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Does rehabilitation pose a risk to patients suffering from haemato-oncological diseases? Results of a monocentric, retrospective analysis in Germany.

Kiefer T, Krahl D, Kohlmann T, Nogai A, Baurmann H, Schüler F, Krüger W, de Wit M, Pink D, Dietz M, Völler H, Buhlert H, Daeschlein G.

Eur J Cancer Care (Engl). 2019 Dec 6:e13201. doi: 10.1111/ecc.13201. [Epub ahead of print]


Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.

Schadt S, Hauri S, Lopes F, Edelmann MR, Staack RF, Villaseñor R, Kettenberger H, Roth AB, Schuler F, Richter WF, Funk C.

Drug Metab Dispos. 2019 Dec;47(12):1443-1456. doi: 10.1124/dmd.119.088997.


[63-year-old male with positive VRE anamnesis, elective indications for surgery and during the course VRE bacteremia : Preparation for the medical specialist examination: part 33].

Schuler F, Kampmeier S, Lanckohr C.

Anaesthesist. 2019 Nov;68(Suppl 3):236-238. doi: 10.1007/s00101-019-00660-1. German. No abstract available.


Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review.

Correa-Martínez CL, Rauwolf KK, Schuler F, Füller M, Kampmeier S, Groll AH.

BMC Infect Dis. 2019 Oct 11;19(1):836. doi: 10.1186/s12879-019-4489-y.


Phosphorylation of Drosophila CENP-A on serine 20 regulates protein turn-over and centromere-specific loading.

Huang A, Kremser L, Schuler F, Wilflingseder D, Lindner H, Geley S, Lusser A.

Nucleic Acids Res. 2019 Nov 18;47(20):10754-10770. doi: 10.1093/nar/gkz809.


Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.

Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A.

EMBO Rep. 2019 Aug;20(8):e47026. doi: 10.15252/embr.201847026. Epub 2019 Jun 17.


Differential Benefit of Collaterals for Stroke Patients Treated with Thrombolysis or Supportive Care : A Propensity Score Matched Analysis.

Schuler F, Rotkopf LT, Apel D, Fabritius MP, Tiedt S, Wollenweber FA, Kellert L, Dorn F, Liebig T, Thierfelder KM, Kunz WG.

Clin Neuroradiol. 2019 Aug 2. doi: 10.1007/s00062-019-00815-y. [Epub ahead of print]


Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.

McAleer CW, Long CJ, Elbrecht D, Sasserath T, Bridges LR, Rumsey JW, Martin C, Schnepper M, Wang Y, Schuler F, Roth AB, Funk C, Shuler ML, Hickman JJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaav1386. doi: 10.1126/scitranslmed.aav1386.


[Hygiene aspects of multidrug-resistant pathogens in the operating room and intensive care unit].

Schuler F, Lanckohr C, Pillukat MH, Scherf R, Mellmann A.

Anaesthesist. 2019 May;68(5):329-340. doi: 10.1007/s00101-019-0594-y. German.


Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.

Hooijmans CR, Hlavica M, Schuler FAF, Good N, Good A, Baumgartner L, Galeno G, Schneider MP, Jung T, de Vries R, Ineichen BV.

Sci Rep. 2019 Jan 29;9(1):822. doi: 10.1038/s41598-018-35734-4.


The World as an External Memory: The Price of Saccades in a Sensorimotor Task.

Melnik A, Schüler F, Rothkopf CA, König P.

Front Behav Neurosci. 2018 Nov 20;12:253. doi: 10.3389/fnbeh.2018.00253. eCollection 2018.


Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs.

Jakubiak P, Reutlinger M, Mattei P, Schuler F, Urtti A, Alvarez-Sánchez R.

J Med Chem. 2018 Nov 21;61(22):10106-10115. doi: 10.1021/acs.jmedchem.8b01281. Epub 2018 Nov 13.


Lattice Microarchitecture for Bone Tissue Engineering from Calcium Phosphate Compared to Titanium.

Chen TH, Ghayor C, Siegenthaler B, Schuler F, Rüegg J, De Wild M, Weber FE.

