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Items: 1 to 50 of 55

1.

High-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy.

Loro E, Sengupta K, Bogdanovich S, Whig K, Schultz DC, Huryn DM, Khurana TS.

Sci Rep. 2020 Feb 7;10(1):2132. doi: 10.1038/s41598-020-58737-6.

2.

Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses.

Hackett BA, Dittmar M, Segrist E, Pittenger N, To J, Griesman T, Gordesky-Gold B, Schultz DC, Cherry S.

mBio. 2019 Jul 9;10(4). pii: e01446-19. doi: 10.1128/mBio.01446-19.

3.

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.

Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL.

Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14.

PMID:
30773298
4.

Comprehensive pharmacological profiling of neurofibromatosis cell lines.

Guo J, Grovola MR, Xie H, Coggins GE, Duggan P, Hasan R, Huang J, Lin DW, Song C, Witek GM, Berritt S, Schultz DC, Field J.

Am J Cancer Res. 2017 Apr 1;7(4):923-934. eCollection 2017.

5.

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.

Yang TB, Chen Q, Deng JT, Jagannathan G, Tobias JW, Schultz DC, Wang S, Lengner CJ, Rustgi AK, Lynch JP, Johnson FB.

Nat Commun. 2017 Mar 17;8:14766. doi: 10.1038/ncomms14766.

6.

Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.

Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, Schultz DC, Coyne CB, Cherry S.

Cell Rep. 2017 Jan 17;18(3):804-815. doi: 10.1016/j.celrep.2016.12.068.

7.

Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.

Ricketts MD, Frederick B, Hoff H, Tang Y, Schultz DC, Singh Rai T, Grazia Vizioli M, Adams PD, Marmorstein R.

Nat Commun. 2015 Jul 10;6:7711. doi: 10.1038/ncomms8711.

8.

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers.

Bitler BG, Aird KM, Garipov A, Li H, Amatangelo M, Kossenkov AV, Schultz DC, Liu Q, Shih IeM, Conejo-Garcia JR, Speicher DW, Zhang R.

Nat Med. 2015 Mar;21(3):231-8. doi: 10.1038/nm.3799. Epub 2015 Feb 16.

9.

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC.

J Natl Cancer Inst. 2015 Feb 3;107(3). pii: dju502. doi: 10.1093/jnci/dju502. Print 2015 Mar.

10.

Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumors.

Faversani A, Vaira V, Moro GP, Tosi D, Lopergolo A, Schultz DC, Rivadeneira D, Altieri DC, Bosari S.

Breast Cancer Res. 2014 May 30;16(3):R55. doi: 10.1186/bcr3666.

11.

Identification and characterization of small molecule human papillomavirus E6 inhibitors.

Malecka KA, Fera D, Schultz DC, Hodawadekar S, Reichman M, Donover PS, Murphy ME, Marmorstein R.

ACS Chem Biol. 2014 Jul 18;9(7):1603-12. doi: 10.1021/cb500229d. Epub 2014 Jun 2.

12.

Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma.

Villanueva J, Infante JR, Krepler C, Reyes-Uribe P, Samanta M, Chen HY, Li B, Swoboda RK, Wilson M, Vultur A, Fukunaba-Kalabis M, Wubbenhorst B, Chen TY, Liu Q, Sproesser K, DeMarini DJ, Gilmer TM, Martin AM, Marmorstein R, Schultz DC, Speicher DW, Karakousis GC, Xu W, Amaravadi RK, Xu X, Schuchter LM, Herlyn M, Nathanson KL.

Cell Rep. 2013 Sep 26;4(6):1090-9. doi: 10.1016/j.celrep.2013.08.023. Epub 2013 Sep 19.

13.

Identification of a new class of small molecules that efficiently reactivate latent Epstein-Barr Virus.

Tikhmyanova N, Schultz DC, Lee T, Salvino JM, Lieberman PM.

ACS Chem Biol. 2014 Mar 21;9(3):785-95. doi: 10.1021/cb4006326. Epub 2014 Feb 19.

14.

R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis.

