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Items: 1 to 50 of 123

1.

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ.

Cell Host Microbe. 2019 Jul 10;26(1):86-99.e7. doi: 10.1016/j.chom.2019.05.008. Epub 2019 Jun 25.

PMID:
31253590
2.

Dual-color pulse-chase ubiquitination assays to simultaneously monitor substrate priming and extension.

Scott DC, Schulman BA.

Methods Enzymol. 2019;618:29-48. doi: 10.1016/bs.mie.2019.01.004. Epub 2019 Feb 11.

PMID:
30850057
3.

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.

Watson ER, Brown NG, Peters JM, Stark H, Schulman BA.

Trends Cell Biol. 2019 Feb;29(2):117-134. doi: 10.1016/j.tcb.2018.09.007. Epub 2018 Oct 25. Review.

PMID:
30482618
4.

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments.

Bouchard JJ, Otero JH, Scott DC, Szulc E, Martin EW, Sabri N, Granata D, Marzahn MR, Lindorff-Larsen K, Salvatella X, Schulman BA, Mittag T.

Mol Cell. 2018 Oct 4;72(1):19-36.e8. doi: 10.1016/j.molcel.2018.08.027. Epub 2018 Sep 20.

PMID:
30244836
5.

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Hammill JT, Scott DC, Min J, Connelly MC, Holbrook G, Zhu F, Matheny A, Yang L, Singh B, Schulman BA, Guy RK.

J Med Chem. 2018 Apr 12;61(7):2680-2693. doi: 10.1021/acs.jmedchem.7b01277. Epub 2018 Mar 26.

6.

Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK.

J Med Chem. 2018 Apr 12;61(7):2694-2706. doi: 10.1021/acs.jmedchem.7b01282. Epub 2018 Mar 26.

7.

SCF E3 Ligase Substrates Switch from CAN-D to Can-ubiquitylate.

Scott DC, Schulman BA.

Mol Cell. 2018 Mar 1;69(5):721-723. doi: 10.1016/j.molcel.2018.02.019.

8.

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D, Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, Paulo JA, Cannon JR, Shelat AA, Chen T, Kelsall IR, Alpi AF, Pagala V, Wang X, Peng J, Singh B, Harper JW, Schulman BA, Guy RK.

Nat Chem Biol. 2017 Aug;13(8):850-857. doi: 10.1038/nchembio.2386. Epub 2017 Jun 5.

9.

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.

Dove KK, Olszewski JL, Martino L, Duda DM, Wu XS, Miller DJ, Reiter KH, Rittinger K, Schulman BA, Klevit RE.

Structure. 2017 Jun 6;25(6):890-900.e5. doi: 10.1016/j.str.2017.04.013. Epub 2017 May 25.

10.

Insights into links between autophagy and the ubiquitin system from the structure of LC3B bound to the LIR motif from the E3 ligase NEDD4.

Qiu Y, Zheng Y, Wu KP, Schulman BA.

Protein Sci. 2017 Aug;26(8):1674-1680. doi: 10.1002/pro.3186. Epub 2017 Jun 12.

11.

Production of Human ATG Proteins for Lipidation Assays.

Zheng Y, Qiu Y, Gunderson JE, Schulman BA.

Methods Enzymol. 2017;587:97-113. doi: 10.1016/bs.mie.2016.09.055. Epub 2016 Nov 11.

12.

Crystallographic Characterization of ATG Proteins and Their Interacting Partners.

Qiu Y, Zheng Y, Taherbhoy AM, Kaiser SE, Schulman BA.

Methods Enzymol. 2017;587:227-246. doi: 10.1016/bs.mie.2016.09.058. Epub 2016 Nov 9.

13.

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.

Scott DC, Rhee DY, Duda DM, Kelsall IR, Olszewski JL, Paulo JA, de Jong A, Ovaa H, Alpi AF, Harper JW, Schulman BA.

Cell. 2016 Aug 25;166(5):1198-1214.e24. doi: 10.1016/j.cell.2016.07.027.

14.

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA.

Mol Cell. 2016 Aug 18;63(4):593-607. doi: 10.1016/j.molcel.2016.07.003. Epub 2016 Aug 10.

15.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA.

Cell. 2016 Jun 2;165(6):1440-1453. doi: 10.1016/j.cell.2016.05.037.

16.

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H.

Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16.

17.

Mechanism of APC/CCDC20 activation by mitotic phosphorylation.

Qiao R, Weissmann F, Yamaguchi M, Brown NG, VanderLinden R, Imre R, Jarvis MA, Brunner MR, Davidson IF, Litos G, Haselbach D, Mechtler K, Stark H, Schulman BA, Peters JM.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2570-8. doi: 10.1073/pnas.1604929113. Epub 2016 Apr 25.

18.

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.

