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Items: 1 to 50 of 237

1.

Mechanotransduction in neuronal cell development and functioning.

Chighizola M, Dini T, Lenardi C, Milani P, Podestà A, Schulte C.

Biophys Rev. 2019 Oct 15. doi: 10.1007/s12551-019-00587-2. [Epub ahead of print] Review.

2.

A combined miRNA-piRNA signature to detect Alzheimer's disease.

Jain G, Stuendl A, Rao P, Berulava T, Pena Centeno T, Kaurani L, Burkhardt S, Delalle I, Kornhuber J, Hüll M, Maier W, Peters O, Esselmann H, Schulte C, Deuschle C, Synofzik M, Wiltfang J, Mollenhauer B, Maetzler W, Schneider A, Fischer A.

Transl Psychiatry. 2019 Oct 7;9(1):250. doi: 10.1038/s41398-019-0579-2.

3.

Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson's disease.

Maass F, Michalke B, Willkommen D, Schulte C, Tönges L, Boerger M, Zerr I, Bähr M, Lingor P.

J Trace Elem Med Biol. 2019 Sep 24:126412. doi: 10.1016/j.jtemb.2019.126412. [Epub ahead of print]

PMID:
31582281
4.

Response by Schulte et al to Letter Regarding Article, "Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury".

Schulte C, Joshi A, Mayr M.

Circ Res. 2019 Aug 2;125(4):e22-e23. doi: 10.1161/CIRCRESAHA.119.315545. Epub 2019 Aug 1. No abstract available.

PMID:
31518205
5.

Alterations in Blood Monocyte Functions in Parkinson's Disease.

Nissen SK, Shrivastava K, Schulte C, Otzen DE, Goldeck D, Berg D, Møller HJ, Maetzler W, Romero-Ramos M.

Mov Disord. 2019 Aug 26. doi: 10.1002/mds.27815. [Epub ahead of print]

PMID:
31449711
6.

Do longitudinal cerebrospinal fluid profiles correspond to postmortem brain pathology in LRRK2 Parkinson's disease?

Wurster I, Lerche S, Hauser AK, Schulte C, Lachmann I, Beschorner R, Neumann M, Brockmann K.

Eur J Neurol. 2019 Aug 17. doi: 10.1111/ene.14060. [Epub ahead of print] No abstract available.

PMID:
31420996
7.

MAPT p.V363I mutation: A rare cause of corticobasal degeneration.

Ahmed S, Fairen MD, Sabir MS, Pastor P, Ding J, Ispierto L, Butala A, Morris CM, Schulte C, Gasser T, Jabbari E, Pletnikova O, Morris HR, Troncoso J, Gelpi E, Pantelyat A, Scholz SW.

Neurol Genet. 2019 Jun 25;5(4):e347. doi: 10.1212/NXG.0000000000000347. eCollection 2019 Aug.

8.

Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.

Lerche S, Machetanz G, Wurster I, Roeben B, Zimmermann M, Pilotto A, Preische O, Stransky E, Deuschle C, Hauser AK, Schulte C, Lachmann I, Waniek K, Gasser T, Berg D, Maetzler W, Brockmann K.

Mov Disord. 2019 Jul;34(7):1069-1073. doi: 10.1002/mds.27731. Epub 2019 Jun 12.

PMID:
31189032
9.

Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury.

Schulte C, Barwari T, Joshi A, Theofilatos K, Zampetaki A, Barallobre-Barreiro J, Singh B, Sörensen NA, Neumann JT, Zeller T, Westermann D, Blankenberg S, Marber M, Liebetrau C, Mayr M.

Circ Res. 2019 Jul 19;125(3):328-340. doi: 10.1161/CIRCRESAHA.119.314937. Epub 2019 Jun 4.

10.

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors.

Hopfner F, Müller SH, Steppat D, Miller J, Schmidt N, Wandinger KP, Leypoldt F, Berg D, Franke A, Lieb W, Tittmann L, Balzer-Geldsetzer M, Baudrexel S, Dodel R, Hilker-Roggendorf R, Kalbe E, Kassubek J, Klockgether T, Liepelt-Scarfone I, Mollenhauer B, Neuser P, Reetz K, Riedel O, Schulte C, Schulz JB, Spottke A, Storch A, Trenkwalder C, Wittchen HU, Witt K, Wüllner U, Deuschl G, Kuhlenbäumer G.

