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Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study.

Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K.

JAMA Neurol. 2019 Jun 3. doi: 10.1001/jamaneurol.2019.1424. [Epub ahead of print]


Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid.

Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ; Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging. 2019 Jun;78:178-185. doi: 10.1016/j.neurobiolaging.2019.02.019. Epub 2019 Mar 7.


An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.

Yang HS, Chhatwal JP, Xu J, White CC, Hanseeuw B, Rabin JS, Papp KV, Buckley RF, Schultz AP, Properzi MJ, Gatchel JR, Amariglio RE, Donovan NJ, Mormino EC, Hedden T, Marshall GA, Rentz DM, Johnson KA, De Jager PL, Sperling RA.

J Alzheimers Dis. 2019;68(3):1161-1170. doi: 10.3233/JAD-180788.


Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer's disease.

Hanseeuw BJ, Lopera F, Sperling RA, Norton DJ, Guzman-Velez E, Baena A, Pardilla-Delgado E, Schultz AP, Gatchel J, Jin D, Chen K, Reiman EM, Johnson KA, Quiroz YT.

Alzheimers Res Ther. 2019 Feb 4;11(1):17. doi: 10.1186/s13195-019-0468-1.


Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults.

Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA.

JAMA Neurol. 2019 Feb 4. doi: 10.1001/jamaneurol.2018.4693. [Epub ahead of print]


Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia.

Marshall GA, Gatchel JR, Donovan NJ, Muniz MC, Schultz AP, Becker JA, Chhatwal JP, Hanseeuw BJ, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA.

J Alzheimers Dis. 2019;67(2):757-768. doi: 10.3233/JAD-170578.


Vascular Risk and β-Amyloid Are Synergistically Associated with Cortical Tau.

Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP.

Ann Neurol. 2019 Feb;85(2):272-279. doi: 10.1002/ana.25399. Epub 2019 Jan 7.


Regional tau pathology and loneliness in cognitively normal older adults.

d'Oleire Uquillas F, Jacobs HIL, Biddle KD, Properzi M, Hanseeuw B, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Donovan NJ.

Transl Psychiatry. 2018 Dec 18;8(1):282. doi: 10.1038/s41398-018-0345-x.


The impact of amyloid-beta and tau on prospective cognitive decline in older individuals.

Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA.

Ann Neurol. 2019 Feb;85(2):181-193. doi: 10.1002/ana.25395. Epub 2019 Jan 21.


Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.

Huijbers W, Schultz AP, Papp KV, LaPoint MR, Hanseeuw B, Chhatwal JP, Hedden T, Johnson KA, Sperling RA.

J Neurosci. 2019 Jan 16;39(3):548-556. doi: 10.1523/JNEUROSCI.1397-18.2018. Epub 2018 Nov 27.


Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers.

Properzi MJ, Buckley RF, Chhatwal JP, Donohue MC, Lois C, Mormino EC, Johnson KA, Sperling RA, Schultz AP.

Neuroimage. 2019 Feb 1;186:446-454. doi: 10.1016/j.neuroimage.2018.11.019. Epub 2018 Nov 17.


Anticholinergic Amnesia is Mediated by Alterations in Human Network Connectivity Architecture.

Chhatwal JP, Schultz AP, Hedden T, Boot BP, Wigman S, Rentz D, Johnson KA, Sperling RA.

Cereb Cortex. 2018 Sep 6. doi: 10.1093/cercor/bhy214. [Epub ahead of print]


Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts.

Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA; Alzheimer's Disease Neuroimaging Initiative; Australian Imaging, Biomarker and Lifestyle study of ageing; Harvard Aging Brain Study.

Alzheimers Dement. 2018 Sep;14(9):1193-1203. doi: 10.1016/j.jalz.2018.04.010. Epub 2018 May 24.


Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study.

Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP.

JAMA Neurol. 2018 Sep 1;75(9):1124-1131. doi: 10.1001/jamaneurol.2018.1123.


PET staging of amyloidosis using striatum.

Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA; Alzheimer's Disease Neuroimaging Initiative; Harvard Aging Brain Study.

Alzheimers Dement. 2018 Oct;14(10):1281-1292. doi: 10.1016/j.jalz.2018.04.011. Epub 2018 May 21.


18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal.

Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA.

J Alzheimers Dis. 2018;62(4):1691-1702. doi: 10.3233/JAD-170840.


Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing.

Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA; Dominantly Inherited Alzheimer Network.

