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Items: 20


MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.

Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, Chalmers S, Sandison ME, Liu Q, Hedley A, McBryan T, Tang HY, Gorman N, Beer T, Speicher DW, Adams PD, Liu X, Schlegel R, McCarron JG, Wakelam MJO, Gottlieb E, Kossenkov AV, Schug ZT.

Br J Cancer. 2020 Jan 16. doi: 10.1038/s41416-019-0711-3. [Epub ahead of print]


Polyunsaturated Fatty Acids from Astrocytes Activate PPARĪ³ Signaling in Cancer Cells to Promote Brain Metastasis.

Zou Y, Watters A, Cheng N, Perry CE, Xu K, Alicea GM, Parris JLD, Baraban E, Ray P, Nayak A, Xu X, Herlyn M, Murphy ME, Weeraratna AT, Schug ZT, Chen Q.

Cancer Discov. 2019 Dec;9(12):1720-1735. doi: 10.1158/2159-8290.CD-19-0270. Epub 2019 Oct 2.


3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers.

Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO, Harris AL.

Mol Cancer Ther. 2019 Feb;18(2):376-388. doi: 10.1158/1535-7163.MCT-17-0857. Epub 2018 Nov 26.


Unique pattern of neutrophil migration and function during tumor progression.

Patel S, Fu S, Mastio J, Dominguez GA, Purohit A, Kossenkov A, Lin C, Alicea-Torres K, Sehgal M, Nefedova Y, Zhou J, Languino LR, Clendenin C, Vonderheide RH, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Schug ZT, Altieri DC, Gabrilovich DI.

Nat Immunol. 2018 Nov;19(11):1236-1247. doi: 10.1038/s41590-018-0229-5. Epub 2018 Oct 15.


Formaldehyde Detoxification Creates a New Wheel for the Folate-Driven One-Carbon "Bi"-cycle.

Schug ZT.

Biochemistry. 2018 Feb 13;57(6):889-890. doi: 10.1021/acs.biochem.7b01261. Epub 2018 Jan 25. No abstract available.


Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.

Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Vande Voorde J, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ.

Cell Rep. 2017 Jan 17;18(3):647-658. doi: 10.1016/j.celrep.2016.12.055.


The metabolic fate of acetate in cancer.

Schug ZT, Vande Voorde J, Gottlieb E.

Nat Rev Cancer. 2016 Nov;16(11):708-717. doi: 10.1038/nrc.2016.87. Epub 2016 Aug 26. Review.


Cancer metabolism at a glance.

Vazquez A, Kamphorst JJ, Markert EK, Schug ZT, Tardito S, Gottlieb E.

J Cell Sci. 2016 Sep 15;129(18):3367-73. doi: 10.1242/jcs.181016. Review.


Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye EO, Critchlow SE, Leung HY, Harris AL, Wakelam MJO, Gottlieb E, Schulze A.

Cancer Metab. 2016 Apr 1;4:6. doi: 10.1186/s40170-016-0146-8. eCollection 2016.


The Nurture of Tumors Can Drive Their Metabolic Phenotype.

Schug ZT, Vande Voorde J, Gottlieb E.

Cell Metab. 2016 Mar 8;23(3):391-2. doi: 10.1016/j.cmet.2016.02.016.


Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.

Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJ, Schulze A, Gottlieb E.

Cancer Cell. 2015 Jan 12;27(1):57-71. doi: 10.1016/j.ccell.2014.12.002.


Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.

Patella F, Schug ZT, Persi E, Neilson LJ, Erami Z, Avanzato D, Maione F, Hernandez-Fernaud JR, Mackay G, Zheng L, Reid S, Frezza C, Giraudo E, Fiorio Pla A, Anderson K, Ruppin E, Gottlieb E, Zanivan S.

Mol Cell Proteomics. 2015 Mar;14(3):621-34. doi: 10.1074/mcp.M114.045575. Epub 2015 Jan 8.


The music of lipids: how lipid composition orchestrates cellular behaviour.

Schug ZT, Frezza C, Galbraith LC, Gottlieb E.

Acta Oncol. 2012 Mar;51(3):301-10. doi: 10.3109/0284186X.2011.643823. Epub 2012 Jan 30.


BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane.

Schug ZT, Gonzalvez F, Houtkooper RH, Vaz FM, Gottlieb E.

Cell Death Differ. 2011 Mar;18(3):538-48. doi: 10.1038/cdd.2010.135. Epub 2010 Nov 12.


Calcium-dependent conformational changes in inositol trisphosphate receptors.

Anyatonwu G, Khan MT, Schug ZT, da Fonseca PC, Morris EP, Joseph SK.

J Biol Chem. 2010 Aug 6;285(32):25085-93. doi: 10.1074/jbc.M110.123208. Epub 2010 Jun 8.


Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.

Schug ZT, Gottlieb E.

Biochim Biophys Acta. 2009 Oct;1788(10):2022-31. doi: 10.1016/j.bbamem.2009.05.004. Epub 2009 May 18. Review.


Cardiolipin provides an essential activating platform for caspase-8 on mitochondria.

Gonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJ, Petit PX, Vaz FM, Gottlieb E.

J Cell Biol. 2008 Nov 17;183(4):681-96. doi: 10.1083/jcb.200803129. Epub 2008 Nov 10.


Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment.

Schug ZT, da Fonseca PC, Bhanumathy CD, Wagner L 2nd, Zhang X, Bailey B, Morris EP, Yule DI, Joseph SK.

J Biol Chem. 2008 Feb 1;283(5):2939-48. Epub 2007 Nov 19.


Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.

Khan MT, Bhanumathy CD, Schug ZT, Joseph SK.

J Biol Chem. 2007 Nov 9;282(45):32983-90. Epub 2007 Sep 17.


The role of the S4-S5 linker and C-terminal tail in inositol 1,4,5-trisphosphate receptor function.

Schug ZT, Joseph SK.

J Biol Chem. 2006 Aug 25;281(34):24431-40. Epub 2006 Jun 30.

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