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The mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patient outcomes.

McNamara CJ, Panzarella T, Kennedy JA, Arruda A, Claudio JO, Daher-Reyes G, Ho J, Siddiq N, Devlin R, Tsui H, Su J, Stockley T, Sukhai M, Kanwar N, Chan S, Maze D, Schimmer A, Schuh A, Sibai H, Viswabandya A, Yee K, Minden MD, Kamel-Reid S, Gupta V.

Blood Adv. 2018 Oct 23;2(20):2658-2671. doi: 10.1182/bloodadvances.2018021469.


Cardiovascular resistance to thrombosis in 13-lined ground squirrels.

Bonis A, Anderson L, Talhouarne G, Schueller E, Unke J, Krus C, Stokka J, Koepke A, Lehrer B, Schuh A, Andersen JJ, Cooper S.

J Comp Physiol B. 2018 Oct 13. doi: 10.1007/s00360-018-1186-x. [Epub ahead of print]


[Clinical examination of the hip joint].

Hönle W, Scheller A, Lerzer S, Schuh A.

MMW Fortschr Med. 2018 Oct;160(17):56-61. doi: 10.1007/s15006-018-0986-y. Review. German. No abstract available.


Improvement in Parameters of Hematologic and Immunologic Function and Patient Well-being in the Phase III RESONATE Study of Ibrutinib Versus Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

Barrientos JC, O'Brien S, Brown JR, Kay NE, Reddy NM, Coutre S, Tam C, Mulligan S, Jaeger U, Devereux S, Pocock C, Robak T, Schuster SJ, Schuh A, Gill D, Bloor A, Dearden C, Moreno C, Cull G, Hamblin M, Jones JA, Eckert K, Solman IG, Suzuki S, Hsu E, James DF, Byrd JC, Hillmen P.

Clin Lymphoma Myeloma Leuk. 2018 Aug 18. pii: S2152-2650(18)30574-3. doi: 10.1016/j.clml.2018.08.007. [Epub ahead of print]


Model-based roentgen stereophotogrammetric analysis using elementary geometrical shape models: 10 years results of an uncemented acetabular cup component.

Jacobsen A, Seehaus F, Hong Y, Cao H, Schuh A, Forst R, Sesselmann S.

BMC Musculoskelet Disord. 2018 Sep 18;19(1):335. doi: 10.1186/s12891-018-2259-4.


Hemocompatibility of plasma electrolytic oxidation (PEO) coated Mg-RE and Mg-Zn-Ca alloys for vascular scaffold applications.

Kröger N, Kopp A, Staudt M, Rusu M, Schuh A, Liehn EA.

Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:819-826. doi: 10.1016/j.msec.2018.07.031. Epub 2018 Jul 18.


Lactic Acidosis in a Critically Ill Patient: Not Always Sepsis.

Schuh AM, Leger KJ, Summers C, Uspal NG.

Pediatr Emerg Care. 2018 Sep;34(9):e165-e167. doi: 10.1097/PEC.0000000000001603.


Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation.

Slosarek EL, Schuh AL, Pustova I, Johnson A, Bird J, Johnson M, Frankel EB, Bhattacharya N, Hanna MG, Burke JE, Ruhl DA, Quinney K, Block S, Peotter JL, Chapman ER, Sheets MD, Butcher SE, Stagg SM, Audhya A.

Cell Rep. 2018 Aug 28;24(9):2248-2260. doi: 10.1016/j.celrep.2018.07.081.


A novel method to generate dynamic boundary conditions for airway CFD by mapping upper airway movement with non-rigid registration of dynamic and static MRI.

Bates AJ, Schuh A, McConnell K, Williams BM, Lanier JM, Willmering MM, Woods JC, Fleck RJ, Dumoulin CL, Amin RS.

Int J Numer Method Biomed Eng. 2018 Aug 21:e3144. doi: 10.1002/cnm.3144. [Epub ahead of print]


Stable Integration and Comparison of hGrx1-roGFP2 and sfroGFP2 Redox Probes in the Malaria Parasite Plasmodium falciparum.

Schuh AK, Rahbari M, Heimsch KC, Mohring F, Gabryszewski SJ, Weder S, Buchholz K, Rahlfs S, Fidock DA, Becker K.

ACS Infect Dis. 2018 Sep 6. doi: 10.1021/acsinfecdis.8b00140. [Epub ahead of print]


Corrigendum: FGF23 in Cardiovascular Disease: Innocent Bystander or Active Mediator?

Stöhr R, Schuh A, Heine GH, Brandenburg V.

