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Items: 1 to 50 of 70

1.

Sensitivity of 18F-fluorodihydrotestosterone PET-CT to count statistics and reconstruction protocol in metastatic castration-resistant prostate cancer.

Cysouw MCF, Kramer GM, Heijtel D, Schuit RC, Morris MJ, van den Eertwegh AJM, Voortman J, Hoekstra OS, Oprea-Lager DE, Boellaard R.

EJNMMI Res. 2019 Jul 30;9(1):70. doi: 10.1186/s13550-019-0531-8.

2.

Simplified Methods for Quantification of 18F-DCFPyL Uptake in Patients with Prostate Cancer.

Jansen BHE, Yaqub M, Voortman J, Cysouw MCF, Windhorst AD, Schuit RC, Kramer GM, van den Eertwegh AJM, Schwarte LA, Hendrikse HN, Vis AN, van Moorselaar RJA, Hoekstra OS, Boellaard R, Oprea-Lager DE.

J Nucl Med. 2019 Apr 18. pii: jnumed.119.227520. doi: 10.2967/jnumed.119.227520. [Epub ahead of print]

PMID:
31000583
3.

Assessment of Simplified Methods for Quantification of 18F-FDHT Uptake in Patients with Metastatic Castration-Resistant Prostate Cancer.

Kramer GM, Yaqub M, Vargas HA, Schuit RC, Windhorst AD, van den Eertwegh AJM, van der Veldt AAM, Bergman AM, Burnazi EM, Lewis JS, Chua S, Staton KD, Beattie BJ, Humm JL, Davis ID, Weickhardt AJ, Scott AM, Morris MJ, Hoekstra OS, Lammertsma AA.

J Nucl Med. 2019 Sep;60(9):1221-1227. doi: 10.2967/jnumed.118.220111. Epub 2019 Mar 8.

PMID:
30850488
4.

Parametric methods for [18F]flortaucipir PET.

Golla SS, Wolters EE, Timmers T, Ossenkoppele R, van der Weijden CW, Scheltens P, Schwarte L, Mintun MA, Devous MD Sr, Schuit RC, Windhorst AD, Lammertsma AA, Yaqub M, van Berckel BN, Boellaard R.

J Cereb Blood Flow Metab. 2018 Dec 20:271678X18820765. doi: 10.1177/0271678X18820765. [Epub ahead of print]

PMID:
30569813
5.

In vivo assessment of neuroinflammation in progressive multiple sclerosis: a proof of concept study with [18F]DPA714 PET.

Hagens MHJ, Golla SV, Wijburg MT, Yaqub M, Heijtel D, Steenwijk MD, Schober P, Brevé JJP, Schuit RC, Reekie TA, Kassiou M, van Dam AM, Windhorst AD, Killestein J, Barkhof F, van Berckel BNM, Lammertsma AA.

J Neuroinflammation. 2018 Nov 13;15(1):314. doi: 10.1186/s12974-018-1352-9.

6.

Synthesis and Preclinical Evaluation of the First Carbon-11 Labeled PET Tracers Targeting Substance P1-7.

Pekošak A, Bulc JŽ, Korat Š, Schuit RC, Kooijman E, Vos R, Rongen M, Verlaan M, Takkenkamp K, Beaino W, Poot AJ, Windhorst AD.

Mol Pharm. 2018 Nov 5;15(11):4872-4883. doi: 10.1021/acs.molpharmaceut.8b00518. Epub 2018 Oct 25.

7.

Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates.

van der Aart J, Yaqub M, Kooijman EJM, Bakker J, Langermans JAM, Schuit RC, Hofman MBM, Christiaans JAM, Lammertsma AA, Windhorst AD, van Berckel BNM.

Mol Imaging Biol. 2019 Aug;21(4):676-685. doi: 10.1007/s11307-018-1284-x.

PMID:
30306318
8.

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression.

Verbeek J, Eriksson J, Syvänen S, Huisman M, Schuit RC, Molthoff CFM, Voskuyl RA, de Lange EC, Lammertsma AA, Windhorst AD.

EJNMMI Radiopharm Chem. 2018 Sep 21;3:11. doi: 10.1186/s41181-018-0046-z. eCollection 2018 Dec.

9.

Open study with (-)-OSU6162 in multiple sclerosis-related fatigue.

Haghighi S, Forsmark S, Carlsson A, Nilsson MKL, Carlsson ML, Schuit RC, Gottfries CG.

Acta Neurol Scand. 2018 Dec;138(6):482-489. doi: 10.1111/ane.13007. Epub 2018 Aug 22.