Weissmann F, Petzold G, VanderLinden R, Huis In 't Veld PJ, Brown NG, Lampert F, Westermann S, Stark H, Schulman BA, Peters JM.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2564-9. doi: 10.1073/pnas.1604935113. Epub 2016 Apr 25.

19.

A role of autophagy in spinocerebellar ataxia-Rare exception or general principle?

Burmeister M, Lee JH, Schulman BA, Yapici Z, Tolun A, Juhasz G, Li JZ, Klionsky DJ.

Autophagy. 2016 Jul 2;12(7):1208-9. doi: 10.1080/15548627.2016.1170266. Epub 2016 Apr 22. No abstract available.

20.

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, Hao Z, Li Y, Brown KR, Lemichez E, Chen J, Tong Y, Harper JW, Moffat J, Rotin D, Schulman BA, Sidhu SS.

Mol Cell. 2016 Apr 7;62(1):121-36. doi: 10.1016/j.molcel.2016.02.005. Epub 2016 Mar 3.

21.

Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.

Kim M, Sandford E, Gatica D, Qiu Y, Liu X, Zheng Y, Schulman BA, Xu J, Semple I, Ro SH, Kim B, Mavioglu RN, Tolun A, Jipa A, Takats S, Karpati M, Li JZ, Yapici Z, Juhasz G, Lee JH, Klionsky DJ, Burmeister M.

Elife. 2016 Jan 26;5. pii: e12245. doi: 10.7554/eLife.12245.

22.

Expanding vocational retraining options for injured workers: An experiment in worker choice.

Sears JM, Wickizer TM, Schulman BA.

Work. 2015;52(3):663-76. doi: 10.3233/WOR-152129.

PMID:
26528841
23.

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.

Pierce WK, Grace CR, Lee J, Nourse A, Marzahn MR, Watson ER, High AA, Peng J, Schulman BA, Mittag T.

J Mol Biol. 2016 Mar 27;428(6):1256-1271. doi: 10.1016/j.jmb.2015.10.002. Epub 2015 Oct 22.

24.

Measuring APC/C-Dependent Ubiquitylation In Vitro.

Jarvis MA, Brown NG, Watson ER, VanderLinden R, Schulman BA, Peters JM.

Methods Mol Biol. 2016;1342:287-303. doi: 10.1007/978-1-4939-2957-3_18.

25.

Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.

Riling C, Kamadurai H, Kumar S, O'Leary CE, Wu KP, Manion EE, Ying M, Schulman BA, Oliver PM.

J Biol Chem. 2015 Sep 25;290(39):23875-87. doi: 10.1074/jbc.M115.649269. Epub 2015 Aug 5.

26.

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space.

Chari A, Haselbach D, Kirves JM, Ohmer J, Paknia E, Fischer N, Ganichkin O, Möller V, Frye JJ, Petzold G, Jarvis M, Tietzel M, Grimm C, Peters JM, Schulman BA, Tittmann K, Markl J, Fischer U, Stark H.

Nat Methods. 2015 Sep;12(9):859-65. doi: 10.1038/nmeth.3493. Epub 2015 Aug 3.

27.

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.

Ordureau A, Heo JM, Duda DM, Paulo JA, Olszewski JL, Yanishevski D, Rinehart J, Schulman BA, Harper JW.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6637-42. doi: 10.1073/pnas.1506593112. Epub 2015 May 12.

28.

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30.

29.

Protein neddylation: beyond cullin-RING ligases.

Enchev RI, Schulman BA, Peter M.

Nat Rev Mol Cell Biol. 2015 Jan;16(1):30-44. doi: 10.1038/nrm3919. Review.

30.

Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.

Yamaguchi M, Yu S, Qiao R, Weissmann F, Miller DJ, VanderLinden R, Brown NG, Frye JJ, Peters JM, Schulman BA.

J Mol Biol. 2015 Apr 24;427(8):1748-64. doi: 10.1016/j.jmb.2014.11.020. Epub 2014 Dec 6.

31.

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Brown NG, Watson ER, Weissmann F, Jarvis MA, VanderLinden R, Grace CRR, Frye JJ, Qiao R, Dube P, Petzold G, Cho SE, Alsharif O, Bao J, Davidson IF, Zheng JJ, Nourse A, Kurinov I, Peters JM, Stark H, Schulman BA.

Mol Cell. 2014 Oct 23;56(2):246-260. doi: 10.1016/j.molcel.2014.09.009. Epub 2014 Oct 9.

32.

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW.

Mol Cell. 2014 Nov 6;56(3):360-75. doi: 10.1016/j.molcel.2014.09.007. Epub 2014 Oct 2. Erratum in: Mol Cell. 2014 Nov 6;56(3):462.

33.

Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.

Scott DC, Sviderskiy VO, Monda JK, Lydeard JR, Cho SE, Harper JW, Schulman BA.

