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Items: 18

1.

Stereospecific antitumor activity of radicicol oxime derivatives.

Soga S, Sharma SV, Shiotsu Y, Shimizu M, Tahara H, Yamaguchi K, Ikuina Y, Murakata C, Tamaoki T, Kurebayashi J, Schulte TW, Neckers LM, Akinaga S.

Cancer Chemother Pharmacol. 2001 Dec;48(6):435-45.

PMID:
11800023
2.

Hsp90 as an anti-cancer target.

Neckers L, Mimnaugh E, Schulte TW.

Drug Resist Updat. 1999 Jun;2(3):165-172.

PMID:
11504487
3.

Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint.

Kim JS, Pirnia F, Choi YH, Nguyen PM, Knepper B, Tsokos M, Schulte TW, Birrer MJ, Blagosklonny MV, Schaefer O, Mushinski JF, Trepel JB.

Oncogene. 2000 Dec 7;19(52):6082-90.

4.
6.

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity.

Neckers L, Schulte TW, Mimnaugh E.

Invest New Drugs. 1999;17(4):361-73. Review.

PMID:
10759403
7.

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins.

Marcu MG, Schulte TW, Neckers L.

J Natl Cancer Inst. 2000 Feb 2;92(3):242-8.

PMID:
10655441
8.

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.

Schulte TW, Akinaga S, Murakata T, Agatsuma T, Sugimoto S, Nakano H, Lee YS, Simen BB, Argon Y, Felts S, Toft DO, Neckers LM, Sharma SV.

Mol Endocrinol. 1999 Sep;13(9):1435-48.

PMID:
10478836
9.

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

Soga S, Neckers LM, Schulte TW, Shiotsu Y, Akasaka K, Narumi H, Agatsuma T, Ikuina Y, Murakata C, Tamaoki T, Akinaga S.

Cancer Res. 1999 Jun 15;59(12):2931-8.

10.

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase.

Ochel HJ, Schulte TW, Nguyen P, Trepel J, Neckers L.

Mol Genet Metab. 1999 Jan;66(1):24-30.

PMID:
9973544
11.
12.

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

Schulte TW, Akinaga S, Soga S, Sullivan W, Stensgard B, Toft D, Neckers LM.

Cell Stress Chaperones. 1998 Jun;3(2):100-8.

13.

Geldanamycin-induced destabilization of Raf-1 involves the proteasome.

Schulte TW, An WG, Neckers LM.

Biochem Biophys Res Commun. 1997 Oct 29;239(3):655-9.

PMID:
9367823
14.

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation.

Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO.

J Biol Chem. 1997 Sep 19;272(38):23843-50.

15.

Expression of PAX3 in Ewing's sarcoma family of tumors.

Schulte TW, Toretsky JA, Ress E, Helman L, Neckers LM.

Biochem Mol Med. 1997 Apr;60(2):121-6.

PMID:
9169092
16.

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.

Schulte TW, Blagosklonny MV, Romanova L, Mushinski JF, Monia BP, Johnston JF, Nguyen P, Trepel J, Neckers LM.

Mol Cell Biol. 1996 Oct;16(10):5839-45.

17.

Taxol induction of p21WAF1 and p53 requires c-raf-1.

Blagosklonny MV, Schulte TW, Nguyen P, Mimnaugh EG, Trepel J, Neckers L.

Cancer Res. 1995 Oct 15;55(20):4623-6.

18.

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association.

Schulte TW, Blagosklonny MV, Ingui C, Neckers L.

J Biol Chem. 1995 Oct 13;270(41):24585-8.

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