PMID:
30132786
10.

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus.

Wolters EE, Golla SSV, Timmers T, Ossenkoppele R, van der Weijden CWJ, Scheltens P, Schwarte L, Schuit RC, Windhorst AD, Barkhof F, Yaqub M, Lammertsma AA, Boellaard R, van Berckel BNM.

EJNMMI Res. 2018 Aug 15;8(1):79. doi: 10.1186/s13550-018-0432-2.

11.

Quantification of O-(2-[18F]fluoroethyl)-L-tyrosine kinetics in glioma.

Koopman T, Verburg N, Schuit RC, Pouwels PJW, Wesseling P, Windhorst AD, Hoekstra OS, de Witt Hamer PC, Lammertsma AA, Boellaard R, Yaqub M.

EJNMMI Res. 2018 Jul 31;8(1):72. doi: 10.1186/s13550-018-0418-0.

12.

Improving metabolic stability of fluorine-18 labeled verapamil analogs.

Raaphorst RM, Luurtsema G, Schokker CJ, Attia KA, Schuit RC, Elsinga PH, Lammertsma AA, Windhorst AD.

Nucl Med Biol. 2018 Sep - Oct;64-65:47-56. doi: 10.1016/j.nucmedbio.2018.06.009. Epub 2018 Jul 5.

13.

First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors.

van der Aart J, Golla SSV, van der Pluijm M, Schwarte LA, Schuit RC, Klein PJ, Metaxas A, Windhorst AD, Boellaard R, Lammertsma AA, van Berckel BNM.

EJNMMI Res. 2018 Jul 27;8(1):69. doi: 10.1186/s13550-018-0424-2.

14.

Quantification of [18F]florbetapir: A test-retest tracer kinetic modelling study.

Golla SS, Verfaillie SC, Boellaard R, Adriaanse SM, Zwan MD, Schuit RC, Timmers T, Groot C, Schober P, Scheltens P, van der Flier WM, Windhorst AD, van Berckel BN, Lammertsma AA.

J Cereb Blood Flow Metab. 2018 Jun 13:271678X18783628. doi: 10.1177/0271678X18783628. [Epub ahead of print]

PMID:
29897009
15.

In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model.

van der Wildt B, Wilhelmus MMM, Beaino W, Kooijman EJM, Schuit RC, Bol JGJM, Breve JJP, Pasternack R, Lammertsma AA, Windhorst AD, Drukarch B.

EJNMMI Res. 2018 May 25;8(1):39. doi: 10.1186/s13550-018-0388-2.

16.

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.

Janssen B, Vugts DJ, Wilkinson SM, Ory D, Chalon S, Hoozemans JJM, Schuit RC, Beaino W, Kooijman EJM, van den Hoek J, Chishty M, Doméné A, Van der Perren A, Villa A, Maggi A, Molenaar GT, Funke U, Shevchenko RV, Baekelandt V, Bormans G, Lammertsma AA, Kassiou M, Windhorst AD.

Sci Rep. 2018 Apr 26;8(1):6580. doi: 10.1038/s41598-018-24814-0.

17.

Reproducibility and Repeatability of Semiquantitative 18F-Fluorodihydrotestosterone Uptake Metrics in Castration-Resistant Prostate Cancer Metastases: A Prospective Multicenter Study.

Vargas HA, Kramer GM, Scott AM, Weickhardt A, Meier AA, Parada N, Beattie BJ, Humm JL, Staton KD, Zanzonico PB, Lyashchenko SK, Lewis JS, Yaqub M, Sosa RE, van den Eertwegh AJ, Davis ID, Ackermann U, Pathmaraj K, Schuit RC, Windhorst AD, Chua S, Weber WA, Larson SM, Scher HI, Lammertsma AA, Hoekstra OS, Morris MJ.

J Nucl Med. 2018 Oct;59(10):1516-1523. doi: 10.2967/jnumed.117.206490. Epub 2018 Apr 6.

18.

A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome.

Nilsson MKL, Zachrisson O, Gottfries CG, Matousek M, Peilot B, Forsmark S, Schuit RC, Carlsson ML, Kloberg A, Carlsson A.

Acta Neuropsychiatr. 2018 Jun;30(3):148-157. doi: 10.1017/neu.2017.35. Epub 2017 Dec 7.

PMID:
29212562
19.

Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood-Brain Barrier.

Raaphorst RM, Luurtsema G, Schuit RC, Kooijman EJM, Elsinga PH, Lammertsma AA, Windhorst AD.