Front Endocrinol (Lausanne). 2018 Jul 18;9:422. doi: 10.3389/fendo.2018.00422. eCollection 2018.


Structural brain imaging in Alzheimer's disease and mild cognitive impairment: biomarker analysis and shared morphometry database.

Ledig C, Schuh A, Guerrero R, Heckemann RA, Rueckert D.

Sci Rep. 2018 Jul 26;8(1):11258. doi: 10.1038/s41598-018-29295-9.


Limited Exchange Transfusion Can Be Very Beneficial in Sickle Cell Anemia with Acute Chest Syndrome: A Case Report from Tanzania.

Chamba C, Iddy H, Tebuka E, Tluway F, Osati E, Budodi N, Meda C, Yonazi M, Schuh A, Luzzatto L, Makani J.

Case Rep Hematol. 2018 Jun 21;2018:5253625. doi: 10.1155/2018/5253625. eCollection 2018.


FGF23 in Cardiovascular Disease: Innocent Bystander or Active Mediator?

Stöhr R, Schuh A, Heine GH, Brandenburg V.

Front Endocrinol (Lausanne). 2018 Jun 27;9:351. doi: 10.3389/fendo.2018.00351. eCollection 2018. Review. Erratum in: Front Endocrinol (Lausanne). 2018 Jul 18;9:422.


Guideline for the treatment of chronic lymphocytic leukaemia: A British Society for Haematology Guideline.

Schuh AH, Parry-Jones N, Appleby N, Bloor A, Dearden CE, Fegan C, Follows G, Fox CP, Iyengar S, Kennedy B, McCarthy H, Parry HM, Patten P, Pettitt AR, Ringshausen I, Walewska R, Hillmen P.

Br J Haematol. 2018 Jul 15. doi: 10.1111/bjh.15460. [Epub ahead of print] No abstract available.


Exposure-adjusted adverse events comparing blinatumomab with chemotherapy in advanced acute lymphoblastic leukemia.

Stein AS, Larson RA, Schuh AC, Stevenson W, Lech-Maranda E, Tran Q, Zimmerman Z, Kormany W, Topp MS.

Blood Adv. 2018 Jul 10;2(13):1522-1531. doi: 10.1182/bloodadvances.2018019034.


The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study.

Stamatopoulos B, Smith T, Crompot E, Pieters K, Clifford R, Mraz M, Robbe P, Burns A, Timbs A, Bruce D, Hillmen P, Meuleman N, Mineur P, Firescu R, Maerevoet M, De Wilde V, Efira A, Philippé J, Verhasselt B, Offner F, Sims D, Heger A, Dreau H, Schuh A.

Clin Cancer Res. 2018 Oct 15;24(20):5048-5057. doi: 10.1158/1078-0432.CCR-18-0133. Epub 2018 Jun 26.


Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.

Pellagatti A, Armstrong RN, Steeples V, Sharma E, Repapi E, Singh S, Sanchi A, Radujkovic A, Horn P, Dolatshad H, Roy S, Broxholme J, Lockstone H, Taylor S, Giagounidis A, Vyas P, Schuh A, Hamblin A, Papaemmanuil E, Killick S, Malcovati L, Hennrich ML, Gavin AC, Ho AD, Luft T, Hellström-Lindberg E, Cazzola M, Smith CWJ, Smith S, Boultwood J.

Blood. 2018 Sep 20;132(12):1225-1240. doi: 10.1182/blood-2018-04-843771. Epub 2018 Jun 21.


Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier.

Tolonen A, Rhodius-Meester HFM, Bruun M, Koikkalainen J, Barkhof F, Lemstra AW, Koene T, Scheltens P, Teunissen CE, Tong T, Guerrero R, Schuh A, Ledig C, Baroni M, Rueckert D, Soininen H, Remes AM, Waldemar G, Hasselbalch SG, Mecocci P, van der Flier WM, Lötjönen J.

Front Aging Neurosci. 2018 Apr 25;10:111. doi: 10.3389/fnagi.2018.00111. eCollection 2018.



Schuh A, Hönle W, Füssl S, Janka M.

MMW Fortschr Med. 2018 Jun;160(11):36-37. doi: 10.1007/s15006-018-0624-8. Review. German. No abstract available.


Construction of a neonatal cortical surface atlas using Multimodal Surface Matching in the Developing Human Connectome Project.

Bozek J, Makropoulos A, Schuh A, Fitzgibbon S, Wright R, Glasser MF, Coalson TS, O'Muircheartaigh J, Hutter J, Price AN, Cordero-Grande L, Teixeira RPAG, Hughes E, Tusor N, Baruteau KP, Rutherford MA, Edwards AD, Hajnal JV, Smith SM, Rueckert D, Jenkinson M, Robinson EC.

