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Items: 42


Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report.

Adamson SE, Polanowska-Grabowska R, Marqueen K, Griffiths R, Angdisen J, Breevoort SR, Schulman IG, Leitinger N.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1020-1029. doi: 10.1161/ATVBAHA.117.310467. Epub 2018 Mar 29.


The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.

Czimmerer Z, Daniel B, Horvath A, Rückerl D, Nagy G, Kiss M, Peloquin M, Budai MM, Cuaranta-Monroy I, Simandi Z, Steiner L, Nagy B Jr, Poliska S, Banko C, Bacso Z, Schulman IG, Sauer S, Deleuze JF, Allen JE, Benko S, Nagy L.

Immunity. 2018 Jan 16;48(1):75-90.e6. doi: 10.1016/j.immuni.2017.12.010.


Liver X receptors link lipid metabolism and inflammation.

Schulman IG.

FEBS Lett. 2017 Oct;591(19):2978-2991. doi: 10.1002/1873-3468.12702. Epub 2017 Jun 13. Review.


Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight.

Gaykema RP, Newmyer BA, Ottolini M, Raje V, Warthen DM, Lambeth PS, Niccum M, Yao T, Huang Y, Schulman IG, Harris TE, Patel MK, Williams KW, Scott MM.

J Clin Invest. 2017 Mar 1;127(3):1031-1045. doi: 10.1172/JCI81335. Epub 2017 Feb 20.


Discovery of Highly Potent Liver X Receptor β Agonists.

Kick EK, Busch BB, Martin R, Stevens WC, Bollu V, Xie Y, Boren BC, Nyman MC, Nanao MH, Nguyen L, Plonowski A, Schulman IG, Yan G, Zhang H, Hou X, Valente MN, Narayanan R, Behnia K, Rodrigues AD, Brock B, Smalley J, Cantor GH, Lupisella J, Sleph P, Grimm D, Ostrowski J, Wexler RR, Kirchgessner T, Mohan R.

ACS Med Chem Lett. 2016 Oct 23;7(12):1207-1212. eCollection 2016 Dec 8.


Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.

Fond AM, Lee CS, Schulman IG, Kiss RS, Ravichandran KS.

J Clin Invest. 2015 Jul 1;125(7):2748-58. doi: 10.1172/JCI80300. Epub 2015 Jun 15.


Macrophage-independent regulation of reverse cholesterol transport by liver X receptors.

Breevoort SR, Angdisen J, Schulman IG.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1650-60. doi: 10.1161/ATVBAHA.114.303383. Epub 2014 Jun 19.


Liver X receptors and atherosclerosis: it is not all cholesterol.

Ignatova ID, Schulman IG.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):242-3. doi: 10.1161/ATVBAHA.113.302987. No abstract available.


Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading.

Ignatova ID, Angdisen J, Moran E, Schulman IG.

Mol Endocrinol. 2013 Jul;27(7):1036-47. doi: 10.1210/me.2013-1051. Epub 2013 May 17.


Phenotypic polarization of macrophages in atherosclerosis.

Leitinger N, Schulman IG.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1120-6. doi: 10.1161/ATVBAHA.112.300173. Epub 2013 May 2. Review.


Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR, Kliewer SA, Mangelsdorf DJ, Schulman IG.

J Clin Invest. 2012 May;122(5):1688-99. doi: 10.1172/JCI59817. Epub 2012 Apr 9.


In vitro transcriptomic prediction of hepatotoxicity for early drug discovery.

Cheng F, Theodorescu D, Schulman IG, Lee JK.

J Theor Biol. 2011 Dec 7;290:27-36. doi: 10.1016/j.jtbi.2011.08.009. Epub 2011 Aug 27.


Nuclear receptors as drug targets for metabolic disease.

Schulman IG.

Adv Drug Deliv Rev. 2010 Oct 30;62(13):1307-15. doi: 10.1016/j.addr.2010.07.002. Epub 2010 Jul 22. Review.


Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice.

Bischoff ED, Daige CL, Petrowski M, Dedman H, Pattison J, Juliano J, Li AC, Schulman IG.

J Lipid Res. 2010 May;51(5):900-6. doi: 10.1194/jlr.M900096.


Cholesterol worships a new idol.

Schulman IG.