ACS Chem Neurosci. 2017 Sep 20;8(9):1925-1936. doi: 10.1021/acschemneuro.7b00086. Epub 2017 Jul 10.

20.

Synthesis, radiolabeling and preclinical evaluation of a [11C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor.

Klein PJ, Schuit RC, Metaxas A, Christiaans JAM, Kooijman E, Lammertsma AA, van Berckel BNM, Windhorst AD.

Nucl Med Biol. 2017 Aug;51:25-32. doi: 10.1016/j.nucmedbio.2017.05.003. Epub 2017 May 8.

21.

Development of [11C]vemurafenib employing a carbon-11 carbonylative Stille coupling and preliminary evaluation in mice bearing melanoma tumor xenografts.

Slobbe P, Windhorst AD, Adamzek K, Bolijn M, Schuit RC, Heideman DAM, van Dongen GAMS, Poot AJ.

Oncotarget. 2017 Jun 13;8(24):38337-38350. doi: 10.18632/oncotarget.16321.

22.

Quantification of Tau Load Using [18F]AV1451 PET.

Golla SSV, Timmers T, Ossenkoppele R, Groot C, Verfaillie S, Scheltens P, van der Flier WM, Schwarte L, Mintun MA, Devous M, Schuit RC, Windhorst AD, Lammertsma AA, Boellaard R, van Berckel BNM, Yaqub M.

Mol Imaging Biol. 2017 Dec;19(6):963-971. doi: 10.1007/s11307-017-1080-z.

23.

Human Dosimetry of the N-Methyl-d-Aspartate Receptor Ligand 11C-GMOM.

van der Aart J, van der Doef TF, Horstman P, Huisman MC, Schuit RC, van Lingen A, Windhorst AD, van Berckel BNM, Lammertsma AA.

J Nucl Med. 2017 Aug;58(8):1330-1333. doi: 10.2967/jnumed.116.188250. Epub 2017 Feb 9.

24.

Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation.

Hugenberg V, Wagner S, Kopka K, Schäfers M, Schuit RC, Windhorst AD, Hermann S.

J Med Chem. 2017 Jan 12;60(1):307-321. doi: 10.1021/acs.jmedchem.6b01284. Epub 2016 Dec 16.

PMID:
27981835
25.

Development of fluorine-18 labeled peptidic PET tracers for imaging active tissue transglutaminase.

van der Wildt B, Wilhelmus MM, Kooijman EJ, Jongenelen CA, Schuit RC, Büchold C, Pasternack R, Lammertsma AA, Drukarch B, Windhorst AD.

Nucl Med Biol. 2017 Jan;44:90-104. doi: 10.1016/j.nucmedbio.2016.10.002. Epub 2016 Oct 18.

PMID:
27837727
26.

Two anti-angiogenic TKI-PET tracers, [(11)C]axitinib and [(11)C]nintedanib: Radiosynthesis, in vivo metabolism and initial biodistribution studies in rodents.

Slobbe P, Poot AJ, Haumann R, Schuit RC, Windhorst AD, van Dongen GA.

Nucl Med Biol. 2016 Oct;43(10):612-24. doi: 10.1016/j.nucmedbio.2016.07.003. Epub 2016 Jul 14.

PMID:
27497236
27.

Parametric Binding Images of the TSPO Ligand 18F-DPA-714.

Golla SS, Boellaard R, Oikonen V, Hoffmann A, van Berckel BN, Windhorst AD, Virta J, Te Beek ET, Groeneveld GJ, Haaparanta-Solin M, Luoto P, Savisto N, Solin O, Valencia R, Thiele A, Eriksson J, Schuit RC, Lammertsma AA, Rinne JO.

J Nucl Med. 2016 Oct;57(10):1543-1547. Epub 2016 Jun 3.

28.

Noninvasive Quantification of Myocardial 11C-Meta-Hydroxyephedrine Kinetics.

Harms HJ, Huisman MC, Rijnierse MT, Greuter H, Hsieh YL, de Haan S, Schuit RC, Knaapen P, Lubberink M, Lammertsma AA.

J Nucl Med. 2016 Sep;57(9):1376-81. doi: 10.2967/jnumed.115.167437. Epub 2016 May 26.

29.

Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate receptor.

Klein PJ, Chomet M, Metaxas A, Christiaans JA, Kooijman E, Schuit RC, Lammertsma AA, van Berckel BN, Windhorst AD.

Eur J Med Chem. 2016 Aug 8;118:143-60. doi: 10.1016/j.ejmech.2016.04.022. Epub 2016 Apr 19.

PMID:
27128179
30.