Neuroimage. 2018 Oct 1;179:11-29. doi: 10.1016/j.neuroimage.2018.06.018. Epub 2018 Jun 14.


Will the reformed Cancer Drugs Fund address the most common types of uncertainty? An analysis of NICE cancer drug appraisals.

Morrell L, Wordsworth S, Schuh A, Middleton MR, Rees S, Barker RW.

BMC Health Serv Res. 2018 May 31;18(1):393. doi: 10.1186/s12913-018-3162-2.


Clinical-grade validation of whole genome sequencing reveals robust detection of low-frequency variants and copy number alterations in CLL.

Klintman J, Barmpouti K, Knight SJL, Robbe P, Dreau H, Clifford R, Ridout K, Burns A, Timbs A, Bruce D, Antoniou P, Sosinsky A, Becq J, Bentley D, Hillmen P, Taylor JC, Caulfield M, Schuh AH.

Br J Haematol. 2018 May 29. doi: 10.1111/bjh.15406. [Epub ahead of print]


[Are There any Differences in Quality or Complication Rate in Total Knee Arthroplasty after Establishing a Centre for Endoprosthesis?]

Düzgünoglu M, Hönle W, Scheller A, Schuh A.

Z Orthop Unfall. 2018 Oct;156(5):574-578. doi: 10.1055/a-0608-5195. Epub 2018 May 18. German.


Health-related quality of life in adults with relapsed/refractory acute lymphoblastic leukemia treated with blinatumomab.

Topp MS, Zimmerman Z, Cannell P, Dombret H, Maertens J, Stein A, Franklin J, Tran Q, Cong Z, Schuh AC.

Blood. 2018 Jun 28;131(26):2906-2914. doi: 10.1182/blood-2017-09-804658. Epub 2018 May 8.


Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial.

Stilgenbauer S, Eichhorst B, Schetelig J, Hillmen P, Seymour JF, Coutre S, Jurczak W, Mulligan SP, Schuh A, Assouline S, Wendtner CM, Roberts AW, Davids MS, Bloehdorn J, Munir T, Böttcher S, Zhou L, Salem AH, Desai M, Chyla B, Arzt J, Kim SY, Verdugo M, Gordon G, Hallek M, Wierda WG.

J Clin Oncol. 2018 Jul 1;36(19):1973-1980. doi: 10.1200/JCO.2017.76.6840. Epub 2018 May 1.


Time to repeal and replace response criteria for acute myeloid leukemia?

Bloomfield CD, Estey E, Pleyer L, Schuh AC, Stein EM, Tallman MS, Wei A.

Blood Rev. 2018 Sep;32(5):416-425. doi: 10.1016/j.blre.2018.03.006. Epub 2018 Mar 27. Review.


Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study.

Cuneo A, Follows G, Rigolin GM, Piciocchi A, Tedeschi A, Trentin L, Perez AM, Coscia M, Laurenti L, Musuraca G, Farina L, Delgado AR, Orlandi EM, Galieni P, Mauro FR, Visco C, Amendola A, Billio A, Marasca R, Chiarenza A, Meneghini V, Ilariucci F, Marchetti M, Molica S, Re F, Gaidano G, Gonzalez M, Forconi F, Ciolli S, Cortelezzi A, Montillo M, Smolej L, Schuh A, Eyre TA, Kennedy B, Bowles KM, Vignetti M, de la Serna J, Moreno C, Foà R, Ghia P; GIMEMA, European Research Initiative on CLL (ERIC) and UK CLL forum.

Haematologica. 2018 Jul;103(7):1209-1217. doi: 10.3324/haematol.2018.189837. Epub 2018 Apr 19.


[Tarsal tunnel syndrome].

Schuh A, Handschu R, Eibl T, Janka M, Hönle W.

MMW Fortschr Med. 2018 Apr;160(6):58-59. doi: 10.1007/s15006-018-0384-5. Review. German. No abstract available.


The Impact of Deep Brain Stimulation on the Quality of Life and Swallowing in Individuals with Parkinson's Disease.

Olchik MR, Ghisi M, Ayres A, Schuh AFS, Oppitz PP, Rieder CRM.

Int Arch Otorhinolaryngol. 2018 Apr;22(2):125-129. doi: 10.1055/s-0037-1603466. Epub 2017 Jun 5.


Clinically actionable mutation profiles in patients with cancer identified by whole-genome sequencing.