J Mol Cell Biol. 2009 Dec;1(2):75-6. doi: 10.1093/jmcb/mjp022. Epub 2009 Sep 25.


Regulation of metabolism by nuclear hormone receptors.

Huang HJ, Schulman IG.

Prog Mol Biol Transl Sci. 2009;87:1-51. doi: 10.1016/S1877-1173(09)87001-4. Epub 2009 Oct 7. Review.


Regulation of complement C3 expression by the bile acid receptor FXR.

Li J, Pircher PC, Schulman IG, Westin SK.

J Biol Chem. 2005 Mar 4;280(9):7427-34. Epub 2004 Dec 7.


Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists.

Levin N, Bischoff ED, Daige CL, Thomas D, Vu CT, Heyman RA, Tangirala RK, Schulman IG.

Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):135-42. Epub 2004 Nov 11.


Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand.

Willy PJ, Murray IR, Qian J, Busch BB, Stevens WC Jr, Martin R, Mohan R, Zhou S, Ordentlich P, Wei P, Sapp DW, Horlick RA, Heyman RA, Schulman IG.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7. Epub 2004 Jun 7.


The flip side: Identifying small molecule regulators of nuclear receptors.

Schulman IG, Heyman RA.

Chem Biol. 2004 May;11(5):639-46. Review.


Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5. Epub 2004 Apr 20. Erratum in: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10405.


Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.

Wagner BL, Valledor AF, Shao G, Daige CL, Bischoff ED, Petrowski M, Jepsen K, Baek SH, Heyman RA, Rosenfeld MG, Schulman IG, Glass CK.

Mol Cell Biol. 2003 Aug;23(16):5780-9.


Farnesoid X receptor regulates bile acid-amino acid conjugation.

Pircher PC, Kitto JL, Petrowski ML, Tangirala RK, Bischoff ED, Schulman IG, Westin SK.

J Biol Chem. 2003 Jul 25;278(30):27703-11. Epub 2003 May 16.


Identification of macrophage liver X receptors as inhibitors of atherosclerosis.

Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11896-901. Epub 2002 Aug 22.


Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors.

Muscat GE, Wagner BL, Hou J, Tangirala RK, Bischoff ED, Rohde P, Petrowski M, Li J, Shao G, Macondray G, Schulman IG.

J Biol Chem. 2002 Oct 25;277(43):40722-8. Epub 2002 Aug 21.


Three amino acids specify coactivator choice by retinoid X receptors.

Shao G, Heyman RA, Schulman IG.

Mol Endocrinol. 2000 Aug;14(8):1198-209.


Retinoid receptors in development and disease.

Schulman IG, Evans RM.

Leukemia. 1997 Apr;11 Suppl 3:376-7.


The phantom ligand effect: allosteric control of transcription by the retinoid X receptor.

Schulman IG, Li C, Schwabe JW, Evans RM.

Genes Dev. 1997 Feb 1;11(3):299-308.


Activation of specific RXR heterodimers by an antagonist of RXR homodimers.

Lala DS, Mukherjee R, Schulman IG, Koch SS, Dardashti LJ, Nadzan AM, Croston GE, Evans RM, Heyman RA.

Nature. 1996 Oct 3;383(6599):450-3.


Role of CBP/P300 in nuclear receptor signalling.

Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, Montminy M, Evans RM.

Nature. 1996 Sep 5;383(6595):99-103.


Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation.

Schulman IG, Chakravarti D, Juguilon H, Romo A, Evans RM.

Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8288-92.


Genetic dissection of centromere function.

Schulman IG, Bloom K.

Mol Cell Biol. 1993 Jun;13(6):3156-66.


The complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena.

Roth SY, Schulman IG, Cook RG, Allis CD.

Nucleic Acids Res. 1987 Oct 12;15(19):8112. No abstract available.


Tetrahymena contain two distinct and unusual high mobility group (HMG)-like proteins.

Schulman IG, Cook RG, Richman R, Allis CD.

J Cell Biol. 1987 Jun;104(6):1485-94.


Deposition-related histone acetylation in micronuclei of conjugating Tetrahymena.

Allis CD, Chicoine LG, Richman R, Schulman IG.

Proc Natl Acad Sci U S A. 1985 Dec;82(23):8048-52.

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