Transl Neurodegener. 2019 Apr 3;8:11. doi: 10.1186/s40035-019-0153-0. eCollection 2019.

11.

Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, Gibbs JR, Hernandez DG, Scholz SW, Jankovic J, Shulman LM, Lesage S, Corvol JC, Brice A, van Hilten JJ, Marinus J; 23andMe Research Team, Eerola-Rautio J, Tienari P, Majamaa K, Toft M, Grosset DG, Gasser T, Heutink P, Shulman JM, Wood N, Hardy J, Morris HR, Hinds DA, Gratten J, Visscher PM, Gan-Or Z, Nalls MA, Singleton AB; International Parkinson's Disease Genomics Consortium (IPDGC).

Mov Disord. 2019 Jun;34(6):866-875. doi: 10.1002/mds.27659. Epub 2019 Apr 7.

PMID:
30957308
12.

Reply to Angé et al.

Inata Y, Piraino G, Hake PW, O'Connor M, Lahni P, Wolfe V, Schulte C, Moore V, James JM, Zingarelli B.

Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H936-H937. doi: 10.1152/ajpheart.00095.2019. No abstract available.

PMID:
30946605
13.

Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria.

Pilotto A, Blau N, Leks E, Schulte C, Deuschl C, Zipser C, Piel D, Freisinger P, Gramer G, Kölker S, Haas D, Burgard P, Nawroth P, Georg H, Scheffler K, Berg D, Trefz F.

J Inherit Metab Dis. 2019 May;42(3):398-406. doi: 10.1002/jimd.12049. Epub 2019 Feb 1.

PMID:
30706953
14.

Serum Inflammatory Profile for the Discrimination of Clinical Subtypes in Parkinson's Disease.

Yilmaz R, Strafella AP, Bernard A, Schulte C, van den Heuvel L, Schneiderhan-Marra N, Knorpp T, Joos TO, Leypoldt F, Geritz J, Hansen C, Heinzel S, Apel A, Gasser T, Lang AE, Berg D, Maetzler W, Marras C.

Front Neurol. 2018 Dec 21;9:1123. doi: 10.3389/fneur.2018.01123. eCollection 2018.

15.

MicroRNAs: A New Understanding of Platelet Physiology and Pathology.

Schulte C, Mayr M.

Thromb Haemost. 2019 Feb;119(2):191. doi: 10.1055/s-0038-1677505. Epub 2019 Jan 8.

PMID:
30620994
16.

STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia-reperfusion injury.

Kemmner S, Bachmann Q, Steiger S, Lorenz G, Honarpisheh M, Foresto-Neto O, Wang S, Carbajo-Lozoya J, Alt V, Schulte C, Chmielewski S, Bluyssen HAR, Heemann U, Baumann M, Lech M, Schmaderer C.

Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F277-F291. doi: 10.1152/ajprenal.00004.2018. Epub 2018 Nov 7.

PMID:
30403164
17.

Inhibition of profibrotic microRNA-21 affects platelets and their releasate.

Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M.

JCI Insight. 2018 Nov 2;3(21). pii: 123335. doi: 10.1172/jci.insight.123335.

18.

Evaluation of cerebrospinal fluid proteins as potential biomarkers for early stage Parkinson's disease diagnosis.

Dos Santos MCT, Scheller D, Schulte C, Mesa IR, Colman P, Bujac SR, Bell R, Berteau C, Perez LT, Lachmann I, Berg D, Maetzler W, Nogueira da Costa A.

PLoS One. 2018 Nov 1;13(11):e0206536. doi: 10.1371/journal.pone.0206536. eCollection 2018.

19.

Parkinson's disease: evolution of cognitive impairment and CSF Aβ1-42 profiles in a prospective longitudinal study.

Lerche S, Wurster I, Röben B, Machetanz G, Zimmermann M, Bernhard F, Stransky E, Deuschle C, Schulte C, Hansson O, Zetterberg H, Gasser T, Berg D, Maetzler W, Brockmann K.

