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Items: 1 to 50 of 140

1.

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C.

Sci Signal. 2018 Dec 4;11(559). pii: eaar5536. doi: 10.1126/scisignal.aar5536.

PMID:
30514810
2.

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.

Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnoš J, Bernatik O, Sri Ganji R, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte G.

J Biol Chem. 2018 Oct 11. pii: jbc.RA118.004656. doi: 10.1074/jbc.RA118.004656. [Epub ahead of print]

3.

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.

Valnohova J, Kowalski-Jahn M, Sunahara RK, Schulte G.

J Biol Chem. 2018 Nov 16;293(46):17875-17887. doi: 10.1074/jbc.RA118.004763. Epub 2018 Sep 20.

PMID:
30237173
4.

Frizzleds as GPCRs - More Conventional Than We Thought!

Schulte G, Wright SC.

Trends Pharmacol Sci. 2018 Sep;39(9):828-842. doi: 10.1016/j.tips.2018.07.001. Epub 2018 Jul 23. Review.

PMID:
30049420
5.

WNT signalling: mechanisms and therapeutic opportunities.

Schulte G, Bryja V.

Br J Pharmacol. 2017 Dec;174(24):4543-4546. doi: 10.1111/bph.14065.

6.

Cognitive Performance of Users Is Affected by Electronic Handovers Depending on Role, Task and Human Factors.

Przysucha M, Flemming D, Schulte G, Hübner U.

Stud Health Technol Inform. 2017;243:117-121.

PMID:
28883183
7.

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.

Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, Friedler A, Strömqvist J, Wennmalm S, Carlsson J, Schulte G.

Nat Commun. 2017 Aug 9;8(1):226. doi: 10.1038/s41467-017-00253-9.

8.

The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.

Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, Arenas E, Carlsson J, Bryja V, Schulte G.

Cell Signal. 2017 Oct;38:85-96. doi: 10.1016/j.cellsig.2017.06.018. Epub 2017 Jun 29.

PMID:
28668722
9.

FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.

Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhlén M, Kostenis E, Mulder J, Schulte G.

Cell Signal. 2017 Apr;32:93-103. doi: 10.1016/j.cellsig.2017.01.023. Epub 2017 Jan 24.

PMID:
28126591
10.

An Iterative Methodology for Developing National Recommendations for Nursing Informatics Curricula.

Egbert N, Thye J, Schulte G, Liebe JD, Hackl WO, Ammenwerth E, Hübner U.

Stud Health Technol Inform. 2016;228:660-4.

PMID:
27577467
11.

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.

Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, Hanakova K, Potesil D, Sedlackova M, Salasova A, Steinhart Z, Angers S, Schulte G, Hampl A, Zdrahal Z, Bryja V.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9304-9. doi: 10.1073/pnas.1608783113. Epub 2016 Aug 2.

12.

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

Arthofer E, Hot B, Petersen J, Strakova K, Jäger S, Grundmann M, Kostenis E, Gutkind JS, Schulte G.

Mol Pharmacol. 2016 Oct;90(4):447-59. doi: 10.1124/mol.116.104919. Epub 2016 Jul 25.

13.

CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.

Strömberg A, Olsson K, Dijksterhuis JP, Rullman E, Schulte G, Gustafsson T.

Am J Physiol Regul Integr Comp Physiol. 2016 Feb 1;310(3):R297-304. doi: 10.1152/ajpregu.00236.2015. Epub 2015 Dec 2.

14.

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.

Dijksterhuis JP, Arthofer E, Marinescu VD, Nelander S, Uhlén M, Pontén F, Mulder J, Schulte G.

Exp Cell Res. 2015 Dec 10;339(2):280-8. doi: 10.1016/j.yexcr.2015.10.022. Epub 2015 Oct 25.

PMID:
26511503
15.

Evaluating a Proof-of-Concept Approach of the German Health Telematics Infrastructure in the Context of Discharge Management.

Hübner U, Schulte G, Sellemann B, Quade M, Rottmann T, Fenske M, Egbert N, Kuhlisch R, Rienhoff O.

Stud Health Technol Inform. 2015;216:492-6.

PMID:
26262099
16.

The first multi-gene phylogeny of the Macrostomorpha sheds light on the evolution of sexual and asexual reproduction in basal Platyhelminthes.

Janssen T, Vizoso DB, Schulte G, Littlewood DT, Waeschenbach A, Schärer L.

Mol Phylogenet Evol. 2015 Nov;92:82-107. doi: 10.1016/j.ympev.2015.06.004. Epub 2015 Jun 17.

PMID:
26093054
17.

Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics.