Development of carbon-11 labeled acryl amides for selective PET imaging of active tissue transglutaminase.

van der Wildt B, Wilhelmus MM, Bijkerk J, Haveman LY, Kooijman EJ, Schuit RC, Bol JG, Jongenelen CA, Lammertsma AA, Drukarch B, Windhorst AD.

Nucl Med Biol. 2016 Apr;43(4):232-42. doi: 10.1016/j.nucmedbio.2016.01.003. Epub 2016 Feb 2.

PMID:
27067043
31.

Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC.

Bahce I, Yaqub M, Errami H, Schuit RC, Schober P, Thunnissen E, Windhorst AD, Lammertsma AA, Smit EF, Hendrikse NH.

EJNMMI Res. 2016 Dec;6(1):10. doi: 10.1186/s13550-016-0169-8. Epub 2016 Feb 9.

32.

Quantitative and Simplified Analysis of 11C-Erlotinib Studies.

Yaqub M, Bahce I, Voorhoeve C, Schuit RC, Windhorst AD, Hoekstra OS, Boellaard R, Hendrikse NH, Smit EF, Lammertsma AA.

J Nucl Med. 2016 Jun;57(6):861-6. doi: 10.2967/jnumed.115.165225. Epub 2016 Feb 4.

33.

Impact of New Scatter Correction Strategies on High-Resolution Research Tomograph Brain PET Studies.

Mansor S, Boellaard R, Huisman MC, van Berckel BN, Schuit RC, Windhorst AD, Lammertsma AA, van Velden FH.

Mol Imaging Biol. 2016 Aug;18(4):627-35. doi: 10.1007/s11307-015-0921-x.

34.

Altered GABAA receptor density and unaltered blood-brain barrier [11C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis.

Froklage FE, Postnov A, Yaqub MM, Bakker E, Boellaard R, Hendrikse NH, Comans EF, Schuit RC, Schober P, Velis DN, Zwemmer J, Heimans JJ, Lammertsma AA, Voskuyl RA, Reijneveld JC.

J Cereb Blood Flow Metab. 2017 Jan;37(1):97-105. Epub 2015 Nov 19.

35.

Quantification of the novel N-methyl-d-aspartate receptor ligand [11C]GMOM in man.

van der Doef TF, Golla SSV, Klein PJ, Oropeza-Seguias GM, Schuit RC, Metaxas A, Jobse E, Schwarte LA, Windhorst AD, Lammertsma AA, van Berckel BNM, Boellaard R.

J Cereb Blood Flow Metab. 2016 Jun;36(6):1111-21. doi: 10.1177/0271678X15608391. Epub 2015 Oct 5.

36.

89Zr-cetuximab PET imaging in patients with advanced colorectal cancer.

Menke-van der Houven van Oordt CW, Gootjes EC, Huisman MC, Vugts DJ, Roth C, Luik AM, Mulder ER, Schuit RC, Boellaard R, Hoekstra OS, van Dongen GA, Verheul HM.

Oncotarget. 2015 Oct 6;6(30):30384-93. doi: 10.18632/oncotarget.4672.

37.

Quantification of 11C-Laniquidar Kinetics in the Brain.

Froklage FE, Boellaard R, Bakker E, Hendrikse NH, Reijneveld JC, Schuit RC, Windhorst AD, Schober P, van Berckel BN, Lammertsma AA, Postnov A.

J Nucl Med. 2015 Nov;56(11):1730-5. doi: 10.2967/jnumed.115.157586. Epub 2015 Aug 20.

38.

Use of a Single 11C-Meta-Hydroxyephedrine Scan for Assessing Flow-Innervation Mismatches in Patients with Ischemic Cardiomyopathy.

Harms HJ, Lubberink M, de Haan S, Knaapen P, Huisman MC, Schuit RC, Windhorst AD, Allaart CP, Lammertsma AA.

J Nucl Med. 2015 Nov;56(11):1706-11. doi: 10.2967/jnumed.115.154377. Epub 2015 Jul 30.

39.

Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium.

Harms HJ, de Haan S, Knaapen P, Allaart CP, Rijnierse MT, Schuit RC, Windhorst AD, Lammertsma AA, Huisman MC, Lubberink M.

EJNMMI Res. 2014 Dec;4(1):52. doi: 10.1186/s13550-014-0052-4. Epub 2014 Sep 26.

40.

[(18)F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models.

Peeters SG, Dubois L, Lieuwes NG, Laan D, Mooijer M, Schuit RC, Vullo D, Supuran CT, Eriksson J, Windhorst AD, Lambin P.