J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):165-170. doi: 10.1136/jnnp-2018-318956. Epub 2018 Sep 25.

PMID:
30254084
20.

Cholinergic Pathway SNPs and Postural Control in 477 Older Adults.

Arnold C, Schulte C, Moscovich M, Sünkel U, Zaunbrecher L, Metzger F, Gasser T, Eschweiler GW, Hauser AK, Berg D, Maetzler W.

Front Aging Neurosci. 2018 Sep 4;10:260. doi: 10.3389/fnagi.2018.00260. eCollection 2018.

21.

Imidazolium-Based Ionic Liquids Affect Morphology and Rigidity of Living Cells: An Atomic Force Microscopy Study.

Galluzzi M, Schulte C, Milani P, Podestà A.

Langmuir. 2018 Oct 16;34(41):12452-12462. doi: 10.1021/acs.langmuir.8b01554. Epub 2018 Oct 2.

PMID:
30213187
22.

Polygenic load: Earlier disease onset but similar longitudinal progression in Parkinson's disease.

Lerche S, Liepelt-Scarfone I, Wurster I, Schulte C, Schäffer E, Röben B, Machetanz G, Zimmermann M, Akbas S, Hauser AK, Gasser T, Maetzler W, Berg D, Brockmann K.

Mov Disord. 2018 Aug;33(8):1349-1353. doi: 10.1002/mds.27427. Epub 2018 Aug 22.

PMID:
30132985
23.

Patient's perception: shorter and more severe prodromal phase in GBA-associated PD.

Zimmermann M, Gaenslen A, Prahl K, Srulijes K, Hauser AK, Schulte C, Csoti I, Berg D, Brockmann K.

Eur J Neurol. 2019 Apr;26(4):694-698. doi: 10.1111/ene.13776. Epub 2018 Sep 14.

PMID:
30107068
24.

Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.

Blauwendraat C, Reed X, Kia DA, Gan-Or Z, Lesage S, Pihlstrøm L, Guerreiro R, Gibbs JR, Sabir M, Ahmed S, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Hernandez DG, Chung SJ, Goldwurm S, Toft M, Schulte C, Bras J, Wood NW, Brice A, Morris HR, Scholz SW, Nalls MA, Singleton AB, Cookson MR; COURAGE-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease) Consortium, the French Parkinson’s Disease Consortium, and the International Parkinson’s Disease Genomics Consortium (IPDGC).

JAMA Neurol. 2018 Nov 1;75(11):1416-1422. doi: 10.1001/jamaneurol.2018.1885.

25.

Age-dependent cardiac function during experimental sepsis: effect of pharmacological activation of AMP-activated protein kinase by AICAR.

Inata Y, Piraino G, Hake PW, O'Connor M, Lahni P, Wolfe V, Schulte C, Moore V, James JM, Zingarelli B.

Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H826-H837. doi: 10.1152/ajpheart.00052.2018. Epub 2018 Jul 6.

26.

Biallelic Parkin (PARK2) mutations can cause a bvFTD phenotype without clinically relevant parkinsonism.

Zimmermann M, Wilke C, Schulte C, Hoffmann J, Klopfer J, Reimold M, Brockmann K, Synofzik M.

Parkinsonism Relat Disord. 2018 Oct;55:145-147. doi: 10.1016/j.parkreldis.2018.06.006. Epub 2018 Jun 6. No abstract available.

PMID:
29910155
27.

Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.

Schulte C, Noels H.

Acta Physiol (Oxf). 2018 Jul;223(3):e13091. doi: 10.1111/apha.13091. Epub 2018 May 22. No abstract available.

PMID:
29749090
28.

miRNA-based signatures in cerebrospinal fluid as potential diagnostic tools for early stage Parkinson's disease.

Dos Santos MCT, Barreto-Sanz MA, Correia BRS, Bell R, Widnall C, Perez LT, Berteau C, Schulte C, Scheller D, Berg D, Maetzler W, Galante PAF, Nogueira da Costa A.

Oncotarget. 2018 Apr 3;9(25):17455-17465. doi: 10.18632/oncotarget.24736. eCollection 2018 Apr 3.

29.

Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease.

Stoessel D, Schulte C, Teixeira Dos Santos MC, Scheller D, Rebollo-Mesa I, Deuschle C, Walther D, Schauer N, Berg D, Nogueira da Costa A, Maetzler W.

Front Aging Neurosci. 2018 Mar 5;10:51. doi: 10.3389/fnagi.2018.00051. eCollection 2018.

30.

Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease.

Blauwendraat C, Kia DA, Pihlstrøm L, Gan-Or Z, Lesage S, Gibbs JR, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Chung SJ, Goldwurm S, Toft M, Schulte C; International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hernandez D, Singleton AB, Nalls MA, Brice A, Scholz SW, Wood NW.

Neurobiol Aging. 2018 Apr;64:159.e5-159.e8. doi: 10.1016/j.neurobiolaging.2017.12.012. Epub 2017 Dec 20.

31.

Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells.

Maffioli E, Schulte C, Nonnis S, Grassi Scalvini F, Piazzoni C, Lenardi C, Negri A, Milani P, Tedeschi G.

Front Cell Neurosci. 2018 Jan 4;11:417. doi: 10.3389/fncel.2017.00417. eCollection 2017.

32.

SNPs in Aβ clearance proteins: Lower CSF Aβ1-42 levels and earlier onset of dementia in PD.

Brockmann K, Lerche S, Dilger SS, Stirnkorb JG, Apel A, Hauser AK, Liepelt-Scarfone I, Berg D, Gasser T, Schulte C, Maetzler W.

Neurology. 2017 Dec 5;89(23):2335-2340. doi: 10.1212/WNL.0000000000004705. Epub 2017 Nov 8.

PMID:
29117956
33.

EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC - Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP®).

Petersen I, Dietel M, Geilenkeuser WJ, Mireskandari M, Weichert W, Steiger K, Scheel AH, Büttner R, Schirmacher P, Warth A, Lasitschka F, Schildhaus HU, Kirchner T, Reu S, Kreipe H, Länger F, Tiemann M, Schulte C, Jöhrens K.

Pathol Res Pract. 2017 Dec;213(12):1530-1535. doi: 10.1016/j.prp.2017.09.021. Epub 2017 Sep 28.

34.

Cognitive impairment in Glucocerebrosidase (GBA)-associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles.

Lerche S, Schulte C, Srulijes K, Pilotto A, Rattay TW, Hauser AK, Stransky E, Deuschle C, Csoti I, Lachmann I, Zetterberg H, Liepelt-Scarfone I, Gasser T, Maetzler W, Berg D, Brockmann K.

Mov Disord. 2017 Dec;32(12):1780-1783. doi: 10.1002/mds.27199. Epub 2017 Nov 2.

PMID:
29094781
35.

Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.

Fitzgerald JC, Zimprich A, Carvajal Berrio DA, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kübler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wüst R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Krüger R.

Brain. 2017 Sep 1;140(9):2444-2459. doi: 10.1093/brain/awx202.

PMID:
29050400
36.

De-escalation of support with veno-arterial extracorporeal membrane oxygenation and Impella for cardiogenic shock: reply.

Schulte C, Schrage B, Pappalardo F, Westermann D.

Eur J Heart Fail. 2018 Mar;20(3):622-623. doi: 10.1002/ejhf.982. Epub 2017 Sep 25. No abstract available.

37.

Dual-Task Performance in GBA Parkinson's Disease.

Srulijes K, Brockmann K, Ogbamicael S, Hobert MA, Hauser AK, Schulte C, Fritzen J, Schwenk M, Gasser T, Berg D, Maetzler W.

Parkinsons Dis. 2017;2017:8582740. doi: 10.1155/2017/8582740. Epub 2017 Jul 27.

38.

Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival.

Kizilors A, Pickard MR, Schulte CE, Yacqub-Usman K, McCarthy NJ, Gan SU, Darling D, Gäken J, Williams GT, Farzaneh F.

Biosci Rep. 2017 Jul 27. pii: BSR20170843. doi: 10.1042/BSR20170843. [Epub ahead of print]

39.

Two Imported Cases of Congenital Rubella Syndrome and Infection-Control Challenges in New York State, 2013-2015.

