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Items: 1 to 50 of 156

1.

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity.

Donepudi AC, Goedken MJ, Schuetz JD, E Manautou J.

Toxicol Rep. 2019 Aug 7;6:841-849. doi: 10.1016/j.toxrep.2019.08.005. eCollection 2019.

2.

Corrigendum to "Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles" [379 (2019) 55-64].

O'Reilly C, Cho JH, Qi Q, Peters JL, Fukuda Y, Frase S, Peng J, Schuetz JD, Cheng Y, Yoon SO, Han MJ.

Exp Cell Res. 2019 Aug 1;381(1):163. doi: 10.1016/j.yexcr.2019.05.002. Epub 2019 May 9. No abstract available.

PMID:
31079852
3.

Regulation of gene expression by miR-144/451 during mouse erythropoiesis.

Xu P, Palmer LE, Lechauve C, Zhao G, Yao Y, Luan J, Vourekas A, Tan H, Peng J, Schuetz JD, Mourelatos Z, Wu G, Weiss MJ, Paralkar VR.

Blood. 2019 Jun 6;133(23):2518-2528. doi: 10.1182/blood.2018854604. Epub 2019 Apr 10.

PMID:
30971389
4.

Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles.

O'Reilly C, Cho JH, Qi Q, Peters JL, Fukuda Y, Frase S, Peng J, Schuetz JD, Cheng Y, Yoon SO, Han MJ.

Exp Cell Res. 2019 Jun 1;379(1):55-64. doi: 10.1016/j.yexcr.2019.03.028. Epub 2019 Mar 25. Erratum in: Exp Cell Res. 2019 Aug 1;381(1):163.

PMID:
30922922
5.

Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice.

Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Traxl A, Schuetz JD, Kuntner C, Pahnke J, Langer O.

Mol Imaging Biol. 2019 Apr;21(2):306-316. doi: 10.1007/s11307-018-1230-y.

6.

Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions.

Crawford RR, Potukuchi PK, Schuetz EG, Schuetz JD.

Drug Metab Dispos. 2018 May;46(5):567-580. doi: 10.1124/dmd.118.080663. Epub 2018 Mar 7. Review.

7.

ABCB6, an ABC Transporter Impacting Drug Response and Disease.

Boswell-Casteel RC, Fukuda Y, Schuetz JD.

AAPS J. 2017 Nov 30;20(1):8. doi: 10.1208/s12248-017-0165-6. Review.

8.

Obstacles to Brain Tumor Therapy: Key ABC Transporters.

Wijaya J, Fukuda Y, Schuetz JD.

Int J Mol Sci. 2017 Nov 27;18(12). pii: E2544. doi: 10.3390/ijms18122544. Review.

9.

A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer.

Nakanishi T, Ohno Y, Aotani R, Maruyama S, Shimada H, Kamo S, Oshima H, Oshima M, Schuetz JD, Tamai I.

Sci Rep. 2017 Nov 29;7(1):16567. doi: 10.1038/s41598-017-16738-y.

10.

An unexpected protein interaction promotes drug resistance in leukemia.

Pitre A, Ge Y, Lin W, Wang Y, Fukuda Y, Temirov J, Phillips AH, Peters JL, Fan Y, Ma J, Nourse A, Sinha C, Lin H, Kriwacki R, Downing JR, Gruber TA, Centonze VE, Naren AP, Chen T, Schuetz JD.

Nat Commun. 2017 Nov 16;8(1):1547. doi: 10.1038/s41467-017-01678-y.

11.

Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency.

Ellis JL, Bove KE, Schuetz EG, Leino D, Valencia CA, Schuetz JD, Miethke A, Yin C.

Hepatology. 2018 Apr;67(4):1531-1545. doi: 10.1002/hep.29632. Epub 2018 Feb 23.

12.

Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD.

JCI Insight. 2017 Aug 3;2(15). pii: 92409. doi: 10.1172/jci.insight.92409. eCollection 2017 Aug 3.

13.

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

Murray J, Valli E, Yu DMT, Truong AM, Gifford AJ, Eden GL, Gamble LD, Hanssen KM, Flemming CL, Tan A, Tivnan A, Allan S, Saletta F, Cheung L, Ruhle M, Schuetz JD, Henderson MJ, Byrne JA, Norris MD, Haber M, Fletcher JI.

Eur J Cancer. 2017 Sep;83:132-141. doi: 10.1016/j.ejca.2017.06.024. Epub 2017 Jul 20.

14.

Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.

Liu C, Janke LJ, Yang JJ, Evans WE, Schuetz JD, Relling MV.

Cancer Chemother Pharmacol. 2017 Aug;80(2):287-293. doi: 10.1007/s00280-017-3361-2. Epub 2017 Jun 16.

15.

Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.

Kanamitsu K, Kusuhara H, Schuetz JD, Takeuchi K, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2566-2575. doi: 10.1016/j.xphs.2017.04.040. Epub 2017 Apr 27.