Mol Imaging Biol. 2015 Oct;17(5):615-9. doi: 10.1007/s11307-015-0831-y.

41.

Synthesis of [3-N-(11) C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [(11) C]methyl iodide.

Eriksson J, Van Kooij R, Schuit RC, Froklage FE, Reijneveld JC, Hendrikse NH, Windhorst AD.

J Labelled Comp Radiopharm. 2015 Mar;58(3):122-6. doi: 10.1002/jlcr.3251. Epub 2015 Feb 17.

PMID:
25693064
42.

Quantification of 18F-fluorocholine kinetics in patients with prostate cancer.

Verwer EE, Oprea-Lager DE, van den Eertwegh AJ, van Moorselaar RJ, Windhorst AD, Schwarte LA, Hendrikse NH, Schuit RC, Hoekstra OS, Lammertsma AA, Boellaard R.

J Nucl Med. 2015 Mar;56(3):365-71. doi: 10.2967/jnumed.114.148007. Epub 2015 Feb 12.

43.

Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients.

Golla SS, Boellaard R, Oikonen V, Hoffmann A, van Berckel BN, Windhorst AD, Virta J, Haaparanta-Solin M, Luoto P, Savisto N, Solin O, Valencia R, Thiele A, Eriksson J, Schuit RC, Lammertsma AA, Rinne JO.

J Cereb Blood Flow Metab. 2015 May;35(5):766-72. doi: 10.1038/jcbfm.2014.261. Epub 2015 Feb 4.

44.

Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-d-aspartate receptor as potential imaging probes for positron emission tomography.

Klein PJ, Christiaans JA, Metaxas A, Schuit RC, Lammertsma AA, van Berckel BN, Windhorst AD.

Bioorg Med Chem. 2015 Mar 1;23(5):1189-206. doi: 10.1016/j.bmc.2014.12.029. Epub 2014 Dec 24.

PMID:
25648682
45.

Preclinical evaluation of [(18)F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors.

Golla SS, Klein PJ, Bakker J, Schuit RC, Christiaans JA, van Geest L, Kooijman EJ, Oropeza-Seguias GM, Langermans JA, Leysen JE, Boellaard R, Windhorst AD, van Berckel BN, Metaxas A.

Nucl Med Biol. 2015 Feb;42(2):205-12. doi: 10.1016/j.nucmedbio.2014.09.006. Epub 2014 Sep 30.

PMID:
25451213
46.

Parametric methods for quantification of 18F-FAZA kinetics in non-small cell lung cancer patients.

Verwer EE, Bahce I, van Velden FH, Yaqub M, Schuit RC, Windhorst AD, Raijmakers P, Hoekstra OS, Lammertsma AA, Smit EF, Boellaard R.

J Nucl Med. 2014 Nov;55(11):1772-7. doi: 10.2967/jnumed.114.141846. Epub 2014 Oct 16.

47.

The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects.

Tolboom N, Berendse HW, Leysen JE, Yaqub M, van Berckel BN, Schuit RC, Ponsen MM, Bakker E, Hoetjes NJ, Windhorst AD, Carlsson ML, Lammertsma AA, Carlsson A.

Neuropsychopharmacology. 2015 Jan;40(2):472-9. doi: 10.1038/npp.2014.195. Epub 2014 Aug 5.

48.

Development of [18F]afatinib as new TKI-PET tracer for EGFR positive tumors.

Slobbe P, Windhorst AD, Stigter-van Walsum M, Schuit RC, Smit EF, Niessen HG, Solca F, Stehle G, van Dongen GA, Poot AJ.

Nucl Med Biol. 2014 Oct;41(9):749-57. doi: 10.1016/j.nucmedbio.2014.06.005. Epub 2014 Jun 25.

PMID:
25066021
49.

Comparison of HRRT and HR+ scanners for quantitative (R)-[11C]verapamil, [11C]raclopride and [11C]flumazenil brain studies.

van Velden FH, Mansor SM, van Assema DM, van Berckel BN, Froklage FE, Wang S, Schuit RC, Asselin MC, Lammertsma AA, Boellaard R, Huisman MC.

Mol Imaging Biol. 2015 Feb;17(1):129-39. doi: 10.1007/s11307-014-0766-8.

PMID:
25028091
50.

Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation.

Janssen B, Vugts DJ, Funke U, Spaans A, Schuit RC, Kooijman E, Rongen M, Perk LR, Lammertsma AA, Windhorst AD.

J Labelled Comp Radiopharm. 2014 Jun 30;57(8):509-16. doi: 10.1002/jlcr.3206. Epub 2014 Jul 3.

PMID:
24995673

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