Cell. 2014 Jun 19;157(7):1671-84. doi: 10.1016/j.cell.2014.04.037.

34.

The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic test.

Boizot A, Talmat-Amar Y, Morrogh D, Kuntz NL, Halbert C, Chabrol B, Houlden H, Stojkovic T, Schulman BA, Rautenstrauss B, Bomont P.

Acta Neuropathol Commun. 2014 Apr 24;2:47. doi: 10.1186/2051-5960-2-47.

35.

Atomistic autophagy: the structures of cellular self-digestion.

Hurley JH, Schulman BA.

Cell. 2014 Apr 10;157(2):300-311. doi: 10.1016/j.cell.2014.01.070. Review.

36.

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins.

Klionsky DJ, Schulman BA.

Nat Struct Mol Biol. 2014 Apr;21(4):336-45. doi: 10.1038/nsmb.2787. Review.

37.

Vocational rehabilitation program evaluation: comparison group challenges and the role of unmeasured return-to-work expectations.

Sears JM, Rolle LR, Schulman BA, Wickizer TM.

J Occup Rehabil. 2014 Dec;24(4):777-89. doi: 10.1007/s10926-014-9509-6.

PMID:
24682775
38.

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.

Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP.

Cancer Cell. 2014 Apr 14;25(4):455-68. doi: 10.1016/j.ccr.2014.02.007. Epub 2014 Mar 20.

39.

Improving vocational rehabilitation services for injured workers in Washington State.

Sears JM, Wickizer TM, Schulman BA.

Eval Program Plann. 2014 Jun;44:26-35. doi: 10.1016/j.evalprogplan.2013.12.006. Epub 2014 Jan 3.

PMID:
24509051
40.

Building and remodelling Cullin-RING E3 ubiquitin ligases.

Lydeard JR, Schulman BA, Harper JW.

EMBO Rep. 2013 Dec;14(12):1050-61. doi: 10.1038/embor.2013.173. Epub 2013 Nov 15. Review.

41.

Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.

Qiu Y, Hofmann K, Coats JE, Schulman BA, Kaiser SE.

Protein Sci. 2013 Dec;22(12):1691-7. doi: 10.1002/pro.2381.

42.

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

Kelsall IR, Duda DM, Olszewski JL, Hofmann K, Knebel A, Langevin F, Wood N, Wightman M, Schulman BA, Alpi AF.

EMBO J. 2013 Oct 30;32(21):2848-60. doi: 10.1038/emboj.2013.209. Epub 2013 Sep 27.

43.

Injured workers' assessment of vocational rehabilitation services before and after retraining.

Sears JM, Wickizer TM, Schulman BA.

J Occup Rehabil. 2014 Sep;24(3):458-68. doi: 10.1007/s10926-013-9479-0.

PMID:
24065344
44.

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.

Kamadurai HB, Qiu Y, Deng A, Harrison JS, Macdonald C, Actis M, Rodrigues P, Miller DJ, Souphron J, Lewis SM, Kurinov I, Fujii N, Hammel M, Piper R, Kuhlman B, Schulman BA.

Elife. 2013 Aug 8;2:e00828. doi: 10.7554/eLife.00828.

45.

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis MA, Kriwacki RW, Peters JM, Stark H, Schulman BA.

Nat Struct Mol Biol. 2013 Jul;20(7):827-35. doi: 10.1038/nsmb.2593. Epub 2013 May 26.

46.

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.

Duda DM, Olszewski JL, Schuermann JP, Kurinov I, Miller DJ, Nourse A, Alpi AF, Schulman BA.

Structure. 2013 Jun 4;21(6):1030-41. doi: 10.1016/j.str.2013.04.019. Epub 2013 May 23.

47.

Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1.

Kaiser SE, Qiu Y, Coats JE, Mao K, Klionsky DJ, Schulman BA.

Autophagy. 2013 May;9(5):778-80. doi: 10.4161/auto.23644. Epub 2013 Feb 6.

48.

Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.

Monda JK, Scott DC, Miller DJ, Lydeard J, King D, Harper JW, Bennett EJ, Schulman BA.

Structure. 2013 Jan 8;21(1):42-53. doi: 10.1016/j.str.2012.10.013. Epub 2012 Nov 29.

49.

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.

Kaiser SE, Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, Schulman BA.

Nat Struct Mol Biol. 2012 Dec;19(12):1242-9. doi: 10.1038/nsmb.2415. Epub 2012 Nov 11.

50.

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.

Uzunova K, Dye BT, Schutz H, Ladurner R, Petzold G, Toyoda Y, Jarvis MA, Brown NG, Poser I, Novatchkova M, Mechtler K, Hyman AA, Stark H, Schulman BA, Peters JM.

Nat Struct Mol Biol. 2012 Nov;19(11):1116-23. doi: 10.1038/nsmb.2412. Epub 2012 Sep 24.

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