Schuh A, Dreau H, Knight SJL, Ridout K, Mizani T, Vavoulis D, Colling R, Antoniou P, Kvikstad EM, Pentony MM, Hamblin A, Protheroe A, Parton M, Shah KA, Orosz Z, Athanasou N, Hassan B, Flanagan AM, Ahmed A, Winter S, Harris A, Tomlinson I, Popitsch N, Church D, Taylor JC.

Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). pii: a002279. doi: 10.1101/mcs.a002279. Print 2018 Apr.


Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

Temko D, Van Gool IC, Rayner E, Glaire M, Makino S, Brown M, Chegwidden L, Palles C, Depreeuw J, Beggs A, Stathopoulou C, Mason J, Baker AM, Williams M, Cerundolo V, Rei M, Taylor JC, Schuh A, Ahmed A, Amant F, Lambrechts D, Smit VT, Bosse T, Graham TA, Church DN, Tomlinson I.

J Pathol. 2018 Jul;245(3):283-296. doi: 10.1002/path.5081. Epub 2018 Apr 30.


[Tick-borne encephalitis].

Handschu R, Janssen F, Schuh A.

MMW Fortschr Med. 2018 Mar;160(Suppl 1):30-35. doi: 10.1007/s15006-018-0008-0. German. No abstract available.


AML refractory to primary induction with Ida-FLAG has a poor clinical outcome.

Kavanagh S, Heath E, Hurren R, Gronda M, Barghout SH, Liyanage SU, Siriwardena TP, Claudio J, Zhang T, Sukhai M, Stockley TL, Kamel-Reid S, Rostom A, Lutynski A, Khalaf D, Rydlewski A, Chan SM, Gupta V, Maze D, Sibai H, Schuh AC, Yee K, Minden MD, Schimmer AD.

Leuk Res. 2018 May;68:22-28. doi: 10.1016/j.leukres.2018.02.012. Epub 2018 Feb 20.


Idelalisib-rituximab induces durable remissions in TP53 disrupted B-PLL but results in significant toxicity: updated results of the UK-wide compassionate use programme.

Eyre TA, Fox CP, Boden A, Bloor A, Dungawalla M, Shankara P, Went R, Schuh AH.

Br J Haematol. 2018 Feb 22. doi: 10.1111/bjh.15151. [Epub ahead of print] No abstract available.


[Suprascapular nerve entrapment].

Schuh A, Handschu R, Eibl T, Janka M, Hönle W.

MMW Fortschr Med. 2017 Sep;159(16):62-64. doi: 10.1007/s15006-017-0068-6. Review. German. No abstract available.


Incidence of perioperative complications in total hip and knee arthroplasty in patients with Parkinson disease.

Sharma T, Hönle W, Handschu R, Adler W, Goyal T, Schuh A.

Arch Orthop Trauma Surg. 2018 Jun;138(6):765-770. doi: 10.1007/s00402-018-2899-8. Epub 2018 Feb 15.


Rituximab plus bendamustine or chlorambucil for chronic lymphocytic leukemia: primary analysis of the randomized, open-label MABLE study.

Michallet AS, Aktan M, Hiddemann W, Ilhan O, Johansson P, Laribi K, Meddeb B, Moreno C, Raposo J, Schuh A, Ünal A, Widenius T, Bernhardt A, Kellershohn K, Messeri D, Osborne S, Leblond V.

Haematologica. 2018 Apr;103(4):698-706. doi: 10.3324/haematol.2017.170480. Epub 2018 Feb 1.


The developing human connectome project: A minimal processing pipeline for neonatal cortical surface reconstruction.

Makropoulos A, Robinson EC, Schuh A, Wright R, Fitzgibbon S, Bozek J, Counsell SJ, Steinweg J, Vecchiato K, Passerat-Palmbach J, Lenz G, Mortari F, Tenev T, Duff EP, Bastiani M, Cordero-Grande L, Hughes E, Tusor N, Tournier JD, Hutter J, Price AN, Teixeira RPAG, Murgasova M, Victor S, Kelly C, Rutherford MA, Smith SM, Edwards AD, Hajnal JV, Jenkinson M, Rueckert D.

Neuroimage. 2018 Jun;173:88-112. doi: 10.1016/j.neuroimage.2018.01.054. Epub 2018 Jan 31.


Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project.

Robbe P, Popitsch N, Knight SJL, Antoniou P, Becq J, He M, Kanapin A, Samsonova A, Vavoulis DV, Ross MT, Kingsbury Z, Cabes M, Ramos SDC, Page S, Dreau H, Ridout K, Jones LJ, Tuff-Lacey A, Henderson S, Mason J, Buffa FM, Verrill C, Maldonado-Perez D, Roxanis I, Collantes E, Browning L, Dhar S, Damato S, Davies S, Caulfield M, Bentley DR, Taylor JC, Turnbull C, Schuh A.