Tissue Eng Part A. 2018 Oct;24(19-20):1554-1561. doi: 10.1089/ten.TEA.2018.0014. Epub 2018 Sep 6.


2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

Giroud M, Kuhn B, Saint-Auret S, Kuratli C, Martin RE, Schuler F, Diederich F, Kaiser M, Brun R, Schirmeister T, Haap W.

J Med Chem. 2018 Apr 26;61(8):3370-3388. doi: 10.1021/acs.jmedchem.7b01870. Epub 2018 Apr 6.


Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W.

J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13.


A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.

Dieckmann A, Hagedorn PH, Burki Y, Brügmann C, Berrera M, Ebeling M, Singer T, Schuler F.

Mol Ther Nucleic Acids. 2018 Mar 2;10:45-54. doi: 10.1016/j.omtn.2017.11.004. Epub 2017 Nov 14.


Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis.

Schuler F, Weiss JG, Lindner SE, Lohmüller M, Herzog S, Spiegl SF, Menke P, Geley S, Labi V, Villunger A.

Nat Commun. 2017 Nov 22;8(1):1697. doi: 10.1038/s41467-017-01850-4.


The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance.

Sladky V, Schuler F, Fava LL, Villunger A.

J Cell Sci. 2017 Nov 15;130(22):3779-3787. doi: 10.1242/jcs.203448. Review.


Signalling strength determines proapoptotic functions of STING.

Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A.

Nat Commun. 2017 Sep 5;8(1):427. doi: 10.1038/s41467-017-00573-w.


The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells.

Lindner SE, Lohmüller M, Kotkamp B, Schuler F, Knust Z, Villunger A, Herzog S.

EMBO Rep. 2017 Sep;18(9):1604-1617. doi: 10.15252/embr.201643735. Epub 2017 Jul 13.


Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research.

Kroll K, Chabria M, Wang K, Häusermann F, Schuler F, Polonchuk L.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):212-222. doi: 10.1016/j.pbiomolbio.2017.07.003. Epub 2017 Jul 6.


Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms.

Jaramillo CAC, Belli S, Cascais AC, Dudal S, Edelmann MR, Haak M, Brun ME, Otteneder MB, Ullah M, Funk C, Schuler F, Simon S.

MAbs. 2017 Jul;9(5):781-791. doi: 10.1080/19420862.2017.1320008. Epub 2017 Apr 25.


Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical Studies.

Lenz B, Brink A, Siam M, De Paepe A, Bassett S, Eichinger-Chapelon A, Maliver P, Neff R, Niederhauser U, Steinhuber B, Zurbach R, Singer T, Funk C, Schuler F, Albassam M, Schadt S.

Toxicol Sci. 2018 Jun 1;163(2):409-419. doi: 10.1093/toxsci/kfx044.


Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.

Moisan A, Gubler M, Zhang JD, Tessier Y, Dumong Erichsen K, Sewing S, Gérard R, Avignon B, Huber S, Benmansour F, Chen X, Villaseñor R, Braendli-Baiocco A, Festag M, Maunz A, Singer T, Schuler F, Roth AB.

Mol Ther Nucleic Acids. 2017 Mar 17;6:89-105. doi: 10.1016/j.omtn.2016.11.006. Epub 2016 Dec 10.


The PIDDosome activates p53 in response to supernumerary centrosomes.

Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A.

Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.


From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.

Braendli-Baiocco A, Festag M, Dumong Erichsen K, Persson R, Mihatsch MJ, Fisker N, Funk J, Mohr S, Constien R, Ploix C, Brady K, Berrera M, Altmann B, Lenz B, Albassam M, Schmitt G, Weiser T, Schuler F, Singer T, Tessier Y.

Toxicol Sci. 2017 May 1;157(1):112-128. doi: 10.1093/toxsci/kfx025.


Crossed cerebellar diaschisis in acute ischemic stroke: Impact on morphologic and functional outcome.