Brain. 2018 May 1;141(5):1486-1500. doi: 10.1093/brain/awy053.


Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.

Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA.

Nat Neurosci. 2018 Mar;21(3):424-431. doi: 10.1038/s41593-018-0070-z. Epub 2018 Feb 5.


Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals.

d'Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P.

Neuroimage Clin. 2017 Oct 31;17:388-396. doi: 10.1016/j.nicl.2017.10.034. eCollection 2018.


Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults.

Dumurgier J, Hanseeuw BJ, Hatling FB, Judge KA, Schultz AP, Chhatwal JP, Blacker D, Sperling RA, Johnson KA, Hyman BT, Gómez-Isla T.

J Alzheimers Dis. 2017;60(4):1451-1459. doi: 10.3233/JAD-170511.


Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden.

Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE.

JAMA Neurol. 2017 Dec 1;74(12):1455-1463. doi: 10.1001/jamaneurol.2017.2216.


Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study.

Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J, Papp KV, Amariglio RE, Rentz DM, Blacker D, Sperling RA, Johnson KA, Marshall GA.

J Alzheimers Dis. 2017;59(3):975-985. doi: 10.3233/JAD-170001.


Functional network integrity presages cognitive decline in preclinical Alzheimer disease.

Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP.

Neurology. 2017 Jul 4;89(1):29-37. doi: 10.1212/WNL.0000000000004059. Epub 2017 Jun 7.


Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex.

Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA.

JAMA Neurol. 2017 Jul 1;74(7):813-820. doi: 10.1001/jamaneurol.2017.0263.


The association between tau PET and retrospective cortical thinning in clinically normal elderly.

LaPoint MR, Chhatwal JP, Sepulcre J, Johnson KA, Sperling RA, Schultz AP.

Neuroimage. 2017 Aug 15;157:612-622. doi: 10.1016/j.neuroimage.2017.05.049. Epub 2017 May 22.


Neuroimaging markers associated with maintenance of optimal memory performance in late-life.

Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, Sperling RA, Rentz DM.

Neuropsychologia. 2017 Jun;100:164-170. doi: 10.1016/j.neuropsychologia.2017.04.037. Epub 2017 May 1.


Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals.

Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA.

J Neurosci. 2017 Apr 19;37(16):4323-4331. doi: 10.1523/JNEUROSCI.3263-16.2017. Epub 2017 Mar 17.


Cued memory decline in biomarker-defined preclinical Alzheimer disease.

Papp KV, Rentz DM, Mormino EC, Schultz AP, Amariglio RE, Quiroz Y, Johnson KA, Sperling RA.

Neurology. 2017 Apr 11;88(15):1431-1438. doi: 10.1212/WNL.0000000000003812. Epub 2017 Mar 10.


Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.

Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA.

Ann Neurol. 2017 Apr;81(4):583-596. doi: 10.1002/ana.24910. Epub 2017 Apr 6.


Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β.

Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA.

Alzheimers Dement. 2017 Sep;13(9):1004-1012. doi: 10.1016/j.jalz.2017.01.018. Epub 2017 Feb 28.


Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study.

Huijbers W, Papp KV, LaPoint M, Wigman SE, Dagley A, Hedden T, Rentz DM, Schultz AP, Sperling RA.

Cereb Cortex. 2017 Sep 1;27(9):4339-4349. doi: 10.1093/cercor/bhw234.


Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals.

Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA.

JAMA Neurol. 2016 Oct 1;73(10):1185-1191. doi: 10.1001/jamaneurol.2016.2237.


Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly.

Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA.

Neurology. 2016 Aug 30;87(9):920-6. doi: 10.1212/WNL.0000000000003050. Epub 2016 Jul 29.


Decreased hippocampal metabolism in high-amyloid mild cognitive impairment.

Hanseeuw BJ, Schultz AP, Betensky RA, Sperling RA, Johnson KA.

Alzheimers Dement. 2016 Dec;12(12):1288-1296. doi: 10.1016/j.jalz.2016.06.2357. Epub 2016 Jul 13.


In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain.

Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA.

J Neurosci. 2016 Jul 13;36(28):7364-74. doi: 10.1523/JNEUROSCI.0639-16.2016.


Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly.

Hsu DC, Mormino EC, Schultz AP, Amariglio RE, Donovan NJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA; Harvard Aging Brain Study.

J Alzheimers Dis. 2016 Jun 18;53(3):1097-105. doi: 10.3233/JAD-150987.


Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging.