Schulte G.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):191-5. doi: 10.1016/j.ejphar.2015.05.031. Epub 2015 May 21. Review.

PMID:
26003275
18.

Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.

Kaucká M, Petersen J, Janovská P, Radaszkiewicz T, Smyčková L, Daulat AM, Borg JP, Schulte G, Bryja V.

Cell Commun Signal. 2015 Jan 28;13:2. doi: 10.1186/s12964-014-0079-1.

19.

Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.

Dijksterhuis JP, Baljinnyam B, Stanger K, Sercan HO, Ji Y, Andres O, Rubin JS, Hannoush RN, Schulte G.

J Biol Chem. 2015 Mar 13;290(11):6789-98. doi: 10.1074/jbc.M114.612648. Epub 2015 Jan 20.

20.

WNT signaling in microglia and the glioma microenvironment.

Schulte G.

Springerplus. 2015 Jun 12;4(Suppl 1):L50. doi: 10.1186/2193-1801-4-S1-L50. eCollection 2015. No abstract available.

21.

Red fluorescence increases with depth in reef fishes, supporting a visual function, not UV protection.

Meadows MG, Anthes N, Dangelmayer S, Alwany MA, Gerlach T, Schulte G, Sprenger D, Theobald J, Michiels NK.

Proc Biol Sci. 2014 Sep 7;281(1790). pii: 20141211. doi: 10.1098/rspb.2014.1211.

22.

Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity.

Kilander MB, Dahlström J, Schulte G.

Cell Signal. 2014 Sep;26(9):1943-9. doi: 10.1016/j.cellsig.2014.05.012. Epub 2014 May 27.

PMID:
24873871
23.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

24.

Minorities remain underrepresented in HIV/AIDS research despite access to clinical trials.

Castillo-Mancilla JR, Cohn SE, Krishnan S, Cespedes M, Floris-Moore M, Schulte G, Pavlov G, Mildvan D, Smith KY; the ACTG Underrepresented Populations Survey Group.

HIV Clin Trials. 2014 Jan-Feb;15(1):14-26. doi: 10.1310/hct1501-14.

25.

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G.

FASEB J. 2014 May;28(5):2293-305. doi: 10.1096/fj.13-246363. Epub 2014 Feb 5.

PMID:
24500924
26.

β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

Kríz V, Pospíchalová V, Masek J, Kilander MB, Slavík J, Tanneberger K, Schulte G, Machala M, Kozubík A, Behrens J, Bryja V.

J Biol Chem. 2014 Jan 10;289(2):1128-41. doi: 10.1074/jbc.M113.498444. Epub 2013 Nov 21.

27.

Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors.

Yang J, Zheng X, Haugen F, Darè E, Lövdahl C, Schulte G, Fredholm BB, Valen G.

Acta Physiol (Oxf). 2014 Mar;210(3):590-9. doi: 10.1111/apha.12176. Epub 2013 Oct 28.

PMID:
24119187
28.

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3.

Dijksterhuis JP, Petersen J, Schulte G.

Br J Pharmacol. 2014 Mar;171(5):1195-209. doi: 10.1111/bph.12364. Review.

29.

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.

Persson A, Sim SC, Virding S, Onishchenko N, Schulte G, Ingelman-Sundberg M.

Mol Psychiatry. 2014 Jun;19(6):733-41. doi: 10.1038/mp.2013.89. Epub 2013 Jul 23.

30.

WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia.

Halleskog C, Schulte G.

J Neurochem. 2013 Jun;125(6):803-8. doi: 10.1111/jnc.12250. Epub 2013 Apr 22.

31.

Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.

Halleskog C, Schulte G.

Cell Signal. 2013 Apr;25(4):822-8. doi: 10.1016/j.cellsig.2012.12.006. Epub 2012 Dec 22.

PMID:
23266471
32.

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation.

Halleskog C, Dijksterhuis JP, Kilander MB, Becerril-Ortega J, Villaescusa JC, Lindgren E, Arenas E, Schulte G.

J Neuroinflammation. 2012 May 30;9:111.

33.

Prolonged attenuation of acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 following sevoflurane exposure.

Wiklund A, Gustavsson D, Ebberyd A, Sundman E, Schulte G, Jonsson Fagerlund M, Eriksson LI.

Acta Anaesthesiol Scand. 2012 May;56(5):608-15. doi: 10.1111/j.1399-6576.2011.02632.x. Epub 2012 Jan 31.

PMID:
22288781
34.

β-Arrestin and dishevelled coordinate biased signaling.

Schulte G, Shenoy SK.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19839-40. doi: 10.1073/pnas.1117444108. Epub 2011 Nov 28. No abstract available.