Kunz WG, Sommer WH, Höhne C, Fabritius MP, Schuler F, Dorn F, Othman AE, Meinel FG, von Baumgarten L, Reiser MF, Ertl-Wagner B, Thierfelder KM.

J Cereb Blood Flow Metab. 2017 Nov;37(11):3615-3624. doi: 10.1177/0271678X16686594. Epub 2017 Jan 13.


Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.

Kratochwil NA, Meille C, Fowler S, Klammers F, Ekiciler A, Molitor B, Simon S, Walter I, McGinnis C, Walther J, Leonard B, Triyatni M, Javanbakht H, Funk C, Schuler F, Lavé T, Parrott NJ.

AAPS J. 2017 Mar;19(2):534-550. doi: 10.1208/s12248-016-0019-7. Epub 2017 Jan 3.


Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design.

Brink A, Pähler A, Funk C, Schuler F, Schadt S.

Drug Discov Today. 2017 May;22(5):751-756. doi: 10.1016/j.drudis.2016.11.018. Epub 2016 Nov 27.


Wavelet-Based Angiographic Reconstruction of Computed Tomography Perfusion Data: Diagnostic Value in Cerebral Venous Sinus Thrombosis.

Kunz WG, Schuler F, Sommer WH, Fabritius MP, Havla L, Meinel FG, Reiser MF, Ertl-Wagner B, Thierfelder KM.

Invest Radiol. 2017 May;52(5):302-309. doi: 10.1097/RLI.0000000000000337.


MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.

Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A.

Oncogene. 2017 Apr;36(15):2066-2073. doi: 10.1038/onc.2016.362. Epub 2016 Oct 3.


Extension of the dissolution-precipitation model for kinetic elucidation of solvent-mediated polymorphic transformations.

Jakubiak P, Schuler F, Alvarez-Sánchez R.

Eur J Pharm Biopharm. 2016 Dec;109:43-48. doi: 10.1016/j.ejpb.2016.08.019. Epub 2016 Sep 17.


Simplified development of multiplex real-time PCR through master mix augmented by universal fluorogenic reporters.

Wadle S, Lehnert M, Schuler F, Köppel R, Serr A, Zengerle R, von Stetten F.

Biotechniques. 2016 Sep 1;61(3):123-8. doi: 10.2144/000114443. eCollection 2016.


Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs.

Sewing S, Boess F, Moisan A, Bertinetti-Lapatki C, Minz T, Hedtjaern M, Tessier Y, Schuler F, Singer T, Roth AB.

PLoS One. 2016 Jul 21;11(7):e0159431. doi: 10.1371/journal.pone.0159431. eCollection 2016.


Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Sakamoto K, Wehde BL, Yoo KH, Kim T, Rajbhandari N, Shin HY, Triplett AA, Rädler PD, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner KU.

Mol Cell Biol. 2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. Print 2016 Jun 1.


Recent developments in using mechanistic cardiac modelling for drug safety evaluation.

Davies MR, Wang K, Mirams GR, Caruso A, Noble D, Walz A, Lavé T, Schuler F, Singer T, Polonchuk L.

Drug Discov Today. 2016 Jun;21(6):924-38. doi: 10.1016/j.drudis.2016.02.003. Epub 2016 Feb 15. Review.


Monochrome Multiplexing in Polymerase Chain Reaction by Photobleaching of Fluorogenic Hydrolysis Probes.

Schuler F, Trotter M, Zengerle R, von Stetten F.

Anal Chem. 2016 Mar 1;88(5):2590-5. doi: 10.1021/acs.analchem.5b02960. Epub 2016 Feb 16.


Development of a Unified Dissolution and Precipitation Model and Its Use for the Prediction of Oral Drug Absorption.

Jakubiak P, Wagner B, Grimm HP, Petrig-Schaffland J, Schuler F, Alvarez-Sánchez R.

Mol Pharm. 2016 Feb 1;13(2):586-98. doi: 10.1021/acs.molpharmaceut.5b00808. Epub 2016 Jan 5.


Digital droplet PCR on disk.