Wang H, Brennan TA, Russell E, Kim JH, Egan KP, Chen Q, Israelite C, Schultz DC, Johnson FB, Pignolo RJ.

J Mol Med (Berl). 2013 Dec;91(12):1421-9. doi: 10.1007/s00109-013-1068-3. Epub 2013 Aug 24.

15.

Structure of the human telomeric Stn1-Ten1 capping complex.

Bryan C, Rice C, Harkisheimer M, Schultz DC, Skordalakes E.

PLoS One. 2013 Jun 24;8(6):e66756. doi: 10.1371/journal.pone.0066756. Print 2013.

16.

Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance.

Mason M, Wanat JJ, Harper S, Schultz DC, Speicher DW, Johnson FB, Skordalakes E.

Structure. 2013 Jan 8;21(1):109-120. doi: 10.1016/j.str.2012.10.012. Epub 2012 Nov 21.

17.

The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.

Krebs CJ, Schultz DC, Robins DM.

Mol Cell Biol. 2012 Sep;32(18):3732-42. doi: 10.1128/MCB.00615-12. Epub 2012 Jul 16.

18.

Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins.

Fera D, Schultz DC, Hodawadekar S, Reichman M, Donover PS, Melvin J, Troutman S, Kissil JL, Huryn DM, Marmorstein R.

Chem Biol. 2012 Apr 20;19(4):518-28. doi: 10.1016/j.chembiol.2012.03.007.

19.

Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.

Tang Y, Puri A, Ricketts MD, Rai TS, Hoffmann J, Hoi E, Adams PD, Schultz DC, Marmorstein R.

Biochemistry. 2012 Mar 27;51(12):2366-77. doi: 10.1021/bi300050b. Epub 2012 Mar 16.

20.

Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.

Ray-Gallet D, Woolfe A, Vassias I, Pellentz C, Lacoste N, Puri A, Schultz DC, Pchelintsev NA, Adams PD, Jansen LE, Almouzni G.

Mol Cell. 2011 Dec 23;44(6):928-41. doi: 10.1016/j.molcel.2011.12.006.

21.

Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.

Rai TS, Puri A, McBryan T, Hoffman J, Tang Y, Pchelintsev NA, van Tuyn J, Marmorstein R, Schultz DC, Adams PD.

Mol Cell Biol. 2011 Oct;31(19):4107-18. doi: 10.1128/MCB.05546-11. Epub 2011 Aug 1.

22.

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae.

Smith JS, Chen Q, Yatsunyk LA, Nicoludis JM, Garcia MS, Kranaster R, Balasubramanian S, Monchaud D, Teulade-Fichou MP, Abramowitz L, Schultz DC, Johnson FB.

Nat Struct Mol Biol. 2011 Apr;18(4):478-85. doi: 10.1038/nsmb.2033. Epub 2011 Mar 13.

23.

Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis.

Mellert HS, Stanek TJ, Sykes SM, Rauscher FJ 3rd, Schultz DC, McMahon SB.

J Biol Chem. 2011 Feb 11;286(6):4264-70. doi: 10.1074/jbc.M110.184663. Epub 2010 Dec 9.

24.

Development of a high-throughput screen for inhibitors of Epstein-Barr virus EBNA1.

Thompson S, Messick T, Schultz DC, Reichman M, Lieberman PM.

J Biomol Screen. 2010 Oct;15(9):1107-15. doi: 10.1177/1087057110379154.

25.

Stromal cell-free conditions favorable for human B lymphopoiesis in culture.

Ichii M, Oritani K, Yokota T, Schultz DC, Holter JL, Kanakura Y, Kincade PW.

J Immunol Methods. 2010 Jul 31;359(1-2):47-55. doi: 10.1016/j.jim.2010.06.002. Epub 2010 Jun 9.

26.

Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening.

Li N, Thompson S, Schultz DC, Zhu W, Jiang H, Luo C, Lieberman PM.

PLoS One. 2010 Apr 12;5(4):e10126. doi: 10.1371/journal.pone.0010126.

27.

Characterization of two recessive genes controlling resistance to all races of bacterial spot in peppers.