35.

Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.

Fröjmark AS, Schuster J, Sobol M, Entesarian M, Kilander MBC, Gabrikova D, Nawaz S, Baig SM, Schulte G, Klar J, Dahl N.

Am J Hum Genet. 2011 Jun 10;88(6):852-860. doi: 10.1016/j.ajhg.2011.05.013.

36.

Recombinant WNTs differentially activate β-catenin-dependent and -independent signalling in mouse microglia-like cells.

Kilander MB, Halleskog C, Schulte G.

Acta Physiol (Oxf). 2011 Nov;203(3):363-72. doi: 10.1111/j.1748-1716.2011.02324.x. Epub 2011 Jun 20.

PMID:
21557822
37.

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease.

Mulder J, Zilberter M, Pasquaré SJ, Alpár A, Schulte G, Ferreira SG, Köfalvi A, Martín-Moreno AM, Keimpema E, Tanila H, Watanabe M, Mackie K, Hortobágyi T, de Ceballos ML, Harkany T.

Brain. 2011 Apr;134(Pt 4):1041-60. doi: 10.1093/brain/awr046.

38.

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.

Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas MV, Kriz V, Schulte G, Bryja V, Behrens J.

EMBO J. 2011 Apr 20;30(8):1433-43. doi: 10.1038/emboj.2011.28. Epub 2011 Feb 8.

39.

Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.

Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V.

J Biol Chem. 2011 Mar 25;286(12):10396-410. doi: 10.1074/jbc.M110.169870. Epub 2011 Feb 1.

40.

International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors.

Schulte G.

Pharmacol Rev. 2010 Dec;62(4):632-67. doi: 10.1124/pr.110.002931. Review.

41.

WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.

Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G.

Cell Signal. 2011 Mar;23(3):550-4. doi: 10.1016/j.cellsig.2010.11.004. Epub 2010 Nov 8.

PMID:
21070854
42.

The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia.

Fagerlund MJ, Kåhlin J, Ebberyd A, Schulte G, Mkrtchian S, Eriksson LI.

Anesthesiology. 2010 Dec;113(6):1270-9. doi: 10.1097/ALN.0b013e3181fac061.

PMID:
20980909
43.

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

Červenka I, Wolf J, Mašek J, Krejci P, Wilcox WR, Kozubík A, Schulte G, Gutkind JS, Bryja V.

Mol Cell Biol. 2011 Jan;31(1):179-89. doi: 10.1128/MCB.00550-10. Epub 2010 Oct 25.

44.

WNT signaling in activated microglia is proinflammatory.

Halleskog C, Mulder J, Dahlström J, Mackie K, Hortobágyi T, Tanila H, Kumar Puli L, Färber K, Harkany T, Schulte G.

Glia. 2011 Jan;59(1):119-31. doi: 10.1002/glia.21081. Epub 2010 Oct 21.

45.

Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.

Li L, Hao JX, Fredholm BB, Schulte G, Wiesenfeld-Hallin Z, Xu XJ.

Neuroscience. 2010 Oct 27;170(3):923-8. doi: 10.1016/j.neuroscience.2010.07.045. Epub 2010 Aug 3.

PMID:
20678550
46.

Vang-like protein 2 and Rac1 interact to regulate adherens junctions.

Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T.

J Cell Sci. 2010 Feb 1;123(Pt 3):472-83. doi: 10.1242/jcs.048074. Epub 2010 Jan 12.

47.

beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

Schulte G, Schambony A, Bryja V.

Br J Pharmacol. 2010 Mar;159(5):1051-8. doi: 10.1111/j.1476-5381.2009.00466.x. Epub 2009 Nov 3. Review.

48.

Regiospecific and stereoselective syntheses of (+/-) morphine, codeine, and thebaine via a highly stereocontrolled intramolecular 4 + 2 cycloaddition leading to a phenanthrofuran system.

Stork G, Yamashita A, Adams J, Schulte GR, Chesworth R, Miyazaki Y, Farmer JJ.

J Am Chem Soc. 2009 Aug 19;131(32):11402-6. doi: 10.1021/ja9038505.

PMID:
19624126
49.

Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways.

Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G.

EMBO Rep. 2008 Dec;9(12):1244-50. doi: 10.1038/embor.2008.193. Epub 2008 Oct 24.

50.

Red fluorescence in reef fish: a novel signalling mechanism?

Michiels NK, Anthes N, Hart NS, Herler J, Meixner AJ, Schleifenbaum F, Schulte G, Siebeck UE, Sprenger D, Wucherer MF.

BMC Ecol. 2008 Sep 16;8:16. doi: 10.1186/1472-6785-8-16.

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