16.

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.

Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, Trent RJ, Schuetz JD.

Nat Commun. 2016 Aug 10;7:12353. doi: 10.1038/ncomms12353.

17.

ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression.

Drenberg CD, Hu S, Li L, Buelow DR, Orwick SJ, Gibson AA, Schuetz JD, Sparreboom A, Baker SD.

Clin Transl Sci. 2016 Feb;9(1):51-9. doi: 10.1111/cts.12366. Epub 2016 Feb 4.

18.

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.

Morgan JA, Lynch J, Panetta JC, Wang Y, Frase S, Bao J, Zheng J, Opferman JT, Janke L, Green DM, Chemaitilly W, Schuetz JD.

Sci Rep. 2015 Nov 18;5:16488. doi: 10.1038/srep16488.

19.

Maternal bile acid transporter deficiency promotes neonatal demise.

Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD.

Nat Commun. 2015 Sep 29;6:8186. doi: 10.1038/ncomms9186.

20.

The ABCC4 membrane transporter modulates platelet aggregation.

Cheepala SB, Pitre A, Fukuda Y, Takenaka K, Zhang Y, Wang Y, Frase S, Pestina T, Gartner TK, Jackson C, Schuetz JD.

Blood. 2015 Nov 12;126(20):2307-19. doi: 10.1182/blood-2014-08-595942. Epub 2015 Sep 24.

21.

ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.

Morfouace M, Cheepala S, Jackson S, Fukuda Y, Patel YT, Fatima S, Kawauchi D, Shelat AA, Stewart CF, Sorrentino BP, Schuetz JD, Roussel MF.

Cancer Res. 2015 Sep 15;75(18):3879-89. doi: 10.1158/0008-5472.CAN-15-0030. Epub 2015 Jul 21.

22.

PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration.

Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP.

Cell Signal. 2015 Jul;27(7):1345-55. doi: 10.1016/j.cellsig.2015.03.022. Epub 2015 Apr 2.

23.

Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.

Moon C, Zhang W, Ren A, Arora K, Sinha C, Yarlagadda S, Woodrooffe K, Schuetz JD, Valasani KR, de Jonge HR, Shanmukhappa SK, Shata MT, Buddington RK, Parthasarathi K, Naren AP.

J Biol Chem. 2015 May 1;290(18):11246-57. doi: 10.1074/jbc.M114.605410. Epub 2015 Mar 11.

24.

ABC transporters and cancer. Preface.

Schuetz JD, Ishikawa T.

Adv Cancer Res. 2015;125:xv-xvii. doi: 10.1016/S0065-230X(15)00010-X. No abstract available.

PMID:
25640273
25.

Leukemia and ABC transporters.

Fukuda Y, Lian S, Schuetz JD.

Adv Cancer Res. 2015;125:171-96. doi: 10.1016/bs.acr.2014.10.006. Epub 2015 Jan 8. Review.

PMID:
25640270
26.

The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJF, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

Cell Metab. 2014 Nov 4;20(5):787-798. doi: 10.1016/j.cmet.2014.09.004.

27.

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP.

Nat Cell Biol. 2014 Sep;16(9):841-51. doi: 10.1038/ncb3029. Epub 2014 Aug 31.

28.

The role of transporters in toxicity and disease.

Schuetz JD, Swaan PW, Tweedie DJ.

Drug Metab Dispos. 2014 Apr;42(4):541-5. doi: 10.1124/dmd.114.057539. Review.

29.

Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.

Murphy AJ, Sarrazy V, Wang N, Bijl N, Abramowicz S, Westerterp M, Welch CB, Schuetz JD, Yvan-Charvet L.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):751-8. doi: 10.1161/ATVBAHA.113.302613. Epub 2014 Feb 6.

PMID:
24504733
30.

Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?

Haslam IS, Pitre A, Schuetz JD, Paus R.

Trends Pharmacol Sci. 2013 Nov;34(11):599-604. doi: 10.1016/j.tips.2013.09.001. Epub 2013 Oct 4.

PMID:
24100054
31.

Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib.

Furmanski BD, Hu S, Fujita KI, Li L, Gibson AA, Janke LJ, Williams RT, Schuetz JD, Sparreboom A, Baker SD.

Clin Cancer Res. 2013 Aug 15;19(16):4359-4370. doi: 10.1158/1078-0432.CCR-13-0980. Epub 2013 Jun 21.

32.

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.

Wang X, Bathina M, Lynch J, Koss B, Calabrese C, Frase S, Schuetz JD, Rehg JE, Opferman JT.

Genes Dev. 2013 Jun 15;27(12):1351-64. doi: 10.1101/gad.215855.113.

33.

Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.

Fukuda Y, Takenaka K, Sparreboom A, Cheepala SB, Wu CP, Ekins S, Ambudkar SV, Schuetz JD.

Mol Pharmacol. 2013 Sep;84(3):361-71. doi: 10.1124/mol.113.086967. Epub 2013 Jun 17.