Genet Med. 2018 Feb 1. doi: 10.1038/gim.2017.241. [Epub ahead of print]


Pediatric Adnexal Torsion: Not Just a Postmenarchal Problem.

Schuh AM, Klein EJ, Allred RJ, Christensen A, Brown J.

J Emerg Med. 2018 Jan;54(1):131-132. doi: 10.1016/j.jemermed.2017.08.070. No abstract available.


Impact of genomic alterations on outcomes in myelofibrosis patients undergoing JAK1/2 inhibitor therapy.

Spiegel JY, McNamara C, Kennedy JA, Panzarella T, Arruda A, Stockley T, Sukhai M, Thomas M, Bartoszko J, Ho J, Siddiq N, Maze D, Schimmer A, Schuh A, Sibai H, Yee K, Claudio J, Devlin R, Minden MD, Kamel-Reid S, Gupta V.

Blood Adv. 2017 Sep 8;1(20):1729-1738. doi: 10.1182/bloodadvances.2017009530. eCollection 2017 Sep 12.


Redox status of patients before cardiac surgery.

Schuh AK, Sheybani B, Jortzik E, Niemann B, Wilhelm J, Boening A, Becker K.

Redox Rep. 2018 Dec;23(1):83-93. doi: 10.1080/13510002.2017.1418620. Epub 2017 Dec 19.


Azacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens.

Seymour JF, Döhner H, Butrym A, Wierzbowska A, Selleslag D, Jang JH, Kumar R, Cavenagh J, Schuh AC, Candoni A, Récher C, Sandhu I, Del Castillo TB, Al-Ali HK, Falantes J, Stone RM, Minden MD, Weaver J, Songer S, Beach CL, Dombret H.

BMC Cancer. 2017 Dec 14;17(1):852. doi: 10.1186/s12885-017-3803-6.


[Peroneal nerve entrapment syndrome].

Schuh A, Handschu R, Eibl T, Janka M, Hönle W.

MMW Fortschr Med. 2017 Dec;159(21-22):84-88. doi: 10.1007/s15006-017-0399-3. Review. German. No abstract available.


Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups.

Burns A, Alsolami R, Becq J, Stamatopoulos B, Timbs A, Bruce D, Robbe P, Vavoulis D, Clifford R, Cabes M, Dreau H, Taylor J, Knight SJL, Mansson R, Bentley D, Beekman R, Martín-Subero JI, Campo E, Houlston RS, Ridout KE, Schuh A.

Leukemia. 2018 Feb;32(2):573. doi: 10.1038/leu.2017.311. Epub 2017 Nov 21.


Effect of an antimicrobial stewardship programme on antimicrobial utilisation and costs in patients with leukaemia: a retrospective controlled study.

So M, Mamdani MM, Morris AM, Lau TTY, Broady R, Deotare U, Grant J, Kim D, Schimmer AD, Schuh AC, Shajari S, Steinberg M, Bell CM, Husain S.

Clin Microbiol Infect. 2018 Aug;24(8):882-888. doi: 10.1016/j.cmi.2017.11.009. Epub 2017 Nov 11.


[Meralgia paraesthetica (Bernhardt-Roth syndrome)].

Schuh A, Handschu R, Eibl T, Janka M, Hönle W.

MMW Fortschr Med. 2017 Nov;159(19):66-68. doi: 10.1007/s15006-017-0282-2. Review. German. No abstract available.


Multimodal surface matching with higher-order smoothness constraints.

Robinson EC, Garcia K, Glasser MF, Chen Z, Coalson TS, Makropoulos A, Bozek J, Wright R, Schuh A, Webster M, Hutter J, Price A, Cordero Grande L, Hughes E, Tusor N, Bayly PV, Van Essen DC, Smith SM, Edwards AD, Hajnal J, Jenkinson M, Glocker B, Rueckert D.

Neuroimage. 2018 Feb 15;167:453-465. doi: 10.1016/j.neuroimage.2017.10.037. Epub 2017 Oct 31.


Assessing the relationship between movement and airflow in the upper airway using computational fluid dynamics with motion determined from magnetic resonance imaging.

Bates AJ, Schuh A, Amine-Eddine G, McConnell K, Loew W, Fleck RJ, Woods JC, Dumoulin CL, Amin RS.

Clin Biomech (Bristol, Avon). 2017 Oct 14. pii: S0268-0033(17)30223-1. doi: 10.1016/j.clinbiomech.2017.10.011. [Epub ahead of print]


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