine chemotaxis receptors and bacterial class III adenylyl cyclases.

Kanchan K, Linder J, Winkler K, Hantke K, Schultz A, Schultz JE.

J Biol Chem. 2010 Jan 15;285(3):2090-9. doi: 10.1074/jbc.M109.051698. Epub 2009 Nov 18.

27.

(Un)body double: a rhapsody on hairless identity.

Schultz JE.

Lit Med. 2009 Fall;28(2):371-93. No abstract available.

PMID:
21141802
28.

Editors' preface: cancer stories. Preface.

Schultz JE, Holmes MS.

Lit Med. 2009 Fall;28(2):xi-xv. No abstract available.

PMID:
21141792
29.

Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.

Jones WK, Fan GC, Liao S, Zhang JM, Wang Y, Weintraub NL, Kranias EG, Schultz JE, Lorenz J, Ren X.

Circulation. 2009 Sep 15;120(11 Suppl):S1-9. doi: 10.1161/CIRCULATIONAHA.108.843938.

30.

Polyphosphates from Mycobacterium bovis--potent inhibitors of class III adenylate cyclases.

Guo YL, Mayer H, Vollmer W, Dittrich D, Sander P, Schultz A, Schultz JE.

FEBS J. 2009 Feb;276(4):1094-103. doi: 10.1111/j.1742-4658.2008.06852.x. Epub 2009 Jan 16.

31.

Structural and biochemical aspects of tandem GAF domains.

Schultz JE.

Handb Exp Pharmacol. 2009;(191):93-109. doi: 10.1007/978-3-540-68964-5_6. Review.

PMID:
19089327
32.

Versatility of signal transduction encoded in dimeric adenylyl cyclases.

Linder JU, Schultz JE.

Curr Opin Struct Biol. 2008 Dec;18(6):667-72. doi: 10.1016/j.sbi.2008.11.008. Review.

PMID:
19054664
33.

Functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains.

Hofbauer K, Schultz A, Schultz JE.

J Biol Chem. 2008 Sep 12;283(37):25164-70. doi: 10.1074/jbc.M800230200. Epub 2008 Jul 17.

34.

The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain.

Gross-Langenhoff M, Stenzl A, Altenberend F, Schultz A, Schultz JE.

FEBS J. 2008 Apr;275(8):1643-50. doi: 10.1111/j.1742-4658.2008.06319.x. Epub 2008 Feb 27.

35.

eNOS deficient mice develop progressive cardiac hypertrophy with altered cytokine and calcium handling protein expression.

Flaherty MP, Brown M, Grupp IL, Schultz JE, Murphree SS, Jones WK.

Cardiovasc Toxicol. 2007;7(3):165-77.

PMID:
17901560
36.

The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid.

Findeisen F, Linder JU, Schultz A, Schultz JE, Brügger B, Wieland F, Sinning I, Tews I.

J Mol Biol. 2007 Jun 22;369(5):1282-95. Epub 2007 Apr 12.

PMID:
17482646
37.
38.

Healing the nation: condolence and correspondence in Civil War hospitals.

Schultz JE.

Proteus. 2000;17(2):32-41. No abstract available.

PMID:
17094211
39.

Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.

Dittrich D, Keller C, Ehlers S, Schultz JE, Sander P.

Int J Med Microbiol. 2006 Dec;296(8):563-6. Epub 2006 Sep 26.

PMID:
17005450
40.

The HAMP domain structure implies helix rotation in transmembrane signaling.

Hulko M, Berndt F, Gruber M, Linder JU, Truffault V, Schultz A, Martin J, Schultz JE, Lupas AN, Coles M.

Cell. 2006 Sep 8;126(5):929-40.

41.

Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv.

Abdel Motaal A, Tews I, Schultz JE, Linder JU.

FEBS J. 2006 Sep;273(18):4219-28. Epub 2006 Aug 21.

42.

Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei.

Zeuthen T, Wu B, Pavlovic-Djuranovic S, Holm LM, Uzcategui NL, Duszenko M, Kun JF, Schultz JE, Beitz E.

Mol Microbiol. 2006 Sep;61(6):1598-608. Epub 2006 Aug 3.

43.

Characterization of the tandem GAF domain of human phosphodiesterase 5 using a cyanobacterial adenylyl cyclase as a reporter enzyme.

Bruder S, Schultz A, Schultz JE.

J Biol Chem. 2006 Jul 21;281(29):19969-76. Epub 2006 May 11.

44.

Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation.

Pavlovic-Djuranovic S, Kun JF, Schultz JE, Beitz E.

Biochim Biophys Acta. 2006 Aug;1758(8):1012-7. Epub 2006 Jan 4.

45.

Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons.

Beitz E, Wu B, Holm LM, Schultz JE, Zeuthen T.

Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):269-74. Epub 2006 Jan 3.

46.

cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11.

Gross-Langenhoff M, Hofbauer K, Weber J, Schultz A, Schultz JE.

J Biol Chem. 2006 Feb 3;281(5):2841-6. Epub 2005 Dec 5.

47.

Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.

Guo YL, Kurz U, Schultz A, Linder JU, Dittrich D, Keller C, Ehlers S, Sander P, Schultz JE.

Mol Microbiol. 2005 Aug;57(3):667-77.

48.

Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection.

Castro LI, Hermsen C, Schultz JE, Linder JU.

FEBS J. 2005 Jun;272(12):3085-92.

49.

The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme.

Tews I, Findeisen F, Sinning I, Schultz A, Schultz JE, Linder JU.

Science. 2005 May 13;308(5724):1020-3.

50.

Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.

Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG.

Circ Res. 2005 Apr 15;96(7):756-66. Epub 2005 Mar 3.

PMID:
15746443

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