34.

Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression.

Cheepala SB, Bao J, Nachagari D, Sun D, Wang Y, Zhong TP, Naren AP, Zheng J, Schuetz JD.

J Biol Chem. 2013 Aug 2;288(31):22207-18. doi: 10.1074/jbc.M113.476218. Epub 2013 Jun 13. Erratum in: J Biol Chem. 2013 Sep 13;288(37):26821. Zhong, Tao [corrected to Zhong, Tao P].

35.

The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.

Schymeinsky J, Mayer H, Tomsic C, Tilp C, Schuetz JD, Cui Y, Wollin L, Gantner F, Erb KJ.

PLoS One. 2013 Apr 22;8(4):e61193. doi: 10.1371/journal.pone.0061193. Print 2013.

36.

Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.

Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Zhang W, Cheepala SB, Schuetz JD, Naren AP.

J Biol Chem. 2013 Feb 8;288(6):3786-94. doi: 10.1074/jbc.M112.435925. Epub 2012 Dec 21.

37.

Forskolin modifies retinal vascular development in Mrp4-knockout mice.

Matsumiya W, Kusuhara S, Hayashibe K, Maruyama K, Kusuhara H, Tagami M, Schuetz JD, Negi A.

Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35. doi: 10.1167/iovs.12-10781.

38.

Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.

Cheepala S, Hulot JS, Morgan JA, Sassi Y, Zhang W, Naren AP, Schuetz JD.

Annu Rev Pharmacol Toxicol. 2013;53:231-53. doi: 10.1146/annurev-pharmtox-010611-134609. Epub 2012 Oct 16. Review.

39.

Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice.

Zhang Y, Li F, Patterson AD, Wang Y, Krausz KW, Neale G, Thomas S, Nachagari D, Vogel P, Vore M, Gonzalez FJ, Schuetz JD.

J Biol Chem. 2012 Jul 13;287(29):24784-94. doi: 10.1074/jbc.M111.329318. Epub 2012 May 22.

40.

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT.

Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488.

41.

Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice.

Morgan JA, Cheepala SB, Wang Y, Neale G, Adachi M, Nachagari D, Leggas M, Zhao W, Boyd K, Venkataramanan R, Schuetz JD.

J Biol Chem. 2012 Apr 27;287(18):14456-66. doi: 10.1074/jbc.M111.319681. Epub 2012 Feb 28.

42.

ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz JD.

J Biol Chem. 2012 Apr 13;287(16):12679-90. doi: 10.1074/jbc.M111.336180. Epub 2012 Jan 31.

43.

ABC transporters and their role in nucleoside and nucleotide drug resistance.

Fukuda Y, Schuetz JD.

Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. doi: 10.1016/j.bcp.2011.12.042. Epub 2012 Jan 20. Review.

44.

IDH1 and IDH2 mutations in pediatric acute leukemia.

Andersson AK, Miller DW, Lynch JA, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, Schulman BA, Downing JR.

Leukemia. 2011 Oct;25(10):1570-7. doi: 10.1038/leu.2011.133. Epub 2011 Jun 7.

45.

Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity.

Nagai S, Takenaka K, Nachagari D, Rose C, Domoney K, Sun D, Sparreboom A, Schuetz JD.

Cancer Res. 2011 Mar 1;71(5):1781-91. doi: 10.1158/0008-5472.CAN-10-1919. Epub 2011 Jan 18.

46.

Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.

Fukuda Y, Aguilar-Bryan L, Vaxillaire M, Dechaume A, Wang Y, Dean M, Moitra K, Bryan J, Schuetz JD.

J Biol Chem. 2011 Mar 11;286(10):8481-92. doi: 10.1074/jbc.M110.174516. Epub 2011 Jan 3.

47.

The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival.

Krishnamurthy P, Schuetz JD.

Curr Pharm Biotechnol. 2011 Apr;12(4):647-55. Review.

PMID:
21118089
48.

Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer.

Li C, Schuetz JD, Naren AP.

Cancer Lett. 2010 Jun 28;292(2):246-53. doi: 10.1016/j.canlet.2009.12.009. Epub 2010 Jan 20.

49.

Cell survival under stress is enhanced by a mitochondrial ATP-binding cassette transporter that regulates hemoproteins.

Lynch J, Fukuda Y, Krishnamurthy P, Du G, Schuetz JD.

Cancer Res. 2009 Jul 1;69(13):5560-7. doi: 10.1158/0008-5472.CAN-09-0078. Epub 2009 Jun 23.

50.

Unimpaired immune functions in the absence of Mrp4 (Abcc4).

van de Ven R, de Groot J, Reurs AW, Wijnands PG, van de Wetering K, Schuetz JD, de Gruijl TD, Scheper RJ, Scheffer GL.

Immunol Lett. 2009 Jun 4;124(2):81-7. doi: 10.1016/j.imlet.2009.04.007. Epub 2009 May 3.

PMID:
19406153

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