Greve DN, Salat DH, Bowen SL, Izquierdo-Garcia D, Schultz AP, Catana C, Becker JA, Svarer C, Knudsen GM, Sperling RA, Johnson KA.

Neuroimage. 2016 May 15;132:334-343. doi: 10.1016/j.neuroimage.2016.02.042. Epub 2016 Feb 23.


Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers.

Malishkevich A, Marshall GA, Schultz AP, Sperling RA, Aharon-Peretz J, Gozes I.

J Alzheimers Dis. 2016;50(1):249-60. doi: 10.3233/JAD-150799.


Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease.

Papp KV, Mormino EC, Amariglio RE, Munro C, Dagley A, Schultz AP, Johnson KA, Sperling RA, Rentz DM.

Neuropsychology. 2016 Jul;30(5):624-30. doi: 10.1037/neu0000246. Epub 2015 Nov 23.


Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study.

Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, Giraldo M, Tirado V, Ramírez DL, Tariot PN, Dickerson BC, Sperling RA, Lopera F, Reiman EM.

JAMA Neurol. 2015 Aug;72(8):912-9. doi: 10.1001/jamaneurol.2015.1099.


Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers.

Gidicsin CM, Maye JE, Locascio JJ, Pepin LC, Philiossaint M, Becker JA, Younger AP, Dekhtyar M, Schultz AP, Amariglio RE, Marshall GA, Rentz DM, Hedden T, Sperling RA, Johnson KA.

Neurology. 2015 Jul 7;85(1):48-55. doi: 10.1212/WNL.0000000000001704. Epub 2015 Jun 10.


Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities.

Reijmer YD, Schultz AP, Leemans A, O'Sullivan MJ, Gurol ME, Sperling R, Greenberg SM, Viswanathan A, Hedden T.

Neuroimage. 2015 Aug 15;117:222-9. doi: 10.1016/j.neuroimage.2015.05.054. Epub 2015 May 27.


Odor identification and Alzheimer disease biomarkers in clinically normal elderly.

Growdon ME, Schultz AP, Dagley AS, Amariglio RE, Hedden T, Rentz DM, Johnson KA, Sperling RA, Albers MW, Marshall GA.

Neurology. 2015 May 26;84(21):2153-60. doi: 10.1212/WNL.0000000000001614. Epub 2015 May 1.


Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment.

Munro CE, Donovan NJ, Guercio BJ, Wigman SE, Schultz AP, Amariglio RE, Rentz DM, Johnson KA, Sperling RA, Marshall GA.

J Alzheimers Dis. 2015;46(3):727-35. doi: 10.3233/JAD-150017.


Harvard Aging Brain Study: Dataset and accessibility.

Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, Papp KV, Amariglio RE, Blacker D, Rentz DM, Johnson KA, Sperling RA, Schultz AP.

Neuroimage. 2017 Jan;144(Pt B):255-258. doi: 10.1016/j.neuroimage.2015.03.069. Epub 2015 Apr 3.


Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults.

Shaw EE, Schultz AP, Sperling RA, Hedden T.

Brain Connect. 2015 Oct;5(8):505-16. doi: 10.1089/brain.2014.0327. Epub 2015 Jun 23.


Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults.

Donovan NJ, Hsu DC, Dagley AS, Schultz AP, Amariglio RE, Mormino EC, Okereke OI, Rentz DM, Johnson KA, Sperling RA, Marshall GA.

J Alzheimers Dis. 2015;46(1):63-73. doi: 10.3233/JAD-142940.


Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression.

Huijbers W, Mormino EC, Schultz AP, Wigman S, Ward AM, Larvie M, Amariglio RE, Marshall GA, Rentz DM, Johnson KA, Sperling RA.

Brain. 2015 Apr;138(Pt 4):1023-35. doi: 10.1093/brain/awv007. Epub 2015 Feb 11.


Functional outcome of septic arthritis after anterior cruciate ligament surgery.

Gille J, Gerlach U, Oheim R, Hintze T, Himpe B, Schultz AP.

Int Orthop. 2015 Jun;39(6):1195-201. doi: 10.1007/s00264-014-2600-y. Epub 2014 Nov 25.


Multiple Brain Markers are Linked to Age-Related Variation in Cognition.

Hedden T, Schultz AP, Rieckmann A, Mormino EC, Johnson KA, Sperling RA, Buckner RL.

Cereb Cortex. 2016 Apr;26(4):1388-400. doi: 10.1093/cercor/bhu238. Epub 2014 Oct 14.

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