Vallejos CE, Jones V, Stall RE, Jones JB, Minsavage GV, Schultz DC, Rodrigues R, Olsen LE, Mazourek M.

Theor Appl Genet. 2010 Jun;121(1):37-46. doi: 10.1007/s00122-010-1289-6. Epub 2010 Feb 24.

PMID:
20180094
28.

Assessment of sera for chromatin-immunoprecipitation.

Nguyen J, Yamada D, Schultz DC, Defossez PA.

Biotechniques. 2008 Jan;44(1):66, 68.

29.

PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.

Ivanov AV, Peng H, Yurchenko V, Yap KL, Negorev DG, Schultz DC, Psulkowski E, Fredericks WJ, White DE, Maul GG, Sadofsky MJ, Zhou MM, Rauscher FJ 3rd.

Mol Cell. 2007 Dec 14;28(5):823-37.

30.

Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression.

Li X, Lee YK, Jeng JC, Yen Y, Schultz DC, Shih HM, Ann DK.

J Biol Chem. 2007 Dec 14;282(50):36177-89. Epub 2007 Oct 17.

31.

Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.

Ingvarsdottir K, Edwards C, Lee MG, Lee JS, Schultz DC, Shilatifard A, Shiekhattar R, Berger SL.

Mol Cell Biol. 2007 Nov;27(22):7856-64. Epub 2007 Sep 17.

33.

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.

Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y.

Nat Cell Biol. 2006 Aug;8(8):870-6. Epub 2006 Jul 23.

PMID:
16862143
34.
35.

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.

Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ 3rd.

Biochem Biophys Res Commun. 2005 Jun 17;331(4):929-37.

PMID:
15882967
36.

Identification of a splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma prone kindred.

Prowse AH, Schultz DC, Guo S, Vanderveer L, Dangel J, Bove B, Cairns P, Daly M, Godwin AK.

J Med Genet. 2003 Aug;40(8):e102. No abstract available.

37.

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation.

Ayyanathan K, Lechner MS, Bell P, Maul GG, Schultz DC, Yamada Y, Tanaka K, Torigoe K, Rauscher FJ 3rd.

Genes Dev. 2003 Aug 1;17(15):1855-69. Epub 2003 Jul 17.

40.
41.

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions.

Peng H, Begg GE, Schultz DC, Friedman JR, Jensen DE, Speicher DW, Rauscher FJ 3rd.

J Mol Biol. 2000 Feb 4;295(5):1139-62.

PMID:
10653693
42.

Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.

Li X, Peng H, Schultz DC, Lopez-Guisa JM, Rauscher FJ 3rd, Marmorstein R.

Cancer Res. 1999 Oct 15;59(20):5275-82.

43.

Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.

Bruening W, Prowse AH, Schultz DC, Holgado-Madruga M, Wong A, Godwin AK.

Cancer Res. 1999 Oct 1;59(19):4973-83.

44.
45.

Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2.

Schultz DC, Balasara BR, Testa JR, Godwin AK.

Genomics. 1998 Sep 1;52(2):186-91.

PMID:
9782084
46.

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.

Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM, Tommerup N, Vissing H, Sekido Y, Minna J, Borodovsky A, Schultz DC, Wilkinson KD, Maul GG, Barlev N, Berger SL, Prendergast GC, Rauscher FJ 3rd.

Oncogene. 1998 Mar 5;16(9):1097-112.

47.

Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells.

Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC.

Cancer Res. 1997 May 15;57(10):2029-34.

48.

Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors.

Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC.

Oncogene. 1997 Apr 24;14(16):1973-9.

49.

A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals.

Berman DB, Costalas J, Schultz DC, Grana G, Daly M, Godwin AK.

Cancer Res. 1996 Aug 1;56(15):3409-14.

50.

Two distinct origins of a common BRCA1 mutation in breast-ovarian cancer families: a genetic study of 15 185delAG-mutation kindreds.

Berman DB, Wagner-Costalas J, Schultz DC, Lynch HT, Daly M, Godwin AK.

Am J Hum Genet. 1996 Jun;58(6):1166-76.

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