Robyn M, Dufort E, Rosen JB, Southwick K, Bryant PW, Greenko J, Adams E, Kurpiel P, Alvarez KJ, Burstein G, Sen K, Vasquez D, Rausch-Phung E, Schulte C, Lutterloh E, Blog D.

J Pediatric Infect Dis Soc. 2018 May 15;7(2):172-174. doi: 10.1093/jpids/pix028.

PMID:
28510706
40.

Both Prenatal and Postnatal Interventions Are Needed to Improve Breastfeeding Outcomes in a Low-Income Population.

Schreck PK, Solem K, Wright T, Schulte C, Ronnisch KJ, Szpunar S.

Breastfeed Med. 2017 Apr;12:142-148. doi: 10.1089/bfm.2016.0131. Epub 2017 Feb 16.

PMID:
28394657
41.

Cardiomyocyte mitochondria as targets of humoral factors released by remote ischemic preconditioning.

Gedik N, Maciel L, Schulte C, Skyschally A, Heusch G, Kleinbongard P.

Arch Med Sci. 2017 Mar 1;13(2):448-458. doi: 10.5114/aoms.2016.61789. Epub 2016 Aug 16.

42.

No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.

Geissler JM; International Parkinson Disease Genomics Consortium members, Romanos M, Gerlach M, Berg D, Schulte C.

Atten Defic Hyperact Disord. 2017 Jun;9(2):121-127. doi: 10.1007/s12402-017-0219-8. Epub 2017 Feb 7.

43.

Quantitative Control of Protein and Cell Interaction with Nanostructured Surfaces by Cluster Assembling.

Schulte C, Podestà A, Lenardi C, Tedeschi G, Milani P.

Acc Chem Res. 2017 Feb 21;50(2):231-239. doi: 10.1021/acs.accounts.6b00433. Epub 2017 Jan 24.

44.

Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.

Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schüle B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W.

Eur J Neurol. 2017 Feb;24(2):427-e6. doi: 10.1111/ene.13223.

PMID:
28102045
45.

Scale Invariant Disordered Nanotopography Promotes Hippocampal Neuron Development and Maturation with Involvement of Mechanotransductive Pathways.

Schulte C, Ripamonti M, Maffioli E, Cappelluti MA, Nonnis S, Puricelli L, Lamanna J, Piazzoni C, Podestà A, Lenardi C, Tedeschi G, Malgaroli A, Milani P.

Front Cell Neurosci. 2016 Nov 18;10:267. eCollection 2016.

46.

microRNAs in cardiovascular disease - clinical application.

Schulte C, Karakas M, Zeller T.

Clin Chem Lab Med. 2017 May 1;55(5):687-704. doi: 10.1515/cclm-2016-0576. Review.

47.

Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.

Dong J, Wyss A, Yang J, Price TR, Nicolas A, Nalls M, Tranah G, Franceschini N, Xu Z, Schulte C, Alonso A, Cummings SR, Fornage M, Zaykin D, Li L, Huang X, Kritchevsky S, Liu Y, Gasser T, Wilson RS, De Jager PL, Singleton AB, Pinto JM, Harris T, Mosley TH Jr, Bennett DA, London S, Yu L, Chen H.

Mol Neurobiol. 2017 Dec;54(10):8021-8032. doi: 10.1007/s12035-016-0282-8. Epub 2016 Nov 23.

48.

Framed, Interactive Theory-Driven Texting: Effects of Message Framing on Health Behavior Change for Weight Loss.

Cohen A, Perozich A, Rajan R, Persky S, Parisi J, Bowie J, Fahle J, Cho J, Krishnan A, Cohen Z, Ezike A, Schulte C, Taylor J, Storey D, Ahmed RS, Cheskin LJ.

Fam Community Health. 2017 Jan/Mar;40(1):43-51.

PMID:
27870754
49.

A genome-wide association study in multiple system atrophy.

Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff HJ, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Höglinger GU, Wüllner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H; European Multiple System Atrophy Study Group and the UK Multiple System Atrophy Study Group.

Neurology. 2016 Oct 11;87(15):1591-1598. Epub 2016 Sep 14.

50.

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