Schuler F, Trotter M, Geltman M, Schwemmer F, Wadle S, Domínguez-Garrido E, López M, Cervera-Acedo C, Santibáñez P, von Stetten F, Zengerle R, Paust N.

Lab Chip. 2016 Jan 7;16(1):208-16. doi: 10.1039/c5lc01068c.


Estimation of Drug Binding to Brain Tissue: Methodology and in Vivo Application of a Distribution Assay in Brain Polar Lipids.

Belli S, Assmus F, Wagner B, Honer M, Fischer H, Schuler F, Alvarez-Sánchez R.

Mol Pharm. 2015 Dec 7;12(12):4529-41. doi: 10.1021/acs.molpharmaceut.5b00717. Epub 2015 Nov 23.


Minimizing DILI risk in drug discovery - A screening tool for drug candidates.

Schadt S, Simon S, Kustermann S, Boess F, McGinnis C, Brink A, Lieven R, Fowler S, Youdim K, Ullah M, Marschmann M, Zihlmann C, Siegrist YM, Cascais AC, Di Lenarda E, Durr E, Schaub N, Ang X, Starke V, Singer T, Alvarez-Sanchez R, Roth AB, Schuler F, Funk C.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):429-37. doi: 10.1016/j.tiv.2015.09.019. Epub 2015 Sep 25.


Shedding light on minipig drug metabolism - elevated amide hydrolysis in vitro.

Jones R, Marschmann M, Keller M, Qiu NH, Fowler S, Singer T, Schuler F, Funk C, Schadt S.

Xenobiotica. 2016;46(6):483-94. doi: 10.3109/00498254.2015.1089452. Epub 2015 Sep 25.


Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases.

Nettekoven M, Adam JM, Bendels S, Bissantz C, Fingerle J, Grether U, Grüner S, Guba W, Kimbara A, Ottaviani G, Püllmann B, Rogers-Evans M, Röver S, Rothenhäusler B, Schmitt S, Schuler F, Schulz-Gasch T, Ullmer C.

ChemMedChem. 2016 Jan 19;11(2):179-89. doi: 10.1002/cmdc.201500218. Epub 2015 Jul 21.


The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.

Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A.

Cell Death Differ. 2016 Jan;23(1):41-51. doi: 10.1038/cdd.2015.61. Epub 2015 Jun 5.


Centrifugal step emulsification applied for absolute quantification of nucleic acids by digital droplet RPA.

Schuler F, Schwemmer F, Trotter M, Wadle S, Zengerle R, von Stetten F, Paust N.

Lab Chip. 2015 Jul 7;15(13):2759-66. doi: 10.1039/c5lc00291e. Epub 2015 May 7.


Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.

Ratni H, Rogers-Evans M, Bissantz C, Grundschober C, Moreau JL, Schuler F, Fischer H, Alvarez Sanchez R, Schnider P.

J Med Chem. 2015 Mar 12;58(5):2275-89. doi: 10.1021/jm501745f. Epub 2015 Feb 18.


Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.

Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A.

Cell Death Dis. 2013 Dec 5;4:e942. doi: 10.1038/cddis.2013.470.


A liposomal fluorescence assay to study permeation kinetics of drug-like weak bases across the lipid bilayer.

Eyer K, Paech F, Schuler F, Kuhn P, Kissner R, Belli S, Dittrich PS, Krämer SD.

J Control Release. 2014 Jan 10;173:102-9. doi: 10.1016/j.jconrel.2013.10.037. Epub 2013 Nov 6.


Circulating t(14;18)-positive cells in healthy individuals: association with age and sex but not with smoking.

Hirt C, Weitmann K, Schüler F, Kiefer T, Rabkin CS, Hoffmann W, Dölken G.

Leuk Lymphoma. 2013 Dec;54(12):2678-84. doi: 10.3109/10428194.2013.788177. Epub 2013 May 7.


Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines.

Manzl C, Baumgartner F, Peintner L, Schuler F, Villunger A.

Methods. 2013 Jun 1;61(2):130-7. doi: 10.1016/j.ymeth.2013.02.012. Epub 2013 Feb 27.

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